Improving triage and management of patients with skin cancer: challenges and considerations for the future

References

• Coory M, Baade P, Aitken J, Smithers M, McLeod GRC, Ring I. Trends for in situ and invasive melanoma in Queensland, Australia, 1982–2002. Cancer Causes Control17(1), 21–27 (2006).
   PubMed Web of Science ®Google Scholar
• Buettner PG, Raasch BA. Incidence rates of skin cancer in Townsville, Australia. Int. J. Cancer78(5), 587–593 (1998).
   PubMed Web of Science ®Google Scholar
• Cox NH. Evaluation of the U.K. 2-week referral rule for skin cancer. Br. J. Dermatol.150(2), 291–298 (2004).
   PubMedGoogle Scholar
• Argenziano G, Puig S, Zalaudek I et al. Dermoscopy improves accuracy of primary care physicians to triage lesions suggestive of skin cancer. J. Clin. Oncol.24(12), 1877–1882 (2006).
   PubMedGoogle Scholar
• Giacomel J. Are superficial basal cell carcinomas the most common cancer in the Australian community? Cancer Forum28(1), 34 (2004).
   Google Scholar
• Soyer HP, Argenziano G, Zalaudek I et al. Three-point checklist of dermoscopy. A new screening method for early detection of melanoma. Dermatology208(1), 27–31 (2004).
   PubMed Web of Science ®Google Scholar
• Price HN, Schaffer JV. Congenital melanocytic nevi-when to worry and how to treat: facts and controversies. Clin. Dermatol.28(3), 293–302 (2010).
   Google Scholar
• Schaffer JV. Pigmented lesions in children: when to worry. Curr. Opin. Pediatr.19(4), 430–440 (2007).
   PubMed Web of Science ®Google Scholar
• Moscarella E, Zalaudek I, Ferrara G, Manzo M, Savarese I, Argenziano G. Problematic melanocytic lesions in children. Expert Rev. Dermatol.4(3), 249–261 (2009).
   Google Scholar
• Paradela S, Fonseca E, Pita S et al. Spitzoid melanoma in children: clinicopathological study and application of immunohistochemistry as an adjunct diagnostic tool. J. Cutan. Pathol.36(7), 740–752 (2008).
   Google Scholar
• Tom WL, Hsu JW, Eichenfield LF, Friedlander SF. Pediatric ‘STUMP’ lesions: evaluation and management of difficult atypical Spitzoid lesions in children. J. Am. Acad. Dermatol.64(3), 559–572 (2011).
   PubMedGoogle Scholar
• Lewis KG. Trends in pediatric melanoma mortality in the United States, 1968 through 2004. Dermatol. Surg.34(2), 152–159 (2008).
   PubMed Web of Science ®Google Scholar
• Bauer J, Garbe C. Acquired melanocytic nevi as risk factor for melanoma development. A comprehensive review of epidemiological data. Pigment Cell Res.16(3), 297–306 (2003).
   Google Scholar
• Quéreux G, Moyse D, Lequeux Y et al. Development of an individual score for melanoma risk. Eur. J. Cancer Prev.20(3), 217–224 (2011).
   PubMed Web of Science ®Google Scholar
• Abbasi NR, Shaw HM, Rigel DS et al. Early diagnosis of cutaneous melanoma: revisiting the ABCD criteria. JAMA292(22), 2771–2776 (2004).
   PubMed Web of Science ®Google Scholar
• Thomas L, Tranchand P, Berard F, Secchi T, Colin C, Moulin G. Semiological value of ABCDE criteria in the diagnosis of cutaneous pigmented tumors. Dermatology197(1), 11–17 (1998).
   PubMed Web of Science ®Google Scholar
• Kelly JW, Chamberlain AJ, Staples MP, McAvoy B. Nodular melanoma. No longer as simple as ABC. Aust. Fam. Physician32(9), 706–709 (2003).
   PubMedGoogle Scholar
• Chamberlain AJ, Fritschi L, Kelly JW. Nodular melanoma: patients’ perceptions of presenting features and implications for earlier detection. J. Am. Dermatol.48(5), 694–701 (2003).
   PubMed Web of Science ®Google Scholar
• Argenziano G, Zalaudek I, Hofmann-Wellenhof R et al. Total body skin examination for skin cancer screening in patients with focused symptoms. J. Am. Acad. Dermatol.66(2), 212–219 (2012).
   PubMed Web of Science ®Google Scholar
• Argenziano G, Soyer HP, Chimenti S et al. Dermoscopy of pigmented skin lesions: results of a consensus meeting via the Internet. J. Am. Acad. Dermatol.48(5), 679–693 (2003).
   PubMed Web of Science ®Google Scholar
• Bafounta ML, Beauchet A, Aegerter P, Saiag P. Is dermoscopy (epiluminescence microscopy) useful for the diagnosis of melanoma? Results of a meta-analysis using techniques adapted to the evaluation of diagnostic tests. Arch. Dermatol.137(10), 1343–1350 (2001).
   PubMedGoogle Scholar
• Kittler H, Pehamberger H, Wolff K, Binder M. Diagnostic accuracy of dermoscopy. Lancet Oncol.3(3), 159–165 (2002).
   PubMed Web of Science ®Google Scholar
• Carli P, De Giorgi V, Chiarugi A et al. Addition of dermoscopy to conventional naked-eye examination in melanoma screening: a randomized study. J. Am. Acad. Dermatol.50(5), 683–689 (2004).
   PubMed Web of Science ®Google Scholar
• Carli P, De Giorgi V, Crocetti E et al. Improvement of malignant/benign ratio in excised melanocytic lesions in the ‘dermoscopy era’: a retrospective study 1997–2001. Br. J. Dermatol.150(4), 687–692 (2004).
   PubMed Web of Science ®Google Scholar
• Vestergaard ME, Macaskill P, Holt PE, Menzies SW. Dermoscopy compared with naked eye examination for the diagnosis of primary melanoma: a meta-analysis of studies performed in a clinical setting. Br. J. Dermatol.159(3), 669–676 (2008).
   PubMed Web of Science ®Google Scholar
• Argenziano G, Cerroni L, Zalaudek I et al. Accuracy in melanoma detection: a 10-year multicenter survey. J. Am. Acad. Dermatol. doi:10.1016/j.jaad.2011.07.019 (2011) (Epub ahead of print).
   Google Scholar
• Zalaudek I, Kittler H, Marghoob AA et al. Time required for a complete skin examination with and without dermoscopy: a prospective, randomized multicenter study. Arch. Dermatol.144(4), 509–513 (2008).
   PubMedGoogle Scholar
• Argenziano G, Ferrara G, Francione S, Di Nola K, Martino A, Zalaudek I. Dermoscopy – the ultimate tool for melanoma diagnosis. Semin. Cutan. Med. Surg.28(3), 142–148 (2009).
   PubMed Web of Science ®Google Scholar
• Kittler H, Seltenheim M, Dawid M, Pehamberger H, Wolff K, Binder M. Morphologic changes of pigmented skin lesions: a useful extension of the ABCD rule for dermatoscopy. J. Am. Acad. Dermatol.40(4), 558–562 (1999).
   Google Scholar
• Menzies SW, Emery J, Staples M et al. Impact of dermoscopy and short-term sequential digital dermoscopy imaging for the management of pigmented lesions in primary care: a sequential intervention trial. Br. J. Dermatol.161(6), 1270–1277 (2009).
   PubMed Web of Science ®Google Scholar
• Malvehy J, Puig S. Follow-up of melanocytic skin lesions with digital total-body photography and digital dermoscopy: a two-step method. Clin. Dermatol.20(3), 297–304 (2002).
   PubMed Web of Science ®Google Scholar
• Geller AC, O’Riordan DL, Oliveria SA, Valvo S, Teich M, Halpern AC. Overcoming obstacles to skin cancer examinations and prevention counseling for high-risk patients: results of a national survey of primary care physicians. J. Am. Board Fam. Pract.17(6), 416–423 (2004).
   PubMedGoogle Scholar
• Geller AC, Koh HK, Miller DR, Clapp RW, Mercer MB, Lew RA. Use of health services before the diagnosis of melanoma: implications for early detection and screening. J. Gen. Intern. Med.7(2), 154–157 (1992).
   PubMedGoogle Scholar
• Menzies SW, Gutenev A, Avramidis M, Batrac A, McCarthy WH. Short-term digital surface microscopic monitoring of atypical or changing melanocytic lesions. Arch. Dermatol.137(12), 1583–1589 (2001).
   PubMedGoogle Scholar
• Argenziano G, Zalaudek I, Ferrara G et al. Dermoscopy features of melanoma incognito: indications for biopsy. J. Am. Acad. Dermatol.56(3), 508–513 (2007).
   PubMed Web of Science ®Google Scholar
• Zalaudek I, Argenziano G, Ferrara G et al. Clinically equivocal melanocytic skin lesions with features of regression: a dermoscopic-pathological study. Br. J. Dermatol.150(1), 64–71 (2004).
   PubMed Web of Science ®Google Scholar
• Argenziano G, Kittler H, Ferrara G et al. Slow-growing melanoma: a dermoscopy follow-up study. Br. J. Dermatol.162(2), 267–273 (2010).
   PubMed Web of Science ®Google Scholar
• Altamura D, Avramidis M, Menzies SW. Assessment of the optimal interval for and sensitivity of short-term sequential digital dermoscopy monitoring for the diagnosis of melanoma. Arch. Dermatol.144(4), 502–506 (2008).
   PubMed Web of Science ®Google Scholar
• Pellacani G, Guitera P, Longo C, Avramidis M, Seidenari S, Menzies S. The impact of in vivo reflectance confocal microscopy for the diagnostic accuracy of melanoma and equivocal melanocytic lesions. J. Invest. Dermatol.127(12), 2759–2765 (2007).
   PubMed Web of Science ®Google Scholar
• Guitera P, Pellacani G, Crotty KA et al. The impact of in vivo reflectance confocal microscopy on the diagnostic accuracy of lentigo maligna and equivocal pigmented and nonpigmented macules of the face. J. Invest. Dermatol.130(8), 2080–2091 (2010).
   PubMed Web of Science ®Google Scholar
• Pellacani G, Cesinaro AM, Seidenari S. Reflectance-mode confocal microscopy of pigmented skin lesions–improvement in melanoma diagnostic specificity. J. Am. Acad. Dermatol.53(6), 979–985 (2005).
   PubMed Web of Science ®Google Scholar
• Gerger A, Koller S, Kern T et al. Diagnostic applicability of in vivo confocal laser scanning microscopy in melanocytic skin tumors. J. Invest. Dermatol.124(3), 493–498 (2005).
   PubMed Web of Science ®Google Scholar
• Busam KJ, Hester K, Charles C et al. Detection of clinically amelanotic malignant melanoma and assessment of its margins by in vivo confocal scanning laser microscopy. Arch. Dermatol.137(7), 923–929 (2001).
   PubMed Web of Science ®Google Scholar
• Braga JCT, Scope A, Klaz I et al. The significance of reflectance confocal microscopy in the assessment of solitary pink skin lesions. J. Am. Acad. Dermatol.61(2), 230–241 (2009).
   PubMed Web of Science ®Google Scholar
• Suh K-Y, Bolognia JL. Signature nevi. J. Am. Acad. Dermatol.60(3), 508–514 (2009).
   Google Scholar
• Scope A, Dusza SW, Halpern AC et al. The ‘ugly duckling’ sign: agreement between observers. Arch. Dermatol.144(1), 58–64 (2008).
   PubMedGoogle Scholar
• Argenziano G, Catricalà C, Ardigo M et al. Dermoscopy of patients with multiple nevi: Improved management recommendations using a comparative diagnostic approach. Arch. Dermatol.147(1), 46–49 (2011).
   Google Scholar
• Haenssle HA, Korpas B, Hansen-Hagge C et al. Selection of patients for long-term surveillance with digital dermoscopy by assessment of melanoma risk factors. Arch. Dermatol.146(3), 257–264 (2010).
   Google Scholar
• Haenssle HA, Krueger U, Vente C et al. Results from an observational trial: digital epiluminescence microscopy follow-up of atypical nevi increases the sensitivity and the chance of success of conventional dermoscopy in detecting melanoma. J. Invest. Dermatol.126(5), 980–985 (2006).
   Google Scholar
• Kittler H, Guitera P, Riedl E et al. Identification of clinically featureless incipient melanoma using sequential dermoscopy imaging. Arch. Dermatol.142(9), 1113–1119 (2006).
   PubMed Web of Science ®Google Scholar
• Kittler H, Binder M. Risks and benefits of sequential imaging of melanocytic skin lesions in patients with multiple atypical nevi. Arch. Dermatol.137(12), 1590–1595 (2001).
   PubMedGoogle Scholar
• Marghoob AA, Kopf AW, Rigel DS et al. Risk of cutaneous malignant melanoma in patients with ‘classic’ atypical-mole syndrome. A case–control study. Arch. Dermatol.130(8), 993–998 (1994).
   Google Scholar
• Argenziano G, Mordente I, Ferrara G, Sgambato A, Annese P, Zalaudek I. Dermoscopic monitoring of melanocytic skin lesions: clinical outcome and patient compliance vary according to follow-up protocols. Br. J. Dermatol.159(2), 331–336 (2008).
   Google Scholar
• Banky JP, Kelly JW, English DR, Yeatman JM, Dowling JP. Incidence of new and changed nevi and melanomas detected using baseline images and dermoscopy in patients at high risk for melanoma. Arch. Dermatol.141(8), 998–1006 (2005).
   PubMed Web of Science ®Google Scholar
• Balch CM, Gershenwald JE, Soong SJ et al. Final version of 2009 AJCC melanoma staging and classification. J. Clin. Oncol.27(36), 6199–6206 (2009).
   PubMed Web of Science ®Google Scholar
• Balch CM, Buzaid AC, Soong SJ et al. Final version of the American Joint Committee on Cancer staging system for cutaneous melanoma. J. Clin. Oncol.19(16), 3635–3648 (2001).
   PubMed Web of Science ®Google Scholar
• Morton DL, Thompson JF, Cochran AJ et al. Sentinel-node biopsy or nodal observation in melanoma. N. Engl. J. Med.355(13), 1307–1317 (2006).
   PubMed Web of Science ®Google Scholar
• Medalie NS, Ackerman AB. Sentinel lymph node biopsy has no benefit for patients with primary cutaneous melanoma metastatic to a lymph node: an assertion based on comprehensive, critical analysis: part I. Am. J. Dermatopathol.25(5), 399–417 (2003).
   PubMed Web of Science ®Google Scholar
• Medalie NS, Ackerman AB. Sentinel lymph node biopsy has no benefit for patients with primary cutaneous melanoma metastatic to a lymph node: an assertion based on comprehensive, critical analysis: part II. Am. J. Dermatopathol.25(6), 473–484 (2003).
   PubMed Web of Science ®Google Scholar
• Gonzàlez U. Cloud over sentinel node biopsy: unlikely survival benefit in melanoma. Arch. Dermatol.143(6), 775–776 (2007).
   Google Scholar
• Broer N, Buonocore S, Goldberg C et al. A proposal for the timing of management of patients with melanoma presenting during pregnancy. J. Surg. Oncol. doi:10.1002/jso.23035 (2012) (Epub ahead of print).
   Google Scholar
• Ackerman AB. A centimeter here, a centimeter there. J. Am. Acad. Dermatol.35(2 Pt 1), 279–280 (1996).
   Google Scholar
• Ackerman AB, Scheiner AM. How wide and deep is wide and deep enough? A critique of surgical practice in excisions of primary cutaneous malignant melanoma. Hum. Pathol.14(9), 743–744 (1983).
   PubMedGoogle Scholar
• Bono A, Bartoli C, Clemente C et al. Ambulatory narrow excision for thin melanoma. Eur. J. Cancer33(8), 1330–1332 (1997).
   Google Scholar
• Gillgren P, Drzewiecki KT, Niin M et al. 2-cm versus 4-cm surgical excision margins for primary cutaneous melanoma thicker than 2 mm: a randomised, multicentre trial. Lancet378(9803), 1635–1642 (2011).
   PubMed Web of Science ®Google Scholar
• Garbe C, Paul A, Kohler-Späth H et al. Prospective evaluation of a follow-up schedule in cutaneous melanoma patients: recommendations for an effective follow-up strategy. J. Clin. Oncol.21(3), 520–529 (2003).
   PubMedGoogle Scholar
• McLoughlin JM, Zager JS, Sondak VK, Berk LB. Treatment options for limited or symptomatic metastatic melanoma. Cancer Control15(3), 239–247 (2008).
   Google Scholar
• Heaston DK, Putman CE, Rodan BA et al. Solitary pulmonary metastases in high-risk melanoma patients: a prospective comparison of conventional and computed tomography. AJR Am. J. Roentgenol.141(1), 169–174 (1983).
   Google Scholar
• Prayer L, Winkelbauer H, Gritzmann N, Winkelbauer F, Helmer M, Pehamberger H. Sonography versus palpation in the detection of regional lymph-node metastases in patients with malignant melanoma. Eur. J. Cancer26(7), 827–830 (1990).
   Google Scholar
• Strobel K, Skalsky J, Steinert HC et al. S-100B and FDG-PET/CT in therapy response assessment of melanoma patients. Dermatology215(3), 192–201 (2007).
   Google Scholar
• Brady MS, Akhurst T, Spanknebel K et al. Utility of preoperative [(18)]F fluorodeoxyglucose-positron emission tomography scanning in high-risk melanoma patients. Ann. Surg. Oncol.13(4), 525–532 (2006).
   PubMedGoogle Scholar
• Savoia P, Osella-Abate S, Deboli T et al. Clinical and prognostic reports from 270 patients with multiple primary melanomas: a 34-year single-institution study. J. Eur. Acad. Dermatol. Venereol. (2011).
   Google Scholar
• Moseley HS, Giuliano AE, Storm FK, Clark WH, Robinson DS, Morton DL. Multiple primary melanoma. Cancer43(3), 939–944 (1979).
   Google Scholar