Current management of bloodstream infections

References

• Reimer LG, Wilson ML, Weinstein MP. Update on detection of bacteremia and fungemia. Clin. Microbiol. Rev.10(3), 444–465 (1997).
   PubMed Web of Science ®Google Scholar
• Weinstein MP, Towns ML, Quartey SM et al. The clinical significance of positive blood cultures in the 1990s: a prospective comprehensive evaluation of the microbiology, epidemiology, and outcome of bacteremia and fungemia in adults. Clin. Infect. Dis.24(4), 584–602 (1997).
   PubMed Web of Science ®Google Scholar
• Cornish CJ, Maki DG. Infections of vascular devices. In: Infectious Diseases 2nd Edition. Cohen J, Powderly WG (Eds). Mosby-Elsevier, London, UK, 629–639 (2004).
   Google Scholar
• Renaud B, Brun-Buisson C, ICU-Bacteremia Study Group. Outcomes of primary and catheter-related bacteremia. A cohort and case-control study in critically ill patients. Am. J. Respir. Crit. Care Med.63(7), 1584–1590 (2001).
   Google Scholar
• Siegman-Igra Y, Fourer B, Orni-Wasserlauf R et al. Reappraisal of community-acquired bacteremia: a proposal of a new classification for the spectrum of acquisition of bacteremia. Clin. Infect. Dis.34(11), 1431–1439 (2002).
   PubMed Web of Science ®Google Scholar
• Thomson RB Jr. Specimen collection, transport, and processing: bacteriology. In: Manual of Clinical Microbiology (9th Edition). Murray PR, Baron EJ, Jorgensen JH, Landry ML, Pfaller MA (Eds). American Society for Microbiology, DC, USA, 291–333 (2007).
   Google Scholar
• López Dupla M, Martínez JA, Vidal F et al. Clinical characterization of breakthrough bacteraemia: a survey of 392 episodes. J. Intern. Med.258(2), 172–180 (2005).
   PubMedGoogle Scholar
• Munford RS, Suffredini AF. Sepsis, severe sepsis, and septic shock. In: Principles and Practice of Infectious Diseases (7th Edition). Mandell GL, Bennett JE, Dolin R (Eds). Churchill Livingstone, PA, USA, 987–1010 (2010).
   Google Scholar
• Hall KK, Lyman JA. Updated review of blood culture contamination. Clin. Microbiol. Rev.19(4), 788–802 (2006).
   PubMed Web of Science ®Google Scholar
• Weinstein MP. Blood culture contamination: persisting problems and partial progress. J. Clin. Microbiol.41(6), 2275–2278 (2003).
   PubMedGoogle Scholar
• Martin GS, Mannino DM, Eaton S, Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N. Engl. J. Med.348(16), 1546–1554 (2003).
   PubMed Web of Science ®Google Scholar
• Reacher M, Livermore D, Wale MC et al. Bacteraemia and antibiotic resistance of its pathogens reported in England and Wales between 1990 and 1998: trend analysis. Br. Med. J.320(7299), 213–216 (2000).
   PubMed Web of Science ®Google Scholar
• Rodríguez-Créixems M, Alcalá L, Muñoz P et al. Bloodstream infections: evolution and trends in the microbiology workload, incidence, and etiology, 1985–2006. Medicine (Baltimore)87(4), 234–249 (2008).
   PubMed Web of Science ®Google Scholar
• Uslan DZ, Crane SJ, Steckelberg JM et al. Age- and sex-associated trends in bloodstream infection: a population-based study in Olmsted County, Minnesota. Arch. Intern. Med.167(8), 834–839 (2007).
   PubMedGoogle Scholar
• Rodriguez-Baño J, López-Prieto M, Portillo M et al. Epidemiology and clinical features of community-acquired, healthcare associated and nosocomial bloodstream infections in tertiary and community hospitals. Clin. Microbiol. Infect. DOI: 10.1111/j.1469–0691.2009.03089.x (2010) (Epub ahead of print).
   Google Scholar
• Laupland KB, Gregson DB, Flemons WW, Hawkins D, Ross T, Church DL. Burden of community-onset bloodstream infection: a population-based assessment. Epidemiol. Infect.135(6), 1037–1042 (2007).
   PubMed Web of Science ®Google Scholar
• Horan TC, Andrus M, Dudeck MA. CDC/NHSN surveillance definition of health care–associated infection and criteria for specific types of infections in the acute care setting. Am. J. Infect. Control36(5), 309–332 (2008).
   PubMed Web of Science ®Google Scholar
• Friedman D, Kaye K, Stout J et al. Health care-associated bloodstream infections in adults: a reason to change the accepted definition of community-acquired infections. Ann. Intern. Med.137(10), 791–797 (2002).
   PubMed Web of Science ®Google Scholar
• Shorr AF, Tabak YP, Killiam AD, Gupta V, Liu LZ, Kollef MH. Healthcare-associated bloodstream infection: a distinct entity? Insights from a large U.S. database. Crit. Care Med.34(10), 1588–1595 (2006).
   Google Scholar
• Valles J, Calbo E, Anoro A et al. Bloodstream infections in adults: importance of healthcare-associated infections. J. Infect.56(1), 27–34 (2008).
   PubMedGoogle Scholar
• Rodríguez-Baño J, Navarro MD, Romero L et al. Bacteremia due to extended-spectrum β-lactamase-producing Escherichia coli in the CTX-M era: a new clinical challenge. Clin. Infect. Dis.43(11), 1407–1414 (2006).
   PubMed Web of Science ®Google Scholar
• Crane SJ, Uslan DZ, Baddour L. Bloodstream infections in a geriatric cohort: a population-based study. Am. J. Med.120(12), 1078–1083 (2007).
   PubMedGoogle Scholar
• Raymond NJ, Blackmore TK, Humble MW et al. Bloodstream infections in a secondary and tertiary care hospital setting. Intern. Med. J.36(12), 765–772 (2006).
   PubMedGoogle Scholar
• McDonald JR, Friedman ND, Stout JE, Sexton D, Kaye KS. Risk factors for ineffective therapy in patients with bloodstream infection. Arch. Intern. Med.165(3), 308–315 (2005).
   PubMedGoogle Scholar
• Mylotte JM. Nursing home-acquired bacteremia. Infect. Control Hosp. Epidemiol.26(10), 833–837 (2005).
   PubMedGoogle Scholar
• Rodríguez-Baño J, Picón E, Gijón P et al. Community-onset bacteremia due to extended-spectrum β-lactamase-producing Escherichia coli: risk factors and prognosis. Clin. Infect. Dis.50(1), 40–48 (2010).
   PubMed Web of Science ®Google Scholar
• Albrech SJ, Fishman NO, Kitchen J et al. Reemergence of Gram-negative health care-associated bloodstream infections. Arch. Intern. Med.166(166), 1289–1294 (2006).
   PubMedGoogle Scholar
• Cisneros Herreros JM, Cobo-Reinoso J, Pujol-Rojo M, Rodriguez-Baño J, Salavert-Lletí M. Guidelines for the diagnosis and treatment of patients with bacteremia. Guidelines of the Sociedad Española de Enfermedades Infecciosas y Microbiología clínica (SEIMC). Enferm. Infecc. Microbiol. Clin.25(2), 111–130 (2007).
   PubMedGoogle Scholar
• Seifert H. The clinical importance of microbiological findings in the diagnosis and management of bloodstream infections. Clin. Infect. Dis.48(Suppl. 4), S238–S245 (2009).
   PubMedGoogle Scholar
• Laupland KB, Zygun DA, Doig CJ, Bagshaw SM, Svenson LW, Fick GH. One-year mortality of bloodstream infection-associated sepsis and septic shock among patients presenting to a regional critical care system. Intensive Care Med.31(2), 213–219 (2005).
   PubMed Web of Science ®Google Scholar
• MacArthur RC, Miller M, Albertson T et al. Adequacy of early empiric antibiotic treatment and survival in severe sepsis: experience from the MONARCS trial. Clin. Infect. Dis.38(2), 244–248 (2004).
   Google Scholar
• Kumar A, Roberts D, Wood KE et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit. Care Med.34(6), 1589–1596 (2006).
   PubMed Web of Science ®Google Scholar
• Garnacho-Montero J, Ortiz-Leyba C, Herrera-Melero I et al. Mortality and morbidity attributable to inadequate empirical antimicrobial therapy in patients admitted to the ICU with sepsis: a matched cohort study. J. Antimicrob. Chemother.61(2), 436–441 (2008).
   PubMed Web of Science ®Google Scholar
• McGregor JC, Rich SE, Harris AD et al. A systematic review of the methods used to assess the association between appropriate antibiotic therapy and mortality in bacteremic patients. Clin. Infect. Dis.45(3), 329–337 (2007).
   PubMed Web of Science ®Google Scholar
• Jaimes F, Arango C, Ruiz G et al. Predicting bacteremia at the bedside. Clin. Infect. Dis.38(3), 357–362 (2004).
   PubMed Web of Science ®Google Scholar
• Lizarralde E, Gutiérrez A, Martínez P, Franco R, García N, Miguel F. Bacteriemia adquirida en la comunidad: elaboración de un modelo de predicción clínica en pacientes ingresados en un servicio de medicina interna. Med. Clin. (Barc.)123(7), 241–246 (2004).
   PubMedGoogle Scholar
• Metersky ML, Ma A, Bratzler DW, Houck PM. Predicting bacteremia in patients with community-acquired pneumonia. Am. J. Respir. Crit. Care Med.169(3), 342–347 (2004).
   PubMed Web of Science ®Google Scholar
• Tokuda Y, Miyasato H, Stein GH. Simple prediction algorithm for bacteraemia in patients with acute febrile illness. Q. J. Med.98(11), 813–820 (2005).
   Google Scholar
• Nakamura T, Takahashi O, Matsui K et al. Clinical prediction rules for bacteremia and in-hospital death based on clinical data at the time of blood withdrawal for culture: an evaluation of their development and use. J. Eval. Clin. Pract.12(6), 692–703 (2006).
   PubMedGoogle Scholar
• Peters RPH, Twisk JWR, van Agtmael MA, Groeneveld ABJ. The role of procalcitonin in a decision tree for prediction of bloodstream infection in febrile patients. Clin. Microbiol. Infect.12(12), 1207–1213 (2006).
   PubMed Web of Science ®Google Scholar
• Shapiro NI, Wolfe RE, Wright SB, Moore R, Bates DW. Who needs a blood culture? A prospectively derived and validated prediction rule. J. Emerg. Med.35(3), 255–264 (2008).
   PubMed Web of Science ®Google Scholar
• Falguera M, Trujillano J, Caro S et al. A prediction rule for estimating the risk of bacteremia in patients with community-acquired pneumonia. Clin. Infect. Dis.49(3), 409–416 (2009).
   PubMed Web of Science ®Google Scholar
• Paul M, Andreassen S, Nielsen AD et al. Prediction of bacteremia using TREAT, a computerized decision-support system. Clin. Infect. Dis.42(9), 1274–1282 (2006).
   PubMed Web of Science ®Google Scholar
• O’Grady NP, Barie PS, Bartlett JG et al. Practice guidelines for evaluating new fever in critically ill adult patients. Clin. Infect. Dis.26(5), 1042–1059 (1998).
   PubMed Web of Science ®Google Scholar
• Hughes WT, Armstrong D, Bodey GP et al. 2002 guidelines for the use of antimicrobial agents in neutropenic patients with cancer. Clin. Infect. Dis.34(6), 730–751 (2002).
   PubMed Web of Science ®Google Scholar
• Levy MM, Fink MP, Marshall JC et al. 2001 SCCM /ESICM/ACCP/ATS/SIS International Sepsis Definition Conference. Crit. Care Med.31(4), 1250–1256 (2003).
   PubMed Web of Science ®Google Scholar
• Dellinger RP, Carlet JM, Masur H et al. Surviving sepsis campaign guidelines for management of severe sepsis and septic shock. Crit. Care Med.32(3), 858–873 (2004).
   PubMed Web of Science ®Google Scholar
• Mermel LA, Farr B, Sherertz RJ et al. Guidelines for the management of intravascular catheter-related infections. Clin. Infect. Dis.32(9), 1249–1272 (2001).
   PubMed Web of Science ®Google Scholar
• Pachón J, Alcántara JD, Cordero E, Lama C, Rivero A. Clinical management of community-acquired pneumonia. Enferm. Infecc. Microbiol. Clin.21(7), 350–357 (2003).
   PubMedGoogle Scholar
• Velasco M, Martínez JA, Moreno-Martínez A et al. Blood cultures for women with uncomplicated acute pyelonephritis: are they necessary? Clin. Infect. Dis.37(8), 1127–1130 (2003).
   PubMed Web of Science ®Google Scholar
• Bentley DW, Bradley S, High K, Schoenbaum S, Taler G, Yoshikawa TT. Practice guidelines for the evaluation of fever and infection in long-term care facilities. Clin. Infect. Dis.31(3), 640–653 (2000).
   PubMedGoogle Scholar
• Mandell LA, Wunderink RG, Anzueto A et al. Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin. Infect. Dis.44(Suppl. 2), S27–S72 (2007).
   PubMed Web of Science ®Google Scholar
• Søgaard M, Nørgaard M, Schønheyder HC. First notification of positive blood cultures and the high accuracy of the Gram stain report. J. Clin. Microbiol.45(4), 1113–1117 (2007).
   PubMed Web of Science ®Google Scholar
• Uehara Y, Yagoshi M, Tanimichi Y et al. Impact of reporting Gram stain results from blood culture bottles on the selection of antimicrobial agents. Am. J. Clin. Pathol.132(1), 18–25 (2009).
   PubMedGoogle Scholar
• Bouza E, Sousa D, Muñoz P et al. Bloodstream infections: a trial of the impact of different methods of reporting positive blood culture results. Clin. Infect. Dis.39(8), 1161–1169 (2004).
   PubMed Web of Science ®Google Scholar
• Rintala E, Kairisto V, Eerola E et al. Antimicrobial therapy of septicemic patients in intensive care units before and after blood culture reporting. Scand. J. Infect. Dis.23(3), 341–346 (1991).
   PubMed Web of Science ®Google Scholar
• Mylotte JM, Tayara A. Blood cultures: clinical aspect and controversies. Eur. J. Clin. Microbiol. Infect. Dis.19(3), 157–163 (2000).
   PubMed Web of Science ®Google Scholar
• Seo SK, Venkataraman L, DeGirolami PC, Samore MH. Molecular typing of coagulase-negative staphylococci from blood cultures does not correlate with clinical criteria for true bacteremia. Am. J. Med.109(9), 697–704 (2000).
   PubMed Web of Science ®Google Scholar
• Peters RP, van Agtmael MA, Danner SA et al. New developments in the diagnosis of bloodstream infections. Lancet Infect. Dis.4(12), 7517–7560 (2004).
   Google Scholar
• Fenollar F, Raoult D. Molecular diagnosis of bloodstream infections caused by non-cultivable bacteria. Int. J. Antimicrob. Agents30(Suppl. 1), S7–S15 (2007).
   PubMed Web of Science ®Google Scholar
• Louie RF, Tang Z, Albertson TE, Cohen S, Tran NK, Kost GJ. Multiplex polymerase chain reaction detection enhancement of bacteremia and fungemia. Crit. Care Med.36(5), 1487–1492 (2008).
   PubMed Web of Science ®Google Scholar
• Sakka SG, Kochem AJ, Disqué C, Wellinghausen N. Blood infection diagnosis by 16S rDNA broad-spectrum polymerase chain reaction: the relationship between antibiotic treatment and bacterial DNA load. Anesth. Analg.109(5), 1707–1708 (2009).
   PubMedGoogle Scholar
• Westh H, Lisby G, Breysse F et al. Multiplex real-time PCR and blood culture for identification of bloodstream pathogens in patients with suspected sepsis. Clin. Microbiol. Infect.15(6), 544–551 (2009).
   PubMed Web of Science ®Google Scholar
• Varani S, Stanzani M, Paolucci M et al. Diagnosis of bloodstream infections in immunocompromised patients by real-time PCR. J. Infect.58(5), 346–351 (2009).
   PubMed Web of Science ®Google Scholar
• Lehmann LE, Alvarez J, Hunfeld KP et al. Potential clinical utility of polymerase chain reaction in microbiological testing for sepsis. Crit. Care Med.37(12), 3085–3090 (2009).
   PubMed Web of Science ®Google Scholar
• Tsalik EL, Jones D, Nicholson B et al. Multiplex PCR to diagnose bloodstream infections in patients admitted from the emergency department with sepsis. J. Clin. Microbiol.48(1), 26–33 (2010).
   PubMed Web of Science ®Google Scholar
• Klouche M, Schröder U. Rapid methods for diagnosis of bloodstream infections. Clin. Chem. Lab. Med.46(7), 888–908 (2008).
   PubMed Web of Science ®Google Scholar
• Nikkari S, McLaughlin IJ, Bi W et al. Does blood of healthy subjects contain bacterial ribosomal DNA? J. Clin. Microbiol.39(5), 1956–1959 (2001).
   PubMed Web of Science ®Google Scholar
• Tissari P, Zumla A, Tarkka E et al. Accurate and rapid identification of bacterial species from positive blood cultures with a DNA-based microarray platform: an observational study. Lancet375(9710), 224–230 (2010).
   PubMed Web of Science ®Google Scholar
• Martínez JA, Pozo L, Almela M et al. Microbial and clinical determinants of time-to-positivity in patients with bacteraemia. Clin. Microbiol. Infect.13(7), 709–716 (2007).
   PubMed Web of Science ®Google Scholar
• Minton J, Clayton J, Sandoe J, McGann H, Wilcox M. Improving early management of bloodstream infections: a quality improvement project. Br. Med. J.336(7641), 440–443 (2008).
   PubMedGoogle Scholar
• Rivers E, Nguyen B, Havstad S et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N. Engl. J. Med.345(19), 1368–1377 (2001).
   PubMed Web of Science ®Google Scholar
• Rodríguez-Baño J. Selection of empiric therapy in patients with catheter-related infections. Clin. Microbiol. Infect.8(5), 275–282 (2002).
   PubMedGoogle Scholar
• Mermel LA, Allon M, Bouza E et al. Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 update by the Infectious Diseases Society of America. Clin. Infect. Dis.49(1), 1–45 (2009).
   PubMed Web of Science ®Google Scholar
• Safdar N, Fine JP, Maki DG. Meta-analysis: methods for diagnosing intravascular device–related bloodstream infection. Ann. Intern. Med.142(6), 451–466 (2005).
   PubMed Web of Science ®Google Scholar
• Wisplinghoff H, Bischoff T, Tallent SM, Seifert H, Wenzel RP, Edmond MB. Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study. Clin. Infect. Dis.39(3), 309–317 (2004).
   PubMed Web of Science ®Google Scholar
• Tenke P, Kovacs B, Johansen TEB, Matsumoto T, Tambyahd PA, Naber KG. European and Asian guidelines on management and prevention of catheter-associated urinary tract infections. Int. J. Antimicrob. Agents31(Suppl. 1), S68–S78 (2008).
   PubMed Web of Science ®Google Scholar
• Corey GR. Staphylococcus aureus bloodstream infections: definitions and treatment. Clin. Infect. Dis.48(Suppl. 4), S254–S259 (2009).
   PubMed Web of Science ®Google Scholar
• Naber CK, Baddour LM, Giamarellos-Bourboulis EJ et al. Clinical consensus conference: survey on Gram positive bloodstream infections with a focus in Staphylococcus aureus. Clin. Infect. Dis.48(Suppl. 4), S260–S270 (2009).
   PubMed Web of Science ®Google Scholar
• Fowler VG Jr, Olsen MK, Corey GR et al. Clinical identifiers of complicated Staphylococcus aureus bacteremia. Arch. Intern. Med.163(17), 2066–2072 (2003).
   PubMed Web of Science ®Google Scholar
• Fowler VG Jr, Justice A, Moore C et al. Risk factors for hematogenous complications of intravascular catheter-associated Staphylococcus aureus bacteremia. Clin. Infect. Dis.40(5), 695–703 (2005).
   PubMed Web of Science ®Google Scholar
• Rosen AB, Fowler VG Jr, Corey GR et al. Cost–effectiveness of transesophageal echocardiography to determine the duration of therapy for intravascular catheter-associated Staphylococcus aureus bacteremia. Ann. Intern. Med.130(10), 810–820 (1999).
   PubMedGoogle Scholar
• Abraham J, Mansour C, Veledar E, Khan B, Lerakis S. Staphylococcus aureus bacteremia and endocarditis: the Grady Memorial Hospital experience with methicillin-sensitive S. aureus and methicillin-resistant S. aureus bacteremia. Am. Heart. J.147(3), 536–539 (2004).
   PubMedGoogle Scholar
• Pigrau C, Rodríguez D, Planes AM et al. Management of catheter-related Staphylococcus aureus bacteremia: when may sonographic study be unnecessary? Eur. J. Clin. Microbiol. Infect. Dis.22(12), 713–719 (2003).
   PubMed Web of Science ®Google Scholar
• Van Hal SJ, Mathur G, Kelly J, Aronis C, Cranney GB, Jones PD. The role of transthoracic echocardiography in excluding left sided infective endocarditis in Staphylococcus aureus bacteraemia. J. Hosp. Infect.51(3), 218–221 (2005).
   Google Scholar
• Jenkins TC, Price CS, Sabel AL, Mehler PS, Burman WJ. Impact of routine infectious diseases service consultation on the evaluation, management, and outcomes of Staphylococcus aureus bacteremia. Clin. Infect. Dis.46(7), 1000–1008 (2008).
   PubMed Web of Science ®Google Scholar
• Lahey T, Shah R, Gittzus J, Schwartzman J, Kirkland K. Infectious Diseases consultation lowers mortality from Staphylococcus aureus bacteremia. Medicine (Baltimore)88(5), 263–267 (2009).
   PubMed Web of Science ®Google Scholar
• Rieg S, Peyerl-Hoffmann G, de With K et al. Mortality of S. aureus bacteremia and infectious diseases specialist consultation: a study of 521 patients in Germany. J. Infect.59(4), 232–239 (2009).
   PubMed Web of Science ®Google Scholar
• Stryjewski ME, Szczech LA, Benjamin DK Jr et al. Use of vancomycin or first-generation cephalosporins for the treatment of hemodialysis-dependent patients with methicillin-susceptible Staphylococcus aureus bacteremia. Clin. Infect. Dis.44(2), 190–196 (2007).
   PubMed Web of Science ®Google Scholar
• Fowler VG Jr, Boucher HW, Corey GR et al. Daptomycin versus standard therapy for bacteremia and endocarditis caused by Staphylococcus aureus. N. Engl. J. Med.355(7), 653–665 (2006).
   PubMed Web of Science ®Google Scholar
• Cosgrove SE, Fowler VG Jr. Management of methicillin-resistant Staphylococcus aureus bacteremia. Clin. Infect. Dis.46(Suppl. 5), S386–S393 (2008).
   PubMed Web of Science ®Google Scholar
• Shorr AF, Kunkel MJ, Kollef M. Linezolid versus vancomycin for Staphylococcus aureus bacteraemia: pooled analysis of randomized studies. J. Antimicrob. Chemother.56(5), 923–929 (2005).
   PubMed Web of Science ®Google Scholar
• Wunderink RG, Rello J, Cammarata SK, Croos-Dabrera RV, Kollef MH. Linezolid vs vancomycin: analysis of two double-blind studies of patients with methicillin-resistant Staphylococcus aureus nosocomial pneumonia. Chest124(5), 1789–1797 (2003).
   PubMed Web of Science ®Google Scholar
• Falagas ME, Siempos II, Vardakas KZ. Linezolid versus glycopeptide or β-lactam for treatment of Gram-positive bacterial infections: meta-analysis of randomised controlled trials. Lancet Infect. Dis.8(1), 53–66 (2008).
   PubMed Web of Science ®Google Scholar
• Beibei L, Yun C, Mengli C, Nan B, Xuhong Y, Rui W. Linezolid versus vancomycin for the treatment of Gram-positive bacterial infections: meta-analysis of randomised controlled trials. Int. J. Antimicrob. Agents.35(1), 3–12 (2010).
   PubMed Web of Science ®Google Scholar
• Gudiol F, Aguado JM, Pascual A et al. Consensus document for the treatment of bacteremia and endocarditis caused by methicillin-resistant Staphylococcus aureus. Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. Enferm. Infecc. Microbiol. Clin.27(2), 105–115 (2009).
   PubMed Web of Science ®Google Scholar
• Soriano A, Marco F, Martínez JA et al. Influence of vancomycin minimum inhibitory concentration on the treatment of methicillin-resistant Staphylococcus aureus bacteremia. Clin. Infect. Dis.46(2), 193–200 (2008).
   PubMed Web of Science ®Google Scholar
• Rybak MJ, Lomaestro BM, Rotschafer JC et al. Therapeutic monitoring of vancomycin in adults summary of consensus recommendations from the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, and the Society of Infectious Diseases Pharmacists. Pharmacotherapy29(11), 1275–1279 (2009).
   PubMed Web of Science ®Google Scholar
• Hidayat LK, Hsu DI, Quist R et al. High-dose vancomycin therapy for methicillin-resistant Staphylococcus aureus infections: efficacy and toxicity. Arch. Intern. Med.166(19), 2138–2144 (2006).
   PubMed Web of Science ®Google Scholar
• Corey GR, Stryjewski ME, Everts RJ. Short-course therapy for bloodstream infections in immunocompetent adults. Int. J. Antimicrob. Agents34(Suppl. 4), S47–S51 (2009).
   PubMedGoogle Scholar
• Heldman AW, Hartert TV, Ray SC et al. Oral antibiotic treatment of right-sided staphylococcal endocarditis in injection drug users: prospective randomized comparison with parenteral therapy. Am. J. Med.101(1), 68–76 (1996).
   PubMed Web of Science ®Google Scholar
• Cervera C, Almela M, Martínez-Martínez JA et al. Risk factors and management of Gram-positive bacteraemia. Int. J. Antimicrob. Agents34(Suppl. 4), S26–S30 (2009).
   PubMedGoogle Scholar
• Chu VH, Woods CW, Miro JM et al. Emergence of coagulase-negative staphylococci as a cause of native valve endocarditis. Clin. Infect. Dis.46(2), 232–242 (2008).
   PubMed Web of Science ®Google Scholar
• Haro JL, Lomas JM, Plata A et al. Left-sided native valve endocarditis by coagulase-negative staphylococci: an emerging disease. Enferm. Infecc. Microbiol. Clin.26(5), 263–268 (2008).
   PubMed Web of Science ®Google Scholar
• Zinkernagel AS, Zinkernagel MS, Elzi MV et al. Significance of Staphylococcus lugdunensis bacteremia: report of 28 cases and review of the literature. Infection36(4), 314–321 (2008).
   PubMed Web of Science ®Google Scholar
• Shaked H, Carmeli Y, Schwartz D, Siegman-Igra Y. Enterococcal bacteraemia: epidemiological, microbiological, clinical and prognostic characteristics, and the impact of high level gentamicin resistance. Scand. J. Infect. Dis.38(11–12), 995–1000 (2006).
   PubMed Web of Science ®Google Scholar
• Gavalda J, Len O, Miro JM et al. Brief communication: treatment of Enterococcus faecalis endocarditis with ampicillin plus ceftriaxone. Ann. Intern. Med.146(8), 574–579 (2007).
   PubMedGoogle Scholar
• Deshpande IM, Fritsche TM, Moet GJ et al. Antimicrobial resistance and molecular epidemiology of vancomycin-resistant enterococci from North America and Europe: a report from the SENTRY antimicrobial surveillance program. Diag. Microbiol. Infect. Dis.58(2), 163–170 (2007).
   PubMed Web of Science ®Google Scholar
• Mave V, Garcia-Diaz J, Islam T, Hasbun R. Vancomycin-resistant enterococcal bacteraemia: is daptomycin as effective as linezolid? J. Antimicrob. Chemother.64(1), 175–180 (2009).
   PubMed Web of Science ®Google Scholar
• Mohr JF, Friedrich LV, Yankelev S, Lamp KC. Daptomycin for the treatment of enterococcal bacteraemia: results from the Cubicin Outcomes Registry and Experience (CORE). Int. J. Antimicrob. Agents33(6), 543–548 (2009).
   PubMed Web of Science ®Google Scholar
• Erlandson KM, Sun J, Iwen PC, Rupp ME. Impact of the more-potent antibiotics quinupristin-dalfopristin and linezolid on outcome measure of patients with vancomycin-resistant Enterococcus bacteremia. Clin. Infect. Dis.46(1), 30–36 (2008).
   PubMed Web of Science ®Google Scholar
• Berjohn CM, Fishman NO, Joffe MM et al. Treatment and outcomes for patients with bacteremic pneumococcal pneumonia. Medicine (Baltimore)87(3), 160–166 (2008).
   PubMed Web of Science ®Google Scholar
• Musher DM, Alexandraki I, Graviss EA et al. Bacteremic and nonbacteremic pneumococcal pneumonia. A prospective study. Medicine (Baltimore)79(4), 210–221 (2000).
   PubMed Web of Science ®Google Scholar
• Kramer MR, Rudensky B, Hadas-Halperin I et al. Pneumococcal bacteremia – no change in mortality in 30 years: analysis of 104 cases and review of the literature. Isr. J. Med. Sci.23(3), 174–180 (1987).
   PubMedGoogle Scholar
• Bouza E, Pintado V, Rivera S et al. Nosocomial bloodstream infections caused by Streptococcus pneumoniae. Clin. Microbiol. Infect.11(11), 919–924 (2005).
   PubMedGoogle Scholar
• Baddour LM, Yu VL, Klugman KP et al. Combination antibiotic therapy lowers mortality among severely ill patients with pneumococcal bacteremia. Am. J. Resp. Crit. Care Med.170(4), 440–444 (2004).
   PubMed Web of Science ®Google Scholar
• de Cueto M, Rodríguez JM, Soriano MJ, López-Cerero L, Venero J, Pascual A. Fatal levofloxacin failure in treatment of a bacteremic patient infected with Streptococcus pneumoniae with a preexisting parC mutation. J. Clin. Microbiol.46(4), 1558–1560 (2008).
   PubMed Web of Science ®Google Scholar
• Homma T, Hori T, Sugimori G, Yamano Y. Pharmacodynamic assessment based on mutant prevention concentrations of fluoroquinolones to prevent the emergence of resistant mutants of Streptococcus pneumoniae. Antimicrob. Agents Chemother.51(11), 3810–3815 (2007).
   PubMed Web of Science ®Google Scholar
• Peralta G, Sánchez MB, Garrido JC et al. Impact of antibiotic resistance and of adequate empirical antibiotic treatment on the prognosis of patients with Escherichia coli bacteraemia. J. Antimicrob. Chemother.60(4), 855–863 (2007).
   PubMed Web of Science ®Google Scholar
• Ortega M, Marco F, Soriano A et al. Analysis of 4758 Escherichia coli bacteraemia episodes: predictive factors for isolation of an antibiotic-resistant strain and their impact on the outcome. J. Antimicrob. Chemother.63(3), 568–574 (2009).
   PubMed Web of Science ®Google Scholar
• Marcos M, Iñurrieta A, Soriano A et al. Effect of antimicrobial therapy on mortality in 377 episodes of Enterobacter spp. bacteraemia. J. Antimicrob. Chemother.62(2), 397–403 (2008).
   PubMed Web of Science ®Google Scholar
• Chow JW, Fine MJ, Shlaes DM et al.Enterobacter bacteremia: clinical features and emergence of antibiotic resistance during therapy. Ann. Intern. Med.115(8), 585–590 (1991).
   PubMed Web of Science ®Google Scholar
• Cosgrove SE, Kaye KS, Eliopoulous GM, Carmeli Y. Health and economic outcomes of the emergence of third generation cephalosporin resistance in Enterobacter species. Arch. Intern. Med.162(2), 185–190 (2002).
   PubMed Web of Science ®Google Scholar
• Livermore DM, Brown DF, Quinn JP, Carmeli Y, Paterson DL, Yu VL. Should third-generation cephalosporins be avoided against AmpC-inducible Enterobacteriaceae? Clin. Microbiol. Infect.10(1), 84–85 (2004).
   PubMed Web of Science ®Google Scholar
• European Center for Disease Prevention and Control. European Antimicrobial Resistance Surveillance System. EARSS Annual Report 2008. European Antimicrobial Resistance Surveillance System Management Team, Bilthoven, The Netherlands (2009).
   Google Scholar
• Rodríguez-Baño J, Pascual A. Clinical significance of extended-spectrum β-lactamases. Expert Rev. Anti Infect. Therapy6(5), 671–683 (2008).
   PubMed Web of Science ®Google Scholar
• Schwaber MJ, Carmeli Y. Mortality and delay in effective therapy associated with extended-spectrum β-lactamase production in Enterobacteriaceae bacteraemia: a systematic review and meta-analysis. J. Antimicrob. Chemother.60(5), 913–920 (2007).
   PubMed Web of Science ®Google Scholar
• Paterson DL, Ko WC, Von Gottberg A et al. International prospective study of Klebsiella pneumoniae bacteremia: implications of extended-spectrum β-lactamase production in nosocomial infections. Ann. Intern. Med.140(1), 26–32 (2004).
   PubMed Web of Science ®Google Scholar
• Kang CI, Kim SH, Kim DM et al. Risk factors for and clinical outcomes of bloodstream infections caused by extended-spectrum β-lactamase-producing Klebsiella pneumoniae. Infect. Control Hosp. Epidemiol.25(10), 860–867 (2007).
   Google Scholar
• Tumbarello M, Spanu T, Sanguinetti M et al. Bloodstream infections caused by extended-spectrum-β-lactamase-producing Klebsiella pneumoniae: risk factors, molecular epidemiology, and clinical outcome. Antimicrob. Agents Chemother.50(2), 498–504 (2006).
   PubMed Web of Science ®Google Scholar
• Mosqueda-Gómez JL, Montaño-Loza A, Rolón AL et al. Molecular epidemiology and risk factors of bloodstream infections caused by extended-spectrum β-lactamase-producing Klebsiella pneumoniae. A case-control study. Int. J. Infect. Dis.12(6), 653–659 (2008).
   PubMedGoogle Scholar
• Pai H, Kang CI, Byeon JH et al. Epidemiology and clinical features of bloodstream infections caused by AmpC-type-β-lactamase-producing Klebsiella pneumoniae. Antimicrob. Agents Chemother.48(10), 3720–3728 (2004).
   PubMed Web of Science ®Google Scholar
• Sidjabat HE, Paterson DL, Qureshi ZA et al. Clinical features and molecular epidemiology of CMY-type β-lactamase-producing Escherichia coli. Clin. Infect. Dis.48(6), 739–744 (2009).
   PubMedGoogle Scholar
• Daikos GL, Petrikkos P, Psichogiou M et al. Prospective observational study of the impact of VIM-1 metallo-β-lactamase on the outcome of patients with Klebsiella pneumoniae bloodstream infections. Antimicrob. Agents Chemother.53(5), 1868–1873 (2009).
   PubMed Web of Science ®Google Scholar
• Souli M, Kontopidou FV, Papadomichelakis E, Galani I, Armaganidis A, Giamarellou H. Clinical experience of serious infections caused by Enterobacteriaceae producing VIM-1 metallo-β-lactamase in a Greek University Hospital. Clin. Infect. Dis.46(6), 847–854 (2008).
   PubMed Web of Science ®Google Scholar
• Cagnacci S, Gualco L, Roveta S et al. Bloodstream infections caused by multidrug-resistant Klebsiella pneumoniae producing the carbapenem-hydrolysing VIM-1 metallo-β-lactamase: first Italian outbreak. J. Antimicrob. Chemother.61(2), 296–300 (2008).
   PubMed Web of Science ®Google Scholar
• Daikos GL, Karabinis A, Paramythiotou E et al. VIM-1-producing Klebsiella pneumoniae bloodstream infections: analysis of 28 cases. Int. J. Antimicrob. Agents29(4), 471–473 (2007).
   PubMedGoogle Scholar
• Nadkarni AS, Schliep T, Khan L, Zeana CB. Cluster of bloodstream infections caused by KPC-2 carbapenemase-producing Klebsiella pneumoniae in Manhattan. Am. J. Infect. Control37(2), 121–126 (2009).
   PubMed Web of Science ®Google Scholar
• Marschall J, Tibbetts RJ, Dunne WM Jr, Frye JG, Fraser VJ, Warren DK. Presence of the KPC carbapenemase gene in Enterobacteriaceae causing bacteremia and its correlation with in vitro carbapenem susceptibility. J. Clin. Microbiol.47(1), 239–241 (2009).
   PubMed Web of Science ®Google Scholar
• Paterson DL, Doi Y. A step closer to extreme drug resistance (XDR) in Gram-negative bacilli. Clin. Infect. Dis.45(9), 1179–1181 (2007).
   PubMed Web of Science ®Google Scholar
• Schwaber MJ, Carmeli Y. Carbapenem-resistant Enterobacteriaceae: a potential threat. JAMA300(24), 2911–2913 (2008).
   PubMed Web of Science ®Google Scholar
• Maltezou HC. Metallo-β-lactamases in Gram-negative bacteria: introducing the era of pan-resistance? Int. J. Antimicrob. Agents33(5), 405. e1–e7 (2009).
   PubMedGoogle Scholar
• Li J, Nation RL, Turnidge JD et al. Colistin: the re-emerging antibiotic for multidrug-resistant Gram-negative bacterial infections. Lancet Infect. Dis.6(9), 589–601 (2006).
   PubMed Web of Science ®Google Scholar
• Gardiner D, Dukart G, Cooper A, Babinchak T. Safety and efficacy of intravenous tigecycline in subjects with secondary bacteremia: pooled results from 8 Phase III clinical trials. Clin. Infect. Dis.50(2), 229–238 (2010).
   PubMed Web of Science ®Google Scholar
• Falagas ME, Kastoris AC, Kapaskelis AM, Karageorgopoulos DE. Fosfomycin for the treatment of multidrug-resistant, including extended-spectrum β-lactamase producing, Enterobacteriaceae infections: a systematic review. Lancet Infect. Dis.10(1), 43–50 (2010).
   PubMed Web of Science ®Google Scholar
• Safdar N, Handelsman J, Maki DG. Does combination antimicrobial therapy reduce mortality in Gram-negative bacteraemia? A meta-analysis. Lancet Infect. Dis.4(8), 519–527 (2004).
   PubMed Web of Science ®Google Scholar
• Mesaros N, Nordmann P, Plésiat P et al.Pseudomonas aeruginosa: resistance and therapeutic options at the turn of the new millennium. Clin. Microbiol. Infect.13(6), 560–578 (2007).
   PubMed Web of Science ®Google Scholar
• Leibovici L, Vidal L, Paul M. Aminoglycoside drugs in clinical practice: an evidence-based approach. J. Antimicrob. Chemother.63(2), 246–251 (2009).
   PubMed Web of Science ®Google Scholar
• Sahm D. In vitro activity of doripenem. Clin. Infect. Dis.49(Suppl. 1), S11–S16 (2009).
   PubMed Web of Science ®Google Scholar
• Crandon JL, Bulik CC, Nicolau DP. In vivo efficacy of 1- and 2-gram human simulated prolonged infusions of doripenem against Pseudomonas aeruginosa. Antimicrob. Agents. Chemother.53(10), 4352–4356 (2009).
   PubMedGoogle Scholar
• Karageorgopoulos DE, Falagas ME. Current control and treatment of multidrug-resistant Acinetobacter baumannii infections. Lancet Infect. Dis.8(12), 751–762 (2008).
   PubMed Web of Science ®Google Scholar
• Vasilev K, Reshedko G, Orasan R et al. A Phase 3, open-label, non-comparative study of tigecycline in the treatment of patients with selected serious infections due to resistant Gram-negative organisms including Enterobacter species, Acinetobacter baumannii and Klebsiella pneumoniae. J. Antimicrob. Chemother.62(Suppl. 1), i29–i40 (2008).
   PubMed Web of Science ®Google Scholar
• Peleg AY, Seifert H, Paterson DL. Acinetobacter baumannii: emergence of a successful pathogen. Clin. Microbiol. Rev.21(3), 538–582 (2008).
   PubMed Web of Science ®Google Scholar
• Gross PA, Saul ZK, Kuyumcu A. Applying a standard of care to the quality assesement of bacteremia. Infect. Control Hosp. Epidemiol.13(7), 403–406 (1992).
   PubMedGoogle Scholar
• Gross PA, Barret TL, Dellinger EP et al. Quality standard for the treatment of bacteremia. Infect. Control Hosp. Epidemiol.15(2), 189–192 (1994).
   PubMedGoogle Scholar
• Herchline T, Gros S. Improving clinical outcome in bacteremia. J. Eval. Clin. Pract.4(3), 191–195 (1998).
   PubMedGoogle Scholar
• Byl B, Clevenbergh P, Jacobs F et al. Impact of infectious diseases specialists and microbiological data on the appropriateness of antimicrobial therapy for bacteremia. Clin. Infect. Dis.29(1), 60–66 (1999).
   PubMed Web of Science ®Google Scholar
• Fluckiger U, Zimmerli W, Sax H, Frei R, Widmer AF. Clinical impact of an infectious disease service on the management of bloodstream infection. Eur. J. Clin. Microbiol. Infect. Dis.19(7), 493–500 (2000).
   PubMed Web of Science ®Google Scholar