Molecular profiling of laryngeal cancer

References

• Chu EA, Kim YJ. Laryngeal cancer: diagnosis and preoperative work-up. Otolaryngol. Clin. N. Am.41, 673–695 (2008).
   PubMed Web of Science ®Google Scholar
• Döbrossy L. Epidemiology of head and neck cancer: magnitude of the problem. Cancer Metastasis Rev.24, 9–17 (2005).
   PubMedGoogle Scholar
• Baumann JL, Cohen S, Evjen AN et al. Human papillomavirus in early laryngeal carcinoma. Laryngoscope119(8),1531–1537 (2009).
   PubMedGoogle Scholar
• Bozec A, Peyrade F, Fischel JL, Milano G. Emerging molecular targeted therapies in the treatment of head and neck cancer. Expert. Opin. Emerg. Drugs14(2), 299–310 (2009).
   PubMed Web of Science ®Google Scholar
• Dean NR, Newman JR, Helman EE et al. Anti-EMMPRIN monoclonal antibody as a novel agent for therapy of head and neck cancer. Clin. Cancer Res.15(12) 4058–4065 (2009).
   PubMed Web of Science ®Google Scholar
• Saba NF, Khuri FR. Optimizing systemic therapy in squamous cell carcinoma of the head and neck with a focus on targeted agents. Curr. Opin. Oncol.21(3), 232–237 (2009).
   PubMedGoogle Scholar
• Matta A, Ralhan R. Overview of current and future biologically based targeted therapies in head and neck squamous cell carcinoma. Head Neck Oncol.1, 6 (2009).
   PubMedGoogle Scholar
• Lefebvre JL, Ang K. Larynx preservation clinical trial design: key issues and recommendations – a consensus panel summary. Head Neck31, 429–441 (2009).
   PubMedGoogle Scholar
• Califano J, van der Riet P, Westra W et al. Genetic progression model for head and neck cancer: implications for field cancerization. Cancer Res.56(11), 2488–2492 (1996).
   PubMed Web of Science ®Google Scholar
• Vogelstein B, Fearon ER, Hamilton SR et al. Genetic alterations during colorectal tumor development. N. Engl. J. Med.319, 525–532 (1988).
   PubMed Web of Science ®Google Scholar
• Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell61, 759–767 (1990).
   PubMed Web of Science ®Google Scholar
• Slaughter DP, Southwick HW, Smejkal W. Field cancerization in oral stratified squamous epithelium: clinical implications of multicentric origin. Cancer6, 963–968 (1953).
   PubMed Web of Science ®Google Scholar
• Califano J, Westra WH, Meininger G, Corio R, Koch WM, Sidransky D. Genetic progression and clonal relationship of recurrent premalignant head and neck lesions. Clin. Cancer Res.6(2), 347–352 (2000).
   PubMedGoogle Scholar
• Tabor MP, Brakenhoff RH, Ruijter-Schippers HJ et al. Multiple head and neck tumors frequently originate from a single preneoplastic lesion. Am. J. Pathol.161(3), 1051–1060 (2002).
   PubMed Web of Science ®Google Scholar
• Tabor MP, Brakenhoff RH, van Houten VM et al. Persistence of genetically altered fields in head and neck cancer patients: biological and clinical implications. Clin. Cancer Res.7(6), 1523–1532 (2001).
   PubMed Web of Science ®Google Scholar
• Braakhuis BJ, Leemans CR, Brakenhoff RH. A genetic progression model of oral cancer: current evidence and clinical implications. J. Oral Pathol. Med.33(6), 317–322 (2004).
   PubMedGoogle Scholar
• van Houten VM, Tabor MP, van den Brekel MW et al. Mutated p53 as a molecular marker for the diagnosis of head and neck cancer. J. Pathol.198(4), 476–486 (2002).
   PubMed Web of Science ®Google Scholar
• Mao L, Lee JS, Fan YH et al. Frequent microsatellite alterations at chromosomes 9p21 and 3p14 in oral premalignant lesions and their value in cancer risk assessment. Nat. Med.2(6), 682–685 (1996).
   PubMed Web of Science ®Google Scholar
• Ha PK, Califano JA. The molecular biology of mucosal field cancerization of the head and neck. Crit. Rev. Oral Biol. Med.14, 363–369 (2003).
   PubMedGoogle Scholar
• Braakhuis BJ, Brakenhoff RH, Leemans CR. Head and neck cancer: molecular carcinogenesis. Ann. Oncol.16(Suppl. 2), ii249–ii250 (2004).
   Google Scholar
• Mao L, Fan YH, Lotan R, Hong WK. Frequent abnormalities of FHIT, a candidate tumor suppressor gene, in head and neck cancer cell lines. Cancer Res.56(22), 5128–5131 (1996).
   PubMedGoogle Scholar
• Rosin MP, Cheng X, Poh C et al. Use of allelic loss to predict malignant risk for low-grade oral epithelial dysplasia. Clin. Cancer Res.6(2), 357–362 (2000).
   PubMed Web of Science ®Google Scholar
• Garnis C, Baldwin C, Zhang L, Rosin MP, Lam WL. Use of complete coverage array comparative genomic hybridization to define copy number alterations on chromosome 3p in oral squamous cell carcinomas. Cancer Res.63(24), 8582–8585 (2003).
   PubMedGoogle Scholar
• Kisielewski AE, Xiao GH, Liu SC et al. Analysis of the FHIT gene and its product in squamous cell carcinomas of the head and neck. Oncogene17(1), 83–91 (1998).
   PubMedGoogle Scholar
• Reed AL, Califano J, Cairns P, Westra WH, Jones RM, Koch W et al. High frequency of p16 (CDKN2/MTS-1/INK4A) inactivation in head and neck squamous cell carcinoma. Cancer Res.56(16), 3630–3633 (1996).
   PubMed Web of Science ®Google Scholar
• Sakai E, Tsuchida N. Most human squamous cell carcinomas in the oral cavity contain mutated p53 tumor-suppressor genes. Oncogene.7(5), 927–933, (1992).
   PubMed Web of Science ®Google Scholar
• Kujawski M, Aalto Y, Jaskula-Sztul R et al. DNA copy number losses are more frequent in primary larynx tumors with lymph node metastases than in tumors without metastases. Cancer Genet. Cytogenet.114, 31–34 (1999).
   PubMedGoogle Scholar
• Stafford ND, Ashman JN, MacDonald AW, Ell SR, Monson JR, Greenman J. Genetic analysis of head and neck squamous cell carcinoma and surrounding mucosa. Arch. Otolaryngol. Head Neck Surg.125, 1341–1348 (1999).
   PubMedGoogle Scholar
• Hermsen M, Guervós MA, Meijer G et al. New chromosomal regions with high-level amplifications in squamous cell carcinomas of the larynx and pharynx, identified by comparative genomic hybridization. J. Pathol.194(2), 177–182 (2001).
   PubMedGoogle Scholar
• Huang Q, Yu GP, McCormick SA et al. Genetic differences detected by comparative genomic hybridization in head and neck squamous cell carcinomas from different tumor sites: construction of oncogenetic trees for tumor progression. Genes Chromosomes Cancer34(2), 224–233 (2002).
   PubMedGoogle Scholar
• Juhász A, Balázs M, Sziklay I et al. Chromosomal imbalances in laryngeal and hypopharyngeal cancers detected by comparative genomic hybridization. Cytometry67(2), 151–160 (2005).
   PubMedGoogle Scholar
• Schlade-Bartusiak K, Stembalska A, Ramsey D. Significant involvement of chromosome 13q deletions in progression of larynx cancer, detected by comparative genomic hybridization. J. Appl. Genet.46(4), 407–413 (2005).
   PubMedGoogle Scholar
• Patmore HS, Ashman JN, Stafford ND et al. Genetic analysis of head and neck squamous cell carcinoma using comparative genomic hybridisation identifies specific aberrations associated with laryngeal origin. Cancer Lett.258(1), 55–62 (2007).
   PubMed Web of Science ®Google Scholar
• Järvinen AK, Autio R, Haapa-Paananen S et al. Identification of target genes in laryngeal squamous cell carcinoma by high-resolution copy number and gene expression microarray analyses. Oncogene25, 6997–7008 (2006).
   PubMed Web of Science ®Google Scholar
• Giefing M, Martin-Subero JI, Kiwerska K et al. Characterization of homozygous deletions in laryngeal squamous cell carcinoma cell lines. Cancer Genet. Cytogenet.184(1), 38–43 (2008).
   PubMedGoogle Scholar
• Baudis M, Cleary ML. Progenetix.net: an online repository for molecular cytogenetic aberration data. Bioinformatics17(12), 1228–1229 (2001).
   PubMedGoogle Scholar
• Järvinen AK, Autio R, Kilpinen S et al. High-resolution copy number and gene expression microarray analyses of head and neck squamous cell carcinoma cell lines of tongue and larynx. Genes Chromosomes Cancer47(6), 500–509 (2008).
   PubMedGoogle Scholar
• Braakhuis BJ, Snijders PJ, Keune WJ et al. Genetic patterns in head and neck cancers that contain or lack transcriptionally active human papillomavirus. J. Natl Cancer Inst.96(13), 998–1006 (2004).
   PubMedGoogle Scholar
• Smeets SJ, Braakhuis BJ, Abbas S et al. Genome-wide DNA copy number alterations in head and neck squamous cell carcinomas with or without oncogene-expressing human papillomavirus. Oncogene25(17), 2558–2564 (2006).
   PubMed Web of Science ®Google Scholar
• Bauer VL, Braselmann H, Henke M et al. Chromosomal changes characterize head and neck cancer with poor prognosis. J. Mol. Med.86(12), 1353–1365 (2008).
   PubMedGoogle Scholar
• Bockmühl U, Schlüns K, Küchler I, Petersen S, Petersen I. Genetic imbalances with impact on survival in head and neck cancer patients. Am. J. Pathol.157(2), 369–375 (2000).
   PubMedGoogle Scholar
• Höglund M, Jin C, Gisselsson D, Hansen GB, Mitelman F, Mertens F. Statistical analyses of karyotypic complexity in head and neck squamous cell carcinoma. Cancer Genet. Cytogenet.150(1), 1–8 (2004).
   PubMedGoogle Scholar
• Knuutila S, Björkqvist AM, Autio K et al. DNA copy number amplifications in human neoplasias – review of comparative genomic hybridization studies. Am. J. Pathol.152, 1107–1123 (1998).
   PubMed Web of Science ®Google Scholar
• Hyman E, Kauraniemi P, Hautaniemi S et al. Impact of DNA amplification on gene expression patterns in breast cancer. Cancer Res.62, 6240–6245 (2002).
   PubMed Web of Science ®Google Scholar
• Pollack JR, Sorlie T, Perou CM et al. Microarray analysis reveals a major direct role of DNA copy number alteration in the transcriptional program of human breast tumors. Proc. Natl Acad. Sci. USA99, 12963–12968 (2002).
   PubMed Web of Science ®Google Scholar
• Chin K, DeVries S, Fridlyand J et al. Genomic and transcriptional aberrations linked to breast cancer pathophysiologies. Cancer Cell10, 529–541 (2006).
   PubMed Web of Science ®Google Scholar
• Snijders AM, Schmidt BL, Fridlyand J et al. Rare amplicons implicate frequent deregulation of cell fate specification pathways in oral squamous cell carcinoma. Oncogene24(26), 4232–4242 (2005).
   PubMed Web of Science ®Google Scholar
• Gibcus JH, Kok K, Menkema L et al. High-resolution mapping identifies a commonly amplified 11q13.3 region containing multiple genes flanked by segmental duplications. Hum. Genet.121(2), 187–201 (2007).
   PubMedGoogle Scholar
• Gibcus JH, Menkema L, Mastik MF et al. Amplicon mapping and expression profiling identify the Fas-associated death domain gene as a new driver in the 11q13.3 amplicon in laryngeal/pharyngeal cancer. Clin. Cancer Res.13(21), 6257–6266 (2007).
   PubMed Web of Science ®Google Scholar
• Gibcus JH, Mastik MF, Menkema L et al. Cortactin expression predicts poor survival in laryngeal carcinoma. Br. J. Cancer98(5), 950–955 (2008).
   PubMed Web of Science ®Google Scholar
• Wreesmann VB, Singh B. Chromosomal aberrations in squamous cell carcinomas of the upper aerodigestive tract: biologic insights and clinical opportunities. J. Oral Pathol. Med.34, 449–459, (2005).
   PubMedGoogle Scholar
• Al Moustafa AE, Alaoui-Jamali MA, Batist G et al. Identification of genes associated with head and neck carcinogenesis by cDNA microarray comparison between matched primary normal epithelial and squamous carcinoma cells. Oncogene21(17), 2634–2640 (2002).
   PubMed Web of Science ®Google Scholar
• Belbin TJ, Singh B, Barber I et al. Molecular classification of head and neck squamous cell carcinoma using cDNA microarrays. Cancer Res.62(4), 1184–1190 (2002).
   PubMed Web of Science ®Google Scholar
• Squire JA, Bayani J, Luk C et al. Molecular cytogenetic analysis of head and neck squamous cell carcinoma: by comparative genomic hybridization, spectral karyotyping, and expression array analysis. Head Neck24(9), 874–887 (2002).
   PubMedGoogle Scholar
• Ha PK, Benoit NE, Yochem R et al. A transcriptional progression model for head and neck cancer. Clin. Cancer Res.9(8), 3058–3064 (2003).
   PubMedGoogle Scholar
• Chung CH, Parker JS, Karaca G et al. Molecular classification of head and neck squamous cell carcinomas using patterns of gene expression. Cancer Cell5(5), 489–500 (2004).
   PubMed Web of Science ®Google Scholar
• Ginos MA, Page GP, Michalowicz BS et al. Identification of a gene expression signature associated with recurrent disease in squamous cell carcinoma of the head and neck. Cancer Res.64(1), 55–63 (2004).
   PubMed Web of Science ®Google Scholar
• Masayesva BG, Ha P, Garrett-Mayer E et al. Gene expression alterations over large chromosomal regions in cancers include multiple genes unrelated to malignant progression. Proc. Natl Acad. Sci. USA101(23), 8715–8720 (2004).
   PubMedGoogle Scholar
• Roepman P, Wessels LF, Kettelarij N et al. An expression profile for diagnosis of lymph node metastases from primary head and neck squamous cell carcinomas. Nat. Genet.37(2), 182–186 (2005).
   PubMed Web of Science ®Google Scholar
• Braakhuis BJ, Senft A, de Bree R et al. Expression profiling and prediction of distant metastases in head and neck squamous cell carcinoma. J. Clin. Pathol.59(12), 1254–1260 (2006).
   PubMedGoogle Scholar
• Chung CH, Parker JS, Ely K et al. Gene expression profiles identify epithelial-to-mesenchymal transition and activation of nuclear factor-kB signaling as characteristics of a high-risk head and neck squamous cell carcinoma. Cancer Res.66(16), 8210–8218 (2006).
   PubMed Web of Science ®Google Scholar
• Dasgupta S, Tripathi PK, Qin H, Bhattacharya-Chatterjee M, Valentino J, Chatterjee SK. Identification of molecular targets for immunotherapy of patients with head and neck squamous cell carcinoma. Oral Oncol.42(3), 306–316 (2006).
   PubMedGoogle Scholar
• Carinci F, Arcelli D, Lo Muzio L et al. Molecular classification of nodal metastasis in primary larynx squamous cell carcinoma. Transl. Res.150(4), 233–245 (2007).
   PubMedGoogle Scholar
• Dumur CI, Ladd AC, Wright HV et al. Genes involved in radiation therapy response in head and neck cancers. Laryngoscope119(1), 91–101 (2009).
   PubMedGoogle Scholar
• Colombo J, Fachel AA, De Freitas Calmon M et al. Gene expression profiling reveals molecular marker candidates of laryngeal squamous cell carcinoma. Oncol. Rep.21(3), 649–663 (2009).
   PubMed Web of Science ®Google Scholar
• Ma LJ, Li W, Zhang X et al. Differential gene expression profiling of laryngeal squamous cell carcinoma by laser capture microdissection and complementary DNA microarrays. Arch. Med. Res.40(2), 114–123 (2009).
   PubMedGoogle Scholar
• Choi P, Chen C. Genetic expression profiles and biologic pathway alterations in head and neck squamous cell carcinoma. Cancer104(6), 1113–1128 (2005).
   PubMed Web of Science ®Google Scholar
• Vlachtsis K, Nikolaou A, Markou K, Fountzilas G, Daniilidis I. Clinical and molecular prognostic factors in operable laryngeal cancer. Eur. Arch. Otorhinolaryngol.262, 890–898 (2005).
   PubMed Web of Science ®Google Scholar
• Thomas GR, Nadiminti H, Regalado J. Molecular predictors of clinical outcome in patients with head and neck squamous cell carcinoma. Int. J. Exp. Path.86, 347–363 (2005).
   PubMed Web of Science ®Google Scholar
• Buffa FM, Bentzen SM, Daley FM et al. Molecular markers profiles predict locoregional control of head and neck squamous cell carcinoma in a randomized trial of continuous hyperfractionated accelerated radiotherapy. Clin. Cancer Res.10, 3745–3754 (2004).
   PubMed Web of Science ®Google Scholar
• Kong WJ, Zhang S, Guo C, Zhang S, Wang Y, Zhang D. Methylation-associated silencing of death-associated protein kinase gene in laryngeal squamous cell cancer. Laryngoscope115, 1395–1401 (2005).
   PubMedGoogle Scholar
• Dikshit RP, Gillio-Tos A, Brennan P et al. Hypermethylation, risk factors, clinical characteristics, and survival in 235 patients with laryngeal and hypopharyngeal cancers. Cancer110, 1745–1751 (2007).
   PubMedGoogle Scholar
• Bennett KL, Karpenko M, Lin MT et al. Frequently methylated tumor suppressor genes in head and neck squamous cell carcinoma. Cancer Res.68, 4494–4499 (2008).
   PubMed Web of Science ®Google Scholar
• El-Naggar AK, Lai S, Clayman GL et al. Expression of p16, Rb, and cyclin D1 gene products in oral and laryngeal squamous carcinoma: biological and clinical implications. Hum. Pathol.30, 1013–1018 (1999).
   PubMedGoogle Scholar
• Smigiel R, Sasiadek M, Krecicki T, Ramsey D, Jagielski J, Blin N. Inactivation of the cyclin-dependent kinase inhibitor 2A (CDKN2A) gene in squamous cell carcinoma of the larynx. Mol. Carcinog.39, 147–154 (2004).
   PubMedGoogle Scholar
• Sasiadek MM, Stembalska-Kozlowska A, Smigiel R, Ramsey D, Kayademir T, Blin N. Impairment of MLH1 and CDKN2A in oncogenesis of laryngeal cancer. Br. J. Cancer90, 1594–1599 (2004).
   PubMedGoogle Scholar
• Swellam M, Ezz El-Arab LR, Adly A. Prognostic value of cell cycle regulators and cellular biomarkers in laryngeal squamous cell cancer. Clin. Biochem.41, 1059–1066 (2008).
   PubMedGoogle Scholar
• Karsai S, Abel U, Roesch-Ely M et al. Comparison of p16 expression with p53 alterations in head and neck cancer by tissue microarray analysis. J. Pathol.211, 314–322 (2007).
   PubMedGoogle Scholar
• Narayana A, Vaughan AT, Gunaratne S, Kathuria S, Walter S, Reddy S. Is p53 an independent prognostic factor in patients with laryngeal carcinoma? Cancer82, 286–291 (1998).
   PubMed Web of Science ®Google Scholar
• Rewari A, Lu H, Parikh R, Yang Q, Shen Z, Haffty BG. BCCIP as a prognostic marker for radiotherapy of laryngeal cancer. Radiother. Oncol.90, 183–188 (2009).
   PubMedGoogle Scholar
• Pignataro L, Pruneri G, Carboni N et al. Clinical relevance of cyclin D1 protein overexpression in laryngeal squamous cell carcinoma. J. Clin. Oncol.16, 3069–3077 (1998).
   PubMed Web of Science ®Google Scholar
• Pruneri G, Pignataro L, Valentini S et al. Cyclin D3 immunoreactivity is an independent predictor of survival in laryngeal squamous cell cancer. Clin. Cancer Res.11, 242–248 (2005).
   PubMedGoogle Scholar
• Freier K, Joos S, Flechtenmacher C et al. Tissue microarray analysis reveals site-specific prevalence of oncogene amplifications in head and neck squamous cell carcinoma. Cancer Res.63, 1179–1182 (2003).
   PubMed Web of Science ®Google Scholar
• Sticht C, Hofele C, Flechtenmacher C et al. Amplification of Cyclin L1 is associated with lymph node metastases in head and neck squamous cell carcinoma (HNSCC). Br. J. Cancer92(4), 770–774 (2005).
   PubMedGoogle Scholar
• Dassonville O, Formento JL, Francoual M et al. Expression of epidermal growth factor receptor and survival in upper aerodigestive tract cancer. J. Clin. Oncol.11(10), 1873–1878 (1993).
   PubMed Web of Science ®Google Scholar
• Koynova DK, Tsenova VS, Jankova RS, Gurov PB, Toncheva DI. Tissue microarray analysis of EGFR and HER2 oncogene copy number alterations in squamous cell carcinoma of the larynx. J. Cancer Res. Clin. Oncol.131, 199–203 (2005).
   PubMedGoogle Scholar
• Teknos TN, Cox C, Yoo S et al. Elevated serum vascular endothelial growth factor and decreased survival in advanced laryngeal carcinoma. Head Neck24, 1004–1011 (2002).
   PubMed Web of Science ®Google Scholar
• Parikh RR, Yang Q, Haffty BG. Prognostic significance of vascular endothelial growth factor protein levels in T1–2 N0 laryngeal cancer treated with primary radiation therapy. Cancer109, 566–573 (2007).
   PubMed Web of Science ®Google Scholar
• Marioni G, Giacomelli L, D’Alessandro E et al. Laryngeal carcinoma recurrence rate and disease-free interval are related to CD105 expression but not to vascular endothelial growth factor 2 (Flk-1/Kdr) expression. Anticancer Res.28, 551–557 (2008).
   PubMed Web of Science ®Google Scholar
• Chan G, Boyle JO, Yang EK et al. Cyclooxygenase-2 expression is up-regulated in squamous cell carcinoma of the head and neck. Cancer Res.59, 991–994 (1999).
   PubMed Web of Science ®Google Scholar
• Ranelletti FO, Almadori G, Rocca B et al. Prognostic significance of cyclooxygenase-2 in laryngeal squamous cell cancer. Int. J. Cancer95, 343–349 (2001).
   PubMed Web of Science ®Google Scholar
• Bayazit YA, Buyukberber S, Sari I et al. Cyclo-oxygenase 2 expression in laryngeal squamous cell carcinoma and its clinical correlates. ORL J. Otorhinolaryngol. Relat. Spec.66, 65–69 (2004).
   PubMedGoogle Scholar
• Cho EI, Kowalski DP, Sasaki CT, Haffty BG. Tissue microarray analysis reveals prognostic significance of COX-2 expression for local relapse in T1–T2N0 larynx cancer treated with primary radiation therapy. Laryngoscope114, 2001–2008 (2004).
   PubMedGoogle Scholar
• Wildeman MA, Gibcus JH, Hauptmann M et al. Radiotherapy in laryngeal carcinoma: can a panel of 13 markers predict response? Laryngoscope119(2), 316–322 (2009).
   PubMedGoogle Scholar
• Dong P, Li X, Yu Z, Lu G. Expression of cyclooxygenase-2, vascular endothelial growth factor and metalloproteinase-2 in patients with primary laryngeal carcinoma: a tissue microarray study. J. Laryngol. Otol.121, 1177–1183 (2007).
   PubMed Web of Science ®Google Scholar
• Cao WF, Zhang LY, Liu MB, Tang PZ, Liu ZH, Sun BC. Prognostic significance of stomatin-like protein 2 overexpression in laryngeal squamous cell carcinoma: clinical, histologic, and immunohistochemistry analyses with tissue microarray. Hum. Pathol.38, 747–752 (2007).
   PubMedGoogle Scholar
• Dong GW, Kim J, Park JH, Choi JY, Cho SI, Lim SC. Galectin-8 expression in laryngeal squamous cell carcinoma. Clin. Exp. Otorhinolaryngol.2, 13–19 (2009).
   PubMedGoogle Scholar