Proteomics of osteoarthritic chondrocytes and cartilage

References

• Lawrence RC, Felson DT, Helmick CG et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. Arthritis Rheum.58(1), 26–35 (2008).
   PubMed Web of Science ®Google Scholar
• Green GA. Understanding NSAIDs: from aspirin to COX-2. Clin. Cornerstone3(5), 50–60 (2001).
   PubMedGoogle Scholar
• Messier SP. Obesity and osteoarthritis: disease genesis and nonpharmacologic weight management. Rheum. Dis. Clin. North Am.34(3), 713–729 (2008).
   PubMed Web of Science ®Google Scholar
• Sandell LJ, Aigner T. Articular cartilage and changes in arthritis. An introduction: cell biology of osteoarthritis. Arthritis Res.3(2), 107–113 (2001).
   PubMedGoogle Scholar
• Abramson SB, Attur M, Yazici Y. Prospects for disease modification in osteoarthritis. Nat. Clin. Pract. Rheumatol.2(6), 304–312 (2006).
   PubMedGoogle Scholar
• Mc Anulty R, Laurent, GJ. In vivo measurement of collagen metabolism in cartilage and bone. In: Methods in Cartilage Research. Academic Press Inc., MA, USA 140–142 (1990).
   Google Scholar
• Aigner T, Reichenberger E, Bertling W et al. Type X collagen expression in osteoarthritic and rheumatoid articular cartilage. Virchows Arch. B Cell Pathol.63(4), 205–211 (1993).
   Google Scholar
• Sato T, Konomi K, Yamasaki S et al. Comparative analysis of gene expression profiles in intact and damaged regions of human osteoarthritic cartilage. Arthritis Rheum.54(3), 808–817 (2006).
   PubMed Web of Science ®Google Scholar
• Watters JW, Cheng C, Pickarski M et al. Inverse relationship between matrix remodeling and lipid metabolism during osteoarthritis progression in the STR/Ort mouse. Arthritis Rheum.56(9), 2999–3009 (2007).
   PubMed Web of Science ®Google Scholar
• Iliopoulos D, Malizos KN, Tsezou A. Epigenetic regulation of leptin affects MMP-13 expression in osteoarthritic chondrocytes: possible molecular target for osteoarthritis therapeutic intervention. Ann. Rheum. Dis.66(12), 1616–1621 (2007).
   PubMed Web of Science ®Google Scholar
• Loeser RF, Im HJ, Richardson B, Lu Q, Chubinskaya S. Methylation of the OP-1 promoter: potential role in the age-related decline in OP-1 expression in cartilage. Osteoarthr. Cartil.17(4), 513–517 (2009).
   PubMed Web of Science ®Google Scholar
• Nasu Y, Nishida K, Miyazawa S et al. Trichostatin A, a histone deacetylase inhibitor, suppresses synovial inflammation and subsequent cartilage destruction in a collagen antibody-induced arthritis mouse model. Osteoarthr. Cartil.16(6), 723–732 (2008).
   PubMed Web of Science ®Google Scholar
• Sakimura R, Tanaka K, Yamamoto S et al. The effects of histone deacetylase inhibitors on the induction of differentiation in chondrosarcoma cells. Clin. Cancer Res.13(1), 275–282 (2007).
   PubMed Web of Science ®Google Scholar
• McManus MT, Sharp PA. Gene silencing in mammals by small interfering RNAs. Nat. Rev. Genet.3(10), 737–747 (2002).
   PubMed Web of Science ®Google Scholar
• Esquela-Kerscher A, Slack FJ. Oncomirs – microRNAs with a role in cancer. Nat. Rev. Cancer6(4), 259–269 (2006).
   PubMed Web of Science ®Google Scholar
• Iliopoulos D, Malizos KN, Oikonomou P, Tsezou A. Integrative microRNA and proteomic approaches identify novel osteoarthritis genes and their collaborative metabolic and inflammatory networks. PLoS ONE3(11), e3740 (2008).
   PubMed Web of Science ®Google Scholar
• Pandey DP, Picard D. miR-22 inhibits estrogen signaling by directly targeting the estrogen receptor a mRNA. Mol. Cell. Biol.29(13), 3783–3790 (2009).
   PubMed Web of Science ®Google Scholar
• Bhaumik D, Scott GK, Schokrpur S et al. MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8. Aging (Albany NY)1(4), 402–411 (2009).
   PubMedGoogle Scholar
• Curtale G, Citarella F, Carissimi C et al. An emerging player in the adaptive immune response: microRNA-146a is a modulator of IL-2 expression and activation-induced cell death in T lymphocytes. Blood115(2), 265–273 (2010).
   PubMed Web of Science ®Google Scholar
• Li G, Luna C, Qiu J, Epstein DL, Gonzalez P. Modulation of inflammatory markers by miR-146a during replicative senescence in trabecular meshwork cells. Invest. Ophthalmol. Vis. Sci.51(6), 2976–2985 (2010).
   PubMed Web of Science ®Google Scholar
• Yamasaki K, Nakasa T, Miyaki S et al. Expression of microRNA-146a in osteoarthritis cartilage. Arthritis Rheum.60(4), 1035–1041 (2009).
   PubMed Web of Science ®Google Scholar
• Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell136(2), 215–233 (2009).
   PubMed Web of Science ®Google Scholar
• Klose RJ, Zhang Y. Regulation of histone methylation by demethylimination and demethylation. Nat. Rev. Mol. Cell Biol.8(4), 307–318 (2007).
   PubMed Web of Science ®Google Scholar
• Ravid T, Hochstrasser M. Diversity of degradation signals in the ubiquitin–proteasome system. Nat. Rev. Mol. Cell Biol.9(9), 679–690 (2008).
   PubMed Web of Science ®Google Scholar
• Ubersax JA, Ferrell JE Jr. Mechanisms of specificity in protein phosphorylation. Nat. Rev. Mol. Cell Biol.8(7), 530–541 (2007).
   PubMed Web of Science ®Google Scholar
• De Ceuninck F, Berenbaum F. Proteomics: addressing the challenges of osteoarthritis. Drug Discov. Today14(13–14), 661–667 (2009).
   PubMed Web of Science ®Google Scholar
• Wilson R, Whitelock M, Bateman JF. Proteomics makes progress in cartilage and arthritis research. Matrix Biol.28(3), 121–128 (2009).
   PubMed Web of Science ®Google Scholar
• Garcia BA, Platt D, Born TL et al. Protein profile of osteoarthritic human articular cartilage using tandem mass spectrometry. Rapid Commun. Mass Spectrom.20(20), 2999–3006 (2006).
   PubMed Web of Science ®Google Scholar
• Guo D, Tan W, Wang F et al. Proteomic analysis of human articular cartilage: identification of differentially expressed proteins in knee osteoarthritis. Joint Bone Spine75(4), 439–444 (2008).
   PubMed Web of Science ®Google Scholar
• Hermansson M, Sawaji Y, Bolton M et al. Proteomic analysis of articular cartilage shows increased type II collagen synthesis in osteoarthritis and expression of inhibin bA (activin A), a regulatory molecule for chondrocytes. J. Biol. Chem.279(42), 43514–43521 (2004).
   PubMed Web of Science ®Google Scholar
• Vincourt JB, Vignaud M, Lionneton F et al. Increased expression of matrilin-3 not only in osteoarthritic articular cartilage but also in cartilage-forming tumors, and down-regulation of SOX9 via epidermal growth factor domain 1-dependent signaling. Arthritis Rheum.58(9), 2798–2808 (2008).
   PubMed Web of Science ®Google Scholar
• Wilson R, Bateman F. A robust method for proteomic characterization of mouse cartilage using solubility-based sequential fractionation and two-dimensional gel electrophoresis. Matrix Biol.27(8), 709–712 (2008).
   PubMed Web of Science ®Google Scholar
• Wilson R, Belluoccio D, Little B, Fosang AJ, Bateman JF. Proteomic characterization of mouse cartilage degradation in vitro.Arthritis Rheum.58(10), 3120–3131 (2008).
   PubMed Web of Science ®Google Scholar
• Wu J, Liu W, Bemis A et al. Comparative proteomic characterization of articular cartilage tissue from normal donors and patients with osteoarthritis. Arthritis Rheum.56(11), 3675–3684 (2007).
   PubMed Web of Science ®Google Scholar
• Zhen EY, Brittain IJ, Laska DA et al. Characterization of metalloprotease cleavage products of human articular cartilage. Arthritis Rheum.58(8), 2420–2431 (2008).
   PubMed Web of Science ®Google Scholar
• De Ceuninck F, Marcheteau E, Berger S et al. Assessment of some tools for the characterization of the human osteoarthritic cartilage proteome. J. Biomol. Tech.16(3), 256–265 (2005).
   PubMedGoogle Scholar
• De Ceuninck F, Dassencourt L, Anract P. The inflammatory side of human chondrocytes unveiled by antibody microarrays. Biochem. Biophys. Res. Commun.323(3), 960–969 (2004).
   PubMed Web of Science ®Google Scholar
• Pecora F, Forlino A, Gualeni B et al. A quantitative and qualitative method for direct 2-DE analysis of murine cartilage. Proteomics7(21), 4003–4007 (2007).
   PubMed Web of Science ®Google Scholar
• Catterall JB, Rowan AD, Sarsfield S et al. Development of a novel 2D proteomics approach for the identification of proteins secreted by primary chondrocytes after stimulation by IL-1 and oncostatin M. Rheumatology (Oxford)45(9), 1101–1109 (2006).
   PubMed Web of Science ®Google Scholar
• Freyria AM, Ronziere MC, Boutillon MM, Herbage D. Two-dimensional electrophoresis of intracellular and secreted protein synthesized by fetal bovine chondrocytes in high-density culture. Electrophoresis16(7), 1268–1272 (1995).
   PubMed Web of Science ®Google Scholar
• Ruiz-Romero C, Lopez-Armada MJ, Blanco FJ. Proteomic characterization of human normal articular chondrocytes: a novel tool for the study of osteoarthritis and other rheumatic diseases. Proteomics5(12), 3048–3059 (2005).
   PubMed Web of Science ®Google Scholar
• Freyria AM, Becchi M. Changes of chondrocyte metabolism in vitro: an approach by proteomic analysis. Methods Mol. Med.100, 165–182 (2004).
   PubMedGoogle Scholar
• Lambrecht S, Verbruggen G, Verdonk PC, Elewaut D, Deforce D. Differential proteome analysis of normal and osteoarthritic chondrocytes reveals distortion of vimentin network in osteoarthritis. Osteoarthr. Cartil.16(2), 163–173 (2008).
   PubMed Web of Science ®Google Scholar
• Ruiz-Romero C, Blanco FJ. The role of proteomics in osteoarthritis pathogenesis research. Curr. Drug Targets10(6), 543–556 (2009).
   PubMed Web of Science ®Google Scholar
• Woods A, Wang G, Beier F. Regulation of chondrocyte differentiation by the actin cytoskeleton and adhesive interactions. J. Cell Physiol.213(1), 1–8 (2007).
   PubMed Web of Science ®Google Scholar
• Vincourt JB, Lionneton F, Kratassiouk G et al. Establishment of a reliable method for direct proteome characterization of human articular cartilage. Mol. Cell Proteomics5(10), 1984–1995 (2006).
   PubMed Web of Science ®Google Scholar
• Perez-Perez R, Ortega-Delgado FJ, Garcia-Santos E et al. Differential proteomics of omental and subcutaneous adipose tissue reflects their unalike biochemical and metabolic properties. J. Proteome Res. DOI: 10.1021/pr800942k (2009) (Epub ahead of print).
   PubMedGoogle Scholar
• Zhao Y, Lee WN, Xiao GG. Quantitative proteomics and biomarker discovery in human cancer. Expert Rev. Proteomics6(2), 115–118 (2009).
   PubMed Web of Science ®Google Scholar
• Cohen NP, Foster RJ, Mow VC. Composition and dynamics of articular cartilage: structure, function, and maintaining healthy state. J. Orthop. Sports Phys. Ther.28(4), 203–215 (1998).
   PubMed Web of Science ®Google Scholar
• Kirsch T. Annexins – their role in cartilage mineralization. Front. Biosci.10, 576–581 (2005).
   PubMed Web of Science ®Google Scholar
• Lorenz P, Ruschpler P, Koczan D, Stiehl P, Thiesen HJ. From transcriptome to proteome: differentially expressed proteins identified in synovial tissue of patients suffering from rheumatoid arthritis and osteoarthritis by an initial screen with a panel of 791 antibodies. Proteomics3(6), 991–1002 (2003).
   PubMed Web of Science ®Google Scholar
• Polacek M, Bruun JA, Johansen O, Martinez I. Differences in the secretome of cartilage explants and cultured chondrocytes unveiled by SILAC technology. J. Orthop. Res.28(8), 1040–1049 (2010).
   PubMed Web of Science ®Google Scholar
• Liao H, Wu J, Kuhn E et al. Use of mass spectrometry to identify protein biomarkers of disease severity in the synovial fluid and serum of patients with rheumatoid arthritis. Arthritis Rheum.50(12), 3792–3803 (2004).
   PubMed Web of Science ®Google Scholar
• Washburn MP, Ulaszek R, Deciu C, Schieltz DM, Yates JR 3rd. Analysis of quantitative proteomic data generated via multidimensional protein identification technology. Anal. Chem.74(7), 1650–1657 (2002).
   PubMed Web of Science ®Google Scholar
• Zerovnik E. The emerging role of cystatins in Alzheimer’s disease. Bioessays31(6), 597–599 (2009).
   PubMed Web of Science ®Google Scholar
• Novinec M, Kovacic L, Skrlj N, Turk V, Lenarcic B. Recombinant human SMOCs produced by in vitro refolding: calcium-binding properties and interactions with serum proteins. Protein Expr. Purif.62(1), 75–82 (2008).
   PubMed Web of Science ®Google Scholar
• Yoshida Y, Chiba T, Tokunaga F et al. E3 ubiquitin ligase that recognizes sugar chains. Nature418(6896), 438–442 (2002).
   PubMed Web of Science ®Google Scholar
• Ruiz-Romero C, Carreira V, Rego I et al. Proteomic analysis of human osteoarthritic chondrocytes reveals protein changes in stress and glycolysis. Proteomics8(3), 495–507 (2008).
   PubMed Web of Science ®Google Scholar
• Messaoudi S, Peyrat JF, Brion JD, Alami M. Recent advances in Hsp90 inhibitors as antitumor agents. Anticancer Agents Med. Chem.8(7), 761–782 (2008).
   PubMed Web of Science ®Google Scholar
• Witke SA W, Hartwig JH, Azuma T, Stossel TP, Kwiatkowski DJ. Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin. Cell81(1), 41–51 (1995).
   PubMed Web of Science ®Google Scholar
• Vasioukhin V, Fuchs E. Actin dynamics and cell–cell adhesion in epithelia. Curr. Opin. Cell Biol.13, 76–84 (2001).
   PubMed Web of Science ®Google Scholar
• Aidinis V, Carninci, P., Armaka G et al. Cytoskeletal rearrangements in synovial fibroblasts as a novel pathophysiological determinant of modeled rheumatoid arthritis. PLoS Genet.1(4), e48 (2005); erratum in PLoS Genet.1(5), e73 (2005).
   PubMed Web of Science ®Google Scholar
• Giganti A, Friederich E. The actin cytoskeleton as a therapeutic target: state of the art and future directions. Prog. Cell Cycle Res.5, 511–525 (2003).
   PubMedGoogle Scholar
• Vasilopoulos Y. Gkretsi V, Armaka M, Aidinis V, Kollias G. Actin cytoskeleton dynamics linked to synovial fibroblast activation as a novel pathogenic principle in TNF-driven arthritis. Ann. Rheum. Dis.66(Suppl. 3), 23–28 (2007).
   PubMed Web of Science ®Google Scholar
• Lee D, Kiener HP, Agarwal SK et al. Cadherin-11 in synovial lining formation and pathology in arthritis. Science315(5814), 1006–1010 (2007).
   PubMed Web of Science ®Google Scholar
• Medici D, Razzaque MS, Deluca S et al. FGF-23-Klotho signaling stimulates proliferation and prevents vitamin D-induced apoptosis. J. Cell Biol.182(3), 459–465 (2008).
   PubMed Web of Science ®Google Scholar
• Perwad F, Zhang MY, Tenenhouse HS, Portale AA. Fibroblast growth factor 23 impairs phosphorus and vitamin D metabolism in vivo and suppresses 25-hydroxyvitamin D-1α-hydroxylase expression in vitro.Am. J. Physiol. Renal Physiol.293(5), F1577–F1583 (2007).
   PubMed Web of Science ®Google Scholar
• Ito G, Uchiyama M, Kondo M et al. Kruppel-like factor 6 is frequently down-regulated and induces apoptosis in non-small cell lung cancer cells. Cancer Res.64(11), 3838–3843 (2004).
   PubMed Web of Science ®Google Scholar
• Sangodkar J, Shi J, DiFeo A et al. Functional role of the KLF6 tumour suppressor gene in gastric cancer. Eur. J. Cancer45(4), 666–676 (2009).
   PubMed Web of Science ®Google Scholar
• Iliopoulos D, Guler G, Han SY et al. Fragile genes as biomarkers: epigenetic control of WWOX and FHIT in lung, breast and bladder cancer. Oncogene24(9), 1625–1633 (2005).
   PubMed Web of Science ®Google Scholar
• Aqeilan RI, Hagan JP, de Bruin A et al. Targeted ablation of the WW domain-containing oxidoreductase tumor suppressor leads to impaired steroidogenesis. Endocrinology150(3), 1530–1535 (2009).
   PubMed Web of Science ®Google Scholar
• Boileau C, J Martel-Pelletier, Fahmi H et al. The peroxisome proliferator-activated receptor g agonist pioglitazone reduces the development of cartilage lesions in an experimental dog model of osteoarthritis: in vivo protective effects mediated through the inhibition of key signaling and catabolic pathways. Arthritis Rheum.56(7), 2288–2298 (2007).
   PubMed Web of Science ®Google Scholar
• Kobayashi T, Notoya K, Naito T et al. Pioglitazone, a peroxisome proliferator-activated receptor g agonist, reduces the progression of experimental osteoarthritis in guinea pigs. Arthritis Rheum.52(2), 479–487 (2005).
   PubMed Web of Science ®Google Scholar
• Gobezie R, Kho A, Krastins B et al. High abundance synovial fluid proteome: distinct profiles in health and osteoarthritis. Arthritis Res. Ther.9(2), R36 (2007).
   PubMed Web of Science ®Google Scholar
• Kamphorst JJ, van der Heijden R, DeGroot J et al. Profiling of endogenous peptides in human synovial fluid by NanoLC-MS: method validation and peptide identification. J. Proteome Res.6(11), 4388–4396 (2007).
   PubMed Web of Science ®Google Scholar
• Sinz A, Bantscheff M, Mikkat S et al. Mass spectrometric proteome analyses of synovial fluids and plasmas from patients suffering from rheumatoid arthritis and comparison to reactive arthritis or osteoarthritis. Electrophoresis23(19), 3445–3456 (2002).
   PubMed Web of Science ®Google Scholar
• Ruiz-Romero C, Blanco FJ. Proteomics role in the search for improved diagnosis, prognosis and treatment of osteoarthritis. Osteoarthr. Cartil.18(4), 500–509 (2010).
   PubMed Web of Science ®Google Scholar
• Mengshol JA, Vincenti MP, Coon CI, Barchowsky A, Brinckerhoff CE. Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor κB: differential regulation of collagenase 1 and collagenase 3. Arthritis Rheum.43(4), 801–811 (2000).
   PubMed Web of Science ®Google Scholar
• Schmidt-Rohlfing B, Gavenis K, Kippels M, Schneider U. New potential markers for cartilage degradation of the knee joint. Scand. J. Rheumatol.31(3), 151–157 (2002).
   PubMed Web of Science ®Google Scholar
• Evans CH. Novel biological approaches to the intra-articular treatment of osteoarthritis. BioDrugs19(6), 355–362 (2005).
   PubMed Web of Science ®Google Scholar
• Evans CH, Gouze JN, Gouze E, Robbins PD, Ghivizzani SC. Osteoarthritis gene therapy. Gene Ther.11(4), 379–389 (2004).
   PubMed Web of Science ®Google Scholar
• Evans CH, Robbins PD, Ghivizzani SC et al. Gene transfer to human joints: progress toward a gene therapy of arthritis. Proc. Natl Acad. Sci. USA102(24), 8698–8703 (2005).
   PubMed Web of Science ®Google Scholar
• Rudolphi K, Gerwin N, Verzijl N, van der Kraan P, van den Berg W. Pralnacasan, an inhibitor of interleukin-1β converting enzyme, reduces joint damage in two murine models of osteoarthritis. Osteoarthr. Cartil.11(10), 738–746 (2003).
   PubMed Web of Science ®Google Scholar
• Chevalier X, Goupille P, Beaulieu AD et al. Intraarticular injection of anakinra in osteoarthritis of the knee: a multicenter, randomized, double-blind, placebo-controlled study. Arthritis Rheum.61(3), 344–352 (2009).
   PubMed Web of Science ®Google Scholar
• Alexeyenko A, Sonnhammer EL. Global networks of functional coupling in eukaryotes from comprehensive data integration. Genome Res.19(6), 1107–1116 (2009).
   PubMed Web of Science ®Google Scholar
• Antal MA, Bode C, Csermely P. Perturbation waves in proteins and protein networks: applications of percolation and game theories in signaling and drug design. Curr. Protein Pept. Sci.10(2), 161–172 (2009).
   PubMed Web of Science ®Google Scholar
• Lee SA, Chan CH, Chen TC et al. POINeT: protein interactome with sub-network analysis and hub prioritization. BMC Bioinformatics10, 114 (2009).
   PubMed Web of Science ®Google Scholar
• Aigner T, Bartnik E, Sohler F, Zimmer R. Functional genomics of osteoarthritis: on the way to evaluate disease hypotheses. Clin. Orthop. Relat. Res. (427 Suppl.), S138–S143 (2004).
   Google Scholar
• Aigner T, Haag J, Zimmer R. Functional genomics, evo–devo and systems biology: a chance to overcome complexity?. Curr. Opin. Rheumatol.19(5), 463–470 (2007).
   PubMed Web of Science ®Google Scholar
• Schadt EE, Lamb J, Yang X et al. An integrative genomics approach to infer causal associations between gene expression and disease. Nat. Genet.37(7), 710–717 (2005).
   PubMed Web of Science ®Google Scholar
• Sieberts SK, Schadt EE. Moving toward a system genetics view of disease. Mamm. Genome18(6–7), 389–401 (2007).
   PubMed Web of Science ®Google Scholar
• Tu Z, Argmann C, Wong KK et al. Integrating siRNA and protein-protein interaction data to identify an expanded insulin signaling network. Genome Res.19(6), 1057–1067 (2009).
   PubMed Web of Science ®Google Scholar
• Dam EB, Loog M, Christiansen C et al. Identification of progressors in osteoarthritis by combining biochemical and MRI-based markers. Arthritis Res. Ther.11(4), R115 (2009).
   PubMed Web of Science ®Google Scholar
• Ruiz-Romero C, Calamia V, Mateos J et al. Mitochondrial dysregulation of osteoarthritic human articular chondrocytes analyzed by proteomics: a decrease in mitochondrial superoxide dismutase points to a redox imbalance. Mol. Cell Proteomics8(1), 172–189 (2009).
   PubMed Web of Science ®Google Scholar
• Uchida T, Fukawa A et al. Application of a novel protein biochip technology for detection and identification of rheumatoid arthritis biomarkers in synovial fluid. J. Proteome Res.1(6), 495–499 (2002).
   PubMed Web of Science ®Google Scholar
• Stoll D, Templin MF et al. Protein microarrays: applications and future challenges. Curr. Opin. Drug Discov. Devel.8(2), 239–252 (2005).
   PubMed Web of Science ®Google Scholar
• Zangar R, Varnum CS et al. Studying cellular processes and detecting disease with protein microarrays. Drug Metab. Rev.37(3), 473–487 (2005).
   PubMed Web of Science ®Google Scholar