Evidence for a causal relationship between respiratory syncytial virus infection and asthma

References

• Glezen WP, Loda FA, Clyde WA Jr et al. Epidemiologic patterns of acute lower respiratory disease of children in a pediatric group practice. J. Pediatr.78(3), 397–406 (1971).
   PubMed Web of Science ®Google Scholar
• Carlsen KH, Orstavik I, Halvorsen K. Viral infections of the respiratory tract in hospitalized children. A study from Oslo during a 90 months’ period. Acta Paediatr. Scand.72(1), 53–58 (1983).
   PubMed Web of Science ®Google Scholar
• Wright AL, Taussig LM, Ray CG, Harrison HR, Holberg CJ. The Tucson Children’s Respiratory Study. II. Lower respiratory tract illness in the first year of life. Am. J. Epidemiol.129(6), 1232–1246 (1989).
   PubMed Web of Science ®Google Scholar
• Jartti T, Lehtinen P, Vuorinen T et al. Respiratory picornaviruses and respiratory syncytial virus as causative agents of acute expiratory wheezing in children. Emerg. Infect. Dis.10(6), 1095–1101 (2004).
   PubMed Web of Science ®Google Scholar
• Calvo C, Garcia-Garcia ML, Blanco C, Pozo F, Flecha IC, Perez-Brena P. Role of rhinovirus in hospitalized infants with respiratory tract infections in Spain. Pediatr. Infect. Dis. J.26(10), 904–908 (2007).
   PubMed Web of Science ®Google Scholar
• Glezen WP, Taber LH, Frank AL, Kasel JA. Risk of primary infection and reinfection with respiratory syncytial virus. Am. J. Dis. Child.140(6), 543–546 (1986).
   PubMedGoogle Scholar
• Noble V, Murray M, Webb MS, Alexander J, Swarbrick AS, Milner AD. Respiratory status and allergy nine to 10 years after acute bronchiolitis. Arch. Dis. Child.76(4), 315–319 (1997).
   PubMed Web of Science ®Google Scholar
• Murray M, Webb MS, O’Callaghan C, Swarbrick AS, Milner AD. Respiratory status and allergy after bronchiolitis. Arch. Dis. Child.67(4), 482–487 (1992).
   PubMed Web of Science ®Google Scholar
• Sigurs N, Bjarnason R, Sigurbergsson F, Kjellman B. Respiratory syncytial virus bronchiolitis in infancy is an important risk factor for asthma and allergy at age 7. Am. J. Respir. Crit. Care Med.161(5), 1501–1507 (2000).
   PubMed Web of Science ®Google Scholar
• Sigurs N, Gustafsson PM, Bjarnason R et al. Severe respiratory syncytial virus bronchiolitis in infancy and asthma and allergy at age 13. Am. J. Respir. Crit. Care Med.171(2), 137–141 (2005).
   PubMed Web of Science ®Google Scholar
• Henderson J, Hilliard TN, Sherriff A, Stalker D, Al Shammari N, Thomas HM. Hospitalization for RSV bronchiolitis before 12 months of age and subsequent asthma, atopy and wheeze: a longitudinal birth cohort study. Pediatr. Allergy Immunol.16(5), 386–392 (2005).
   PubMed Web of Science ®Google Scholar
• Carroll KN, Wu P, Gebretsadik T et al. The severity-dependent relationship of infant bronchiolitis on the risk and morbidity of early childhood asthma. J. Allergy Clin. Immunol.123(5), 1055–1061 (2009).
   PubMed Web of Science ®Google Scholar
• Bartz H, Buning-Pfaue F, Turkel O, Schauer U. Respiratory syncytial virus induces prostaglandin E2, IL-10 and IL-11 generation in antigen presenting cells. Clin. Exp. Immunol.129(3), 438–445 (2002).
   PubMed Web of Science ®Google Scholar
• Larsen GL, Colasurdo GN. Neural control mechanisms within airways: disruption by respiratory syncytial virus. J. Pediatr.135(2 Pt 2), 21–27 (1999).
   PubMed Web of Science ®Google Scholar
• Hall GL, Hantos Z, Sly PD. Altered respiratory tissue mechanics in asymptomatic wheezy infants. Am. J. Respir. Crit. Care Med.164(8 Pt 1), 1387–1391 (2001).
   PubMed Web of Science ®Google Scholar
• Hibbert ME, Hudson IL, Lanigan A, Landau LI, Phelan PD. Tracking of lung function in healthy children and adolescents. Pediatr. Pulmonol.8(3), 172–177 (1990).
   PubMed Web of Science ®Google Scholar
• Lemanske RF Jr. Issues in understanding pediatric asthma: epidemiology and genetics. J. Allergy Clin. Immunol.109(Suppl. 6), S521–S524 (2002).
   PubMed Web of Science ®Google Scholar
• Martinez FD, Wright AL, Taussig LM, Holberg CJ, Halonen M, Morgan WJ. Asthma and wheezing in the first six years of life. The Group Health Medical Associates. N. Engl. J. Med.332(3), 133–138 (1995).
   PubMed Web of Science ®Google Scholar
• Openshaw PJ, Yamaguchi Y, Tregoning JS. Childhood infections, the developing immune system, and the origins of asthma. J. Allergy Clin. Immunol.114(6), 1275–1277 (2004).
   PubMed Web of Science ®Google Scholar
• Collins PL, Crowe JE. Respiratory syncytial virus and metapneumovirus. In: Field Virology. Knipe DM, Howley PM (Eds). Lippincott-Williams & Wilkins, Philadelphia, PA, USA, 1601–1646 (2007).
   Google Scholar
• Anderson LJ, Hierholzer JC, Tsou C et al. Antigenic characterization of respiratory syncytial virus strains with monoclonal antibodies. J. Infect. Dis.151(4), 626–633 (1985).
   PubMed Web of Science ®Google Scholar
• Mufson MA, Orvell C, Rafnar B, Norrby E. Two distinct subtypes of human respiratory syncytial virus. J. Gen. Virol.66(Pt 10), 2111–2124 (1985).
   PubMed Web of Science ®Google Scholar
• Cane PA , Pringle CR. Respiratory syncytial virus heterogeneity during an epidemic: analysis by limited nucleotide sequencing (SH gene) and restriction mapping (N gene). J. Gen. Virol.72(Pt 2), 349–357 (1991).
   PubMed Web of Science ®Google Scholar
• Storch GA, Anderson LJ, Park CS, Tsou C, Dohner DE. Antigenic and genomic diversity within group A respiratory syncytial virus. J. Infect. Dis.163(4), 858–861 (1991).
   PubMed Web of Science ®Google Scholar
• Peret TC, Hall CB, Schnabel KC, Golub JA, Anderson LJ. Circulation patterns of genetically distinct group A and B strains of human respiratory syncytial virus in a community. J. Gen. Virol.79(Pt 9), 2221–2229 (1998).
   PubMed Web of Science ®Google Scholar
• Peret TC, Hall CB, Hammond GW et al. Circulation patterns of group A and B human respiratory syncytial virus genotypes in 5 communities in North America. J. Infect. Dis.181(6), 1891–1896 (2000).
   PubMed Web of Science ®Google Scholar
• Walsh EE, McConnochie KM, Long CE, Hall CB. Severity of respiratory syncytial virus infection is related to virus strain. J. Infect. Dis.175(4), 814–820 (1997).
   PubMed Web of Science ®Google Scholar
• Hall CB, Walsh EE, Schnabel KC et al. Occurrence of groups A and B of respiratory syncytial virus over 15 years: associated epidemiologic and clinical characteristics in hospitalized and ambulatory children. J. Infect. Dis.162(6), 1283–1290 (1990).
   PubMed Web of Science ®Google Scholar
• Hall CB, Walsh EE, Long CE, Schnabel KC. Immunity to and frequency of reinfection with respiratory syncytial virus. J. Infect. Dis.163(4), 693–698 (1991).
   PubMed Web of Science ®Google Scholar
• Shay DK, Holman RC, Newman RD, Liu LL, Stout JW, Anderson LJ. Bronchiolitis-associated hospitalizations among US children, 1980–1996. JAMA282(15), 1440–1446 (1999).
   PubMed Web of Science ®Google Scholar
• Kim HW, Arrobio JO, Brandt CD et al. Epidemiology of respiratory syncytial virus infection in Washington, D.C. I. Importance of the virus in different respiratory tract disease syndromes and temporal distribution of infection. Am. J. Epidemiol.98(3), 216–225 (1973).
   PubMed Web of Science ®Google Scholar
• Baschat AA, Towbin J, Bowles NE, Harman CR, Weiner CP. Prevalence of viral DNA in amniotic fluid of low-risk pregnancies in the second trimester. J. Matern. Fetal Neonatal. Med.13(6), 381–384 (2003).
   PubMedGoogle Scholar
• Pullan CR, Hey EN. Wheezing, asthma, and pulmonary dysfunction 10 years after infection with respiratory syncytial virus in infancy. Br. Med. J. (Clin. Res. Ed.)284(6330), 1665–1669 (1982).
   PubMed Web of Science ®Google Scholar
• Schauer U, Hoffjan S, Bittscheidt J et al. RSV bronchiolitis and risk of wheeze and allergic sensitisation in the first year of life. Eur. Respir. J.20(5), 1277–1283 (2002).
   PubMed Web of Science ®Google Scholar
• Singleton RJ, Redding GJ, Lewis TC et al. Sequelae of severe respiratory syncytial virus infection in infancy and early childhood among Alaska native children. Pediatrics112(2), 285–290 (2003).
   PubMed Web of Science ®Google Scholar
• Sigurs N, Bjarnason R, Sigurbergsson F, Kjellman B, Bjorksten B. Asthma and immunoglobulin E antibodies after respiratory syncytial virus bronchiolitis: a prospective cohort study with matched controls. Pediatrics95(4), 500–505 (1995).
   PubMed Web of Science ®Google Scholar
• Stein RT, Sherrill D, Morgan WJ et al. Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years. Lancet354(9178), 541–545 (1999).
   PubMed Web of Science ®Google Scholar
• Sigurs N, Aljassim F, Kjellman B et al. Asthma and allergy patterns over 18 years after severe RSV bronchiolitis in the first year of life. Thorax65(12), 1045–1052 (2010).
   PubMed Web of Science ®Google Scholar
• Korppi M, Piippo-Savolainen E, Korhonen K, Remes S. Respiratory morbidity 20 years after RSV infection in infancy. Pediatr. Pulmonol.38(2), 155–160 (2004).
   PubMed Web of Science ®Google Scholar
• Escobar GJ, Ragins A, Li SX, Prager L, Masaquel AS, Kipnis P. Recurrent wheezing in the third year of life among children born at 32 weeks’ gestation or later: relationship to laboratory-confirmed, medically attended infection with respiratory syncytial virus during the first year of life. Arch. Pediatr. Adolesc. Med.164(10), 915–922 (2010).
   PubMedGoogle Scholar
• Carroll KN, Wu P, Gebretsadik T et al. Season of infant bronchiolitis and estimates of subsequent risk and burden of early childhood asthma. J. Allergy Clin. Immunol.123(4), 964–966 (2009).
   PubMed Web of Science ®Google Scholar
• Mok JY, Simpson H. Outcome of acute lower respiratory tract infection in infants: preliminary report of seven-year follow-up study. Br. Med. J. (Clin. Res. Ed.)285(6338), 333–337 (1982).
   PubMed Web of Science ®Google Scholar
• Fjaerli HO, Farstad T, Rod G, Ufert GK, Gulbrandsen P, Nakstad B. Acute bronchiolitis in infancy as risk factor for wheezing and reduced pulmonary function by seven years in Akershus County, Norway. BMC Pediatr.5, 31 (2005).
   PubMedGoogle Scholar
• Stern DA, Morgan WJ, Halonen M, Wright AL, Martinez FD. Wheezing and bronchial hyper-responsiveness in early childhood as predictors of newly diagnosed asthma in early adulthood: a longitudinal birth-cohort study. Lancet372(9643), 1058–1064 (2008).
   PubMed Web of Science ®Google Scholar
• Wu P, Dupont WD, Griffin MR et al. Evidence of a causal role of winter virus infection during infancy in early childhood asthma. Am. J. Respir. Crit. Care Med.178(11), 1123–1129 (2008).
   PubMed Web of Science ®Google Scholar
• Hartter HK, Oyedele OI, Dietz K, Kreis S, Hoffman JP, Muller CP. Placental transfer and decay of maternally acquired antimeasles antibodies in Nigerian children. Pediatr. Infect. Dis. J.19(7), 635–641 (2000).
   PubMed Web of Science ®Google Scholar
• de FA, Hall AJ, Unicomb L, Chakraborty J, Yunus M, Sack RB. Maternal measles antibody decay in rural Bangladeshi infants – implications for vaccination schedules. Vaccine16(6), 564–568 (1998).
   PubMed Web of Science ®Google Scholar
• Buckley RH. T-, B-, and NK-cell systems. In: Nelson Textbook of Pediatrics. Behrman RE, Kliegman RM, Arvin AM, Nelson WE (Eds). W.B. Saunders Company, Philadelphia, PA, USA 561–567 (1996).
   Google Scholar
• Gern JE, Rosenthal LA, Sorkness RL, Lemanske RF Jr. Effects of viral respiratory infections on lung development and childhood asthma. J. Allergy Clin. Immunol.115(4), 668–674 (2005).
   PubMed Web of Science ®Google Scholar
• Thomsen SF, van der SS, Stensballe LG et al. Exploring the association between severe respiratory syncytial virus infection and asthma: a registry-based twin study. Am. J. Respir. Crit. Care Med.179(12), 1091–1097 (2009).
   PubMed Web of Science ®Google Scholar
• Stensballe LG, Simonsen JB, Thomsen SF et al. The causal direction in the association between respiratory syncytial virus hospitalization and asthma. J. Allergy Clin. Immunol.123(1), 131–137 (2009).
   PubMed Web of Science ®Google Scholar
• Poorisrisak P, Halkjaer LB, Thomsen SF et al. Causal direction between respiratory syncytial virus bronchiolitis and asthma studied in monozygotic twins. Chest138(2), 338–344 (2010).
   PubMed Web of Science ®Google Scholar
• Singh AM, Moore PE, Gern JE, Lemanske RF Jr, Hartert TV. Bronchiolitis to asthma: a review and call for studies of gene–virus interactions in asthma causation. Am. J. Respir. Crit. Care Med.175(2), 108–119 (2007).
   PubMed Web of Science ®Google Scholar
• Janssen R, Bont L, Siezen CL et al. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. J. Infect. Dis.196(6), 826–834 (2007).
   PubMed Web of Science ®Google Scholar
• Poon AH, Laprise C, Lemire M et al. Association of vitamin D receptor genetic variants with susceptibility to asthma and atopy. Am. J. Respir. Crit. Care Med.170(9), 967–973 (2004).
   PubMed Web of Science ®Google Scholar
• Islam T, Breton C, Salam MT et al. Role of inducible nitric oxide synthase in asthma risk and lung function growth during adolescence. Thorax65(2), 139–145 (2010).
   PubMed Web of Science ®Google Scholar
• Amanatidou V, Sourvinos G, Apostolakis S, Tsilimigaki A, Spandidos DA. T280M variation of the CX3C receptor gene is associated with increased risk for severe respiratory syncytial virus bronchiolitis. Pediatr. Infect. Dis. J.25(5), 410–414 (2006).
   PubMed Web of Science ®Google Scholar
• Tremblay K, Lemire M, Provost V et al. Association study between the CX3CR1 gene and asthma. Genes. Immun.7(8), 632–639 (2006).
   PubMed Web of Science ®Google Scholar
• Depner M, Kormann MS, Klopp N et al. CX3CR1 polymorphisms are associated with atopy but not asthma in German children. Int. Arch. Allergy Immunol.144(1), 91–94 (2007).
   PubMed Web of Science ®Google Scholar
• Kurt-Jones EA, Popova L, Kwinn L et al. Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nat. Immunol.1(5), 398–401 (2000).
   PubMed Web of Science ®Google Scholar
• Tulic MK, Hurrelbrink RJ, Prele CM et al. TLR4 polymorphisms mediate impaired responses to respiratory syncytial virus and lipopolysaccharide. J. Immunol.179(1), 132–140 (2007).
   PubMed Web of Science ®Google Scholar
• Fageras BM, Hmani-Aifa M, Lindstrom A et al. A TLR4 polymorphism is associated with asthma and reduced lipopolysaccharide-induced interleukin-12(p70) responses in Swedish children. J. Allergy Clin. Immunol.114(3), 561–567 (2004).
   PubMed Web of Science ®Google Scholar
• Raby BA, Klimecki WT, Laprise C et al. Polymorphisms in Toll-like receptor 4 are not associated with asthma or atopy-related phenotypes. Am. J. Respir. Crit. Care Med.166(11), 1449–1456 (2002).
   PubMed Web of Science ®Google Scholar
• Yang IA, Barton SJ, Rorke S et al. Toll-like receptor 4 polymorphism and severity of atopy in asthmatics. Genes. Immun.5(1), 41–45 (2004).
   PubMed Web of Science ®Google Scholar
• Ghildyal R, Hartley C, Varrasso A et al. Surfactant protein A binds to the fusion glycoprotein of respiratory syncytial virus and neutralizes virion infectivity. J. Infect. Dis.180(6), 2009–2013 (1999).
   PubMed Web of Science ®Google Scholar
• Griese M. Respiratory syncytial virus and pulmonary surfactant. Viral. Immunol.15(2), 357–363 (2002).
   PubMed Web of Science ®Google Scholar
• Lahti M, Lofgren J, Marttila R et al. Surfactant protein D gene polymorphism associated with severe respiratory syncytial virus infection. Pediatr. Res.51(6), 696–699 (2002).
   PubMed Web of Science ®Google Scholar
• Lofgren J, Ramet M, Renko M, Marttila R, Hallman M. Association between surfactant protein A gene locus and severe respiratory syncytial virus infection in infants. J. Infect. Dis.185(3), 283–289 (2002).
   PubMed Web of Science ®Google Scholar
• Puthothu B, Forster J, Heinze J, Heinzmann A, Krueger M. Surfactant protein B polymorphisms are associated with severe respiratory syncytial virus infection, but not with asthma. BMC Pulm. Med.7, 6 (2007).
   PubMedGoogle Scholar
• Puthothu B, Krueger M, Heinze J, Forster J, Heinzmann A. Haplotypes of surfactant protein C are associated with common paediatric lung diseases. Pediatr. Allergy Immunol.17(8), 572–577 (2006).
   PubMed Web of Science ®Google Scholar
• Amanatidou V, Sourvinos G, Apostolakis S et al. RANTES promoter gene polymorphisms and susceptibility to severe respiratory syncytial virus-induced bronchiolitis. Pediatr. Infect. Dis. J.27(1), 38–42 (2008).
   PubMed Web of Science ®Google Scholar
• Lachheb J, Chelbi H, Hamzaoui K, Hamzaoui A. Association between RANTES polymorphisms and asthma severity among Tunisian children. Hum. Immunol.68(8), 675–680 (2007).
   PubMed Web of Science ®Google Scholar
• Sheeran P, Jafri H, Carubelli C et al. Elevated cytokine concentrations in the nasopharyngeal and tracheal secretions of children with respiratory syncytial virus disease. Pediatr. Infect. Dis. J.18(2), 115–122 (1999).
   PubMed Web of Science ®Google Scholar
• Tian M, Liu F, Wen GY, Shi SY, Chen RH, Zhao DY. Effect of variation in RANTES promoter on serum RANTES levels and risk of recurrent wheezing after RSV bronchiolitis in children from Han, Southern China. Eur. J. Pediatr.168(8), 963–967 (2009).
   PubMed Web of Science ®Google Scholar
• Puthothu B, Krueger M, Forster J, Heinzmann A. Association between severe respiratory syncytial virus infection and IL13/IL4 haplotypes. J. Infect. Dis.193(3), 438–441 (2006).
   PubMed Web of Science ®Google Scholar
• Hoebee B, Rietveld E, Bont L et al. Association of severe respiratory syncytial virus bronchiolitis with interleukin-4 and interleukin-4 receptor α polymorphisms. J. Infect. Dis.187(1), 2–11 (2003).
   PubMed Web of Science ®Google Scholar
• Moore KW, de Waal MR, Coffman RL, O’Garra A. Interleukin-10 and the interleukin-10 receptor. Ann. Rev. Immunol.19, 683–765 (2001).
   PubMed Web of Science ®Google Scholar
• Hoebee B, Bont L, Rietveld E et al. Influence of promoter variants of interleukin-10, interleukin-9, and tumor necrosis factor-α genes on respiratory syncytial virus bronchiolitis. J. Infect. Dis.189(2), 239–247 (2004).
   PubMed Web of Science ®Google Scholar
• Wilson J, Rowlands K, Rockett K et al. Genetic variation at the IL10 gene locus is associated with severity of respiratory syncytial virus bronchiolitis. J. Infect. Dis.191(10), 1705–1709 (2005).
   PubMed Web of Science ®Google Scholar
• Gentile DA, Doyle WJ, Zeevi A et al. Cytokine gene polymorphisms moderate illness severity in infants with respiratory syncytial virus infection. Hum. Immunol.64(3), 338–344 (2003).
   PubMed Web of Science ®Google Scholar
• Kunkel SL, Standiford T, Kasahara K, Strieter RM. Interleukin-8 (IL-8): the major neutrophil chemotactic factor in the lung. Exp. Lung Res.17(1), 17–23 (1991).
   PubMed Web of Science ®Google Scholar
• Hull J, Thomson A, Kwiatkowski D. Association of respiratory syncytial virus bronchiolitis with the interleukin 8 gene region in UK families. Thorax55(12), 1023–1027 (2000).
   PubMed Web of Science ®Google Scholar
• Hull J, Ackerman H, Isles K et al. Unusual haplotypic structure of IL8, a susceptibility locus for a common respiratory virus. Am. J. Hum. Genet.69(2), 413–419 (2001).
   PubMed Web of Science ®Google Scholar
• Puthothu B, Krueger M, Heinze J, Forster J, Heinzmann A. Impact of IL8 and IL8-receptor α polymorphisms on the genetics of bronchial asthma and severe RSV infections. Clin. Mol. Allergy4, 2 (2006).
   PubMedGoogle Scholar
• Goetghebuer T, Isles K, Moore C, Thomson A, Kwiatkowski D, Hull J. Genetic predisposition to wheeze following respiratory syncytial virus bronchiolitis. Clin. Exp. Allergy34(5), 801–803 (2004).
   PubMed Web of Science ®Google Scholar
• Dinarello CA. IL-18: a Th1-inducing, proinflammatory cytokine and new member of the IL-1 family. J. Allergy Clin. Immunol.103(1 Pt 1), 11–24 (1999).
   PubMed Web of Science ®Google Scholar
• Puthothu B, Krueger M, Forster J, Heinze J, Weckmann M, Heinzmann A. Interleukin (IL)-18 polymorphism 133C/G is associated with severe respiratory syncytial virus infection. Pediatr. Infect. Dis. J.26(12), 1094–1098 (2007).
   PubMed Web of Science ®Google Scholar
• Harada M, Obara K, Hirota T et al. A functional polymorphism in IL-18 is associated with severity of bronchial asthma. Am. J. Respir. Crit. Care Med.180(11), 1048–1055 (2009).
   PubMed Web of Science ®Google Scholar
• El-Mezzein RE, Matsumoto T, Nomiyama H, Miike T. Increased secretion of IL-18 in vitro by peripheral blood mononuclear cells of patients with bronchial asthma and atopic dermatitis. Clin. Exp. Immunol.126(2), 193–198 (2001).
   PubMed Web of Science ®Google Scholar
• Howard TD, Koppelman GH, Xu J et al. Gene–gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma. Am. J. Hum. Genet.70(1), 230–236 (2002).
   PubMed Web of Science ®Google Scholar
• Eder W, Klimecki W, Yu L et al. Opposite effects of CD 14/-260 on serum IgE levels in children raised in different environments. J. Allergy Clin. Immunol.116(3), 601–607 (2005).
   PubMed Web of Science ®Google Scholar
• Simpson A, John SL, Jury F et al. Endotoxin exposure, CD14, and allergic disease: an interaction between genes and the environment. Am. J. Respir. Crit. Care Med.174(4), 386–392 (2006).
   PubMed Web of Science ®Google Scholar
• Williams LK, McPhee RA, Ownby DR et al. Gene–environment interactions with CD14 C-260T and their relationship to total serum IgE levels in adults. J. Allergy Clin. Immunol.118(4), 851–857 (2006).
   PubMed Web of Science ®Google Scholar
• Zambelli-Weiner A, Ehrlich E, Stockton ML et al. Evaluation of the CD14/-260 polymorphism and house dust endotoxin exposure in the Barbados Asthma Genetics Study. J. Allergy Clin. Immunol.115(6), 1203–1209 (2005).
   PubMed Web of Science ®Google Scholar
• Martinez FD, Stern DA, Wright AL, Taussig LM, Halonen M. Differential immune responses to acute lower respiratory illness in early life and subsequent development of persistent wheezing and asthma. J. Allergy Clin. Immunol.102(6 Pt 1), 915–920 (1998).
   PubMed Web of Science ®Google Scholar
• Macaubas C, de Klerk NH, Holt BJ et al. Association between antenatal cytokine production and the development of atopy and asthma at age 6 years. Lancet362(9391), 1192–1197 (2003).
   PubMed Web of Science ®Google Scholar
• Stephens R, Randolph DA, Huang G, Holtzman MJ, Chaplin DD. Antigen-nonspecific recruitment of Th2 cells to the lung as a mechanism for viral infection-induced allergic asthma. J. Immunol.169(10), 5458–5467 (2002).
   PubMed Web of Science ®Google Scholar
• Culley FJ, Pollott J, Openshaw PJ. Age at first viral infection determines the pattern of T cell-mediated disease during reinfection in adulthood. J. Exp. Med.196(10), 1381–1386 (2002).
   PubMed Web of Science ®Google Scholar
• Tregoning JS, Yamaguchi Y, Harker J, Wang B, Openshaw PJ. The role of T cells in the enhancement of respiratory syncytial virus infection severity during adult reinfection of neonatally sensitized mice. J. Virol.82(8), 4115–4124 (2008).
   PubMed Web of Science ®Google Scholar
• Dakhama A, Park JW, Taube C et al. The enhancement or prevention of airway hyperresponsiveness during reinfection with respiratory syncytial virus is critically dependent on the age at first infection and IL-13 production. J. Immunol.175(3), 1876–1883 (2005).
   PubMed Web of Science ®Google Scholar
• Dakhama A, Lee YM, Ohnishi H et al. Virus-specific IgE enhances airway responsiveness on reinfection with respiratory syncytial virus in newborn mice. J. Allergy Clin. Immunol.123(1), 138–145 (2009).
   PubMed Web of Science ®Google Scholar
• Peebles RS Jr, Graham BS. Pathogenesis of respiratory syncytial virus infection in the murine model. Proc. Am. Thorac. Soc.2(2), 110–115 (2005).
   PubMedGoogle Scholar
• Welliver RC, Garofalo RP, Ogra PL. β-chemokines, but neither T helper type 1 nor T helper type 2 cytokines, correlate with severity of illness during respiratory syncytial virus infection. Pediatr. Infect. Dis. J.21(5), 457–461 (2002).
   PubMed Web of Science ®Google Scholar
• Aberle JH, Aberle SW, Dworzak MN et al. Reduced interferon-γ expression in peripheral blood mononuclear cells of infants with severe respiratory syncytial virus disease. Am. J. Respir. Crit. Care Med.160(4), 1263–1268 (1999).
   PubMed Web of Science ®Google Scholar
• Renzi PM, Turgeon JP, Marcotte JE et al. Reduced interferon-γ production in infants with bronchiolitis and asthma. Am. J. Respir. Crit. Care Med.159(5 Pt 1), 1417–1422 (1999).
   PubMed Web of Science ®Google Scholar
• Hammad H, Chieppa M, Perros F, Willart MA, Germain RN, Lambrecht BN. House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells. Nat. Med.15(4), 410–416 (2009).
   PubMed Web of Science ®Google Scholar
• Devincenzo JP, Wilkinson T, Vaishnaw A et al. Viral load drives disease in humans experimentally infected with respiratory syncytial virus. Am. J. Respir. Crit. Care Med.182(10), 1305–1314 (2010).
   PubMed Web of Science ®Google Scholar
• Wang Y, Bai C, Li K, Adler KB, Wang X. Role of airway epithelial cells in development of asthma and allergic rhinitis. Respir. Med.102(7), 949–955 (2008).
   PubMed Web of Science ®Google Scholar
• Kim EY, Battaile JT, Patel AC et al. Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease. Nat. Med.14(6), 633–640 (2008).
   PubMed Web of Science ®Google Scholar
• Hu C, Wedde-Beer K, Auais A, Rodriguez MM, Piedimonte G. Nerve growth factor and nerve growth factor receptors in respiratory syncytial virus-infected lungs. Am. J. Physiol. Lung Cell. Mol. Physiol.283(2), L494–L502 (2002).
   PubMed Web of Science ®Google Scholar
• Tortorolo L, Langer A, Polidori G et al. Neurotrophin overexpression in lower airways of infants with respiratory syncytial virus infection. Am. J. Respir. Crit. Care Med.172(2), 233–237 (2005).
   PubMed Web of Science ®Google Scholar
• Kernie SG, Parada LF. The molecular basis for understanding neurotrophins and their relevance to neurologic disease. Arch. Neurol.57(5), 654–657 (2000).
   PubMedGoogle Scholar
• Wright M, Piedimonte G. Respiratory syncytial virus prevention and therapy: past, present, and future. Pediatr. Pulmonol.46(4), 324–347 (2011).
   PubMed Web of Science ®Google Scholar
• Auais A, Adkins B, Napchan G, Piedimonte G. Immunomodulatory effects of sensory nerves during respiratory syncytial virus infection in rats. Am. J. Physiol. Lung Cell. Mol. Physiol.285(1), L105–L113 (2003).
   PubMed Web of Science ®Google Scholar
• Braun A, Lommatzsch M, Lewin GR, Virchow JC, Renz H. Neurotrophins: a link between airway inflammation and airway smooth muscle contractility in asthma?. Int. Arch. Allergy Immunol.118(2–4), 163–165 (1999).
   PubMed Web of Science ®Google Scholar
• American Thoracic Society ad hoc Statement Committee. Mechanisms and limits of induced postnatal lung growth. Am. J. Respir. Crit. Care Med.170(3), 319–343 (2004).
   PubMed Web of Science ®Google Scholar
• Hall WJ, Hall CB. Clinical significance of pulmonary function tests. Alterations in pulmonary function following respiratory viral infection. Chest76(4), 458–465 (1979).
   PubMed Web of Science ®Google Scholar
• Lukacs NW, Tekkanat KK, Berlin A et al. Respiratory syncytial virus predisposes mice to augmented allergic airway responses via IL-13-mediated mechanisms. J. Immunol.167(2), 1060–1065 (2001).
   PubMed Web of Science ®Google Scholar
• Tekkanat KK, Maassab HF, Cho DS et al. IL-13-induced airway hyperreactivity during respiratory syncytial virus infection is STAT6 dependent. J. Immunol.166(5), 3542–3548 (2001).
   PubMed Web of Science ®Google Scholar
• Peebles RS Jr, Sheller JR, Collins RD et al. Respiratory syncytial virus infection does not increase allergen-induced type 2 cytokine production, yet increases airway hyperresponsiveness in mice. J. Med. Virol.63(2), 178–188 (2001).
   PubMed Web of Science ®Google Scholar
• Castleman WL, Sorkness RL, Lemanske RF, Grasee G, Suyemoto MM. Neonatal viral bronchiolitis and pneumonia induces bronchiolar hypoplasia and alveolar dysplasia in rats. Lab. Invest.59(3), 387–396 (1988).
   PubMed Web of Science ®Google Scholar
• Uhl EW, Castleman WL, Sorkness RL, Busse WW, Lemanske RF Jr, McAllister PK. Parainfluenza virus-induced persistence of airway inflammation, fibrosis, and dysfunction associated with TGF-β 1 expression in brown Norway rats. Am. J. Respir. Crit. Care Med.154(6 Pt 1), 1834–1842 (1996).
   PubMed Web of Science ®Google Scholar
• Kumar A, Sorkness RL, Kaplan MR, Lemanske RF Jr. Chronic, episodic, reversible airway obstruction after viral bronchiolitis in rats. Am. J. Respir. Crit. Care Med.155(1), 130–134 (1997).
   PubMed Web of Science ®Google Scholar
• Groothuis JR, Simoes EA, Levin MJ et al. Prophylactic administration of respiratory syncytial virus immune globulin to high-risk infants and young children. The Respiratory Syncytial Virus Immune Globulin Study Group. N. Engl. J. Med.329(21), 1524–1530 (1993).
   PubMed Web of Science ®Google Scholar
• The Impact-RSV Study Group. Palivizumab, a humanized respiratory syncytial virus monoclonal antibody, reduces hospitalization from respiratory syncytial virus infection in high-risk infants. Pediatrics102(3 Pt 1), 531–537 (1998).
   PubMed Web of Science ®Google Scholar
• Wenzel SE, Gibbs RL, Lehr MV, Simoes EA. Respiratory outcomes in high-risk children 7 to 10 years after prophylaxis with respiratory syncytial virus immune globulin. Am. J. Med.112(8), 627–633 (2002).
   PubMed Web of Science ®Google Scholar
• Simoes EA, Groothuis JR, Carbonell-Estrany X et al. Palivizumab prophylaxis, respiratory syncytial virus, and subsequent recurrent wheezing. J. Pediatr.151(1), 34–42, 42.e1 (2007).
   PubMed Web of Science ®Google Scholar
• Meissner HC, Long SS. Respiratory syncytial virus infection and recurrent wheezing: a complex relationship. J. Pediatr.151(1), 6–7 (2007).
   PubMed Web of Science ®Google Scholar
• Simoes EA. Treatment and prevention of respiratory syncytial virus lower respiratory tract infection. Long-term effects on respiratory outcomes. Am. J. Respir. Crit. Care Med.163(3 Pt 2), S14–S17 (2001).
   PubMed Web of Science ®Google Scholar
• Chen CH, Lin YT, Yang YH et al. Ribavirin for respiratory syncytial virus bronchiolitis reduced the risk of asthma and allergen sensitization. Pediatr. Allergy Immunol.19(2), 166–172 (2008).
   PubMed Web of Science ®Google Scholar