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Theme: Myocardial Disorders - Review

Chemotherapy-induced cardiomyopathy

, &
Pages 231-243 | Published online: 10 Jan 2014

References

  • Fuster V, Voute J. MDGs: chronic diseases are not on the agenda. Lancet366(9496), 1512–1514 (2005).
  • Armstrong GT, Liu Q, Yasui Y et al. Late mortality among 5-year survivors of childhood cancer: a summary from the Childhood Cancer Survivor Study. J. Clin. Oncol.27(14), 2328–2338 (2009).
  • Tukenova M, Guibout C, Oberlin O et al. Role of cancer treatment in long-term overall and cardiovascular mortality after childhood cancer. J. Clin. Oncol.28(8), 1308–1315 (2010).
  • van Dalen EC, van den Brug M, Caron HN, Kremer LC. Anthracycline-induced cardiotoxicity: comparison of recommendations for monitoring cardiac function during therapy in paediatric oncology trials. Eur. J. Cancer42(18), 3199–3205 (2006).
  • Steinherz LJ, Graham T, Hurwitz R et al. Guidelines for cardiac monitoring of children during and after anthracycline therapy: report of the Cardiology Committee of the Children’s Cancer Study Group. Pediatrics89(5 Pt 1), 942–949 (1992).
  • Schwartz RG, McKenzie WB, Alexander J et al. Congestive heart failure and left ventricular dysfunction complicating doxorubicin therapy. Seven-year experience using serial radionuclide angiocardiography. Am. J. Med.82(6), 1109–1118 (1987).
  • Tjeerdsma G, Meinardi MT, van Der Graaf WT et al. Early detection of anthracycline induced cardiotoxicity in asymptomatic patients with normal left ventricular systolic function: autonomic versus echocardiographic variables. Heart81(4), 419–423 (1999).
  • Stoddard MF, Seeger J, Liddell NE, Hadley TJ, Sullivan DM, Kupersmith J. Prolongation of isovolumetric relaxation time as assessed by Doppler echocardiography predicts doxorubicin-induced systolic dysfunction in humans. J. Am. Coll. Cardiol.20(1), 62–69 (1992).
  • Ganz WI, Sridhar KS, Forness TJ. Detection of early anthracycline cardiotoxicity by monitoring the peak filling rate. Am. J. Clin. Oncol.16(2), 109–112 (1993).
  • Morandi P, Ruffini PA, Benvenuto GM, La Vecchia L, Mezzena G, Raimondi R. Serum cardiac troponin I levels and ECG/Echo monitoring in breast cancer patients undergoing high-dose (7 g/m2) cyclophosphamide. Bone Marrow Transplant.28(3), 277–282 (2001).
  • Ewer MS, Ali MK, Mackay B et al. A comparison of cardiac biopsy grades and ejection fraction estimations in patients receiving adriamycin. J. Clin. Oncol.2(2), 112–117 (1984).
  • Jassal DS, Han SY, Hans C et al. Utility of tissue Doppler and strain rate imaging in the early detection of trastuzumab and anthracycline-mediated cardiomyopathy. J. Am. Soc. Echocardiogr.22(4), 418–424 (2009).
  • Hoit BD. Detection of myocardial dysfunction during cancer chemotherapy with tissue Doppler imaging: a canary in the coal mine? J. Am. Soc. Echocardiogr.22(4), 425–426 (2009).
  • Urbanova D, Urban L, Carter A, Maasova D, Mladosievicova B. Cardiac troponins – biochemical markers of cardiac toxicity after cytostatic therapy. Neoplasma53(3), 183–190 (2006).
  • Cardinale D, Sandri MT, Colombo A et al. Prognostic value of troponin I in cardiac risk stratification of cancer patients undergoing high-dose chemotherapy. Circulation109(22), 2749–2754 (2004).
  • Cardinale D, Sandri MT, Martinoni A et al. Left ventricular dysfunction predicted by early troponin I release after high-dose chemotherapy. J. Am. Coll. Cardiol.36(2), 517–522 (2000).
  • Price JF, Thomas AK, Grenier M et al. B-type natriuretic peptide predicts adverse cardiovascular events in pediatric outpatients with chronic left ventricular systolic dysfunction. Circulation114(10), 1063–1069 (2006).
  • Morrison LK, Harrison A, Krishnaswamy P, Kazanegra R, Clopton P, Maisel A. Utility of a rapid B-natriuretic peptide assay in differentiating congestive heart failure from lung disease in patients presenting with dyspnea. J. Am. Coll. Cardiol.39(2), 202–209 (2002).
  • Suzuki T, Hayashi D, Yamazaki T et al. Elevated B-type natriuretic peptide levels after anthracycline administration. Am. Heart J.136(2), 362–363 (1998).
  • Okumura H, Iuchi K, Yoshida T et al. Brain natriuretic peptide is a predictor of anthracycline-induced cardiotoxicity. Acta Haematol.104(4), 158–163 (2000).
  • Nousiainen T, Vanninen E, Jantunen E et al. Natriuretic peptides during the development of doxorubicin-induced left ventricular diastolic dysfunction. J. Intern. Med.251(3), 228–234 (2002).
  • Jaffe AS, Babuin L, Apple FS. Biomarkers in acute cardiac disease: the present and the future. J. Am. Coll. Cardiol.48(1), 1–11 (2006).
  • Tulevski, II, Wolde MT, van Veldhuisen DJ et al. Combined utility of brain natriuretic peptide and cardiac troponine T may improve rapid triage and risk stratification in normotensive patients with pulmonary embolism. Int. J. Cardiol.116(2), 161–166 (2006).
  • Favory R, Neviere R. Bench-to-bedside review: significance and interpretation of elevated troponin in septic patients. Crit. Care10(4), 224 (2006).
  • Polena S, Shikara M, Naik S et al. Troponin I as a marker of doxorubicin induced cardiotoxicity. Proc. West Pharmacol. Soc.48, 142–144 (2005).
  • Gaze DC, Collinson PO. Cardiac troponins as biomarkers of drug- and toxin-induced cardiac toxicity and cardioprotection. Expert Opin. Drug Metab. Toxicol.1(4), 715–725 (2005).
  • Nousiainen T, Jantunen E, Vanninen E, Remes J, Vuolteenaho O, Hartikainen J. Natriuretic peptides as markers of cardiotoxicity during doxorubicin treatment for non-Hodgkin’s lymphoma. Eur. J. Haematol.62(2), 135–141 (1999).
  • van Royen N, Jaffe CC, Krumholz HM et al. Comparison and reproducibility of visual echocardiographic and quantitative radionuclide left ventricular ejection fractions. Am. J. Cardiol.77(10), 843–850 (1996).
  • Ko SM, Kim YJ, Park JH, Choi NM. Assessment of left ventricular ejection fraction and regional wall motion with 64-slice multidetector CT: a comparison with two-dimensional transthoracic echocardiography. Br. J. Radiol.83(985), 28–34 (2010).
  • Gallagher MJ, Ross MA, Raff GL, Goldstein JA, O’Neill WW, O’Neil B. The diagnostic accuracy of 64-slice computed tomography coronary angiography compared with stress nuclear imaging in emergency department low-risk chest pain patients. Ann. Emerg. Med.49(2), 125–136 (2007).
  • Ewer MS, Vooletich MT, Durand JB et al. Reversibility of trastuzumab-related cardiotoxicity: new insights based on clinical course and response to medical treatment. J. Clin. Oncol.23(31), 7820–7826 (2005).
  • Panjrath GS, Jain D. Monitoring chemotherapy-induced cardiotoxicity: role of cardiac nuclear imaging. J. Nucl. Cardiol.13(3), 415–426 (2006).
  • Flotats A, Carrio I. Non-invasive in vivo imaging of myocardial apoptosis and necrosis. Eur. J. Nucl. Med. Mol. Imaging30(4), 615–630 (2003).
  • Boogers MJ, Fukushima K, Bengel FM, Bax JJ. The role of nuclear imaging in the failing heart: myocardial blood flow, sympathetic innervation, and future applications. Heart Fail. Rev. DOI: 10.1007/s10741-010-9196-0 (2010) (Epub ahead of print).
  • Carrio I, Estorch M, Berna L, Lopez-Pousa J, Tabernero J, Torres G. Indium-111-antimyosin and iodine-123-MIBG studies in early assessment of doxorubicin cardiotoxicity. J. Nucl. Med.36(11), 2044–2049 (1995).
  • Yeh ET. Cardiotoxicity induced by chemotherapy and antibody therapy. Annu. Rev. Med.57, 485–498 (2006).
  • Ali MK, Ewer MS, Gibbs HR, Swafford J, Graff KL. Late doxorubicin-associated cardiotoxicity in children. The possible role of intercurrent viral infection. Cancer74(1), 182–188 (1994).
  • Banks J, Marmot M, Oldfield Z, Smith JP. Disease and disadvantage in the United States and in England. JAMA295(17), 2037–2045 (2006).
  • Piccirillo JF, Tierney RM, Costas I, Grove L, Spitznagel EL Jr. Prognostic importance of comorbidity in a hospital-based cancer registry. JAMA291(20), 2441–2447 (2004).
  • Zambetti M, Moliterni A, Materazzo C et al. Long-term cardiac sequelae in operable breast cancer patients given adjuvant chemotherapy with or without doxorubicin and breast irradiation. J. Clin. Oncol.19(1), 37–43 (2001).
  • Yeh ET, Tong AT, Lenihan DJ et al. Cardiovascular complications of cancer therapy: diagnosis, pathogenesis, and management. Circulation109(25), 3122–3131 (2004).
  • Mulrooney DA, Yeazel MW, Kawashima T et al. Cardiac outcomes in a cohort of adult survivors of childhood and adolescent cancer: retrospective analysis of the Childhood Cancer Survivor Study cohort. BMJ339, b4606 (2009).
  • Von Hoff DD, Layard MW, Basa P et al. Risk factors for doxorubicin-induced congestive heart failure. Ann. Intern. Med.91(5), 710–717 (1979).
  • Swain SM, Whaley FS, Ewer MS. Congestive heart failure in patients treated with doxorubicin: a retrospective analysis of three trials. Cancer97(11), 2869–2879 (2003).
  • Steinherz LJ, Steinherz PG, Tan CT, Heller G, Murphy ML. Cardiac toxicity 4 to 20 years after completing anthracycline therapy. JAMA266(12), 1672–1677 (1991).
  • Hequet O, Le QH, Moullet I et al. Subclinical late cardiomyopathy after doxorubicin therapy for lymphoma in adults. J. Clin. Oncol.22(10), 1864–1871 (2004).
  • No authors listed. Favourable and unfavourable effects on long-term survival of radiotherapy for early breast cancer: an overview of the randomised trials. Early Breast Cancer Trialists’ Collaborative Group. Lancet355(9217), 1757–1770 (2000).
  • Sawyer DB, Peng X, Chen B, Pentassuglia L, Lim CC. Mechanisms of anthracycline cardiac injury: can we identify strategies for cardioprotection? Prog. Cardiovasc. Dis.53(2), 105–113 (2010).
  • Shan K, Lincoff AM, Young JB. Anthracycline-induced cardiotoxicity. Ann. Intern. Med.125(1), 47–58 (1996).
  • Andrieu-Abadie N, Jaffrezou JP, Hatem S, Laurent G, Levade T, Mercadier JJ. L-carnitine prevents doxorubicin-induced apoptosis of cardiac myocytes: role of inhibition of ceramide generation. Faseb J.13(12), 1501–1510 (1999).
  • Falcone G, Filippelli W, Mazzarella B et al. Cardiotoxicity of doxorubicin: effects of 21-aminosteroids. Life Sci.63(17), 1525–1532 (1998).
  • Bordoni A, Biagi P, Hrelia S. The impairment of essential fatty acid metabolism as a key factor in doxorubicin-induced damage in cultured rat cardiomyocytes. Biochim. Biophys. Acta1440(1), 100–106 (1999).
  • Unverferth DV, Fertel RH, Talley RL, Magorien RD, Balcerzak SP. The effect of first-dose doxorubicin on the cyclic nucleotide levels of the human myocardium. Toxicol. Appl. Pharmacol.60(1), 151–154 (1981).
  • Lipshultz SE, Rifai N, Sallan SE et al. Predictive value of cardiac troponin T in pediatric patients at risk for myocardial injury. Circulation96(8), 2641–2648 (1997).
  • Maeda A, Honda M, Kuramochi T, Takabatake T. Doxorubicin cardiotoxicity: diastolic cardiac myocyte dysfunction as a result of impaired calcium handling in isolated cardiac myocytes. Jpn Circ. J.62(7), 505–511 (1998).
  • Billingham ME, Mason JW, Bristow MR, Daniels JR. Anthracycline cardiomyopathy monitored by morphologic changes. Cancer Treat. Rep.62(6), 865–872 (1978).
  • Billingham M, Bristow MR. Evaluation of anthracycline cardiotoxicity: predictive ability and functional correlation of endomyocardial biopsy. Cancer Treat. Symp.3, 71–76 (1984).
  • Gaudin PB, Hruban RH, Beschorner WE et al. Myocarditis associated with doxorubicin cardiotoxicity. Am. J. Clin. Pathol.100(2), 158–163 (1993).
  • Topalov V, Popovic K, Cikos J, Pejin D, Uzurov V. [Cardiotoxic aspects of daunorubicin used in the treatment of acute myeloblastic and lymphoblastic leukoses]. Med. Pregl.34(3–4), 119–122 (1981).
  • Wouters KA, Kremer LC, Miller TL, Herman EH, Lipshultz SE. Protecting against anthracycline-induced myocardial damage: a review of the most promising strategies. Br. J. Haematol.131(5), 561–578 (2005).
  • Slamon D, Pegram M. Rationale for trastuzumab (Herceptin) in adjuvant breast cancer trials. Semin. Oncol.28(1 Suppl. 3), 13–19 (2001).
  • Seidman A, Hudis C, Pierri MK et al. Cardiac dysfunction in the trastuzumab clinical trials experience. J. Clin. Oncol.20(5), 1215–1221 (2002).
  • Friedman MA, Bozdech MJ, Billingham ME, Rider AK. Doxorubicin cardiotoxicity. Serial endomyocardial biopsies and systolic time intervals. JAMA240(15), 1603–1606 (1978).
  • Cardinale D, Colombo A, Lamantia G et al. Anthracycline-induced cardiomyopathy: clinical relevance and response to pharmacologic therapy. J. Am. Coll. Cardiol.55(3), 213–220 (2010).
  • Jones RL, Swanton C, Ewer MS. Anthracycline cardiotoxicity. Expert Opin. Drug Saf.5(6), 791–809 (2006).
  • Lipshultz SE, Rifai N, Dalton VM et al. The effect of dexrazoxane on myocardial injury in doxorubicin-treated children with acute lymphoblastic leukemia. N. Engl. J. Med.351(2), 145–153 (2004).
  • Felker GM, Thompson RE, Hare JM et al. Underlying causes and long-term survival in patients with initially unexplained cardiomyopathy. N. Engl. J. Med.342(15), 1077–1084 (2000).
  • Kalay N, Basar E, Ozdogru I et al. Protective effects of carvedilol against anthracycline-induced cardiomyopathy. J. Am. Coll. Cardiol.48(11), 2258–2262 (2006).
  • Nakamae H, Tsumura K, Terada Y et al. Notable effects of angiotensin II receptor blocker, valsartan, on acute cardiotoxic changes after standard chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisolone. Cancer104(11), 2492–2498 (2005).
  • Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell103(2), 211–225 (2000).
  • Heisterkamp N, Jenster G, ten Hoeve J, Zovich D, Pattengale PK, Groffen J. Acute leukaemia in bcr/abl transgenic mice. Nature344(6263), 251–253 (1990).
  • Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science235(4785), 177–182 (1987).
  • Perez EA, Koehler M, Byrne J, Preston AJ, Rappold E, Ewer MS. Cardiac safety of lapatinib: pooled analysis of 3689 patients enrolled in clinical trials. Mayo Clin. Proc.83(6), 679–686 (2008).
  • Kerkela R, Grazette L, Yacobi R et al. Cardiotoxicity of the cancer therapeutic agent imatinib mesylate. Nat. Med.12(8), 908–916 (2006).
  • Kerkela R, Woulfe KC, Durand JB et al. Sunitinib-induced cardiotoxicity is mediated by off-target inhibition of AMP-activated protein kinase. Clin. Transl. Sci.2(1), 15–25 (2009).
  • Chu TF, Rupnick MA, Kerkela R et al. Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib. Lancet370(9604), 2011–2019 (2007).
  • Di Lorenzo G, Autorino R, Bruni G et al. Cardiovascular toxicity following sunitinib therapy in metastatic renal cell carcinoma: a multicenter analysis. Ann. Oncol.20(9), 1535–1542 (2009).
  • Machiels JP, Bletard N, Pirenne P, Jacquet L, Bonbled F, Duck L. Acute cardiac failure after sunitinib. Ann. Oncol.19(3), 597–599 (2008).
  • Atallah E, Durand JB, Kantarjian H, Cortes J. Congestive heart failure is a rare event in patients receiving imatinib therapy. Blood110(4), 1233–1237 (2007).
  • Kerkela R, Grazette L, Yacobi R et al. Cardiotoxicity of the cancer therapeutic agent imatinib mesylate. Nat. Med.12(8), 908–916 (2006).
  • Sprycel®. Prescribing information. Bristol-Myers Squibb Company, NJ, USA (2006).
  • Champion JC. Cardiotoxicity of other chemotherapeutic agents. In: Cancer and the Heart. BC Decker Inc., ON, Canada, 115–128 (2006).
  • Dow E, Schulman H, Agura E. Cyclophosphamide cardiac injury mimicking acute myocardial infarction. Bone Marrow Transplant.12(2), 169–172 (1993).
  • Kupari M, Volin L, Suokas A, Timonen T, Hekali P, Ruutu T. Cardiac involvement in bone marrow transplantation: electrocardiographic changes, arrhythmias, heart failure and autopsy findings. Bone Marrow Transplant.5(2), 91–98 (1990).
  • Biganzoli L, Piccart MJ. The bigger the better? …or what we know and what we still need to learn about anthracycline dose per course, dose density and cumulative dose in the treatment of breast cancer. Ann. Oncol.8(12), 1177–1182 (1997).
  • Nieto Y, Cagnoni PJ, Bearman SI, Shpall EJ, Matthes S, Jones RB. Cardiac toxicity following high-dose cyclophosphamide, cisplatin, and BCNU (STAMP-I) for breast cancer. Biol. Blood Marrow Transplant.6(2A), 198–203 (2000).
  • Quezado ZM, Wilson WH, Cunnion RE et al. High-dose ifosfamide is associated with severe, reversible cardiac dysfunction. Ann. Intern. Med.118(1), 31–36 (1993).
  • Klastersky J. Side effects of ifosfamide. Oncology65(Suppl. 2), 7–10 (2003).
  • Kandylis K, Vassilomanolakis M, Tsoussis S, Efremidis AP. Ifosfamide cardiotoxicity in humans. Cancer Chemother. Pharmacol.24(6), 395–396 (1989).
  • Schimmel KJ, Richel DJ, van den Brink RB, Guchelaar HJ. Cardiotoxicity of cytotoxic drugs. Cancer Treat. Rev.30(2), 181–191 (2004).
  • Meinardi MT, Gietema JA, van der Graaf WT et al. Cardiovascular morbidity in long-term survivors of metastatic testicular cancer. J. Clin. Oncol.18(8), 1725–1732 (2000).
  • Togna GI, Togna AR, Franconi M, Caprino L. Cisplatin triggers platelet activation. Thromb. Res.99(5), 503–509 (2000).
  • Vaughn DJ, Palmer SC, Carver JR, Jacobs LA, Mohler ER. Cardiovascular risk in long-term survivors of testicular cancer. Cancer112(9), 1949–1953 (2008).
  • Shao Y, Pardini L, Pardini RS. Enhancement of the antineoplastic effect of mitomycin C by dietary fat. Cancer Res.54(24), 6452–6457 (1994).
  • Verweij J, Funke-Kupper AJ, Teule GJ, Pinedo HM. A prospective study on the dose dependency of cardiotoxicity induced by mitomycin C. Med. Oncol. Tumor Pharmacother.5(3), 159–163 (1988).
  • Gradishar WJ, Vokes EE. 5-Fluorouracil cardiotoxicity: a critical review. Ann. Oncol.1(6), 409–414 (1990).
  • Kuropkat C, Griem K, Clark J, Rodriguez ER, Hutchinson J, Taylor SG 4th. Severe cardiotoxicity during 5-fluorouracil chemotherapy: a case and literature report. Am. J. Clin. Oncol.22(5), 466–470 (1999).
  • Schober C, Papageorgiou E, Harstrick A et al. Cardiotoxicity of 5-fluorouracil in combination with folinic acid in patients with gastrointestinal cancer. Cancer72(7), 2242–2247 (1993).
  • Bathina JD, Yusuf SW. 5-fluorouracil-induced coronary vasospasm. J. Cardiovasc. Med. (Hagerstown)11(4), 281–284 (2010).
  • Gianni L, Kearns CM, Giani A et al. Nonlinear pharmacokinetics and metabolism of paclitaxel and its pharmacokinetic/pharmacodynamic relationships in humans. J. Clin. Oncol.13(1), 180–190 (1995).
  • Seidman AD, Reichman BS, Crown JP et al. Paclitaxel as second and subsequent therapy for metastatic breast cancer: activity independent of prior anthracycline response. J. Clin. Oncol.13(5), 1152–1159 (1995).
  • Dombernowsky P, Gehl J, Boesgaard M, Paaske T, Jensen BV. Doxorubicin and paclitaxel, a highly active combination in the treatment of metastatic breast cancer. Semin. Oncol.23(5 Suppl. 11), 23–27 (1996).
  • Markman M, Kennedy A, Webster K, Kulp B, Peterson G, Belinson J. Paclitaxel administration to gynecologic cancer patients with major cardiac risk factors. J. Clin. Oncol.16(11), 3483–3485 (1998).
  • Dillman RO. Monoclonal antibodies in the treatment of malignancy: basic concepts and recent developments. Cancer Invest.19(8), 833–841 (2001).
  • Kilickap S, Yavuz B, Aksoy S et al. Addition of rituximab to chop does not increase the risk of cardiotoxicity in patients with non-Hodgkin’s lymphoma. Med. Oncol.25(4), 437–442 (2008).
  • Oshima K, Sakata-Yanagimoto M, Asano-Mori Y et al. Cardiac complications after haploidentical HLA-mismatched hematopoietic stem cell transplantation using in vivo alemtuzumab. Bone Marrow Transplant.36(9), 821–824 (2005).
  • Lenihan DJ, Alencar AJ, Yang D, Kurzrock R, Keating MJ, Duvic M. Cardiac toxicity of alemtuzumab in patients with mycosis fungoides/Sezary syndrome. Blood104(3), 655–658 (2004).
  • Basquiera AL, Berretta AR, Garcia JJ, Palazzo ED. Coronary ischemia related to alemtuzumab therapy. Ann. Oncol.15(3), 539–540 (2004).
  • Shih T, Lindley C. Bevacizumab: an angiogenesis inhibitor for the treatment of solid malignancies. Clin. Ther.28(11), 1779–1802 (2006).
  • D’Adamo DR, Anderson SE, Albritton K et al. Phase II study of doxorubicin and bevacizumab for patients with metastatic soft-tissue sarcomas. J. Clin. Oncol.23(28), 7135–7142 (2005).
  • Ewer MS, Perez EA, Baselga J et al. Cardiac Safety Guidelines for the adjuvant use of trastuzumab (Herceptin) in HER-2 positive breast cancer. Presented at: St.Gallen 10th International Conference on Primary Therapy of Early Breast Cancer. St Gallen, Switzlerland, 14–17 March 2007.
  • Mackey JR, Clemons M, Cote MA et al. Cardiac management during adjuvant trastuzumab therapy: recommendations of the Canadian Trastuzumab Working Group. Curr. Oncol.15(1), 24–35 (2008).
  • Procter M, Suter TM, de Azambuja E et al. Longer-term assessment of trastuzumab-related cardiac adverse events in the Herceptin Adjuvant (HERA) trial. J. Clin. Oncol.28(21), 3422–3428 (2010).
  • Cohen MC, Huberman MS, Nesto RW. Recombinant α2 interferon-related cardiomyopathy. Am. J. Med.85(4), 549–551 (1988).
  • Sonnenblick M, Rosenmann D, Rosin A. Reversible cardiomyopathy induced by interferon. BMJ300(6733), 1174–1175 (1990).
  • Deyton LR, Walker RE, Kovacs JA et al. Reversible cardiac dysfunction associated with interferon α therapy in AIDS patients with Kaposi’s sarcoma. N. Engl. J. Med.321(18), 1246–1249 (1989).
  • Zimmerman S, Adkins D, Graham M et al. Irreversible, severe congestive cardiomyopathy occurring in association with interferon α therapy. Cancer Biother.9(4), 291–299 (1994).
  • Hunt SA, Abraham WT, Chin MH et al. ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure): developed in collaboration with the American College of Chest Physicians and the International Society for Heart and Lung Transplantation: endorsed by the Heart Rhythm Society. Circulation112(12), E154–E235 (2005).
  • Sarkiss MG, Yusuf SW, Warneke CL et al. Impact of aspirin therapy in cancer patients with thrombocytopenia and acute coronary syndromes. Cancer109(3), 621–627 (2007).
  • Jensen BV, Skovsgaard T, Nielsen SL. Functional monitoring of anthracycline cardiotoxicity: a prospective, blinded, long-term observational study of outcome in 120 patients. Ann. Oncol.13(5), 699–709 (2002).
  • Cadeddu C, Piras A, Mantovani G et al. Protective effects of the angiotensin II receptor blocker telmisartan on epirubicin-induced inflammation, oxidative stress, and early ventricular impairment. Am. Heart J.160(3), 487.e1–e7 (2010).
  • Tallaj JA, Franco V, Rayburn BK et al. Response of doxorubicin-induced cardiomyopathy to the current management strategy of heart failure. J. Heart Lung Transplant.24(12), 2196–2201 (2005).
  • Iliescu C, Yusuf SW, Swafford J. Impact of angiotensin converting enzyme inhibitors and carvedilol on recovery of cardiac function in Imatinib (gleevac) associated cardiomyopathy. J. Cardiac Fail.11(Suppl.), 54 (2005).
  • Shukla A, Yusuf SW, Daher I, Lenihan DJ, Durand JB. High mortality rates are associated with withdrawal of β blockers and ace-inhibitors in chemotherapy induced heart failure. Circulation118, S797 (2008).
  • Shaik N, Yusuf SW, Swafford J et al. The role of valsartan and carvedilol in patients with chemotherapy associated cardiomyopathy who are intolerant to angiotensin converting enzyme inhibitors. J. Cardiac Fail. (Suppl. 11), 87 (2005).
  • Woods ML, Yusuf SW, Swafford J et al. Milrinone and carvedilol in medical management of chemotherapy induced acute decompensated class 1V heart failure. J. Cardiac Fail.8(Suppl.), 296 (2002).
  • Rickard J, Kumbhani DJ, Baranowski B, Martin DO, Tang WH, Wilkoff BL. Usefulness of cardiac resynchronization therapy in patients with adriamycin-induced cardiomyopathy. Am. J. Cardiol.105(4), 522–526 (2010).
  • Ganame J, Claus P, Eyskens B et al. Acute cardiac functional and morphological changes after anthracycline infusions in children. Am. J. Cardiol.99(7), 974–977 (2007).
  • Nexavar® package insert. Bayer Health Care Pharmaceuticals, CA, USA (2009).
  • Khakoo AY, Kassiotis CM, Tannir N et al. Heart failure associated with sunitinib malate: a multitargeted receptor tyrosine kinase inhibitor. Cancer112, 2500–2508 (2008).
  • Gressent SM, Shah SR. Intricacies of bevacizumab-induced toxicities and their management. Ann. Pharmacother.43, 490–501 (2009).

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