217
Views
15
CrossRef citations to date
0
Altmetric
Drug Profile

Bevacizumab in glioblastoma multiforme

Pages 9-18 | Published online: 10 Jan 2014

References

  • Wen PY, Kesari S. Malignant gliomas in adults. N. Engl. J. Med.359(5), 492–507 (2008).
  • Stupp R, Mason WP, van den Bent MJ et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N. Engl. J. Med.352(10), 987–996 (2005).
  • Stupp R, Hegi ME, Mason WP et al. Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised Phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol.10(5), 459–466 (2009).
  • Bauchet L, Mathieu-Daude H, Fabbro-Peray P et al. Oncological patterns of care and outcome for 952 patients with newly diagnosed glioblastoma in 2004. Neuro Oncol. doi:10.1093/neuonc/noq030 (2010) (Epub ahead of print).
  • Fuentes-Raspall R, Vilardell L, Perez-Bueno F et al. Population-based incidence and survival of central nervous system (CNS) malignancies in Girona (Spain) 1994–2005. J. Neurooncol.101(1), 117–123 (2011).
  • Scoccianti S, Magrini SM, Ricardi U et al. Patterns of care and survival in a retrospective analysis of 1059 patients with glioblastoma multiforme treated between 2002 and 2007: a multicenter study by the Central Nervous System Study Group of Airo (Italian Association of Radiation Oncology). Neurosurgery67(2), 446–458 (2010).
  • Koshy M, Vilano JL, Dolecek TA et al. Improved survival time trends for glioblastoma using the SEER 17 population-based registries. J. Clin. Oncol.29(Suppl.), 2013 (2011).
  • Lwin Z, MacFadden D, Al-Zahrani A et al. A population-based study of glioblastoma multiforme (GBM) in the new stupp paradigm: have we improved outcome? J. Clin. Oncol.29(Suppl.), 2012 (2011) (Abstract).
  • Preusser M, Woehrer A, Zielonke N et al. Real-life survival in unselected adult glioblastoma patients: A population-based study. J. Clin. Oncol.29(Suppl.), 2014 (2011) (Abstract).
  • Norden AD, Drappatz J, Wen PY. Novel anti-angiogenic therapies for malignant gliomas. Lancet Neurol.7(12), 1152–1160 (2008).
  • Lu JF, Bruno R, Eppler S, Novotnv W, Lum B, Gaudreault J. Clinical pharmacokinetics of bevacizumab in patients with solid tumors. Cancer Chemother. Pharmacol.62(5), 779–786 (2008).
  • Stark-Vance V. Bevacizumab and CPT-11 in the treatment of relapsed malignant glioma. Neuro Oncol.7(369), (2005) (Abstract).
  • Taillibert S, Hoang-Xuan K, Barrie M et al. Bevacizumab (B) with irinotecan (I) in recurrent glioblastoma (Gbm): a national retrospective cohort of the ANOCEF (Association des Neuro-Oncologues D’Expression Francaise) Group. Neuro Oncol.12, 52–53 (2010) (Abstract).
  • Francesconi AB, Dupre S, Matos M et al. Carboplatin and etoposide combined with bevacizumab for the treatment of recurrent glioblastoma multiforme. J. Clin. Neurosci.17(8), 970–974 (2010).
  • Sehebjam S, Ang C, Guiot M et al. Efficacy, safety and pattern of relapse of bevacizumab versus chemotherapy for recurrent glioblastoma multiforme: a McGill University study. Ann. Oncol.21(Suppl. 8), 1059P (2010) (Abstract).
  • Chamberlain MC, Johnston SK. Salvage therapy with single-agent bevacizumab for recurrent glioblastoma. J. Neurooncol.96(2), 259–269 (2010).
  • Hofer S, Elandt K, Greil R et al. Clinical outcome with bevacizumab in patients with recurrent high-grade glioma treated outside clinical trials. Acta Oncol.50(5), 630–635 (2011).
  • Nghiemphu PL, Liu W, Lee Y et al. Bevacizumab and chemotherapy for recurrent glioblastoma: a single-institution experience. Neurology72(14), 1217–1222 (2009).
  • Poulsen HS, Grunnet K, Sorensen M et al. Bevacizumab plus irinotecan in the treatment patients with progressive recurrent malignant brain tumours. Acta Oncol.48(1), 52–58 (2009).
  • Zuniga RM, Torcuator R, Jain R et al. Efficacy, safety and patterns of response and recurrence in patients with recurrent high-grade gliomas treated with bevacizumab plus irinotecan. J. Neurooncol.91(3), 329–336 (2009).
  • Chamberlain MC, Johnston SK. Recurrent spinal cord glioblastoma: salvage therapy with bevacizumab. J. Neurooncol.102(3), 427–432 (2011).
  • Vredenburgh JJ, Desjardins A, Herndon JE et al. Bevacizumab plus irinotecan in recurrent glioblastoma multiforme. J. Clin. Oncol.25(30), 4722–4729 (2007).
  • Reardon DA, Desjardins A, Vredenburgh JJ et al. Metronomic chemotherapy with daily, oral etoposide plus bevacizumab for recurrent malignant glioma: a Phase II study. Br. J. Cancer101(12), 1986–1994 (2009).
  • Soffietti R, Trevisan E, Ruda R et al. Phase II trial of bevacizumab with fotemustine in recurrent glioblastoma: final results of a multicenter study of AINO (Italian Association of Neuro-oncology). J. Clin. Oncol.29(Suppl.), 2027 (2011) (Abstract).
  • Trevisan E, Ruda R, Picco E et al. Bevacizumab and fotemustine as salvage therapy in recurrent glioblastoma: a Phase II multicenter Italian study. Neuro Oncol.12(iii), P117 (2010) (Abstract).
  • Kobyakov G, Absalyamova O, Amanov R. Bevacizumab in combination with irinotecan or temozolomide in recurrent glioblastoma: efficacy and safety results from a pilot study. Neuro Oncol.12, 54 (2010) (Abstract).
  • Keyrouz VR, Elias EF, Chahine GY, Comair YG, Dimassi H, Kamar FG. Updated results of a Phase II trial of bevacizumab and irinotecan in relapsed high grade glioma. Neuro Oncol.12(iii), P108 (2010) (Abstract).
  • Verhoeff JJC, Lavini C, van Linde ME et al. Bevacizumab and dose-intense temozolomide in recurrent high-grade glioma. Ann. Oncol.21(8), 1723–1727 (2010).
  • Kreisl TN, Kim L, Moore K et al. Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma. J. Clin. Oncol.27(5), 740–745 (2009).
  • Raizer JJ, Grimm S, Chamberlain MC et al. A Phase 2 trial of single-agent bevacizumab given in an every-3-week schedule for patients with recurrent high-grade gliomas. Cancer116(22), 5297–5305 (2010).
  • Desjardins A, Vredenburgh JJ, Reardon DA et al. Long-term survival from the initial trial of bevacizumab and irinotecan. J. Clin. Oncol.28(15s), 2045 (2010) (Abstract).
  • Geludkova OG, Borodina ID, Melikian AG et al. Results of treatment pediatric recurrent high grade glioma with combination of bevacizumab and irinotecan. Neuro Oncol.12(iii), P131 (2010) (Abstract).
  • Gururangan S, Chi SN, Poussaint TY et al. Lack of efficacy of bevacizumab plus irinotecan in children with recurrent malignant glioma and diffuse brainstem glioma: a pediatric brain tumor consortium study. J. Clin. Oncol.28(18), 3069–3075 (2010).
  • Friedman HS, Prados MD, Wen PY et al. Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma. J. Clin. Oncol.27(28), 4733–4740 (2009).
  • Cloughesy TF, Vredenburgh JJ, Day B, Das A, Friedland HS. Updated safety and survival of patients with relapsed glioblastoma treated with bevacizumab in the BRAIN study. J. Clin. Oncol.28(15s), 2008 (2010) (Abstract).
  • Prados M, Cloughesy T, Samant M et al. Response as a predictor of survival in patients with recurrent glioblastoma treated with bevacizumab. Neuro Oncol.13(1), 143–151 (2011).
  • Vredenburgh JJ, Cloughesy T, Samant M et al. Corticosteroid use in patients with glioblastoma at first or second relapse treated with bevacizumab in the BRAIN study. Oncologist15(12), 1329–1334 (2010).
  • Gilbert MR, Wang MH, Aldape K et al. Rtog 0625: a randomized Phase II trial of bevacizumab with either irinotecan (Cpt) or dose-dense temozolomide (Tmz) in recurrent glioblastoma (Gbm). Neuro Oncol.12, 39 (2010) (Abstract).
  • van den Bent M, Taal W, Sleijfer S et al. Toxicity of combined bevacizumab-lomustine treatment in patients with recurrent glioblastoma (Gbm): report from a randomized Phase II study. Neuro Oncol.12, 42 (2010) (Abstract).
  • Wong ET, Gautam S, Malchow C, Lun M, Pan E, Brem S. Bevacizumab for recurrent glioblastoma multiforme: a meta-analysis. Ann. Neurol.68(4), S61–S62 (2010) (Abstract).
  • Norden AD, Bartolomeo J, Tanaka S et al. Safety of concurrent bevacizumab therapy and anticoagulation in glioma patients. J. Neurooncol. doi:10.1007/s11060-011-0642-1 (2011) (Epub ahead of print).
  • Clark AJ, Butowski NA, Chang SM et al. Impact of bevacizumab chemotherapy on craniotomy wound healing. J. Neurosurg.114(6), 1609–1616 (2011).
  • Chamberlain MC, Raizer J. Optic neuropathy in patients with glioblastoma receiving bevacizumab. Neurology75(3), 289–290 (2010).
  • Sherman JH, Aregawi DG, Lai A et al. Optic neuropathy in patients with glioblastoma receiving bevacizumab. Neurology73(22), 1924–1926 (2009).
  • Batchelor TT, Duda DG, di Tomaso E et al. Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma. J. Clin. Oncol.28(17), 2817–2823 (2010).
  • Batchelor TT, Mulholland P, Neyns B, et al. A Phase III randomized study comparing the efficacy of cediranib as monotherapy, and in combination with lomustine, with lomustine alone in recurrent glioblastoma patients. Ann. Oncol.21(Suppl. 8), LBA7 (2010) (Abstract).
  • Wick W, Puduvalli VK, Chamberlain MC et al. Phase III study of enzastaurin compared with lomustine in the treatment of recurrent intracranial glioblastoma. J. Clin. Oncol.28(7), 1168–1174 (2010).
  • Carson KA, Grossman SA, Fisher JD, Shaw EG. Prognostic factors for survival in adult patients with recurrent glioma enrolled onto the new approaches to brain tumor therapy CNS consortium Phase I and II clinical trials. J. Clin. Oncol.25(18), 2601–2606 (2007).
  • Pace A, Conti L, Russillo M et al. Bevacizumab-based therapy recurrent malignant glioma: correlation between serum VEGF and response to treatment. Neuro Oncol.12, 33–34 (2010).
  • Nangia CS, Wang D, Scarpace L, Schultz L, Khanshour A, Mikkelsen T. The role of the development of hypertension or proteinuria in predicting outcome with the use of bevacizumab for patients with glioblastoma multiforme (GBM). J. Clin. Oncol.29(Suppl.), 2021 (2011) (Abstract).
  • Wu J, Gilbert MR, de Groot JF, Yung WA, Puduvalli VK. Diffusion restriction as a predictor of response in recurrent glioblastoma patients receiving bevacizumab. J. Clin. Oncol.28(15s), 2024 (2010) (Abstract).
  • Gupta A, Young RJ, Karimi S, et al. Isolated diffusion restriction precedes the development of enhancing tumor in a subset of patients with glioblastoma. AJNR Am. J. Neuroradiol.32(7), 1301–1306 (2011).
  • Gerstner ER, Frosch MP, Batchelor TT. Diffusion magnetic resonance imaging detects pathologically confirmed, nonenhancing tumor progression in a patient with recurrent glioblastoma receiving bevacizumab. J. Clin. Oncol.28(6), e91–e93 (2010).
  • Chen W, Delaloye S, Silverman DHS et al. Predicting treatment response of malignant gliomas to bevacizumab and irinotecan by imaging proliferation with [18F] fluorothymidine positron emission tomography: a pilot study. J. Clin. Oncol.25, 4714–4721 (2007).
  • Quant EC, Norden AD, Drappatz J et al. Role of a second chemotherapy in recurrent malignant glioma patients who progress on bevacizumab. Neuro Oncol.11(5), 550–555 (2009).
  • Iwamoto FM, Abrey LE, Beal K et al. Patterns of relapse and prognosis after bevacizumab failure in recurrent glioblastoma. Neurology73(15), 1200–1206 (2009).
  • Zuniga RM, Torcuator R, Jain R et al. Rebound tumour progression after the cessation of bevacizumab therapy in patients with recurrent high-grade glioma. J. Neurooncol.99(2), 237–242 (2010).
  • Reardon DA, Desjardins A, Peters K et al. Phase II study of metronomic chemotherapy with bevacizumab for recurrent glioblastoma after progression on bevacizumab therapy. J. Neurooncol.103(2), 371–379 (2011).
  • Reardon DA, Vredenburgh JJ, Desjardins A et al. Meta-analysis of five consecutive recurrent glioblastoma (GBM) trials. J. Clin. Oncol.29(Suppl.), 2030 (2011) (Abstract).
  • Wick A, Dörner N, Schäfer N et al. Bevacizumab does not increase the risk of remote relapse in malignant glioma. Ann. Neurol.69(3), 586–592 (2011).
  • Cuneo KC, Cabrera AR, Sampson JH et al. Safety results from a prospective study of concurrent radiosurgery and bevacizumab for recurrent malignant glioma. J. Clin. Oncol.29(Suppl.), 2082 (2011) (Abstract).
  • Gutin PH, Iwamoto FM, Beal K et al. Safety and efficacy of bevacizumab with hypofractionated stereotactic irradiation for recurrent malignant gliomas. Int. J. Radiat. Oncol. Biol. Phys.75(1), 156–163 (2009).
  • Sathornsumetee S, Desjardins A, Vredenburgh JJ et al. Phase II trial of bevacizumab and erlotinib in patients with recurrent malignant glioma. Neuro Oncol.12(12), 1300–1310 (2010).
  • Hasselbalch B, Lassen U, Hansen S et al. Cetuximab, bevacizumab, and irinotecan for patients with primary glioblastoma and progression after radiation therapy and temozolomide: a Phase II trial. Neuro Oncol.12(5), 508–516 (2010).
  • Moustakas A, Iwamoto FM, Kreisl TN et al. Phase II trial of enzastaurin (Enz) with bevacizumab (Bv) in adults with recurrent glioblastoma (Gem). Neuro Oncol.12, 37 (2010) (Abstract).
  • Gaziel TB, Soerensen M, Hasselbalch B, Poulsen HS, Lassen U. Phase II study of bevacizumab and temsirolimus in patients with progressive glioblastoma multiforme after prior bevacizumab treatment. Neuro Oncol.12, 40 (2010).
  • Bota DA, Eroglu Z, Reardon DA et al. Phase II clinical trial of bortezomib and bevacizumab combination in recurrent glioblastoma. J. Clin. Oncol.29(Suppl.), 2056 (2011) (Abstract).
  • Galanis E, Jaeckle KA, Anderson SK et al. NCCTG Phase II trial of bevacizumab in combination with sorafenib in recurrent GBM. J. Clin. Oncol.28(15s), 2018 (2010).
  • Drappatz J, Raizer JJ, Schiff D et al. A Phase I trial of LBH589 and bevacizumab for recurrent high-grade glioma (HGG). J. Clin. Oncol.29(Suppl.), 2050 (2011) (Abstract).
  • Lou E, Reardon DA, Peters K et al. Upfront bevacizumab with temozolomide or with temozolomide and irinotecan for unresectable or multifocal glioblastoma. J. Clin. Oncol.29(Suppl.), 2055 (2011) (Abstract).
  • Chauffert B, Feuvet L, Bonnetain F et al. Randomized multicenter Phase II trial of irinotecan and bevacizumab as neoadjuvant and adjuvant to temozolomide-based chemoradiation versus chemoradiation for unresectable glioblastoma: interim results of the TEMAVIR study from the ANOCEF group. J. Clin. Oncol.29(Suppl.), 2029 (2011) (Abstract).
  • Hofland KF, Poulsen HS, Sorensen MP et al. First-line therapy with bevacizumab and irinotecan versus bevacizumab and temozolomide and delayed concomitant radiotherapy in newly diagnosed primary glioblastoma multiforme: early results from a randomized Phase II study. Neuro Oncol.11(5), 620 (2009) (Abstract).
  • Vredenburgh JJ, Desjardins A, Reardon DA et al. The addition of bevacizumab to standard radiation therapy and temozolomide followed by bevacizumab, temozolomide and irinotecan for newly diagnosed glioblastoma. Clin.Cancer Res.69(3), 586–592 (2011).
  • Lai A, Tran A, Nghiemphu PL et al. Phase II study of bevacizumab plus temozolomide during and after radiation therapy for patients with newly diagnosed glioblastoma multiforme. J. Clin. Oncol.29(2), 142–148 (2011).
  • Omuro AM, Beal K, Karimi S et al. Phase II study of bevacizumab (BEV), temozolomide (TMZ), and hypofractionated stereotactic radiotherapy (HFSRT) for newly diagnosed glioblastoma (GBM). J. Clin. Oncol.29(Suppl.), 2028 (2011) (Abstract).
  • Chinot OL, de La Motte Rouge T, Moore N et al. AVAglio: Phase 3 trial of bevacizumab plus temozolomide and radiotherapy in newly diagnosed glioblastoma multiforme. Adv. Ther.28(4), 334–340 (2011).
  • Shih KC, Spikel DR, Burris HA III, Brown RH, Shepard GC, Hainsworth JD. Phase II trial of radiation therapy/temozolomide/bevacizumab followed by bevacizumab/everolimus in the first-line treatment of glioblastoma multiforme (GBM). J. Clin. Oncol.28(15s), 2075 (2010) (Abstract).
  • Cohen MH, Shen YL, Keegan P, Pazdur R. FDA Drug Approval Summary: bevacizumab (Avastin®) as treatment of recurrent glioblastoma multiforme. Oncologist14(11), 1131–1138 (2009).
  • Balana C, Etxaniz O, Buges C, Martinez A. Approval denied by the European Medicines Agency (EMA) for bevacizumab in the treatment of high-grade glioma recurrence: a good idea or a grave error? Clin. Transl. Oncol.13(3), 209–210 (2011).

Websites

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.