553
Views
11
CrossRef citations to date
0
Altmetric
Editorial

The role of T cells in the pathogenesis of classical Whipple’s disease

&
Pages 253-255 | Published online: 10 Jan 2014

References

  • Raoult D, Ogata H, Audic S et al.Tropheryma whipplei twist: a human pathogenic Actinobacteria with a reduced genome. Genome Res.13(8), 1800–1809 (2003).
  • Fenollar F, Trani M, Davoust B et al. Prevalence of asymptomatic Tropheryma whipplei carriage among humans and nonhuman primates. J. Infect. Dis.197(6), 880–887 (2008).
  • Raoult D, Fenollar F, Rolain JM et al.Tropheryma whipplei in children with gastroenteritis. Emerg. Infect. Dis.16(5), 776–782 (2010).
  • Fenollar F, Mediannikov O, Socolovschi C et al.Tropheryma whipplei bacteremia during fever in rural west Africa. Clin. Infect. Dis.51(5), 515–521 (2010).
  • Geissdorfer W, Moos V, Moter A et al. High frequency of Tropheryma whipplei in culture-negative endocarditis. J. Clin. Microbiol.50(2), 216–222 (2011).
  • Fenollar F, Amphoux B, Raoult D. A paradoxical Tropheryma whipplei western blot differentiates patients with whipple disease from asymptomatic carriers. Clin. Infect. Dis.49(5), 717–723 (2009).
  • Moos V, Kunkel D, Marth T et al. Reduced peripheral and mucosal Tropheryma whipplei-specific Th1 response in patients with Whipple’s disease. J. Immunol.177(3), 2015–2022 (2006).
  • Schneider T, Moos V, Loddenkemper C, Marth T, Fenollar F, Raoult D. Whipple’s disease: new aspects of pathogenesis and treatment. Lancet Infect. Dis.8(3), 179–190 (2008).
  • Marth T, Roux M, Von Herbay A, Meuer SC, Feurle GE. Persistent reduction of complement receptor 3 alpha-chain expressing mononuclear blood cells and transient inhibitory serum factors in Whipple’s disease. Clin. Immunol. Immunopathol.72(2), 217–226 (1994).
  • Marth T, Kleen N, Stallmach A et al. Dysregulated peripheral and mucosal Th1/Th2 response in Whipple’s disease. Gastroenterology123(5), 1468–1477 (2002).
  • Schinnerling K, Moos V, Geelhaar A et al. Regulatory T cells in patients with Whipple’s disease. J. Immunol.187(8), 4061–4067 (2011).
  • Bai JC, Sen L, Diez R et al. Impaired monocyte function in patients successfully treated for Whipple’s disease. Acta Gastroenterol. Latinoam.26(2), 85–89 (1996).
  • Marth T, Neurath M, Cuccherini BA, Strober W. Defects of monocyte interleukin 12 production and humoral immunity in Whipple’s disease. Gastroenterology113(2), 442–448 (1997).
  • Moos V, Schmidt C, Geelhaar A et al. Impaired immune functions of monocytes and macrophages in Whipple’s disease. Gastroenterology138(1), 210–220 (2010).
  • Desnues B, Ihrig M, Raoult D, Mege JL. Whipple’s disease: a macrophage disease. Clin. Vaccine Immunol.13(2), 170–178 (2006).
  • Schoedon G, Goldenberger D, Forrer R et al. Deactivation of macrophages with interleukin-4 is the key to the isolation of Tropheryma whippelii. J. Infect. Dis.176(3), 672–677 (1997).
  • Al Moussawi K, Ghigo E, Kalinke U, Alexopoulou L, Mege JL, Desnues B. Type I interferon induction is detrimental during infection with the Whipple’s disease bacterium, Tropheryma whipplei. PLoS Pathog.6(1), e1000722 (2010).
  • Ghigo E, Barry AO, Pretat L et al. IL-16 promotes T. whipplei replication by inhibiting phagosome conversion and modulating macrophage activation. PLoS One5(10), e13561 (2010).
  • Martinetti M, Biagi F, Badulli C et al. The HLA alleles DRB1*13 and DQB1*06 are associated to Whipple’s disease. Gastroenterology136(7), 2289–2294 (2009).
  • Feurle GE, Moos V, Schinnerling K et al. The immune reconstitution inflammatory syndrome in whipple disease: a cohort study. Ann. Intern. Med.153(11), 710–717 (2010).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.