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Review

CT and MRI of hepatocellular carcinoma: an update

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Pages 507-519 | Published online: 10 Jan 2014

References

  • El-Serag HB, Rudolph KL. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology132(7), 2557–2576 (2007).
  • Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J. Clin.55(2), 74–108 (2005).
  • El-Serag HB, Mason AC. Rising incidence of hepatocellular carcinoma in the United States. N. Engl. J. Med.340(10), 745–750 (1999).
  • Bruix J, Boix L, Sala M, Llovet JM. Focus on hepatocellular carcinoma. Cancer Cell5(3), 215–219 (2004).
  • Jemal A, Siegel R, Ward E et al. Cancer statistics, 2008. CA Cancer J. Clin.58(2), 71–96 (2008).
  • Llovet JM, Burroughs A, Bruix J. Hepatocellular carcinoma. Lancet362(9399), 1907–1917 (2003).
  • Di Bisceglie AM, Goodman ZD, Ishak KG, Hoofnagle JH, Melpolder JJ, Alter HJ. Long-term clinical and histopathological follow-up of chronic posttransfusion hepatitis. Hepatology14(6), 969–974 (1991).
  • Di Bisceglie AM, Rustgi VK, Hoofnagle JH, Dusheiko GM, Lotze MT. NIH Conference. Hepatocellular carcinoma. Ann. Intern. Med.108(3), 390–401 (1988).
  • Llovet JM, Schwartz M, Mazzaferro V. Resection and liver transplantation for hepatocellular carcinoma. Semin. Liver Dis.25(2), 181–200 (2005).
  • Bolondi L, Sofia S, Siringo S et al. Surveillance programme of cirrhotic patients for early diagnosis and treatment of hepatocellular carcinoma: a cost–effectiveness analysis. Gut48(2), 251–259 (2001).
  • Zhang BH, Yang BH, Tang ZY. Randomized controlled trial of screening for hepatocellular carcinoma. J. Cancer Res. Clin. Oncol.130(7), 417–422 (2004).
  • Bruix J, Sherman M. Practice Guidelines Committee, American Association for the Study of Liver Diseases: management of hepatocellular carcinoma. Hepatology42(5), 1208–1236 (2005).
  • Takayama T, Makuuchi M, Hirohashi S et al. Malignant transformation of adenomatous hyperplasia to hepatocellular carcinoma. Lancet336(8724), 1150–1153 (1990).
  • Sakamoto M, Hirohashi S, Shimosato Y. Early stages of multistep hepatocarcinogenesis: adenomatous hyperplasia and early hepatocellular carcinoma. Hum. Pathol.22(2), 172–178 (1991).
  • Hayashi M, Matsui O, Ueda K, Kawamori Y, Gabata T, Kadoya M. Progression to hypervascular hepatocellular carcinoma: correlation with intranodular blood supply evaluated with CT during intraarterial injection of contrast material. Radiology225(1), 143–149 (2002).
  • Kitao A, Zen Y, Matsui O, Gabata T, Nakanuma Y. Hepatocarcinogenesis: multistep changes of drainage vessels at CT during arterial portography and hepatic arteriography – radiologic–pathologic correlation. Radiology252(2), 605–614 (2009).
  • Cancer of the Liver Italian Program (CLIP) Investigators. Prospective validation of the CLIP score: a new prognostic system for patients with cirrhosis and hepatocellular carcinoma. Hepatology31(4), 840–845 (2000).
  • Llovet JM, Bru C, Bruix J. Prognosis of hepatocellular carcinoma: the BCLC staging classification. Semin. Liver Dis.19(3), 329–338 (1999).
  • Hemming AW, Cattral MS, Reed AI, Van Der Werf WJ, Greig PD, Howard RJ. Liver transplantation for hepatocellular carcinoma. Ann. Surg.233(5), 652–659 (2001).
  • Stevens WR, Johnson CD, Stephens DH, Batts KP. CT findings in hepatocellular carcinoma: correlation of tumor characteristics with causative factors, tumor size, and histologic tumor grade. Radiology191(2), 531–537 (1994).
  • Baron RL, Oliver JH 3rd, Dodd GD 3rd, Nalesnik M, Holbert BL, Carr B. Hepatocellular carcinoma: evaluation with biphasic, contrast-enhanced, helical CT. Radiology199(2), 505–511 (1996).
  • Lee HM, Lu DS, Krasny RM, Busuttil R, Kadell B, Lucas J. Hepatic lesion characterization in cirrhosis: significance of arterial hypervascularity on dual-phase helical CT. AJR Am. J. Roentgenol.169(1), 125–130 (1997).
  • Murakami T, Kim T, Takamura M et al. Hypervascular hepatocellular carcinoma: detection with double arterial phase multi-detector row helical CT. Radiology218(3), 763–767 (2001).
  • Laghi A, Iannaccone R, Rossi P et al. Hepatocellular carcinoma: detection with triple-phase multi-detector row helical CT in patients with chronic hepatitis. Radiology226(2), 543–549 (2003).
  • Monzawa S, Ichikawa T, Nakajima H, Kitanaka Y, Omata K, Araki T. Dynamic CT for detecting small hepatocellular carcinoma: usefulness of delayed phase imaging. AJR Am. J. Roentgenol.188(1), 147–153 (2007).
  • Jang HJ, Lim JH, Lee SJ, Park CK, Park HS, Do YS. Hepatocellular carcinoma: are combined CT during arterial portography and CT hepatic arteriography in addition to triple-phase helical CT all necessary for preoperative evaluation? Radiology215(2), 373–380 (2000).
  • Tajima T, Honda H, Taguchi K et al. Sequential hemodynamic change in hepatocellular carcinoma and dysplastic nodules: CT angiography and pathologic correlation. AJR Am. J. Roentgenol.178(4), 885–897 (2002).
  • Yoon SH, Lee JM, So YH et al. Multiphasic MDCT enhancement pattern of hepatocellular carcinoma smaller than 3 cm in diameter: tumor size and cellular differentiation. AJR Am. J. Roentgenol.193(6), W482–W489 (2009).
  • Bolondi L, Gaiani S, Celli N et al. Characterization of small nodules in cirrhosis by assessment of vascularity: the problem of hypovascular hepatocellular carcinoma. Hepatology42(1), 27–34 (2005).
  • Kudo M. Atypical large well-differentiated hepatocellular carcinoma with benign nature: a new clinical entity. Intervirology47(3–5), 227–237 (2004).
  • Koike Y, Nakagawa K, Shiratori Y et al. Factors affecting the prognosis of patients with hepatocellular carcinoma invading the portal vein: a retrospective analysis using 952 consecutive HCC patients. Hepatogastroenterology50(54), 2035–2039 (2003).
  • Pirisi M, Avellini C, Fabris C et al. Portal vein thrombosis in hepatocellular carcinoma: age and sex distribution in an autopsy study. J. Cancer Res. Clin. Oncol.124(7), 397–400 (1998).
  • Takizawa D, Kakizaki S, Sohara N et al. Hepatocellular carcinoma with portal vein tumor thrombosis: clinical characteristics, prognosis, and patient survival analysis. Dig. Dis. Sci.52(11), 3290–3295 (2007).
  • Ogren M, Bergqvist D, Bjorck M, Acosta S, Eriksson H, Sternby NH. Portal vein thrombosis: prevalence, patient characteristics and lifetime risk: a population study based on 23,796 consecutive autopsies. World J. Gastroenterol.12(13), 2115–2211 (2006).
  • Rossi S, Ghittoni G, Ravetta V et al. Contrast-enhanced ultrasonography and spiral computed tomography in the detection and characterization of portal vein thrombosis complicating hepatocellular carcinoma. Eur. Radiol.18(8), 1749–1756 (2008).
  • Tarantino L, Francica G, Sordelli I et al. Diagnosis of benign and malignant portal vein thrombosis in cirrhotic patients with hepatocellular carcinoma: color Doppler US, contrast-enhanced US, and fine-needle biopsy. Abdom. Imaging31(5), 537–544 (2006).
  • Krinsky GA, Lee VS, Theise ND et al. Transplantation for hepatocellular carcinoma and cirrhosis: sensitivity of magnetic resonance imaging. Liver Transpl.8(12), 1156–1164 (2002).
  • Noguchi Y, Murakami T, Kim T et al. Detection of hepatocellular carcinoma: comparison of dynamic MR imaging with dynamic double arterial phase helical CT. AJR Am. J. Roentgenol.180(2), 455–460 (2003).
  • Burrel M, Llovet JM, Ayuso C et al. MRI angiography is superior to helical CT for detection of HCC prior to liver transplantation: an explant correlation. Hepatology38(4), 1034–1042 (2003).
  • Kimura T, Hirokawa Y, Murakami Y et al. Reproducibility of organ position using voluntary breath-hold method with spirometer for extracranial stereotactic radiotherapy. Int. J. Radiat. Oncol. Biol. Phys.60(4), 1307–1313 (2004).
  • Hussain SM, Wielopolski PA, Martin DR. Abdominal magnetic resonance imaging at 3.0T: problem or a promise for the future? Top. Magn. Reson. Imaging16(4), 325–335 (2005).
  • Earls JP, Theise ND, Weinreb JC et al. Dysplastic nodules and hepatocellular carcinoma: thin-section MR imaging of explanted cirrhotic livers with pathologic correlation. Radiology201(1), 207–214 (1996).
  • Kelekis NL, Semelka RC, Worawattanakul S et al. Hepatocellular carcinoma in North America: a multiinstitutional study of appearance on T1-weighted, T2-weighted, and serial gadolinium-enhanced gradient-echo images. AJR Am. J. Roentgenol.170(4), 1005–1013 (1998).
  • Krinsky GA, Lee VS. MR imaging of cirrhotic nodules. Abdom. Imaging25(5), 471–482 (2000).
  • Kelekis NL, Semelka RC, Woosley JT. Malignant lesions of the liver with high signal intensity on T1-weighted MR images. J. Magn. Reson. Imaging6(2), 291–294 (1996).
  • Mitchell DG, Palazzo J, Hann HW, Rifkin MD, Burk DL Jr, Rubin R. Hepatocellular tumors with high signal on T1-weighted MR images: chemical shift MR imaging and histologic correlation. J. Comput. Assist. Tomogr.15(5), 762–769 (1991).
  • Stevens WR, Gulino SP, Batts KP, Stephens DH, Johnson CD. Mosaic pattern of hepatocellular carcinoma: histologic basis for a characteristic CT appearance. J. Comput. Assist. Tomogr.20(3), 337–342 (1996).
  • van den Bos IC, Hussain SM, Dwarkasing RS et al. MR imaging of hepatocellular carcinoma: relationship between lesion size and imaging findings, including signal intensity and dynamic enhancement patterns. J. Magn. Reson. Imaging26(6), 1548–1555 (2007).
  • Ebara M, Ohto M, Watanabe Y et al. Diagnosis of small hepatocellular carcinoma: correlation of MR imaging and tumor histologic studies. Radiology159(2), 371–377 (1986).
  • Onaya H, Itai Y. MR imaging of hepatocellular carcinoma. Magn. Reson. Imaging Clin. N. Am.8(4), 757–768 (2000).
  • Grazioli L, Olivetti L, Fugazzola C et al. The pseudocapsule in hepatocellular carcinoma: correlation between dynamic MR imaging and pathology. Eur. Radiol.9(1), 62–67 (1999).
  • Ng IO, Lai EC, Ng MM, Fan ST. Tumor encapsulation in hepatocellular carcinoma: a pathologic study of 189 cases. Cancer70(1), 45–49 (1992).
  • Wakasa K, Sakurai M, Kuroda C et al. Effect of transcatheter arterial embolization on the boundary architecture of hepatocellular carcinoma. Cancer65(4), 913–919 (1990).
  • Ishigami K, Yoshimitsu K, Nishihara Y et al. Hepatocellular carcinoma with a pseudocapsule on gadolinium-enhanced MR images: correlation with histopathologic findings. Radiology250(2), 435–443 (2009).
  • Freeny PC, Grossholz M, Kaakaji K, Schmiedl UP. Significance of hyperattenuating and contrast-enhancing hepatic nodules detected in the cirrhotic liver during arterial phase helical CT in pre-liver transplant patients: radiologic–histopathologic correlation of explanted livers. Abdom. Imaging28(3), 333–346 (2003).
  • Brancatelli G, Baron RL, Peterson MS, Marsh W. Helical CT screening for hepatocellular carcinoma in patients with cirrhosis: frequency and causes of false positive interpretation. AJR Am. J. Roentgenol.180(4), 1007–1014 (2003).
  • Jeong YY, Mitchell DG, Kamishima T. Small (<20 mm) enhancing hepatic nodules seen on arterial phase MR imaging of the cirrhotic liver: clinical implications. AJR Am. J. Roentgenol.178(6), 1327–1334 (2002).
  • Sheu JC, Sung JL, Chen DS et al. Growth rate of asymptomatic hepatocellular carcinoma and its clinical implications. Gastroenterology89(2), 259–266 (1985).
  • Willatt JM, Hussain HK, Adusumilli S, Marrero JA. MR Imaging of hepatocellular carcinoma in the cirrhotic liver: challenges and controversies. Radiology247(2), 311–330 (2008).
  • Kim YK, Kwak HS, Kim CS, Chung GH, Han YM, Lee JM. Hepatocellular carcinoma in patients with chronic liver disease: comparison of SPIO-enhanced MR imaging and 16–detector row CT. Radiology238(2), 531–541 (2006).
  • Bhartia B, Ward J, Guthrie JA, Robinson PJ. Hepatocellular carcinoma in cirrhotic livers double-contrast thin-section MR imaging with pathologic correlation of explanted tissue. AJR Am. J. Roentgenol.180(3), 577–584 (2003).
  • Lee JM, Kim IH, Kwak HS, Youk JH, Han YM, Kim CS. Detection of small hypervascular hepatocellular carcinomas in cirrhotic patients: comparison of superparamagnetic iron oxide-enhanced MR imaging with dual-phase spiral CT. Kor. J. Radiol.4(1), 1–8 (2003).
  • Kim SH, Choi D, Kim SH et al. Ferucarbotran-enhanced MRI versus triple-phase MDCT for the preoperative detection of hepatocellular carcinoma. AJR Am. J. Roentgenol.184(4), 1069–1076 (2005).
  • Tang Y, Yamashita Y, Arakawa A et al. Detection of hepatocellular carcinoma arising in cirrhotic livers: comparison of gadolinium- and ferumoxides-enhanced MR imaging. Am. J. Roentgenol.172(6), 1547–1554 (1999).
  • Pauleit D, Textor J, Bachmann R et al. Hepatocellular carcinoma: detection with gadolinium- and ferumoxides-enhanced MR imaging of the liver. Radiology222(1), 73–80 (2002).
  • Ward J, Guthrie JA, Scott DJ et al. Hepatocellular carcinoma in the cirrhotic liver: double-contrast MR imaging for diagnosis. Radiology216(1), 154–162 (2000).
  • Huppertz A, Haraida S, Kraus A et al. Enhancement of focal liver lesions at gadoxetic acid-enhanced MR imaging: correlation with histopathologic findings and spiral CT – initial observations. Radiology234(2), 468–478 (2005).
  • Sahani DV, O’Malley ME, Bhat S, Hahn PF, Saini S. Contrast-enhanced MRI of the liver with mangafodipir trisodium: imaging technique and results. J. Comput. Assist. Tomogr.26(2), 216–222 (2002).
  • Kim SH, Kim SH, Lee J et al. Gadoxetic acid-enhanced MRI versus triple-phase MDCT for the preoperative detection of hepatocellular carcinoma. AJR Am. J. Roentgenol.192(6), 1675–1681 (2009).
  • Kim YK, Kim CS, Lee YH, Kwak HS, Lee JM. Comparison of superparamagnetic iron oxide-enhanced and gadobenate dimeglumine-enhanced dynamic MRI for detection of small hepatocellular carcinomas. AJR Am. J. Roentgenol.182(5), 1217–1223 (2004)
  • But DY, Lai CL, Yuen MF. Natural history of hepatitis-related hepatocellular carcinoma. World J. Gastroenterol.14(11), 1652–1656 (2008).
  • Kaczynski J, Hansson G, Wallerstedt S. Metastases in cases with hepatocellular carcinoma in relation to clinicopathologic features of the tumor: an autopsy study from a low endemic area. Acta Oncol.34(1), 43–48 (1995).
  • Lee YT, Geer DA. Primary liver cancer: pattern of metastasis. J. Surg. Oncol.36(1), 26–31 (1987).
  • Catalano OA, Choy G, Zhu A, Hahn PF, Sahani DV. Differentiation of malignant thrombus from bland thrombus of the portal vein in patients with hepatocellular carcinoma: application of diffusion-weighted MR imaging. Radiology254(1), 154–162 (2010).
  • Ichikawa T, Haradome H, Hachiya J, Nitatori T, Araki T. Diffusion-weighted MR imaging with a single-shot echoplanar sequence: detection and characterization of focal hepatic lesions. AJR Am. J. Roentgenol.170(2), 397–402 (1998).
  • Vandecaveye V, De Keyzer F, Verslype C et al. Diffusion-weighted MRI provides additional value to conventional dynamic contrast-enhanced MRI for detection of hepatocellular carcinoma. Eur. Radiol.19(10), 2456–2466 (2009).
  • Naik M, Mannelli L, Chandarana H, Lee V, Taouli B. Hepatocellular carcinoma: assessment of tumor oxygenation with BOLD MRI. Proc. Intl Soc. Mag. Reson. Med.16, 3741 (2008).
  • Curley SA, Izzo F, Ellis LM, Nicolas Vauthey J, Vallone P. Radiofrequency ablation of hepatocellular cancer in 110 patients with cirrhosis. Ann. Surg.232(3), 381–391 (2000).
  • Lim HK, Choi D, Lee WJ et al. Hepatocellular carcinoma treated with percutaneous radio-frequency ablation: evaluation with follow-up multiphase helical CT. Radiology221(2), 447–454 (2001).
  • Park Y, Choi D, Lim HK et al. Growth rate of new hepatocellular carcinoma after percutaneous radiofrequency ablation: evaluation with multiphase CT. AJR Am. J. Roentgenol.191(1), 215–220 (2008).
  • Lencioni R, Cioni D, Crocetti L et al. Early-stage hepatocellular carcinoma in patients with cirrhosis: long-term results of percutaneous image-guided radiofrequency ablation. Radiology234(3), 961–967 (2005).
  • Harrison LE, Koneru B, Baramipour P et al. Locoregional recurrences are frequent after radiofrequency ablation for hepatocellular carcinoma. J. Am. Coll. Surg.197(5), 759–764 (2003).
  • Park MH, Rhim H, Kim YS, Choi D, Lim HK, Lee WJ. Spectrum of CT findings after radiofrequency ablation of hepatic tumors. Radiographics28(2), 379–390 (2008).
  • Choi D, Lim HK, Kim SH et al. Assessment of therapeutic response in hepatocellular carcinoma treated with percutaneous radio frequency ablation: comparison of multiphase helical computed tomography and power Doppler ultrasonography with a microbubble contrast agent. J. Ultrasound Med.21(4), 391–401 (2002).
  • Bruix J, Llovet JM, Castells A et al. Transarterial embolization versus symptomatic treatment in patients with advanced hepatocellular carcinoma: results of a randomized, controlled trial in a single institution. Hepatology27(6), 1578–1583 (1998).
  • Llovet JM, Real MI, Montana X et al. Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomized controlled trial. Lancet359(9319), 1734–1739 (2002).
  • Kubota K, Hisa N, Nishikawa T et al. Evaluation of hepatocellular carcinoma after treatment with transcatheter arterial chemoembolization: comparison of lipiodol CT, power Doppler sonography, and dynamic MRI. Abdom. Imaging26(2), 184–190 (2001).
  • Morimoto M, Shirato K, Sugimori K et al. Contrast-enhanced harmonic gray-scale sonographic–histologic correlation of the therapeutic effects of transcatheter arterial chemoembolization in patients with hepatocellular carcinoma. Am. J. Roentgenol.181(1), 65–69 (2003).
  • Chen CY, Li CW, Kuo YT et al. Early response of hepatocellular carcinoma to transcatheter arterial chemoembolization: choline levels and MR diffusion constants – initial experience. Radiology239(2), 448–456 (2006).
  • Mannelli L, Kim S, Hajdu C et al. Assessment of tumor necrosis of hepatocellular carcinoma after chemoembolization: diffusion-weighted and contrast-enhanced MRI with histopathologic correlation of the explanted liver. AJR Am. J. Roentgenol.193(4), 1044–1052 (2009).
  • Choi SH, Lee JM, Yu NC et al. Hepatocellular carcinoma in liver transplantation candidates: detection with gadobenate dimeglumine-enhanced MRI. AJR Am. J. Roentgenol.191(2), 529–536 (2008).
  • Rode A, Bancel B, Douek P et al. Small nodule detection in cirrhotic livers: evaluation with US, spiral CT, and MRI and correlation with pathologic examination of explanted liver. J. Comput. Assist. Tomogr.25(3), 327–336 (2001).
  • Peterson MS, Baron RL, Marsh JW Jr, Oliver JH 3rd, Confer SR, Hunt LE. Pretransplantation surveillance for possible hepatocellular carcinoma in patients with cirrhosis: epidemiology and CT-based tumor detection rate in 430 cases with surgical pathologic correlation. Radiology217(3), 743–749 (2000).

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