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Review

Proteomics: a new way to improve human African trypanosomiasis diagnosis?

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Pages 289-301 | Published online: 09 Jan 2014

References

  • Omamo SW, d’Ieteren GD. Managing animal trypanosomosis in Africa: issues and options. Rev. Off. Int. Epizoot. 22(3), 989–1002 (2003).
  • Mahama CI, Desquesnes M, Dia ML, Losson B, De Deken R, Geerts S. A cross-sectional epidemiological survey of bovine trypanosomosis and its vectors in the Savelugu and West Mamprusi districts of northern Ghana. Vet. Parasitol. 122(1), 1–13 (2004).
  • Simarro PP, Diarra A, Ruiz Postigo JA, Franco JR, Jannin JG. The human African trypanosomiasis control and surveillance programme of the World Health Organization 2000–2009: the way forward. PLoS Negl. Trop. Dis. 5(2), e1007 (2011).
  • Fèvre EM, Wissmann BV, Welburn SC, Lutumba P. The burden of human African trypanosomiasis. PLoS Negl. Trop. Dis. 2(12), e333 (2008).
  • Stich A. African sleeping sickness: an ancient threat returns. Pharm. Unserer Zeit. 38(6), 546–550 (2009).
  • Simarro PP, Jannin J, Cattand P. Eliminating human African trypanosomiasis: where do we stand and what comes next? PLoS Med. 5(2), e55 (2008).
  • Nimmo C. Time to put out the lights on sleeping sickness? Travel Med. Infect. Dis. 8(4), 263–268 (2010).
  • Chappuis F, Loutan L, Simarro P, Lejon V, Büscher P. Options for field diagnosis of human african trypanosomiasis. Clin. Microbiol. Rev. 18(1), 133–146 (2005).
  • Simarro PP, Cecchi G, Franco JR et al. Estimating and mapping the population at risk of sleeping sickness. PLoS Negl. Trop. Dis. 6(10), e1859 (2012).
  • Cattand P, Jannin J, Lucas P. Sleeping sickness surveillance: an essential step towards elimination. Trop. Med. Int. Health 6(5), 348–361 (2001).
  • Chappuis F, Lima MA, Flevaud L, Ritmeijer K. Human African trypanosomiasis in areas without surveillance. Emerging Infect. Dis. 16(2), 354–356 (2010).
  • Truc P, Lando A, Penchenier L, Vatunga G, Josenando T. Human African trypanosomiasis in Angola: clinical observations, treatment, and use of PCR for stage determination of early stage of the disease. Trans. R. Soc. Trop. Med. Hyg. 106(1), 10–14 (2012).
  • Berrang-Ford L, Lundine J, Breau S. Conflict and human African trypanosomiasis. Soc. Sci. Med. 72(3), 398–407 (2011).
  • Njiokou F, Nimpaye H, Simo G et al. Domestic animals as potential reservoir hosts of Trypanosoma brucei gambiense in sleeping sickness foci in Cameroon. Parasite 17(1), 61–66 (2010).
  • Migchelsen SJ, Büscher P, Hoepelman AI, Schallig HD, Adams ER. Human African trypanosomiasis: a review of non-endemic cases in the past 20 years. Int. J. Infect. Dis. 15(8), e517–e524 (2011).
  • Moore S, Shrestha S, Tomlinson KW, Vuong H. Predicting the effect of climate change on African trypanosomiasis: integrating epidemiology with parasite and vector biology. J. R. Soc. Interface 9(70), 817–830 (2012).
  • Vanhollebeke B, Truc P, Poelvoorde P et al. Human Trypanosoma evansi infection linked to a lack of apolipoprotein L-I. N. Engl. J. Med. 355(26), 2752–2756 (2006).
  • Dumas M, Bouteille B. Current status of trypanosomiasis. Med. Trop. 57(Suppl. 3), 65–69 (1997).
  • Barrett MP. Potential new drugs for human African trypanosomiasis: some progress at last. Curr. Opin. Infect. Dis. 23(6), 603–608 (2010).
  • Jacobs RT, Plattner JJ, Nare B et al. Benzoxaboroles: a new class of potential drugs for human African trypanosomiasis. Future Med. Chem. 3(10), 1259–1278 (2011).
  • Torreele E, Bourdin TB, Tweats D et al. Fexinidazole – a new oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness. PLoS Negl. Trop. Dis. 4(12), e923 (2010).
  • Bacchi CJ. Chemotherapy of human african trypanosomiasis. Interdiscip. Perspect. Infect. Dis. 2009, 195040 (2009).
  • WHO. Human African trypanosomiasis (sleeping sickness): epidemiological update. Wkly Epidemiol. Rec. 81, 71–80 (2006).
  • Barrett MP, Vincent IM, Burchmore RJ, Kazibwe AJ, Matovu E. Drug resistance in human African trypanosomiasis. Future Microbiol. 6(9), 1037–1047 (2011).
  • Priotto G, Fogg C, Balasegaram M et al. Three drug combinations for late-stage Trypanosoma brucei gambiense sleeping sickness: a randomized clinical trial in Uganda. PLoS Clin. Trials 1(8), e39 (2006).
  • Molyneux D, Ndung’u J, Maudlin I. Controlling sleeping sickness – ‘when will they ever learn?’. PLoS Negl. Trop. Dis. 4(5), e609 (2010).
  • Artzrouni M, Gouteux JP. Control strategies for sleeping sickness in Central Africa: a model-based approach. Trop. Med. Int. Health 1(6), 753–764 (1996).
  • Leak SG, Peregrine AS, Mulatu W, Rowlands GJ, D’Ieteren G. Use of insecticide-impregnated targets for the control of tsetse flies (Glossina spp.) and trypanosomiasis occurring in cattle in an area of south-west Ethiopia with a high prevalence of drug-resistant trypanosomes. Trop. Med. Int. Health 1(5), 599–609 (1996).
  • Vreysen MJ, Saleh KM, Ali MY et al. Glossina austeni (Diptera: Glossinidae) eradicated on the island of Unguja, Zanzibar, using the sterile insect technique. J. Econ. Entomol. 93(1), 123–135 (2000).
  • Brun R, Don R, Jacobs RT, Wang MZ, Barrett MP. Development of novel drugs for human African trypanosomiasis. Future Microbiol. 6(6), 677–691 (2011).
  • Geiger A, Simo G, Grébaut P, Peltier JB, Cuny G, Holzmuller P. Transcriptomics and proteomics in human African trypanosomiasis: current status and perspectives. J. Proteomics 74(9), 1625–1643 (2011).
  • Ndung’u JM, Bieler S, Roscigno G. ‘Piggy-backing’ on diagnostic platforms brings hope to neglected diseases: the case of sleeping sickness. PLoS Negl. Trop. Dis. 4(5), e715 (2010).
  • Burri C. Chemotherapy against human African trypanosomiasis: is there a road to success? Parasitology 137(14), 1987–1994 (2010).
  • Matovu E, Mugasa CM, Ekangu RA et al. Phase II evaluation of sensitivity and specificity of PCR and NASBA followed by oligochromatography for diagnosis of human African trypanosomiasis in clinical samples from D.R. Congo and Uganda. PLoS Negl. Trop. Dis. 4(7), e737 (2010).
  • Hainard A, Tiberti N, Robin X et al. A combined CXCL10, CXCL8 and H-FABP panel for the staging of human African trypanosomiasis patients. PLoS Negl. Trop. Dis. 3(6), e459 (2009).
  • Hainard A, Tiberti N, Robin X et al. Matrix metalloproteinase-9 and intercellular adhesion molecule 1 are powerful staging markers for human African trypanosomiasis. Trop. Med. Int. Health 16(1), 119–126 (2011).
  • Tiberti N, Hainard A, Lejon V et al. Discovery and verification of osteopontin and beta-2-microglobulin as promising markers for staging human African trypanosomiasis. Mol. Cell Proteomics 9(12), 2783–2795 (2010).
  • Tiberti N, Hainard A, Lejon V et al. Cerebrospinal fluid neopterin as marker of the meningo-encephalitic stage of Trypanosoma brucei gambiense sleeping sickness. PLoS ONE 7(7), e40909 (2012).
  • Courtioux B, Pervieux L, Vatunga G et al. Increased CXCL-13 levels in human African trypanosomiasis meningo-encephalitis. Trop. Med. Int. Health 14(5), 529–534 (2009).
  • Tiberti N, Matovu E, Hainard A et al. New biomarkers for stage determination in Trypanosoma brucei rhodesiense sleeping sickness patients. Clin. Transl. Med. 2(1), 1 (2013).
  • Checchi F, Filipe JA, Barrett MP, Chandramohan D. The natural progression of Gambiense sleeping sickness: what is the evidence? PLoS Negl. Trop. Dis. 2(12), e303 (2008).
  • Magnus E, Vervoort T, Van Meirvenne N. A card-agglutination test with stained trypanosomes (C.A.T.T.) for the serological diagnosis of T. b. gambiense trypanosomiasis. Ann. Soc. Belg. Med. Trop. 58(3), 169–176 (1978).
  • Van Meirvenne N. Diagnosis of human African trypanosomiasis. Ann. Soc. Belg. Med. Trop. 72(Suppl. 1), 53–56 (1992).
  • Vincendeau P, Bouteille B. Immunology and immunopathology of African trypanosomiasis. An. Acad. Bras. Cienc. 78(4), 645–665 (2006).
  • Elrayah IE, Rhaman MA, Karamalla LT, Khalil KM, Büscher P. Evaluation of serodiagnostic tests for T.b. gambiense human African trypanosomiasis in southern Sudan. East. Mediterr. Health J. 13(5), 1098–1107 (2007).
  • Inojosa WO, Augusto I, Bisoffi Z et al. Diagnosing human African trypanosomiasis in Angola using a card agglutination test: observational study of active and passive case finding strategies. BMJ 332(7556), 1479 (2006).
  • Truc P, Lejon V, Magnus E et al. Evaluation of the micro-CATT, CATT/Trypanosoma brucei gambiense, and LATEX/T b gambiense methods for serodiagnosis and surveillance of human African trypanosomiasis in West and Central Africa. Bull. World Health Organ. 80(11), 882–886 (2002).
  • Chappuis F, Pittet A, Bovier PA et al. Field evaluation of the CATT/Trypanosoma brucei gambiense on blood-impregnated filter papers for diagnosis of human African trypanosomiasis in southern Sudan. Trop. Med. Int. Health 7(11), 942–948 (2002).
  • Hasker E, Mitashi P, Baelmans R et al. A new format of the CATT test for the detection of human African trypanosomiasis, designed for use in peripheral health facilities. Trop. Med. Int. Health 15(2), 263–267 (2010).
  • Simarro PP, Ruiz JA, Franco JR, Josenando T. Attitude towards CATT-positive individuals without parasitological confirmation in the African trypanosomiasis (T.b. gambiense) focus of Quiçama (Angola). Trop. Med. Int. Health 4(12), 858–861 (1999).
  • Lejon V, Ngoyi DM, Boelaert M, Büscher P. A CATT negative result after treatment for human African trypanosomiasis is no indication for cure. PLoS Negl. Trop. Dis. 4(1), e590 (2010).
  • Delespaux V, de Koning HP. Drugs and drug resistance in African trypanosomiasis. Drug Resist. Updat. 10(1–2), 30–50 (2007).
  • Mehlitz D. Serological studies on subgenus-differentiation and persistence of antibodies following infections with trypanosomes. Tropenmed. Parasitol. 26(3), 265–275 (1975).
  • Noireau F, Lemesre JL, Nzoukoudi MY, Louembet MT, Gouteux JP, Frezil JL. Serodiagnosis of sleeping sickness in the Republic of the Congo: comparison of indirect immunofluorescent antibody test and card agglutination test. Trans. R. Soc. Trop. Med. Hyg. 82(2), 237–240 (1988).
  • Van Knapen F, Buys J, Ruitenberg EJ. Enzyme linked immunosorbent assay (ELISA) and its application to the serodiagnosis of African trypanosomiasis. Ann. Soc. Belg. Med. Trop. 57(4-5), 281–292 (1977).
  • Van Meirvenne N, Magnus E, Buscher P. Evaluation of variant specific trypanolysis tests for serodiagnosis of human infections with Trypanosoma brucei gambiense. Acta Trop. 60(3), 189–199 (1995).
  • Jamonneau V, Bucheton B, Kaboré J et al. Revisiting the immune trypanolysis test to optimise epidemiological surveillance and control of sleeping sickness in West Africa. PLoS Negl. Trop. Dis. 4(12), e917 (2010).
  • Woo PT. The haematocrit centrifuge technique for the diagnosis of African trypanosomiasis. Acta Trop. 27(4), 384–386 (1970).
  • Sachs R. The superiority of the miniature anion-exchange centrifugation technique for detecting low grade trypanosome parasitaemias. Trans. R. Soc. Trop. Med. Hyg. 78(5), 694–696 (1984).
  • Bailey JW, Smith DH. The use of the acridine orange QBC technique in the diagnosis of African trypanosomiasis. Trans. R. Soc. Trop. Med. Hyg. 86(6), 630 (1992).
  • Truc P, Aerts D, McNamara JJ et al. Direct isolation in vitro of Trypanosoma brucei from man and other animals, and its potential value for the diagnosis of gambian trypanosomiasis. Trans. R. Soc. Trop. Med. Hyg. 86(6), 627–629 (1992).
  • Gibson WC. Will the real Trypanosoma b. gambiense please stand up. Parasitol. Today (Regul. Ed.) 2(9), 255–257 (1986).
  • Mugasa CM, Adams ER, Boer KR et al. Diagnostic accuracy of molecular amplification tests for human African trypanosomiasis – systematic review. PLoS Negl. Trop. Dis. 6(1), e1438 (2012).
  • Deborggraeve S, Lejon V, Ekangu RA et al. Diagnostic accuracy of PCR in gambiense sleeping sickness diagnosis, staging and post-treatment follow-up: a 2-year longitudinal study. PLoS Negl. Trop. Dis. 5(2), e972 (2011).
  • Mathieu-Daude F, Bicart-See A, Bosseno MF, Breniere SF, Tibayrenc M. Identification of Trypanosoma brucei gambiense group I by a specific kinetoplast DNA probe. Am. J. Trop. Med. Hyg. 50(1), 13–19 (1994).
  • Kabiri M, Franco JR, Simarro PP, Ruiz JA, Sarsa M, Steverding D. Detection of Trypanosoma brucei gambiense in sleeping sickness suspects by PCR amplification of expression-site-associated genes 6 and 7. Trop. Med. Int. Health 4(10), 658–661 (1999).
  • Biteau N, Bringaud F, Gibson W, Truc P, Baltz T. Characterization of Trypanozoon isolates using a repeated coding sequence and microsatellite markers. Mol. Biochem. Parasitol. 105(2), 185–201 (2000).
  • Herder S, Simo G, Nkinin S, Njiokou F. Identification of trypanosomes in wild animals from southern Cameroon using the polymerase chain reaction (PCR). Parasite 9(4), 345–349 (2002).
  • Radwanska M, Claes F, Magez S et al. Novel primer sequences for polymerase chain reaction-based detection of Trypanosoma brucei gambiense. Am. J. Trop. Med. Hyg. 67(3), 289–295 (2002).
  • Njiru ZK. Rapid and sensitive detection of human African trypanosomiasis by loop-mediated isothermal amplification combined with a lateral-flow dipstick. Diagn. Microbiol Infect. Dis. 69(2), 205–209 (2011).
  • Radwanska M, Chamekh M, Vanhamme L et al. The serum resistance-associated gene as a diagnostic tool for the detection of Trypanosoma brucei rhodesiense. Am. J. Trop. Med. Hyg. 67(6), 684–690 (2002).
  • Bouteille B, Mpandzou G, Cespuglio R et al. Cerebrospinal fluid B lymphocyte identification for diagnosis and follow-up in human African trypanosomiasis in the field. Trop. Med. Int. Health 15(4), 454–461 (2010).
  • Mumba Ngoyi D, Lejon V, Pyana P et al. How to shorten patient follow-up after treatment for Trypanosoma brucei gambiense sleeping sickness. J. Infect. Dis. 201(3), 453–463 (2010).
  • Armour RH. Comment on: diagnosing central nervous system trypanosomiasis: two stage or not to stage. Trans. R. Soc. Trop. Med. Hyg. 103(1), 105 (2009).
  • Mpandzou G, Cespuglio R, Ngampo S et al. Polysomnography as a diagnosis and post-treatment follow-up tool in human African trypanosomiasis: a case study in an infant. J. Neurol. Sci. 305(1–2), 112–115 (2011).
  • Deborggraeve S, Büscher P. Molecular diagnostics for sleeping sickness: what is the benefit for the patient? Lancet Infect. Dis. 10(6), 433–439 (2010).
  • Bucheton B, MacLeod A, Jamonneau V. Human host determinants influencing the outcome of Trypanosoma brucei gambiense infections. Parasite Immunol. 33(8), 438–447 (2011).
  • De Bock M, de Seny D, Meuwis MA et al. Challenges for biomarker discovery in body fluids using SELDI-TOF-MS. J. Biomed. Biotechnol. 2010, 906082 (2010).
  • Roche S, Tiers L, Provansal M, Piva MT, Lehmann S. Interest of major serum protein removal for surface-enhanced laser desorption/ionization - time of flight (SELDI-TOF) proteomic blood profiling. Proteome Sci. 4, 20 (2006).
  • Papadopoulos MC, Abel PM, Agranoff D et al. A novel and accurate diagnostic test for human African trypanosomiasis. Lancet 363(9418), 1358–1363 (2004).
  • Agranoff D, Stich A, Abel P, Krishna S. Proteomic fingerprinting for the diagnosis of human African trypanosomiasis. Trends Parasitol. 21(4), 154–157 (2005).
  • Courtioux B, Bisser S, M’belesso P et al. Dot enzyme-linked immunosorbent assay for more reliable staging of patients with Human African trypanosomiasis. J. Clin. Microbiol. 43(9), 4789–4795 (2005).
  • Maclean L, Odiit M, Sternberg JM. Intrathecal cytokine responses in Trypanosoma brucei rhodesiense sleeping sickness patients. Trans. R. Soc. Trop. Med. Hyg. 100(3), 270–275 (2006).
  • Manful T, Mulindwa J, Frank FM, Clayton CE, Matovu E. A search for Trypanosoma brucei rhodesiense diagnostic antigens by proteomic screening and targeted cloning. PLoS ONE 5(3), e9630 (2010).
  • Foucher AL, McIntosh A, Douce G, Wastling J, Tait A, Turner CM. A proteomic analysis of arsenical drug resistance in Trypanosoma brucei. Proteomics 6(9), 2726–2732 (2006).
  • Kuettel S, Mosimann M, Mäser P et al. Adenosine kinase of T. b. rhodesiense identified as the putative target of 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine using chemical proteomics. PLoS Negl. Trop. Dis. 3(8), e506 (2009).
  • Mercer L, Bowling T, Perales J et al. 2,4-diaminopyrimidines as potent inhibitors of Trypanosoma brucei and identification of molecular targets by a chemical proteomics approach. PLoS Negl. Trop. Dis. 5(2), e956 (2011).
  • Bociaga-Jasik M, Ciesla A, Kalinowska-Nowak A, Skwara P, Garlicki A, Mach T. Role of IL-6 and neopterin in the pathogenesis of herpetic encephalitis. Pharmacol. Rep. 63(5), 1203–1209 (2011).
  • Edén A, Price RW, Spudich S, Fuchs D, Hagberg L, Gisslén M. Immune activation of the central nervous system is still present after >4 years of effective highly active antiretroviral therapy. J. Infect. Dis. 196(12), 1779–1783 (2007).
  • Bechter K, Reiber H, Herzog S, Fuchs D, Tumani H, Maxeiner HG. Cerebrospinal fluid analysis in affective and schizophrenic spectrum disorders: identification of subgroups with immune responses and blood–CSF barrier dysfunction. J. Psychiatr. Res. 44(5), 321–330 (2010).
  • Dale RC, Brilot F, Fagan E, Earl J. Cerebrospinal fluid neopterin in paediatric neurology: a marker of active central nervous system inflammation. Dev. Med. Child Neurol. 51(4), 317–323 (2009).
  • Du Pasquier RA, Jilek S, Kalubi M et al. Marked increase of the astrocytic marker S100B in the cerebrospinal fluid of HIV-infected patients on LPV/r-monotherapy. AIDS 27(2), 203–210 (2012).
  • Angel TE, Jacobs JM, Spudich SS et al. The cerebrospinal fluid proteome in HIV infection: change associated with disease severity. Clin. Proteomics 9(1), 3 (2012).
  • Valcour V, Chalermchai T, Sailasuta N et al.; RV254/SEARCH 010 Study Group. Central nervous system viral invasion and inflammation during acute HIV infection. J. Infect. Dis. 206(2), 275–282 (2012).
  • De Cock KM, Jaffe HW, Curran JW. The evolving epidemiology of HIV/AIDS. AIDS 26(10), 1205–1213 (2012).
  • Fan J, Gallagher JW, Wu HJ et al. Low molecular weight protein enrichment on mesoporous silica thin films for biomarker discovery. J. Vis. Exp. 62, 3876 (2012).
  • Tang HY, Beer LA, Speicher DW. In-depth analysis of a plasma or serum proteome using a 4D protein profiling method. Methods Mol. Biol. 728, 47–67 (2011).
  • Franco JR, Simarro PP, Diarra A, Ruiz-Postigo JA, Jannin JG. The Human African trypanosomiasis specimen biobank: a necessary tool to support research of new diagnostics. PLoS Negl. Trop. Dis. 6(6), e1571 (2012).
  • Kennedy PG. Novel biomarkers for late-stage human African trypanosomiasis – the search goes on. Am. J. Trop. Med. Hyg. 82(6), 981–982 (2010).
  • Maes M, Twisk FN, Ringel K. Inflammatory and cell-mediated immune biomarkers in myalgic encephalomyelitis/chronic fatigue syndrome and depression: inflammatory markers are higher in myalgic encephalomyelitis/chronic fatigue syndrome than in depression. Psychother. Psychosom. 81(5), 286–295 (2012).
  • Paulo JA, Kadiyala V, Banks PA, Steen H, Conwell DL. Mass spectrometry-based proteomics for translational research: a technical overview. Yale J. Biol. Med. 85(1), 59–73 (2012).
  • Righetti PG, Fasoli E, Boschetti E. Combinatorial peptide ligand libraries: the conquest of the ‘hidden proteome’ advances at great strides. Electrophoresis 32(9), 960–966 (2011).
  • Hause RJ, Kim HD, Leung KK, Jones RB. Targeted protein-omic methods are bridging the gap between proteomic and hypothesis-driven protein analysis approaches. Expert Rev. Proteomics 8(5), 565–575 (2011).

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