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Editorial

Xanthine oxidase inhibition for the treatment of stroke disease: a novel therapeutic approach

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Pages 399-401 | Published online: 10 Jan 2014

References

  • The European Stroke Organisation (ESO) Executive Committee and the ESCO Writing Committee. Guidelines for Management of Ischaemic Stroke and Transient Ischaemic Attack 2008. Cerebrovasc. Dis.25, 457–507 (2008).
  • Higgins P, Dawson J, Walters M. The potential for xanthine oxidase inhibition in the prevention and treatment of cardiovascular and cerebrovascular disease. Cardiovasc. Psychiatry Neurol.2009, 282059 (2009).
  • Dawson J, Walters M. Uric acid and xanthine oxidase: future therapeutic targets in the prevention of cardiovascular disease? Br. J. Clin. Pharmacol.62(6), 633–644 (2006).
  • Noman A, Ang DS, Ogston S, Lang CC, Struthers AD. Effect of high-dose allopurinol on exercise in patients with chronic stable angina: a randomised, placebo controlled crossover trial. Lancet375(9732), 2161–2167 (2010).
  • George J, Carr E, Davies J, Belch JF, Struthers A. High-dose allopurinol improves endothelial function by profoundly reducing vascular oxidative stress and not by lowering uric acid. Circulation114(23), 2508–2516 (2006).
  • Feig DI, Soletsky B, Johnson RJ. Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial. JAMA300(8), 924–932 (2008).
  • Luk AJ, Levin GP, Moore EE, Zhou XH, Kestenbaum BR, Choi HK. Allopurinol and mortality in hyperuricaemic patients. Rheumatology48, 804–806 (2009).
  • Hare JM, Mangal B, Brown J et al. Impact of oxypurinol in patients with symptomatic heart failure: results of the OPT-CHF study. J. Am. Coll. Cardiol.51(24), 2301–2309 (2008).
  • Muir SW, Harrow C, Dawson J et al. Allopurinol use yields potentially beneficial effects on inflammatory indices in those with recent ischemic stroke: a randomized, double-blind, placebo-controlled trial. Stroke39(12), 3303–3307 (2008).
  • Khan F, George J, Wong K, McSwiggan S, Struthers AD, Belch JF. Allopurinol treatment reduces arterial wave reflection in stroke survivors. Cardiovasc. Ther.26(4), 247–252 (2008).
  • Dawson J, Quinn T, Harrow C et al. Allopurinol and nitric oxide activity in the cerebral circulation of those with diabetes. Diabetes Care32(1), 135–137 (2009).
  • Dawson J, Quinn TJ, Harrow C, Lees KR, Walters MR. The effect of allopurinol on the cerebral vasculature of patients with subcortical stroke; a randomized trial. Br. J. Clin. Pharmacol.68(5), 662–668 (2009).
  • Amaro S, Urra X, Gómez-Choco M et al. Uric acid levels are relevant in patients with stroke treated with thrombolysis. Stroke.42(Suppl. 1), S28–S32 (2011).
  • Amaro S, Planas AM, Chamorro A. Uric acid administration in patients with acute stroke: a novel approach to neuroprotection. Expert Rev. Neurother.8(2), 259–270 (2008).

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