Heart rate recovery: a practical clinical indicator of abnormal cardiac autonomic function

References

• Imai K, Sato H, Hori M et al. Vagally mediated heart rate recovery after exercise is accelerated in athletes but blunted in patients with chronic heart failure. J. Am. Coll. Cardiol.24(6), 1529–1535 (1994).
   PubMed Web of Science ®Google Scholar
• Pierpont GL, Stolpman DR, Gornick CC. Heart rate recovery postexercise as an index of parasympathetic activity. J. Auton. Nerv. Syst.80(3), 169–174 (2000).
   PubMedGoogle Scholar
• Shetler K, Marcus R, Froelicher VF et al. Heart rate recovery: validation and methodologic issues. J. Am. Coll. Cardiol.38(7), 1980–1987 (2001).
   PubMed Web of Science ®Google Scholar
• Ferrari AU. Modulation of parasympathetic and baroreceptor control of heart rate. Cardioscience4(1), 9–13 (1993).
   Google Scholar
• Jose AD, Collison D. The normal range and determinants of the intrinsic heart rate in man. Cardiovasc. Res.4(2), 160–167 (1970).
   PubMed Web of Science ®Google Scholar
• Robertson D, Johnson GA, Robertson RM, Nies AS, Shand DG, Oates JA. Comparative assessment of stimuli that release neuronal and adrenomedullary catecholamines in man. Circulation59(4), 637–643 (1979).
   PubMed Web of Science ®Google Scholar
• Gillum RF, Makuc DM, Feldman JJ. Pulse rate, coronary heart disease, and death: the NHANES I epidemiologic follow-up study. Am. Heart J.121(1 Pt 1), 172–177 (1991).
   PubMed Web of Science ®Google Scholar
• Shaper AG, Wannamethee G, Macfarlane PW, Walker M. Heart rate, ischaemic heart disease, and sudden cardiac death in middle-aged British men. Br. Heart J.70(1), 49–55 (1993).
   PubMedGoogle Scholar
• Robinson BF, Epstein SE, Beiser GD, Braunwald E. Control of heart rate by the autonomic nervous system. Studies in man on the interrelation between baroreceptor mechanisms and exercise. Circ. Res.19(2), 400–411 (1966).
   PubMed Web of Science ®Google Scholar
• Fagraeus L, Linnarsson D. Autonomic origin of heart rate fluctuations at the onset of muscular exercise. J. Appl. Physiol.40(5), 679–682 (1976).
   PubMed Web of Science ®Google Scholar
• Ellestad MH. Chronotropic incompetence. The implications of heart rate response to exercise (compensatory parasympathetic hyperactivity?). Circulation93(8), 1485–1487 (1996).
   Web of Science ®Google Scholar
• Kannankeril PJ, Le FK, Kadish AH, Goldberger JJ. Parasympathetic effects on heart rate recovery after exercise. J. Investig. Med.52(6), 394–401 (2004).
   PubMed Web of Science ®Google Scholar
• Londeree BR, Thomas TR, Ziogas G, Smith TD, Zhang Q. %VO2max versus %HRmax regressions for six modes of exercise. Med. Sci. Sports Exerc.27(3), 458–461 (1995).
   PubMed Web of Science ®Google Scholar
• Freeman JV, Dewey FE, Hadley DM, Myers J, Froelicher VF. Autonomic nervous system interaction with the cardiovascular system during exercise. Prog. Cardiovasc. Dis.48(5), 342–362 (2006).
   PubMed Web of Science ®Google Scholar
• Gordon DJ, Leon AS, Ekelund LG et al. Smoking, physical activity, and other predictors of endurance and heart rate response to exercise in asymptomatic hypercholesterolemic men. The Lipid Research Clinics Coronary Primary Prevention Trial. Am. J. Epidemiol.125(4), 587–600 (1987).
   PubMed Web of Science ®Google Scholar
• Spodick DH, Raju P, Bishop RL, Rifkin RD. Operational definition of normal sinus heart rate. Am. J. Cardiol.69(14), 1245–1246 (1992).
   Google Scholar
• Warner HR, Russell RO Jr. Effect of combined sympathetic and vagal stimulation on heart rate in the dog. Circ. Res.24(4), 567–573 (1969).
   Google Scholar
• Wiens RD, Lafia P, Marder CM, Evans RG, Kennedy HL. Chronotropic incompetence in clinical exercise testing. Am. J. Cardiol.54(1), 74–78 (1984).
   PubMed Web of Science ®Google Scholar
• Elhendy A, Mahoney DW, Khandheria BK, Burger K, Pellikka PA. Prognostic significance of impairment of heart rate response to exercise: impact of left ventricular function and myocardial ischemia. J. Am. Coll. Cardiol.42(5), 823–830 (2003).
   PubMed Web of Science ®Google Scholar
• Leeper NJ, Dewey FE, Ashley EA et al. Prognostic value of heart rate increase at onset of exercise testing. Circulation115(4), 468–474 (2007).
   Google Scholar
• Sundaram S, Shoushtari C, Carnethon M, Kadish AH, Goldberger JJ. Autonomic and nonautonomic determinants of heart rate recovery. Heart Rhythm1, S100–S101 (2004).
   Google Scholar
• Skaluba SJ, Litwin SE. Doppler-derived left ventricular filling pressures and the regulation of heart rate recovery after exercise in patients with suspected coronary artery disease. Am. J. Cardiol.95(7), 832–837 (2005).
   Google Scholar
• Billman GE, Kukielka M. Effects of endurance exercise training on heart rate variability and susceptibility to sudden cardiac death: protection is not due to enhanced cardiac vagal regulation. J. Appl. Physiol.100(3), 896–906 (2006).
   Google Scholar
• Gibbons RJ, Balady GJ, Bricker JT et al. ACC/AHA 2002 guideline update for exercise testing: summary article. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Update the 1997 Exercise Testing Guidelines). J. Am. Coll. Cardiol.40(8), 1531–1540 (2002).
   PubMed Web of Science ®Google Scholar
• Fletcher GF, Balady GJ, Amsterdam EA et al. Exercise standards for testing and training: a statement for healthcare professionals from the American Heart Association. Circulation104(14), 1694–1740 (2001).
   PubMed Web of Science ®Google Scholar
• Chen YL, Lee YH. Effect of combined dynamic and static workload on heart rate recovery cost. Ergonomics41(1), 29–38 (1998).
   PubMed Web of Science ®Google Scholar
• Myers J, Froelicher VF. Exercise testing. Procedures and implementation. Cardiol. Clin.11(2), 199–213 (1993).
   PubMedGoogle Scholar
• Maeder MT, Ammann P, Rickli H, Brunner-La Rocca HP. Impact of the exercise mode on heart rate recovery after maximal exercise. Eur. J. Appl. Physiol.105(2), 247–255 (2009).
   Google Scholar
• Cole CR, Foody JM, Blackstone EH, Lauer MS. Heart rate recovery after submaximal exercise testing as a predictor of mortality in a cardiovascularly healthy cohort. Ann. Intern. Med.132(7), 552–555 (2000).
   PubMed Web of Science ®Google Scholar
• Gorelik DD, Hadley D, Myers J, Froelicher V. Is there a better way to predict death using heart rate recovery? Clin. Cardiol.29(9), 399–404 (2006).
   Google Scholar
• Hadley DM, Dewey FE, Freeman JV, Myers JN, Froelicher VF. Prediction of cardiovascular death using a novel heart rate recovery parameter. Med. Sci. Sports Exerc.40(6), 1072–1079 (2008).
   Google Scholar
• Okutucu S, Karakulak UN, Kabakci G. Circadian blood pressure pattern and cardiac autonomic functions: different aspects of same pathophysiology. Anadolu Kardiyol. Derg.11, 168–173 (2011).
   PubMedGoogle Scholar
• Vivekananthan DP, Blackstone EH, Pothier CE, Lauer MS. Heart rate recovery after exercise is a predictor of mortality, independent of the angiographic severity of coronary disease. J. Am. Coll. Cardiol.42(5), 831–838 (2003).
   PubMed Web of Science ®Google Scholar
• Arena R, Guazzi M, Myers J, Peberdy MA. Prognostic value of heart rate recovery in patients with heart failure. Am. Heart J.151(4), 851.e857–e813 (2006).
   Google Scholar
• Goldberger JJ, Cain ME, Hohnloser SH et al. American Heart Association/American College of Cardiology Foundation/Heart Rhythm Society scientific statement on noninvasive risk stratification techniques for identifying patients at risk for sudden cardiac death: a scientific statement from the American Heart Association Council on Clinical Cardiology Committee on Electrocardiography and Arrhythmias and Council on Epidemiology and Prevention. Heart Rhythm5(10), e1–e21 (2008).
   Google Scholar
• Chaitman BR. Abnormal heart rate responses to exercise predict increased long-term mortality regardless of coronary disease extent: the question is why? J. Am. Coll. Cardiol.42(5), 839–841 (2003).
   PubMed Web of Science ®Google Scholar
• Mora S, Redberg RF, Cui Y et al. Ability of exercise testing to predict cardiovascular and all-cause death in asymptomatic women: a 20-year follow-up of the lipid research clinics prevalence study. JAMA290(12), 1600–1607 (2003).
   PubMed Web of Science ®Google Scholar
• Morshedi-Meibodi A, Larson MG, Levy D, O’Donnell CJ, Vasan RS. Heart rate recovery after treadmill exercise testing and risk of cardiovascular disease events (The Framingham Heart Study). Am. J. Cardiol.90(8), 848–852 (2002).
   PubMed Web of Science ®Google Scholar
• Messinger-Rapport B, Pothier Snader CE, Blackstone EH, Yu D, Lauer MS. Value of exercise capacity and heart rate recovery in older people. J. Am. Geriatr. Soc.51(1), 63–68 (2003).
   Google Scholar
• Yawn BP, Ammar KA, Thomas R, Wollan PC. Test–retest reproducibility of heart rate recovery after treadmill exercise. Ann. Fam. Med.1(4), 236–241 (2003).
   Google Scholar
• Tulumen E, Xalilayeva I, Aytemir K et al. The reproducibility of heart rate recovery after treadmill exercise test. Ann. Noninvasive Electrocardiol. (2011) (In Press).
   Google Scholar
• Nishime EO, Cole CR, Blackstone EH, Pashkow FJ, Lauer MS. Heart rate recovery and treadmill exercise score as predictors of mortality in patients referred for exercise ECG. JAMA284(11), 1392–1398 (2000).
   PubMed Web of Science ®Google Scholar
• Kizilbash MA, Carnethon MR, Chan C, Jacobs DR, Sidney S, Liu K. The temporal relationship between heart rate recovery immediately after exercise and the metabolic syndrome: the CARDIA study. Eur. Heart J.27(13), 1592–1596 (2006).
   PubMed Web of Science ®Google Scholar
• Huang PH, Leu HB, Chen JW et al. Usefulness of attenuated heart rate recovery immediately after exercise to predict endothelial dysfunction in patients with suspected coronary artery disease. Am. J. Cardiol.93(1), 10–13 (2004).
   PubMed Web of Science ®Google Scholar
• Ghaffari S, Kazemi B, Aliakbarzadeh P. Abnormal heart rate recovery after exercise predicts coronary artery disease severity. Cardiol. J.18(1), 47–54 (2011).
   PubMed Web of Science ®Google Scholar
• Gera N, Taillon LA, Ward RP. Usefulness of abnormal heart rate recovery on exercise stress testing to predict high-risk findings on single-photon emission computed tomography myocardial perfusion imaging in men. Am. J. Cardiol.103(5), 611–614 (2009).
   Google Scholar
• Chen MS, Blackstone EH, Pothier CE, Lauer MS. Heart rate recovery and impact of myocardial revascularization on long-term mortality. Circulation110(18), 2851–2857 (2004).
   Google Scholar
• Tiukinhoy S, Beohar N, Hsie M. Improvement in heart rate recovery after cardiac rehabilitation. J. Cardiopulm. Rehabil.23(2), 84–87 (2003).
   Google Scholar
• Tsai SW, Lin YW, Wu SK. The effect of cardiac rehabilitation on recovery of heart rate over 1 min after exercise in patients with coronary artery bypass graft surgery. Clin. Rehabil.19(8), 843–849 (2005).
   PubMed Web of Science ®Google Scholar
• Turker Y, Ozaydin M, Yucel H. Heart rate variability and heart rate recovery in patients with coronary artery ectasia. Coron. Artery Dis.21(1), 8–12 (2010).
   Google Scholar
• Curtis BM, O’Keefe JH Jr. Autonomic tone as a cardiovascular risk factor: the dangers of chronic fight or flight. Mayo Clin. Proc.77(1), 45–54 (2002).
   PubMed Web of Science ®Google Scholar
• Schwartz PJ, La Rovere MT, Vanoli E. Autonomic nervous system and sudden cardiac death. Experimental basis and clinical observations for post-myocardial infarction risk stratification. Circulation85(Suppl. 1), I77–I91 (1992).
   PubMed Web of Science ®Google Scholar
• Sheppard RJ, Racine N, Roof A, Ducharme A, Blanchet M, White M. Heart rate recovery – a potential marker of clinical outcomes in heart failure patients receiving β-blocker therapy. Can. J. Cardiol.23(14), 1135–1138 (2007).
   Google Scholar
• Lipinski MJ, Vetrovec GW, Gorelik D, Froelicher VF. The importance of heart rate recovery in patients with heart failure or left ventricular systolic dysfunction. J. Card. Fail.11(8), 624–630 (2005).
   Google Scholar
• Bilsel T, Terzi S, Akbulut T, Sayar N, Hobikoglu G, Yesilcimen K. Abnormal heart rate recovery immediately after cardiopulmonary exercise testing in heart failure patients. Int. Heart J.47(3), 431–440 (2006).
   PubMed Web of Science ®Google Scholar
• Nanas S, Anastasiou-Nana M, Dimopoulos S et al. Early heart rate recovery after exercise predicts mortality in patients with chronic heart failure. Int. J. Cardiol.110(3), 393–400 (2006).
   PubMed Web of Science ®Google Scholar
• Tang YD, Dewland TA, Wencker D, Katz SD. Postexercise heart rate recovery independently predicts mortality risk in patients with chronic heart failure. J. Card. Fail.15(10), 850–855 (2009).
   PubMedGoogle Scholar
• Arena R, Guazzi M, Myers J, Peberdy MA, Bensimhon D, Chase P. Heart rate recovery predicts sudden cardiac death in heart failure. Int. J. Cardiol.144(1), 121–123 (2010).
   Google Scholar
• Watanabe J, Thamilarasan M, Blackstone EH, Thomas JD, Lauer MS. Heart rate recovery immediately after treadmill exercise and left ventricular systolic dysfunction as predictors of mortality: the case of stress echocardiography. Circulation104(16), 1911–1916 (2001).
   PubMed Web of Science ®Google Scholar
• Kubrychtova V, Olson TP, Bailey KR, Thapa P, Allison TG, Johnson BD. Heart rate recovery and prognosis in heart failure patients. Eur. J. Appl. Physiol.105(1), 37–45 (2009).
   Google Scholar
• Guazzi M, Myers J, Ann Peberdy M et al. Heart rate recovery and tissue Doppler echocardiography in heart failure. Clin. Cardiol.33(2), E61–E64 (2010).
   Google Scholar
• Nakamura M, Endo H, Nasu M, Arakawa N, Segawa T, Hiramori K. Value of plasma B type natriuretic peptide measurement for heart disease screening in a Japanese population. Heart87(2), 131–135 (2002).
   PubMed Web of Science ®Google Scholar
• Lee JE, Kim BS, Park W et al. The relationship between heart rate recovery and brain natruretic peptide in patients with chest discomfort: a study for relationship between heart rate recovery and pre-exercise, postexercise levels of brain natruretic peptide in patients with normal systolic function and chest discomfort. Korean Circ. J.40(4), 172–178 (2010).
   Google Scholar
• Hunt SA, Abraham WT, Chin MH et al. 2009 Focused update incorporated into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines Developed in Collaboration With the International Society for Heart and Lung Transplantation. J. Am. Coll. Cardiol.53(15), e1–e90 (2009).
   Google Scholar
• Arena R, Myers J, Abella J et al. The prognostic value of the heart rate response during exercise and recovery in patients with heart failure: influence of β-blockade. Int. J. Cardiol.138(2), 166–173 (2010).
   Google Scholar
• Racine N, Blanchet M, Ducharme A et al. Decreased heart rate recovery after exercise in patients with congestive heart failure: effect of β-blocker therapy. J. Card. Fail.9(4), 296–302 (2003).
   Google Scholar
• Sa Cunha R, Pannier B, Benetos A et al. Association between high heart rate and high arterial rigidity in normotensive and hypertensive subjects. J. Hypertens.15(12 Pt 1), 1423–1430 (1997).
   PubMed Web of Science ®Google Scholar
• Guazzi M, Arena R, Pinkstaff S, Guazzi MD. Six months of Sildenafil therapy improves heart rate recovery in patients with heart failure. Int. J. cardiol.136(3), 341–343 (2009).
   PubMed Web of Science ®Google Scholar
• Gademan MG, Van Bommel RJ, Borleffs CJ et al. Biventricular pacing-induced acute response in baroreflex sensitivity has predictive value for midterm response to cardiac resynchronization therapy. Am. J. Physiol. Heart Circ. Physiol.297(1), H233–H237 (2009).
   Google Scholar
• Okutucu S, Aytemir K, Evranos B et al. Cardiac resynchronization therapy improves exercise heart rate recovery in patients with heart failure. Europace13(4), 526–532 (2011).
   Google Scholar
• Thomas DE, Exton SA, Yousef ZR. Heart rate deceleration after exercise predicts patients most likely to respond to cardiac resynchronisation therapy. Heart96(17), 1385–1389 (2010).
   Google Scholar
• Tsarouhas K, Karatzaferi C, Tsitsimpikou C et al. Effects of walking on heart rate recovery, endothelium modulators and quality of life in patients with heart failure. Eur. J. Cardiovasc. Prev. Rehabil. DOI: 10.1177/1741826710397099 (2011) (Epub ahead of print).
   Google Scholar
• Dimopoulos S, Anastasiou-Nana M, Sakellariou D et al. Effects of exercise rehabilitation program on heart rate recovery in patients with chronic heart failure. Eur. J. Cardiovasc. Prev. Rehabil.13(1), 67–73 (2006).
   PubMed Web of Science ®Google Scholar
• Myers J, Hadley D, Oswald U et al. Effects of exercise training on heart rate recovery in patients with chronic heart failure. Am. Heart J.153(6), 1056–1063 (2007).
   PubMed Web of Science ®Google Scholar
• Buendia Fuentes F, Martinez-Dolz L, Almenar Bonet L et al. Normalization of the heart rate response to exercise 6 months after cardiac transplantation. Transplant. Proc.42(8), 3186–3188 (2010).
   Google Scholar
• Phan TT, Shivu GN, Abozguia K et al. Impaired heart rate recovery and chronotropic incompetence in patients with heart failure with preserved ejection fraction. Circ. Heart Fail.3(1), 29–34 (2010).
   PubMed Web of Science ®Google Scholar
• Fukutomi M, Matsui Y, Shimada K. [Dipper and nondipper]. Nippon Rinsho64(Suppl. 6), 33–38 (2006).
   Google Scholar
• Izzedine H, Launay-Vacher V, Deray G. Abnormal blood pressure circadian rhythm: a target organ damage? Int. J. Cardiol.107(3), 343–349 (2006).
   PubMed Web of Science ®Google Scholar
• Nakano Y, Oshima T, Ozono R et al. Non-dipper phenomenon in essential hypertension is related to blunted nocturnal rise and fall of sympatho–vagal nervous activity and progress in retinopathy. Auton Neurosci.88(3), 181–186 (2001).
   PubMed Web of Science ®Google Scholar
• Okutucu S, Kabakci G, Deveci OS et al. Relationship between exercise heart rate recovery and circadian blood pressure pattern. J. Clin. Hypertens. (Greenwich)12(6), 407–413 (2010).
   Google Scholar
• Polonia J, Amaral C, Bertoquini S, Martins L. Attenuation of heart rate recovery after exercise in hypertensive patients with blunting of the nighttime blood pressure fall. Int. J. Cardiol.106(2), 238–243 (2006).
   PubMed Web of Science ®Google Scholar
• Fei DY, Arena R, Arrowood JA, Kraft KA. Relationship between arterial stiffness and heart rate recovery in apparently healthy adults. Vasc. Health Risk Manag.1(1), 85–89 (2005).
   PubMedGoogle Scholar
• Georgoulias P, Demakopoulos N, Valotassiou V et al. Long-term prognostic value of heart-rate recovery after treadmill testing in patients with diabetes mellitus. Int. J. Cardiol.134(1), 67–74 (2009).
   Google Scholar
• Chacko KM, Bauer TA, Dale RA, Dixon JA, Schrier RW, Estacio RO. Heart rate recovery predicts mortality and cardiovascular events in patients with Type 2 diabetes. Med. Sci. Sports Exerc.40(2), 288–295 (2008).
   Google Scholar
• Yamada T, Yoshitama T, Makino K, Lee T, Saeki F. Heart rate recovery after exercise is a predictor of silent myocardial ischemia in patients with Type 2 diabetes. Diabetes Care34(3), 724–726 (2011).
   Google Scholar
• Panzer C, Lauer MS, Brieke A, Blackstone E, Hoogwerf B. Association of fasting plasma glucose with heart rate recovery in healthy adults: a population-based study. Diabetes51(3), 803–807 (2002).
   PubMed Web of Science ®Google Scholar
• Van De Borne P, Hausberg M, Hoffman RP, Mark AL, Anderson EA. Hyperinsulinemia produces cardiac vagal withdrawal and nonuniform sympathetic activation in normal subjects. Am. J. Physiol.276(1 Pt 2), R178–R183 (1999).
   Google Scholar
• Carnethon MR, Jacobs DR Jr, Sidney S, Liu K. Influence of autonomic nervous system dysfunction on the development of Type 2 diabetes: the CARDIA study. Diabetes Care26(11), 3035–3041 (2003).
   PubMed Web of Science ®Google Scholar
• Sung J, Choi YH, Park JB. Metabolic syndrome is associated with delayed heart rate recovery after exercise. J. Korean Med. Sci.21(4), 621–626 (2006).
   PubMed Web of Science ®Google Scholar
• Spies C, Otte C, Kanaya A, Pipkin SS, Schiller NB, Whooley MA. Association of metabolic syndrome with exercise capacity and heart rate recovery in patients with coronary heart disease in the heart and soul study. Am. J. Cardiol.95(10), 1175–1179 (2005).
   PubMed Web of Science ®Google Scholar
• Shishehbor MH, Hoogwerf BJ, Lauer MS. Association of triglyceride-to-HDL cholesterol ratio with heart rate recovery. Diabetes Care27(4), 936–941 (2004).
   Google Scholar
• Lind L, Andren B. Heart rate recovery after exercise is related to the insulin resistance syndrome and heart rate variability in elderly men. Am. Heart J.144(4), 666–672 (2002).
   PubMed Web of Science ®Google Scholar
• Wasmund SL, Owan T, Yanowitz FG et al. Improved heart rate recovery after marked weight loss induced by gastric bypass surgery: two-year follow up in the Utah Obesity Study. Heart Rhythm8(1), 84–90 (2011).
   Google Scholar
• Brinkworth GD, Noakes M, Buckley JD, Clifton PM. Weight loss improves heart rate recovery in overweight and obese men with features of the metabolic syndrome. Am. Heart J.152(4), 693.e691–e696 (2006).
   Google Scholar
• Maeder MT, Ammann P, Schoch OD et al. Determinants of postexercise heart rate recovery in patients with the obstructive sleep apnea syndrome. Chest137(2), 310–317 (2010).
   Google Scholar
• Nanas S, Sakellariou D, Kapsimalakou S et al. Heart rate recovery and oxygen kinetics after exercise in obstructive sleep apnea syndrome. Clin. Cardiol.33(1), 46–51 (2010).
   Google Scholar
• Bradley TD, Floras JS. Obstructive sleep apnoea and its cardiovascular consequences. Lancet373(9657), 82–93 (2009).
   PubMed Web of Science ®Google Scholar
• Hilton MF, Chappell MJ, Bartlett WA, Malhotra A, Beattie JM, Cayton RM. The sleep apnoea/hypopnoea syndrome depresses waking vagal tone independent of sympathetic activation. Eur. Respir. J.17(6), 1258–1266 (2001).
   PubMed Web of Science ®Google Scholar
• Maeder MT, Munzer T, Rickli H et al. Association between heart rate recovery and severity of obstructive sleep apnea syndrome. Sleep Med9(7), 753–761 (2008).
   Google Scholar
• Maeder MT, Ammann P, Munzer T et al. Continuous positive airway pressure improves exercise capacity and heart rate recovery in obstructive sleep apnea. Int. J. Cardiol.132(1), 75–83 (2009).
   Google Scholar
• Kaya EB, Okutucu S, Aksoy H et al. Evaluation of cardiac autonomic functions in patients with ankylosing spondylitis via heart rate recovery and heart rate variability. Clin. Res. Cardiol.99(12), 803–808 (2010).
   PubMed Web of Science ®Google Scholar
• Dogdu O, Yarlioglues M, Kaya MG et al. Deterioration of heart rate recovery index in patients with systemic lupus erythematosus. J. Rheumatol.37(12), 2511–2515 (2010).
   Google Scholar
• Kaya EB, Yorgun H, Akdogan A et al. Heart-rate recovery index is impaired in Behcet’s disease. Tex. Heart Inst. J.36(4), 282–286 (2009).
   Web of Science ®Google Scholar
• Ardic I, Kaya MG, Yarlioglues M et al. Impaired heart rate recovery index in patients with sarcoidosis. Chest139(1), 60–68 (2011).
   PubMed Web of Science ®Google Scholar
• Ardic I, Kaya MG, Yarlioglues M et al. Assessment of heart rate recovery index in patients with familial Mediterranean fever. Rheumatol. Int.31(1), 121–125 (2011).
   PubMed Web of Science ®Google Scholar
• Chick TW, Cagle TG, Vegas FA, Poliner JK, Murata GH. Recovery of gas exchange variables and heart rate after maximal exercise in COPD. Chest97(2), 276–279 (1990).
   Google Scholar
• Seshadri N, Gildea TR, Mccarthy K, Pothier C, Kavuru MS, Lauer MS. Association of an abnormal exercise heart rate recovery with pulmonary function abnormalities. Chest125(4), 1286–1291 (2004).
   PubMed Web of Science ®Google Scholar
• Lacasse M, Maltais F, Poirier P et al. Postexercise heart rate recovery and mortality in chronic obstructive pulmonary disease. Respir. Med.99(7), 877–886 (2005).
   PubMed Web of Science ®Google Scholar
• Sun XG, Hansen JE, Oudiz RJ, Wasserman K. Exercise pathophysiology in patients with primary pulmonary hypertension. Circulation104(4), 429–435 (2001).
   PubMed Web of Science ®Google Scholar
• Dimopoulos S, Anastasiou-Nana M, Katsaros F et al. Impairment of autonomic nervous system activity in patients with pulmonary arterial hypertension: a case control study. J. Card. Fail.15(10), 882–889 (2009).
   PubMedGoogle Scholar
• Kesoi I, Sagi B, Vas T, Kovacs T, Wittmann I, Nagy J. Heart rate recovery after exercise is associated with renal function in patients with a homogenous chronic renal disease. Nephrol. Dial. Transplant.25(2), 509–513 (2010).
   Google Scholar
• O’Keefe JH Jr, Abuissa H, Sastre A, Steinhaus DM, Harris WS. Effects of omega-3 fatty acids on resting heart rate, heart rate recovery after exercise, and heart rate variability in men with healed myocardial infarctions and depressed ejection fractions. Am. J. Cardiol.97(8), 1127–1130 (2006).
   PubMed Web of Science ®Google Scholar
• Maddox TM, Ross C, Ho PM, Magid D, Rumsfeld JS. Impaired heart rate recovery is associated with new-onset atrial fibrillation: a prospective cohort study. BMC Cardiovasc. Disord.9, 11 (2009).
   Google Scholar
• Giallauria F, Orio F, Lombardi G et al. Relationship between heart rate recovery and inflammatory markers in patients with polycystic ovary syndrome: a cross-sectional study. J. Ovarian Res.2, 3 (2009).
   PubMed Web of Science ®Google Scholar
• Tekin G, Tekin A, Kilicarslan EB et al. Altered autonomic neural control of the cardiovascular system in patients with polycystic ovary syndrome. Int. J. Cardiol.130(1), 49–55 (2008).
   Google Scholar
• Giallauria F, Palomba S, Manguso F et al. Abnormal heart rate recovery after maximal cardiopulmonary exercise stress testing in young overweight women with polycystic ovary syndrome. Clin. Endocrinol.68(1), 88–93 (2008).
   PubMedGoogle Scholar
• Thomson RL, Buckley JD, Noakes M, Clifton PM, Norman RJ, Brinkworth GD. Heart rate recovery improves after weight loss in overweight and obese women with polycystic ovary syndrome. Fertil. Steril.93(4), 1173–1178 (2010).
   Google Scholar
• Kocabas U, Kaya EB, Aytemir K et al. A novel method for the diagnosis of neurocardiogenic syncope: heart rate recovery index. Cardiology114(1), 50–55 (2009).
   Google Scholar
• Yerdelen D, Acil T, Goksel B, Karatas M. Heart rate recovery in migraine and tension-type headache. Headache48(2), 221–225 (2008).
   PubMed Web of Science ®Google Scholar
• Boettger S, Wetzig F, Puta C et al. Physical fitness and heart rate recovery are decreased in major depressive disorder. Psychosom. Med.71(5), 519–523 (2009).
   Google Scholar
• Cade WT, Reeds DN, Lassa-Claxton S et al. Postexercise heart rate recovery in HIV-positive individuals on highly active antiretroviral therapy. Early indicator of cardiovascular disease? HIV Med.9(2), 96–100 (2008).
   PubMed Web of Science ®Google Scholar
• Guazzi M, Myers J, Peberdy MA, Bensimhon D, Chase P, Arena R. Heart rate recovery predicts sudden cardiac death in heart failure. Int. J. Cardiol.144(1), 121–123 (2010).
   Google Scholar