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The role of obesity, salt and exercise on blood pressure in children and adolescents

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Pages 753-761 | Published online: 10 Jan 2014

References

  • Din-Dzietham R, Liu Y, Bielo MV, Shamsa F. High blood pressure trends in children and adolescents in national surveys, 1963 to 2002. Circulation116(13), 1488–1496 (2007).
  • National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics114(2), 555–576 (2004).
  • Feber J, Ahmed M. Hypertension in children: new trends and challenges. Clin. Sci. (Lond.)119(4), 151–161 (2010)
  • Falkner B. Hypertension in children and adolescents: epidemiology and natural history. Pediatr. Nephrol.25(7), 1219–1224 (2010).
  • Bao W, Threefoot SA, Srinivasan SR, Berenson GS. Essential hypertension predicted by tracking of elevated blood pressure from childhood to adulthood: the Bogalusa Heart Study. Am. J. Hypertens.8(7), 657–665 (1995).
  • Lauer RM, Clarke WR. Childhood risk factors for high adult blood pressure: the Muscatine Study. Pediatrics84(4), 633–641 (1989).
  • Berenson GS, Srinivasan SR, Bao W, Newman WP, Tracy RE, Wattigney WA. Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. The Bogalusa Heart Study. N. Engl. J. Med.338(23), 1650–1656 (1998).
  • Muntner P, He J, Cutler JA, Wildman RP, Whelton PK. Trends in blood pressure among children and adolescents. JAMA291(17), 2107–2113 (2004).
  • Chiolero A, Bovet P, Paradis G, Paccaud F. Has blood pressure increased in children in response to the obesity epidemic? Pediatrics119(3), 544–553 (2007).
  • Sorof JM, Portman RJ. Ambulatory blood pressure measurements. Curr. Opin. Pediatr.13(2), 133–137 (2001).
  • Simckes AM, Srivastava T, Alon US. Ambulatory blood pressure monitoring in children and adolescents. Clin. Pediatr. (Phila.)41(8), 549–564 (2002).
  • Graves JW, Althaf MM. Utility of ambulatory blood pressure monitoring in children and adolescents. Pediatr. Nephrol.21(11), 1640–1652 (2006).
  • Stabouli S, Kotsis V, Zakopoulos N. Ambulatory blood pressure monitoring and target organ damage in pediatrics. J. Hyperten.25(10), 1979–1986 (2007).
  • Lurbe E, Redon J. Discrepancies.in office and ambulatory blood pressure in adolescents: help or hindrance? Pediatr. Nephrol.23(3), 341–345 (2008).
  • Lurbe E, Sorof JM, Daniels SR. Clinical and research aspects of ambulatory blood pressure monitoring in children. J. Pediatr.144(1), 7–16 (2004).
  • Urbina E, Alpert B, Flynn J, Hayman L, Harshfield GA, Jacobson M; American Heart Association Atherosclerosis, Hypertension, and Obesity in Youth Committee. Ambulatory blood pressure monitoring in children and adolescents. Recommendations for standard assessment: a scientific statement from the American Heart Association Atherosclerosis, Hypertension, and Obesity in Youth Committee of the council on cardiovascular disease in the young and the council for high blood pressure research. Hypertension52(3), 433–451 (2008).
  • Sorof JM. White-coat hypertension in children. Blood Press. Monit.5(4), 197–202 (2000).
  • Stabouli S, Kotsis V, Toumanidis S, Papamichael C, Constantopoulos A, Zakopoulos N. White-coat and masked hypertension in children: association with target-organ damage. Pediatr. Nephrol.20(8), 1151–1155 (2005).
  • Kotsis V, Stabouli S, Toumanidis S et al. Target organ damage in ‘white coat hypertension’ and ‘masked hypertension’. Am. J. Hypertens.21(4), 393–399 (2008).
  • Kario K, Matsuo T, Kobayashi H, Imiya M, Matsuo M, Shimada K. Nocturnal fall of blood pressure and silent cerebrovascular damage in elderly hypertensive subjects: advanced silent cerebrovascular damage in extreme dippers. Hypertension27(1), 130–135 (1996).
  • Parati G, Lantelme P. Blood pressure variability, target organ damage and cardiovascular events. J. Hypertens.20(9), 1725–1729 (2002).
  • Stabouli S, Kotsis V, Rizos Z, Toumanidis S, Karagianni C, Constantopoulos A. Left ventricular mass in normotensive, prehypertensive and hypertensive children and adolescents. Pediatr. Nephrol.24(8), 1545–1551 (2009).
  • Stabouli S, Kotsis V, Karagianni C, Toumanidis S, Constantopoulos A, Zakopoulos N. 24-h pulse pressure predicts left ventricular mass index in children and adolescents. J. Hypertens.25(Suppl. 2), S297 (2007).
  • Garrison RJ, Kannel WB, Stokes J 3rd, Castelli WP. Incidence and precursors of hypertension in young adults: the Framingham Offspring Study. Prev. Med.16(2), 235–251 (1987).
  • Ostchega Y, Carroll M, Prineas RJ, McDowell MA, Louis T, Tilert T. Trends of elevated blood pressure among children and adolescents: data from the national health and nutrition examination survey 1988–2006. Am. J. Hypertens.22(1), 59–67 (2009).
  • Sorof J, Daniels S. Obesity hypertension in children: a problem of epidemic proportions. Hypertension40(4), 441–447 (2002).
  • Krebs NF, Jacobson MS; American Academy of Pediatrics Committee on Nutrition. Prevention of pediatric overweight and obesity. Pediatrics112(2), 424–430 (2003).
  • Cole TJ, Bellizzi MC, Flegal KM, Dietz WH. Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ320(7244), 1240–1243 (2000).
  • Stabouli S, Kotsis V, Papamichael C, Constantopoulos A, Zakopoulos N. Adolescent obesity is associated with high ambulatory blood pressure and increased carotid intimal-medial thickness. J. Pediatr.147(5), 651–656 (2005).
  • Lurbe E, Alvarez V, Liao Y, Tacons J, Cooper R, Cremades B et al. The impact of obesity and body fat distribution in children and adolescents. Am. J. Hypertens.11(4 Pt 1), 418–424 (1998).
  • Lurbe E, Invitti C, Torro I, Maronati A, Aguilar F, Sartorio G. The impact of the degree of obesity on the discrepancies between office and ambulatory blood pressure values in youth. J. Hypertens.24(8), 1557–1564 (2006).
  • Daniels S, Kimball T, Khoury P, Witt S, Morrison J. Correlates of the hemodynamic determinants of blood pressure. Hypertension28(1), 37–41 (1996).
  • Sabo RT, Lu Z, Daniels S, Sun SS. Relationships between serial childhood adiposity measures and adult blood pressure: the Fels Longitudinal Study. Am. J. Hum. Biol.22(6), 830–835 (2010).
  • Kotsis V, Stabouli S, Papakatsika S, Rizos Z, Parati G. Mechanisms of obesity-induced hypertension. Hypertens. Res.33(5), 386–393 (2010).
  • Sorof JM, Poffenbarger T, Franco K, Bernard L, Portman RJ. Isolated systolic hypertension, obesity and hyperkinetic hemodynamic states in children. J. Pediatr.140(6), 660–666 (2002).
  • Martini G, Riva P, Rabbia F, Molini V, Ferrero GB, Cerutti F. Heart rate variability in childhood obesity. Clin. Auton. Res.11(2), 87–91 (2001).
  • Riva P, Martini G, Rabbia F et al. Obesity and autonomic function in adolescence. Clin. Exp. Hypertens.23(1–2), 57–67 (2001).
  • Rocchini AP, Key J, Bondie D et al. The effect of weight loss on the sensitivity of blood pressure to sodium in obese adolescents. N. Engl. J. Med.321(9), 580–585 (1989).
  • Lurbe E, Alvarez V, Liao Y et al. Obesity modifies the relationship between ambulatory blood pressure and natriuresis in children. Blood Press. Monit.5(5–6), 275–280 (2000).
  • Chen W, Srinivasan SR, Elkasabany A, Berenson GS. Cardiovascular risk factors clustering features of insulin resistance syndrome (Syndrome X) in a biracial (Black–White) population of children, adolescents, and young adults. The Bogalusa Heart Study. Am. J. Epidemiol.150(7), 667–674 (1999).
  • Kanai H, Matsuzawa Y, Tokunaga K et al. Hypertension in obese children: fasting serum insulin levels are closely correlated with blood pressure. Int. J. Obes.14(12), 1047–1056 (1990).
  • Lurbe E, Torro I, Aguilar F et al. Added impact of obesity and insulin resistance in nocturnal blood pressure elevation in children and adolescents. Hypertension51(3), 635–641 (2008).
  • Finta KM, Rocchini AP, Moorehead C, Key J, Katch V. Urine sodium excretion in response to an oral glucose tolerance test in obese and non-obese adolescents. Pediatrics90(3), 442–446 (1992).
  • Csábi G, Molnár D, Hartmann G. Urinary sodium excretion: association with hyperinsulinaemia, hypertension and sympathetic nervous system activity in obese and control children. Eur. J. Pediatr.155(10), 895–897 (1996).
  • Kotsis V, Stabouli S, Papamichael CM, Zakopoulos NA. Impact of obesity in intima media thickness of carotid arteries. Obesity (Silver Spring)14(10), 1708–1715 (2006).
  • Kotsis V, Pitiriga V, Stabouli S et al. Carotid intima-media thickness could predict the presence of coronary artery lesions. Am. J. Hypertens.18(5 Pt 1), 601–606 (2005).
  • Tounian P, Aggoun Y, Dubern B et al. Presence of increased stiffness of the common carotid artery and endothelial dysfunction in severely obese children: a prospective study. Lancet358(9291), 1400–1404 (2001).
  • Ledoux S, Queguiner J, Msika S et al. Angiogenesis associated with visceral and subcutaneous adipose tissue in severe human obesity. Diabetes57(12), 3247–3257 (2008).
  • Kapiotis S, Holzer G, Schaller G et al. A Proinflammatory state is detectable in obese children and is accompanied by functional and morphological vascular changes. Arterioscler. Thromb. Vasc. Biol.26(11), 2541–2546 (2006).
  • Rocchini AP, Katch V, Anderson J et al. Blood pressure in obese adolescents: effect of weight loss. Pediatrics82(1), 16–23 (1988).
  • Sorof JM, Turner J, Martin D et al. Cardiovascular risk factors and sequelae in hypertensive children by referral versus school-based screening. Hypertension43(2), 214–218 (2004).
  • Sorof JM, Alexandrov A, Cardwell G, Portman RJ. Carotid artery intimal-medial thickness and left ventricular hypertrophy in children with elevated blood pressure. Pediatrics111(1), 61–66 (2003).
  • Lurbe E, Carvajal E, Torro I, Aguilar F, Alvarez J, Redon J. Influence of concurrent obesity and low birth weight on blood pressure phenotype in youth. Hypertension53(6), 912–917 (2009).
  • Adair LS, Cole TJ. Rapid child growth raises blood pressure in adolescent boys who were thin at birth. Hypertension41(3), 451–456 (2003).
  • Martyn CN, Barker DJ, Jespersen S, Greenwald S, Osmond C, Berry C. Growth in utero, adult blood pressure and arterial compliance. Br. Heart J.73(2), 116–121 (1995).
  • Adair LS, Martorell R, Stein AD et al. Sizeat birth, weight gain in infancy and childhood, and adult blood pressure in 5 low- and middle-income-country cohorts: when does weight gain matter? Am. J. Clin. Nutr.89(5), 1383–1392 (2009).
  • Intersalt Cooperative Research Group. Intersalt: an international study of electrolyte excretion and blood pressure: results for 24 h urinary sodium and potassium excretion. BMJ297(6644), 319–328 (1988).
  • Mancilha-Carvalho JJ, de Oliveira R, Esposito RJ. Blood pressure and electrolyte excretion in the Yanomamo Indians, an isolated population. J. Hum. Hypertens.3(5), 309–314 (1989).
  • He FJ, MacGregor GA. Effect of modest salt reduction on blood pressure: a meta-analysis of randomized trials: implications for public health. J. Hum. Hypertens.16(11), 761–770 (2002).
  • Cook NR, Cutler JA, Obarzanek E et al. Long term effects of dietary sodium reduction on cardiovascular disease outcomes: observational follow-up of the Trials Of Hypertension Prevention (TOHP). BMJ334(7599), 885–888 (2007).
  • Frank GC, Webber LS, Nicklas TA, Berenson GS. Sodium, potassium, calcium, magnesium, and phosphorus intakes of infants and children: Bogalusa Heart Study. J. Am. Diet. Assoc.88(7), 801–807 (1988).
  • Hofman A, Hazebroek A, Valkenburg HA. A randomized trial of sodium intake and blood pressure in newborn infants. JAMA250(3), 370–373 (1983).
  • Geleijnse JM, Hofman A, Witteman JC, Hazebroek AA, Valkenburg HA, Grobbee DE. Long-term effect of neonatal sodium restriction on blood pressure. Hypertension29(4), 913–917 (1997).
  • Maldonado-Martín A, García-Matarín L, Gil-Extremera B et al. Blood pressure and urinary excretion of electrolytes in Spanish schoolchildren. J. Hum. Hypertens.16(7), 473–478 (2002).
  • Howe PR, Cobiac L, Smith RM. Lack of effect of short-term changes in sodium intake on blood pressure in adolescent school children. J. Hypertens.9(2), 181–186 (1991).
  • Sinaiko AR, Gomez-Marin O, Prineas RJ. Effect of low sodium diet or potassium supplementation on adolescent blood pressure. Hypertension21(6 Pt 2), 989–994 (1993).
  • He FJ, MacGregor GA. Importance of salt in determining blood pressure in children: meta-analysis of controlled trials. Hypertension48(5), 861–869 (2006).
  • Falkner B, Kushner H, Khalsa DK, Canessa M, Katz S. Sodium sensitivity, growth and family history of hypertension in young blacks. J. Hypertens.4(Suppl. 5), S381–S383 (1986).
  • Simonetti GD, Raio L, Surbel D et al. Salt sensitivity of children with low birth weight. Hypertension52(4), 625–630 (2008).
  • de Boer MP, Ijzerman RG, de Jongh RT et al. Birth weight relates to salt sensitivity of blood pressure in healthy adults. Hypertension51(4), 928–932 (2008).
  • Kimura G, Dohi Y, Fukuda M. Salt sensitivity and circadian rhythm of blood pressure: the keys to connect CKD with cardiovascular events. Hypertens. Res.33(6), 515–510 (2010).
  • Sachdeva A, Weder AB. Nocturnal sodium excretion, blood pressure dipping, and sodium sensitivity. Hypertension48(4), 527–533 (2006).
  • Wilson DK, Sica DA, Miller SB. Ambulatory blood pressure nondipping status in salt-sensitive and salt-resistant black adolescents. Am. J. Hypertens.12(2 Pt 1), 159–165 (1999).
  • Simonetti GD, Farese S, Aregger F, Uehlinger D, Frey FJ, Mohaupt MG. Nocturnal dipping behaviour in normotensive white children and young adults in response to changes in salt intake. J. Hypertens.28(5), 1027–1033 (2010).
  • Yuan CM, Manunta P, Hamlyn JM et al. Long-term ouabain administration produces hypertension in rats. Hypertension22(2), 178–187 (1993).
  • Hamlyn JM, Manunta P. Endogenous ouabain: a link between sodium intake and hypertension. Curr. Hypertens. Rep.13(1), 14–20 (2011).
  • Frisbee JC, Lombard JH. Acute elevations in salt intake and reduced renal mass hypertension compromise arteriolar dilation in rat cremaster muscle. Microvasc. Res.57(3), 273–283 (1999).
  • Frisbee JC, Lombard JH. Chronic elevations in salt intake and reduced renal mass hypertension compromise mechanisms of arteriolar dilation. Microvasc. Res.56(3), 218–227 (1998).
  • Falkner B, Michel S. Blood pressure response to sodium in children and adolescents. Am. J. Clin. Nutr.65(Suppl. 65), 618S–621S (1997).
  • Thompson PD, Buchner D, Pina IL et al. American Heart Association Council on Clinical Cardiology Subcommittee on Exercise, Rehabilitation and Prevention; American Heart Association Council on Nutrition, Physical Activity and Metabolism Subcommittee on Physical Activity. Exercise and physical activity in the prevention and treatment of atherosclerotic cardiovascular disease: a statement from the Council on Clinical Cardiology (Subcommittee on Exercise, Rehabilitation and Prevention) and the Council on Nutrition, Physical Activity and Metabolism (Subcommittee on Physical Activity). Circulation107(24), 3109–3116 (2003).
  • Whelton SP, Chin A, Xin X, He J. Effect of aerobic exercise on blood pressure: a meta-analysis of randomized, controlled trials. Ann. Intern. Med.136(7), 493–503 (2002).
  • Barengo NC, Hu G, Kastarinen M et al. Low physical activity as a predictor for antihypertensive drug treatment in 25–64-year-old populations in eastern and south-western Finland. J. Hypertens.23(2), 293–299 (2005).
  • Pescatello LS, Franklin BA, Fagard R, Farquhar WB, Kelley GA, Ray CA; American College of Sports Medicine. American College of Sports Medicine position stand. Exercise and hypertension. Med. Sci. Sports Exerc.36(3), 533–553 (2004).
  • Quinn TJ. Twenty-four hour, ambulatory blood pressure responses following acute exercise: impact of exercise intensity. J. Hum. Hypertens.14(9), 547–553 (2000).
  • Halbert JA, Silagy CA, Finucane P, Withers RT, Hamdorf PA, Andrews GR. The effectiveness of exercise training in lowering blood pressure: a meta-analysis of randomised controlled trials of 4 weeks or longer. J. Hum. Hypertens.11(10), 641–649 (1997).
  • Grassi G, Seravalle G, Calhoun DA, Mancia G. Physical training and baroreceptor control of sympathetic nerve activity in humans. Hypertension23(3), 294–301 (1994).
  • Brownley KA, Hinderliter AL, West SG, Girdler SS, Sherwood A, Light KC. Sympathoadrenergic mechanisms in reduced hemodynamic stress responses after exercise. Med. Sci. Sports Exerc.35(6), 978–986 (2003).
  • Nagai N, Moritani T. Effect of physical activity on autonomic nervous system function in lean and obese children. Int. J. Obes. Relat. Metab. Disord.28(1), 27–33 (2004).
  • Goto C, Higashi Y, Kimura M et al. Effect of different intensities of exercise on endothelium-dependent vasodilation in humans: role of endothelium-dependent nitric oxide and oxidative stress. Circulation108(5), 530–535 (2003).
  • Carnethon MR, Gulati M, Greenland P. Prevalence and cardiovascular disease correlates of low cardiorespiratory fitness in adolescents and adults. JAMA294(23), 2981–2988 (2005).
  • Lobelo F, Pate RR, Dowda M, Liese AD, Daniels SR. Cardiorespiratory fitness and clustered cardiovascular disease risk in U.S. adolescents. J. Adolesc. Health47(4), 352–359 (2010).
  • Grøntved A, Brage S, Møller NC, Kristensen PL, Wedderkopp N, Froberg K. Hemodynamic variables during exercise in childhood and resting systolic blood pressure levels 6 years later in adolescence: the European Youth Heart Study. J. Hum. Hypertens. DOI: 10.1038/jhh.2010.103 (2010) (Epub ahead of print).
  • Maximova K, O’Loughlin J, Paradis G, Hanley JA, Lynch J. Declines in physical activity and higher systolic blood pressure in adolescence. Am. J. Epidemiol.170(9), 1084–1094 (2009).
  • Hagberg JM, Ehsani AA, Goldring D, Hernandez A, Sinacore DR, Holloszy JO. Effect of weight training on blood pressure and hemodynamics in hypertensive adolescents. J. Pediatr.104(1), 147–151 (1984).
  • Kelley GA, Kelley KS, Tran ZV. The effects of exercise on resting blood pressure in children and adolescents: a meta-analysis of randomized controlled trials. Prev. Cardiol.6(1), 8–16 (2003).
  • Torrance B, McGuire KA, Lewanczuk R, McGavock J. Overweight, physical activity and high blood pressure in children: a review of the literature. Vasc. Health Risk Manag.3(1), 139–149 (2007).
  • Farpour-Lambert NJ, Aggoun Y, Marchand LM, Martin XE, Herrmann FR, Beghetti M. Physical activity reduces systemic blood pressure and improves early markers of atherosclerosis in pre-pubertal obese children. J. Am. Coll. Cardiol.54(25), 2396–2406 (2009).
  • Maggio AB, Aggoun Y, Martin XE, Marchand LM, Beghetti M, Farpour-Lambert NJ. Long-term follow-up of cardiovascular risk factors after exercise training in obese children. Int. J. Pediatr. Obes. DOI: 10.3109/17477166.2010.530665 (2010) (Epub ahead of print).
  • Meyer AA, Kundt G, Lenschow U, Schuff-Werner P, Kienast W. Improvement of early vascular changes and cardiovascular risk factors in obese children after a six-month exercise program. J. Am. Coll. Cardiol.48(9), 1865–1870 (2006).
  • Moore LL, Lombardi DA, White MJ, Campbell JL, Oliveria SA, Ellison RC. Influence of parents’ physical activity levels on activity levels of young children. J. Pediatr.118(2), 215–219 (1991).
  • Lee KS, Loprinzi PD, Trost SG. Determinants of physical activity in Singaporean adolescents. Int. J. Behav. Med.17(4), 279–286 (2010).
  • Rosner B, Prineas R, Daniels SR, Loggie J. Blood pressure differences between blacks and whites in relation to body size among US children and adolescents. Am. J. Epidemiol.151(10), 1007–1019 (2000).
  • Freedman DS, Dietz WH, Srinivasan SR, Berenson GS. The relation of overweight to cardiovascular risk factors among children and adolescents: the Bogalusa Heart Study. Pediatrics103(6 Pt 1), 1175–1182 (1999).
  • Sorof JM, Lai D, Turner J, Poffenbarger T, Portman RJ. Overweight, ethnicity, and the prevalence of hypertension in school-aged children. Pediatrics113(3 Pt 1), 475–482 (2004).
  • McNiece KL, Poffenbarger TS, Turner JL, Franco KD, Sorof JM, Portman RJ. Prevalence of hypertension and pre-hypertension among adolescents. J. Pediatr.150(6), 640–644 (2007).
  • Paradis G, Lambert M, O’Loughlin J, Lavallée C, Aubin J, Delvin E. Blood pressure and adiposity in children and adolescents. Circulation110(13), 1832–1838 (2004).
  • Harding S, Maynard MJ, Cruickshank K, Teyhan A. Overweight, obesity and high blood pressure in an ethnically diverse sample of adolescents in Britain: the Medical Research Council DASH study. Int. J. Obes. (Lond.)32(1), 82–90 (2008).

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