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Theme: Stroke - Review

Ascertainment of any and all neurologic and myocardial damage in carotid revascularization: the key to optimization?

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Pages 469-484 | Published online: 10 Jan 2014

References

  • Brott TG, Hobson RW 2nd, Howard G et al.; CREST Investigators. Stenting versus endarterectomy for treatment of carotid-artery stenosis. N. Engl. J. Med. 363(1), 11–23 (2010).
  • Ederle J, Dobson J, Featherstone RL et al. Carotid artery stenting compared with endarterectomy in patients with symptomatic carotid stenosis (International Carotid Stenting Study): an interim analysis of a randomised controlled trial. Lancet 375(9719), 985–997 (2010).
  • Bangalore S, Kumar S, Wetterslev J et al. Carotid artery stenting vs carotid endarterectomy: meta-analysis and diversity-adjusted trial sequential analysis of randomized trials. Arch. Neurol. 68(2), 172–184 (2011).
  • Bendszus M, Stoll G. Silent cerebral ischaemia: hidden fingerprints of invasive medical procedures. Lancet Neurol. 5(4), 364–372 (2006).
  • Babu GG, Walker JM, Yellon DM, Hausenloy DJ. Peri-procedural myocardial injury during percutaneous coronary intervention: an important target for cardioprotection. Eur. Heart J. 32(1), 23–31 (2011).
  • Thygesen K, Alpert JS, Jaffe AS et al.; Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction. Third universal definition of myocardial infarction. Circulation 126(16), 2020–2035 (2012).
  • Levy M, Heels-Ansdell D, Hiralal R et al. Prognostic value of troponin and creatine kinase muscle and brain isoenzyme measurement after noncardiac surgery: a systematic review and meta-analysis. Anesthesiology 114(4), 796–806 (2011).
  • Devereaux PJ, Yang H, Yusuf S et al. Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomised controlled trial. Lancet 371(9627), 1839–1847 (2008).
  • Devereaux PJ, Xavier D, Pogue J et al.; POISE (PeriOperative ISchemic Evaluation) Investigators. Characteristics and short-term prognosis of perioperative myocardial infarction in patients undergoing noncardiac surgery: a cohort study. Ann. Intern. Med. 154(8), 523–528 (2011).
  • Devereaux PJ, Chan MT, Alonso-Coello P et al. Association between postoperative troponin levels and 30-day mortality among patients undergoing noncardiac surgery. JAMA 307(21), 2295–2304 (2012).
  • Motamed C, Motamed-Kazerounian G, Merle JC et al. Cardiac troponin I assessment and late cardiac complications after carotid stenting or endarterectomy. J. Vasc. Surg. 41(5), 769–774 (2005).
  • Feringa HH, Hendriks JM, Karagiannis S et al. Carotid artery stenting versus endarterectomy in relation to perioperative myocardial ischemia, troponin T release and major cardiac events. Coron. Artery Dis. 18(6), 483–487 (2007).
  • Yadav JS, Wholey MH, Kuntz RE et al.; Stenting and Angioplasty with Protection in Patients at High Risk for Endarterectomy Investigators. Protected carotid-artery stenting versus endarterectomy in high-risk patients. N. Engl. J. Med. 351(15), 1493–1501 (2004).
  • Massop D, Dave R, Metzger C et al.; SAPPHIRE Worldwide Investigators. Stenting and angioplasty with protection in patients at high-risk for endarterectomy: SAPPHIRE Worldwide Registry first 2,001 patients. Catheter. Cardiovasc. Interv. 73(2), 129–136 (2009).
  • Sidawy AN, Zwolak RM, White RA, Siami FS, Schermerhorn ML, Sicard GA; Outcomes Committee for the Society for Vascular Surgery. Risk-adjusted 30-day outcomes of carotid stenting and endarterectomy: results from the SVS Vascular Registry. J. Vasc. Surg. 49(1), 71–79 (2009).
  • Mas JL, Chatellier G, Beyssen B et al.; EVA-3S Investigators. Endarterectomy versus stenting in patients with symptomatic severe carotid stenosis. N. Engl. J. Med. 355(16), 1660–1671 (2006).
  • Omland T, de Lemos JA, Sabatine MS et al.; Prevention of Events with Angiotensin Converting Enzyme Inhibition (PEACE) Trial Investigators. A sensitive cardiac troponin T assay in stable coronary artery disease. N. Engl. J. Med. 361(26), 2538–2547 (2009).
  • de Lemos JA, Drazner MH, Omland T et al. Association of troponin T detected with a highly sensitive assay and cardiac structure and mortality risk in the general population. JAMA 304(22), 2503–2512 (2010).
  • deFilippi CR, de Lemos JA, Christenson RH et al. Association of serial measures of cardiac troponin T using a sensitive assay with incident heart failure and cardiovascular mortality in older adults. JAMA 304(22), 2494–2502 (2010).
  • Hallén J, Johansen OE, Birkeland KI et al. Determinants and prognostic implications of cardiac troponin T measured by a sensitive assay in Type 2 diabetes mellitus. Cardiovasc. Diabetol. 9, 52 (2010).
  • Saunders JT, Nambi V, de Lemos JA et al. Cardiac troponin T measured by a highly sensitive assay predicts coronary heart disease, heart failure, and mortality in the Atherosclerosis Risk in Communities Study. Circulation 123(13), 1367–1376 (2011).
  • Egstrup M, Schou M, Tuxen CD et al. Prediction of outcome by highly sensitive troponin T in outpatients with chronic systolic left ventricular heart failure. Am. J. Cardiol. 110(4), 552–557 (2012).
  • Reichlin T, Schindler C, Drexler B et al. One-hour rule-out and rule-in of acute myocardial infarction using high-sensitivity cardiac troponin T. Arch. Intern. Med. 172(16), 1211–1218 (2012).
  • Kavsak PA, Walsh M, Srinathan S et al. High sensitivity troponin T concentrations in patients undergoing noncardiac surgery: a prospective cohort study. Clin. Biochem. 44(12), 1021–1024 (2011).
  • Turer AT, Addo TA, Martin JL et al. Myocardial ischemia induced by rapid atrial pacing causes troponin T release detectable by a highly sensitive assay: insights from a coronary sinus sampling study. J. Am. Coll. Cardiol. 57(24), 2398–2405 (2011).
  • McFalls EO, Ward HB, Moritz TE et al. Predictors and outcomes of a perioperative myocardial infarction following elective vascular surgery in patients with documented coronary artery disease: results of the CARP trial. Eur. Heart J. 29(3), 394–401 (2008).
  • Fleisher LA, Beckman JA, Brown KA et al. 2009 ACCF/AHA focused update on perioperative β blockade incorporated into the ACC/AHA 2007 guidelines on perioperative cardiovascular evaluation and care for noncardiac surgery: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation 120(21), e169–e276 (2009).
  • Smith I, Jackson I. β-blockers, calcium channel blockers, angiotensin converting enzyme inhibitors and angiotensin receptor blockers: should they be stopped or not before ambulatory anaesthesia? Curr. Opin. Anaesthesiol. 23(6), 687–690 (2010).
  • Moffitt EA, Sethna DH. The coronary circulation and myocardial oxygenation in coronary artery disease: effects of anesthesia. Anesth. Analg. 65(4), 395–410 (1986).
  • Ricotta JJ, Aburahma A, Ascher E, Eskandari M, Faries P, Lal BK; Society for Vascular Surgery. Updated Society for Vascular Surgery guidelines for management of extracranial carotid disease. J. Vasc. Surg. 54(3), e1–31 (2011).
  • Sbarigia E, DarioVizza C, Antonini M et al. Locoregional versus general anesthesia in carotid surgery: is there an impact on perioperative myocardial ischemia? Results of a prospective monocentric randomized trial. J. Vasc. Surg. 30(1), 131–138 (1999).
  • Thadani U. Secondary preventive potential of nitrates in ischaemic heart disease. Eur. Heart J. 17(Suppl. F), 30–36 (1996).
  • Horinaka S. Use of nicorandil in cardiovascular disease and its optimization. Drugs 71(9), 1105–1119 (2011).
  • Sakai K, Yamagata T, Teragawa H, Matsuura H, Chayama K. Nicorandil-induced preconditioning as evidenced by troponin T measurements after coronary angioplasty in patients with stable angina pectoris. Jpn. Heart J. 43(5), 443–453 (2002).
  • Morrow DA, Scirica BM, Karwatowska-Prokopczuk E et al.; MERLIN-TIMI 36 Trial Investigators. Effects of ranolazine on recurrent cardiovascular events in patients with non-ST-elevation acute coronary syndromes: the MERLIN-TIMI 36 randomized trial. JAMA 297(16), 1775–1783 (2007).
  • Hoole SP, Heck PM, Sharples L et al. Cardiac Remote Ischemic Preconditioning in Coronary Stenting (CRISP Stent) Study: a prospective, randomized control trial. Circulation 119(6), 820–827 (2009).
  • Winchester DE, Wen X, Xie L, Bavry AA. Evidence of pre-procedural statin therapy a meta-analysis of randomized trials. J. Am. Coll. Cardiol. 56(14), 1099–1109 (2010).
  • Durazzo AE, Machado FS, Ikeoka DT et al. Reduction in cardiovascular events after vascular surgery with atorvastatin: a randomized trial. J. Vasc. Surg. 39(5), 967–975; discussion 975 (2004).
  • Blackshear JL, Cutlip DE, Roubin GS et al.; CREST Investigators. Myocardial infarction after carotid stenting and endarterectomy: results from the carotid revascularization endarterectomy versus stenting trial. Circulation 123(22), 2571–2578 (2011).
  • Bolognese L, Angiolillo DJ. Unravelling the benefit against the risk of long-term dual antiplatelet therapy. Curr. Opin. Cardiol. 26(Suppl. 1), S22–S30 (2011).
  • Eriksson P. Long-term clopidogrel therapy after percutaneous coronary intervention in PCI-CURE and CREDO: the ‘Emperor’s New Clothes’ revisited. Eur. Heart J. 25(9), 720–722 (2004).
  • Sun X, Lindsay J, Monsein LH, Hill PC, Corso PJ. Silent brain injury after cardiac surgery: a review: cognitive dysfunction and magnetic resonance imaging diffusion-weighted imaging findings. J. Am. Coll. Cardiol. 60(9), 791–797 (2012).
  • Ghanem A, Müller A, Sinning JM et al. Prognostic value of cerebral injury following transfemoral aortic valve implantation. EuroIntervention pii: 20120710-05 (2012) (Epub ahead of print).
  • Kidwell CS. MRI biomarkers in acute ischemic stroke: a conceptual framework and historical analysis. Stroke 44(2), 570–578 (2013).
  • Fairbairn TA, Mather AN, Bijsterveld P et al. Diffusion-weighted MRI determined cerebral embolic infarction following transcatheter aortic valve implantation: assessment of predictive risk factors and the relationship to subsequent health status. Heart 98(1), 18–23 (2012).
  • Ghanem A, Müller A, Nähle CP et al. Risk and fate of cerebral embolism after transfemoral aortic valve implantation: a prospective pilot study with diffusion-weighted magnetic resonance imaging. J. Am. Coll. Cardiol. 55(14), 1427–1432 (2010).
  • Kahlert P, Knipp SC, Schlamann M et al. Silent and apparent cerebral ischemia after percutaneous transfemoral aortic valve implantation: a diffusion-weighted magnetic resonance imaging study. Circulation 121(7), 870–878 (2010).
  • Restrepo L, Wityk RJ, Grega MA et al. Diffusion- and perfusion-weighted magnetic resonance imaging of the brain before and after coronary artery bypass grafting surgery. Stroke 33(12), 2909–2915 (2002).
  • Stolz E, Gerriets T, Kluge A, Klövekorn WP, Kaps M, Bachmann G. Diffusion-weighted magnetic resonance imaging and neurobiochemical markers after aortic valve replacement: implications for future neuroprotective trials? Stroke 35(4), 888–892 (2004).
  • Floyd TF, Shah PN, Price CC et al. Clinically silent cerebral ischemic events after cardiac surgery: their incidence, regional vascular occurrence, and procedural dependence. Ann. Thorac. Surg. 81(6), 2160–2166 (2006).
  • Knipp SC, Matatko N, Schlamann M et al. Small ischemic brain lesions after cardiac valve replacement detected by diffusion-weighted magnetic resonance imaging: relation to neurocognitive function. Eur. J. Cardiothorac. Surg. 28(1), 88–96 (2005).
  • Büsing KA, Schulte-Sasse C, Flüchter S et al. Cerebral infarction: incidence and risk factors after diagnostic and interventional cardiac catheterization – prospective evaluation at diffusion-weighted MR imaging. Radiology 235(1), 177–183 (2005).
  • Bonati LH, Jongen LM, Haller S et al.; ICSS-MRI study group. New ischaemic brain lesions on MRI after stenting or endarterectomy for symptomatic carotid stenosis: a substudy of the International Carotid Stenting Study (ICSS). Lancet Neurol. 9(4), 353–362 (2010).
  • Hebb MO, Heiserman JE, Forbes KP, Zabramski JM, Spetzler RF. Perioperative ischemic complications of the brain after carotid endarterectomy. Neurosurgery 67(2), 286–293; discussion 293 (2010).
  • Schnaudigel S, Gröschel K, Pilgram SM, Kastrup A. New brain lesions after carotid stenting versus carotid endarterectomy: a systematic review of the literature. Stroke 39(6), 1911–1919 (2008).
  • Kobayashi M, Ogasawara K, Yoshida K et al. Intentional hypertension during dissection of carotid arteries in endarterectomy prevents postoperative development of new cerebral ischemic lesions caused by intraoperative microemboli. Neurosurgery 69(2), 301–307 (2011).
  • Skjelland M, Krohg-Sørensen K, Tennøe B, Bakke SJ, Brucher R, Russell D. Cerebral microemboli and brain injury during carotid artery endarterectomy and stenting. Stroke 40(1), 230–234 (2009).
  • Posacioglu H, Engin C, Cinar C et al. Carotid endarterectomy versus carotid artery stenting: findings in regard to neuroclinical outcomes and diffusion-weighted imaging. Tex. Heart Inst. J. 35(4), 395–401 (2008).
  • Huang KL, Ho MY, Chang CH et al. Impact of silent ischemic lesions on cognition following carotid artery stenting. Eur. Neurol. 66(6), 351–358 (2011).
  • Russjan A, Goebell E, Havemeister S et al. Predictors of periprocedural brain lesions associated with carotid stenting. Cerebrovasc. Dis. 33(1), 30–36 (2012).
  • Wu YM, Wong HF, Chen YL, Wong MC, Toh CH. Carotid stenting of asymptomatic and symptomatic carotid artery stenoses with and without the use of a distal embolic protection device. Acta Cardiol. 66(4), 453–458 (2011).
  • Wolf O, Heider P, Heinz M et al. Microembolic signals detected by transcranial Doppler sonography during carotid endarterectomy and correlation with serial diffusion-weighted imaging. Stroke 35(11), e373–e375 (2004).
  • Ogasawara K, Suga Y, Sasaki M et al. Intraoperative microemboli and low middle cerebral artery blood flow velocity are additive in predicting development of cerebral ischemic events after carotid endarterectomy. Stroke 39(11), 3088–3091 (2008).
  • Jeong HS, Song HJ, Lee JH, Choi SW, Kim J. Interpretation of TCD spectral patterns detected during carotid artery stent interventions. J. Endovasc. Ther. 18(4), 518–526 (2011).
  • Mayor I, Comelli M, Vassileva E, Burkhard P, Sztajzel R. Microembolic signals and carotid plaque morphology: a study of 71 patients with moderate or high grade carotid stenosis. Acta Neurol. Scand. 108(2), 114–117 (2003).
  • Madani A, Beletsky V, Tamayo A, Munoz C, Spence JD. High-risk asymptomatic carotid stenosis: ulceration on 3D ultrasound vs TCD microemboli. Neurology 77(8), 744–750 (2011).
  • Spence JD, Coates V, Li H et al. Effects of intensive medical therapy on microemboli and cardiovascular risk in asymptomatic carotid stenosis. Arch. Neurol. 67(2), 180–186 (2010).
  • Spence JD. Cerebrovascular disease: identifying high-risk patients from carotid plaque composition. Nat. Rev. Cardiol. 7(8), 426–428 (2010).
  • Marquardt L, Geraghty OC, Mehta Z, Rothwell PM. Low risk of ipsilateral stroke in patients with asymptomatic carotid stenosis on best medical treatment: a prospective, population-based study. Stroke 41(1), e11–e17 (2010).
  • Aichner FT, Topakian R, Alberts MJ et al.; REACH Registry Investigators. High cardiovascular event rates in patients with asymptomatic carotid stenosis: the REACH Registry. Eur. J. Neurol. 16(8), 902–908 (2009).
  • Mathiesen EB, Bønaa KH, Joakimsen O. Echolucent plaques are associated with high risk of ischemic cerebrovascular events in carotid stenosis: the Tromsø study. Circulation 103(17), 2171–2175 (2001).
  • Biasi GM, Froio A, Diethrich EB et al. Carotid plaque echolucency increases the risk of stroke in carotid stenting: the Imaging in Carotid Angioplasty and Risk of Stroke (ICAROS) study. Circulation 110(6), 756–762 (2004).
  • Gahremanpour A, Perin EC, Silva G. Carotid artery stenting versus endarterectomy: a systematic review. Tex. Heart Inst. J. 39(4), 474–487 (2012).
  • Stabile E, Salemme L, Sorropago G et al. Proximal endovascular occlusion for carotid artery stenting: results from a prospective registry of 1300 patients. J. Am. Coll. Cardiol. 55(16), 1661–1667 (2010).
  • Garami ZF, Bismuth J, Charlton-Ouw KM, Davies MG, Peden EK, Lumsden AB. Feasibility of simultaneous pre- and postfilter transcranial Doppler monitoring during carotid artery stenting. J. Vasc. Surg. 49(2), 340–344, 345.e1 (2009).
  • Montorsi P, Caputi L, Galli S et al. Microembolization during carotid artery stenting in patients with high-risk, lipid-rich plaque. A randomized trial of proximal versus distal cerebral protection. J. Am. Coll. Cardiol. 58(16), 1656–1663 (2011).
  • Payne DA, Jones CI, Hayes PD et al. Beneficial effects of clopidogrel combined with aspirin in reducing cerebral emboli in patients undergoing carotid endarterectomy. Circulation 109(12), 1476–1481 (2004).
  • Vogten JM, Gerritsen WB, Ackerstaff RG, van Dongen EP, de Vries JP. Perioperative microemboli and platelet aggregation in patients undergoing carotid endarterectomy. Vascular 16(3), 154–160 (2008).
  • Sharpe RY, Dennis MJ, Nasim A et al. Dual antiplatelet therapy prior to carotid endarterectomy reduces post-operative embolisation and thromboembolic events: post-operative transcranial Doppler monitoring is now unnecessary. Eur. J. Vasc. Endovasc. Surg. 40(2), 162–167 (2010).
  • Tsivgoulis G, Kerasnoudis A, Krogias C et al. Clopidogrel load for emboli reduction in patients with symptomatic carotid stenosis undergoing urgent carotid endarterectomy. Stroke 43(7), 1957–1960 (2012).
  • Markus HS, McCollum C, Imray C, Goulder MA, Gilbert J, King A. The von Willebrand inhibitor ARC1779 reduces cerebral embolization after carotid endarterectomy: a randomized trial. Stroke 42(8), 2149–2153 (2011).
  • White CJ. Proximal embolic protection: a ‘game changer’ for carotid stents. J. Am. Coll. Cardiol. 55(16), 1668–1670 (2010).
  • Macdonald S, Halliday A. The Asymptomatic Carotid Surgery Trial 2. Endovascular Today 71–74 (2012).
  • Ederle J, Bonati LH, Dobson J et al. CAVATAS Investigators. Endovascular treatement with angioplasty or stenting vs endarterectomy in patients with carotid artery stenosis in the Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS): long-term follow-up of a randomized trial. Lancet Neurol. 8, 898–907 (2009).
  • Brooks WH, McClure RR, Jones MR et al. Carotid angioplasty and stenting vs carotid endarterectomy: randomized trial in a community hospital. J. Am. Coll. Cardiol. 38, 1589–2324 (2001).
  • Brooks WH, McClure RR, Jones MR et al. Carotid angioplasty and stenting vs carotid endarterectomy for treatment of asymptomatic carotid stenosis: a randomized trial in a community hospital. Neurosurgery 54, 318–324 (2004).
  • Hoffmann A, Engelter S, Taschner C et al. Carotid artery stenting vs carotid endarterectomy: a prospective randomised controlled single-centre trial with long-term follow-up (BACASS). Schweiz Arch. Neurol. Psychiatr. 159, 84–89 (2008).
  • Eckstein HH, Ringleb P, Allenberg JR et al. Results of the Stent-Protected Angioplasty vs Carotid Endarterectomy (SPACE) study to treat symptomatic stenoses at 2 years: a multinational, prospective, randomised trial. Lancet Neurol. 7, 893–902 (2008).
  • Steinbauer MG, Pfister K, Greindl M et al. Alert for increased long-term follow-up after carotid artery stenting: results of a prospective, randomized, single center trial of carotid artery stenting vs carotid endarterectomy. J. Vasc. Surg. 28, 93–98 (1998).
  • Alberts MJ. Results of a multicenter prospective randomized trial of carotid artery stenting vs carotid endarterectomy. Stroke 32, 325d (2001).
  • Naylor AR, Bolia A, Abbott RJ et al. Randomized study of carotid angioplasty and stenting vs carotid endarterectomy: a stopped trial. J. Vasc. Surg. 28, 326–334 (1998).
  • Ling F, Jiao LQ. Preliminary report of Trial of Endarterectomy vs Stenting for the Treatment of Carotid Atherosclerotic Stenosis in China (TESCAS-C). Chin. J. Cerebrovasc. Dis. 3, 4–8 (2006).
  • Landesberg G, Shatz A, Akopnik I et al. Association of cardiac troponin, CK-MB, and postoperative survival after major vascular surgery. J. Am. Coll. Cardiol. 42, 1547–1554 (2003).
  • Oscarsson A, Eintrei C, Anskar S et al. Troponin T-values provide long-term prognosis in elderly patients undergoing non-cardiac surgery. Acta Anaesth. Scand. 48, 1071–1079 (2004).
  • Kim LJ, Martinez EA, Faraday N et al. Cardiac troponin I predicts short-term mortality in vascular surgery patients. Circ. 106, 2366–2371 (2002).
  • Godet G, Dumerat M, Baillard C et al. Cardiac troponin I is reliable with immediate but not medium-term cardiac complications after abdominalaortic repair. Acta Anaesthesiol. Scand. 44, 572–577 (2000).
  • Higham H, Sear JW, Sear YM et al. Peri-operative troponin I concentration as a marker of long-term postoperative adverse cardiac outcomes: a study in high-risk surgical patients. Anaesthesia 59, 318–323 (2004).
  • Kertai MD, Boersma E, Klein J et al. Long-term prognostic value of asymptomatic cardiac troponin T elevations in patients aftr major vascular surgery. Eur. J. Vasc. Endovasc. Surg. 28, 59–66 (2004).
  • Bursi F, Babuin L, Barbieri A et al. Vascular surgery patients: perioperative and long-term risk according to the ACC/AHA guidelines, the additive roles of post-operative troponin elevation. Eur. Heart J. 26, 2448–2456 (2005).
  • Blecha MJ, Clark ET, Worley TA et al. Predictors of electrocardiographic change, cardiac troponin elevation, and survival after major vascular surgery: a community hospital experience. Am. Surg. 73, 697–702 (2007).
  • Ausset S, Auroy Y, Lambert E et al. Cardiac tropnoin I release after hip surgery correlates with poor long-term cardiac outcome. Eur. J. Anaesthesiol. 25, 158–164 (2008).
  • McFalls EO, Ward HB, Mortiz TE et al. Predictors and outcomes of a perioperative myocardial infarction following elective vascular surgery in patients with a documented coronary artery disease: results of the CARP trial. Eur. Heart J. 29, 394–401 (2008).
  • Bollinger D, Seeberger MD, Lurati Buse GA et al. A preliminary report on the prognostic significance of preoperative brain natriuretic peptide and postoperative cardiac troponin in patients undergoing major vascular surgery. Anesth. Analg. 108, 1069–1075 (2009).
  • Filipovic M, Jeger R, Probst C et al. Heart rate variability and cardiac troponin I are incremental and independent predictors of one-year all-cause mortality after major noncardiac surgery in patients at rist of coronary artery disease. J. Am. Coll. Cardiol. 42, 1767–1776 (2003).
  • Chong CP, Lam QT, Ryan JE, Sinnappu RN, Lim WK,. Incidence of post-operative troponin I rises and 1-year mortality after emergency orthopaedic surgery in older patients. Age Ageing 38, 168–174 (209).
  • Oscarsson A, Fredrikson M, Sorliden M et al. Predictors of cardiac events in high-risk patients undergoing emergency surgery. Acta Anaesthesiol. Scand. 53, 386–394 (2009).

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