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Special Report

GUCY2C reverse transcriptase PCR to stage pN0 colorectal cancer patients

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Pages 777-785 | Published online: 09 Jan 2014

References

  • Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ. Cancer statistics, 2007. CA Cancer J. Clin.57, 43–66 (2007).
  • Compton CC, Greene FL. The staging of colorectal cancer. 2004 and beyond. CA Cancer J. Clin.54, 295–308 (2004).
  • Greene FL. AJCC Cancer Staging Manual. (6th Edition). Springer, NY, USA (2002).
  • Iddings D, Ahmad A, Elashoff D, Bilchik A. The prognostic effect of micrometastases in previously staged lymph node negative (N0) colorectal carcinoma. a meta-analysis. Ann. Surg. Oncol.13, 1386–1392 (2006).
  • Nicastri DG, Doucette JT, Godfrey TE, Hughes SJ. Is occult lymph node disease in colorectal cancer patients clinically significant? A review of the relevant literature. J. Mol. Diagn.9, 563–571 (2007).
  • Meyerhardt JA, Mayer RJ. Systemic therapy for colorectal cancer. N. Engl. J. Med.352, 476–487 (2005).
  • Ries LA, Wingo PA, Miller DS et al. The annual report to the nation on the status of cancer, 1973–1997, with a special section on colorectal cancer. Cancer88, 2398–2424 (2000).
  • Sobrero A, Kerr D, B Glimelius et al. New directions in the treatment of colorectal cancer. a look to the future. Eur. J. Cancer36, 559–566 (2000).
  • Wolpin BM, Meyerhardt JA, Mamon HJ, Mayer RJ. Adjuvant treatment of colorectal cancer. CA Cancer J. Clin.57, 168–185 (2007).
  • Allee PE, Tepper JE, Gunderson LL, Munzenrider JE. Postoperative radiation therapy for incompletely resected colorectal carcinoma. Int. J. Radiat. Oncol. Biol. Phys.17, 1171–1176 (1989).
  • Dukes CE, Bussey HJ. The spread of rectal cancer and its effect on prognosis. Br. J. Cancer12, 309–320 (1958).
  • Galandiuk S, Wieand HS, Moertel CG et al. Patterns of recurrence after curative resection of carcinoma of the colon and rectum. Surg. Gynecol. Obstet.174, 27–32 (1992).
  • Minsky BD, Mies C, Rich TA, Recht A, Chaffey JT. Potentially curative surgery of colon cancer. the influence of blood vessel invasion. J. Clin. Oncol.6, 119–127 (1988).
  • Newland RC, Chapuis PH, Pheils MT, MacPherson JG. The relationship of survival to staging and grading of colorectal carcinoma. a prospective study of 503 cases. Cancer47, 1424–1429 (1981).
  • Olson RM, Perencevich NP, Malcolm AW, Chaffey JT, Wilson RE. Patterns of recurrence following curative resection of adenocarcinoma of the colon and rectum. Cancer45, 2969–2974 (1980).
  • Phillips RK, Hittinger R, Blesovsky L, Fry JS, Fielding LP. Large bowel cancer. surgical pathology and its relationship to survival. Br. J. Surg.71, 604–610 (1984).
  • Rubio CA, Emas S, Nylander G. A critical reappraisal of Dukes’ classification. Surg. Gynecol. Obstet.145, 682–684 (1977).
  • Sinicrope FA, Sugarman SM. Role of adjuvant therapy in surgically resected colorectal carcinoma. Gastroenterology109, 984–993 (1995).
  • Willett CG, Tepper JE, Cohen AM, Orlow E, Welch CE. Failure patterns following curative resection of colonic carcinoma. Ann. Surg.200, 685–690 (1984).
  • Andre T, Boni C, L Mounedji-Boudiaf et al. Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. N. Engl. J. Med.350, 2343–2351 (2004).
  • Bilchik AJ, Hoon DS, S Saha et al. Prognostic impact of micrometastases in colon cancer. interim results of a prospective multicenter trial. Ann. Surg.246, 568–575; discussion 575–577 (2007).
  • Mamounas E, Wieand S, N Wolmark et al. Comparative efficacy of adjuvant chemotherapy in patients with Dukes’ B versus Dukes’ C colon cancer. Results from four National Surgical Adjuvant Breast and Bowel Project adjuvant studies (C-01, C-02, C-03, and C-04). J. Clin. Oncol.17, 1349–1355 (1999).
  • Quasar Collaborative Group, Gray R, Barnwell J et al. Adjuvant chemotherapy versus observation in patients with colorectal cancer. a randomised study. Lancet370, 2020–2029 (2007).
  • Iddings D, Bilchik A. The biologic significance of micrometastatic disease and sentinel lymph node technology on colorectal cancer. J. Surg. Oncol.96, 671–677 (2007).
  • Ratto C, Sofo L, Ippoliti M et al. Accurate lymph-node detection in colorectal specimens resected for cancer is of prognostic significance. Dis. Colon Rectum42, 143–154; discussion 154–158 (1999).
  • Buie WD, Rothernberger DA. Surveillance after curative resection o colorectal cancer. individualing follow-up. Gastrointest. Endosc. Clin. N. Am.3, 691–713 (1993).
  • Sloane JP. Molecules and micrometastases. Lancet345, 1255–6 (1995).
  • Greenson JK, Isenhart CE, Rice R, Mojzisik C, Houchens D, Martin EW Jr. Identification of occult micrometastases in pericolic lymph nodes of Duke’s B colorectal cancer patients using monoclonal antibodies against cytokeratin and CC49. Correlation with long-term survival. Cancer73, 563–569 (1994).
  • Liefers GJ, AM Cleton-Jansen, CJ van de Velde et al. Micrometastases and survival in stage II colorectal cancer. N. Engl. J. Med.339, 223–228 (1998).
  • Andre T, Sargent D, Tabernero J et al. Current issues in adjuvant treatment of stage II colon cancer. Ann. Surg. Oncol.13, 887–898 (2006).
  • de Gramont A, Tournigand C, Andre T, Larsen AK, Louvet C. Targeted agents for adjuvant therapy of colon cancer. Semin. Oncol.33, S42–S45 (2006).
  • de Gramont A, Tournigand C, Andre T, Larsen AK, Louvet C. Adjuvant therapy for stage II and III colorectal cancer. Semin. Oncol.34, S37–S40 (2007).
  • Fuchs CS, Mayer RJ. Adjuvant chemotherapy for colon and rectal cancer. Semin. Oncol.22, 472–487 (1995).
  • Krook JE, Moertel CG, Gunderson LL et al. Effective surgical adjuvant therapy for high-risk rectal carcinoma. N. Engl. J. Med.324, 709–715 (1991).
  • Moertel CG, Fleming TR, Macdonald JS et al. Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma. N. Engl. J. Med.322, 352–358 (1990).
  • Wolmark N, Rockette H, B Fisher et al. The benefit of leucovorin-modulated fluorouracil as postoperative adjuvant therapy for primary colon cancer. results from National Surgical Adjuvant Breast and Bowel Project protocol C-03. J. Clin. Oncol.11, 1879–1887 (1993).
  • Kopetz S, Chang GJ, Overman MJ et al. Improved survival in metastatic colorectal cancer is associated with adoption of hepatic resection and improved chemotherapy. J. Clin. Oncol.27(22), 3677–3683 (2009).
  • Benson AB, 3rd, Schrag D, Somerfield MR et al. American Society of Clinical Oncology recommendations on adjuvant chemotherapy for stage II colon cancer. J. Clin. Oncol.22, 3408–3419 (2004).
  • Figueredo A, Charette ML, Maroun J, Brouwers MC, Zuraw L. Adjuvant therapy for stage II colon cancer. a systematic review from the Cancer Care Ontario Program in evidence-based care’s gastrointestinal cancer disease site group. J. Clin. Oncol.22, 3395–3407 (2004).
  • Winn R, McClure J. The NCCN clinical practice guidelines in oncology. J. Natl Compr. Canc. Netw.1, 9 (2005).
  • Frick GS, Pitari GM, Weinberg DS, Hyslop T, Schulz S, Waldman SA. Guanylyl cyclase C: a molecular marker for staging and postoperative surveillance of patients with colorectal cancer. Expert Rev. Mol. Diagn.5, 701–713 (2005).
  • Gelmann A, Desnoyers R, Cagir B, Weinberg D, Boman BM, Waldman SA. Colorectal cancer staging and adjuvant chemotherapy. Expert Opin. Pharmacother.1, 737–755 (2000).
  • Waldman SA, Hyslop T, S Schulz et al. Association of GUCY2C expression in lymph nodes with time to recurrence and disease-free survival in pN0 colorectal cancer. JAMA301, 745–752 (2009).
  • Cagir B, Gelmann A, J Park et al. Guanylyl cyclase C messenger RNA is a biomarker for recurrent stage II colorectal cancer. Ann. Intern. Med.131, 805–812 (1999).
  • Almenoff JS, Williams SI, Scheving LA, Judd AK, Schoolnik GK. Ligand-based histochemical localization and capture of cells expressing heat-stable enterotoxin receptors. Mol. Microbiol.8, 865–873 (1993).
  • Carrithers SL, Barber MT, Biswas S et al. Guanylyl cyclase C is a selective marker for metastatic colorectal tumors in human extraintestinal tissues. Proc. Natl Acad. Sci. USA93, 14827–14832 (1996).
  • Carrithers SL, Parkinson SJ, Goldstein S, Park P, Robertson DC, Waldman SA. Escherichia coli heat-stable toxin receptors in human colonic tumors. Gastroenterology107, 1653–1661 (1994).
  • Cohen MB, Guarino A, Shukla R, Giannella RA. Age-related differences in receptors for Escherichia coli heat-stable enterotoxin in the small and large intestine of children. Gastroenterology94, 367–373 (1988).
  • Cohen MB, Moyer MS, Luttrell M, Giannella RA. The immature rat small intestine exhibits an increased sensitivity and response to Escherichia coli heat-stable enterotoxin. Pediatr. Res.20, 555–560 (1986).
  • Guarino A, Cohen M, Thompson M, Dharmsathaphorn K, Giannella R. T84 cell receptor binding and guanyl cyclase activation by Escherichia coli heat-stable toxin. Am. J. Physiol.253, G775–G780 (1987).
  • Guarino A, Cohen MB, Giannella RA. Small and large intestinal guanylate cyclase activity in children. effect of age and stimulation by Escherichia coli heat-stable enterotoxin. Pediatr. Res.21, 551–555 (1987).
  • Guarino A, Cohen MB, Overmann G, Thompson MR, Giannella RA. Binding of E. coli heat-stable enterotoxin to rat intestinal brush borders and to basolateral membranes. Dig. Dis. Sci.32, 1017–1026 (1987).
  • Lucas KA, Pitari GM, Kazerounian S et al. Guanylyl cyclases and signaling by cyclic GMP. Pharmacol. Rev.52, 375–414 (2000).
  • Rao MC, Guandalini S, Smith PL, Field M. Mode of action of heat-stable Escherichia coli enterotoxin. Tissue and subcellular specificities and role of cyclic GMP. Biochim. Biophys. Acta632, 35–46 (1980).
  • Carrithers SL, Ott CE, Hill MJ et al. Guanylin and uroguanylin induce natriuresis in mice lacking guanylyl cyclase-C receptor. Kidney Int.65, 40–53 (2004).
  • Field M. Mechanisms of action of cholera and Escherichia coli enterotoxins. Am. J. Clin. Nutr.32, 189–196 (1979).
  • Field M, Graf LH Jr, Laird WJ, Smith PL. Heat-stable enterotoxin of Escherichia coli.in vitro effects on guanylate cyclase activity, cyclic GMP concentration, and ion transport in small intestine. Proc. Natl Acad. Sci. USA75, 2800–2804 (1978).
  • Guerrant RL, Hughes JM, Chang B, Robertson DC, Murad F. Activation of intestinal guanylate cyclase by heat-stable enterotoxin of Escherichia coli. Studies of tissue specificity, potential receptors, and intermediates. J. Infect. Dis.142, 220–228 (1980).
  • Hughes JM, Murad F, Chang B, Guerrant RL. Role of cyclic GMP in the action of heat-stable enterotoxin of Escherichia coli.Nature271, 755–756 (1978).
  • Kuno T, Kamisaki Y, Waldman SA, Gariepy J, Schoolnik G, Murad F. Characterization of the receptor for heat-stable enterotoxin from Escherichia coli in rat intestine. J. Biol. Chem.261, 1470–1476 (1986).
  • Schulz S, Green CK, Yuen PS, Garbers DL. Guanylyl cyclase is a heat-stable enterotoxin receptor. Cell63, 941–948 (1990).
  • Li P, Lin JE, Chervoneva I, Schulz S, Waldman SA, Pitari GM. Homeostatic control of the crypt-villus axis by the bacterial enterotoxin receptor guanylyl cyclase C restricts the proliferating compartment in intestine. Am. J. Pathol.171, 1847–1858 (2007).
  • Li P, Lin JE, Snook AE et al. Colorectal cancer as a paracrine deficiency syndrome amenable to oral hormone replacement therapy. Clin. Trans. Sci.1, 163–167 (2008).
  • Li P, Lin JE, Snook AE, Schulz S, Pitari GM, Waldman SA. Colorectal cancer is a paracrine deficiency syndrome which can be prevented and treated by oral hormone replacement therapy. Curr. Mol. Pharm.1(2), 163–167. (2008).
  • Li P, Schulz S, A Bombonati et al. Guanylyl cyclase C suppresses intestinal tumorigenesis by restricting proliferation and maintaining genomic integrity. Gastroenterology133, 599–607 (2007).
  • Lin EJ, Li P, Snook AE, Schulz S, Pitari GM, Waldman SA. Guanylyl cyclase C in colorectal cancer. susceptibility gene and potential therapeutic target. Future Oncol.5(4), 509–522 (2009).
  • Lin JE, Li P, Snook AE et al. GUCY2C establishes lineage dependence in intestinal tumorigenesis through AKT. Gastroenterology (2009) (In press).
  • Pitari GM, Baksh RI, Harris DM, Li P, Kazerounian S, Waldman SA. Interruption of homologous desensitization in cyclic guanosine 3´,5´-monophosphate signaling restores colon cancer cytostasis by bacterial enterotoxins. Cancer Res.65, 11129–11135 (2005).
  • Pitari GM, MD Di Guglielmo, Park J, Schulz S, Waldman SA. Guanylyl cyclase C agonists regulate progression through the cell cycle of human colon carcinoma cells. Proc. Natl Acad. Sci. USA98, 7846–7851 (2001).
  • Pitari GM, Li P, Lin JE et al. The paracrine hormone hypothesis of colorectal cancer. Clin. Pharmacol. Ther.82, 441–447 (2007).
  • Pitari GM, Lin JE, Shah FJ et al. Enterotoxin preconditioning restores calcium-sensing receptor-mediated cytostasis in colon cancer cells. Carcinogenesis29, 1601–1607 (2008).
  • Pitari GM, Zingman LV, Hodgson DM et al. Bacterial enterotoxins are associated with resistance to colon cancer. Proc. Natl Acad. Sci. USA100, 2695–2699 (2003).
  • Shailubhai K, Yu HH, Karunanandaa K et al. Uroguanylin treatment suppresses polyp formation in the Apc(Min/+) mouse and induces apoptosis in human colon adenocarcinoma cells via cyclic GMP. Cancer Res.60, 5151–5157 (2000).
  • Steinbrecher KA, Wowk SA, Rudolph JA, Witte DP, Cohen MB. Targeted inactivation of the mouse guanylin gene results in altered dynamics of colonic epithelial proliferation. Am. J. Pathol.161, 2169–2178 (2002).
  • Birkenkamp-Demtroder K, Christensen LL, Harder Olesen S et al. Gene expression in colorectal cancer. Cancer Res.62, 4352–4363 (2002).
  • Cohen MB, Hawkins JA, Witte DP. Guanylin mRNA expression in human intestine and colorectal adenocarcinoma. Lab. Invest.78, 101–108 (1998).
  • Notterman DA, Alon U, Sierk AJ, Levine AJ. Transcriptional gene expression profiles of colorectal adenoma, adenocarcinoma, and normal tissue examined by oligonucleotide arrays. Cancer Res.61, 3124–3130 (2001).
  • Steinbrecher KA, Tuohy TM, Heppner Goss K et al. Expression of guanylin is downregulated in mouse and human intestinal adenomas. Biochem. Biophys. Res. Commun.273, 225–230 (2000).
  • Wilson C, Schulz S, Hyslop, Waldman SA, Silencing of guanylin and uroguanylin expression in colon cancer. (2009) (In press).
  • Birbe R, Palazzo JP, Walters R, Weinberg D, Schulz S, Waldman SA. Guanylyl cyclase C is a marker of intestinal metaplasia, dysplasia, and adenocarcinoma of the gastrointestinal tract. Hum. Pathol.36, 170–179 (2005).
  • Fava TA, Desnoyers R, S Schulz et al. Ectopic expression of guanylyl cyclase C in CD34+ progenitor cells in peripheral blood. J. Clin. Oncol.19, 3951–3959 (2001).
  • Waldman SA, Barber M, Pearlman J, Park J, George R, Parkinson SJ. Heterogeneity of guanylyl cyclase C expressed by human colorectal cancer cell lines in vitro.Cancer Epidemiol. Biomarkers Prev.7, 505–514 (1998).
  • Waldman SA, Cagir B, J Rakinic et al. Use of guanylyl cyclase C for detecting micrometastases in lymph nodes of patients with colon cancer. Dis. Colon Rectum41, 310–315 (1998).
  • Schulz S, Hyslop T, Haaf J et al. A validated quantitative assay to detect occult micrometastases by reverse transcriptase-polymerase chain reaction of guanylyl cyclase C in patients with colorectal cancer. Clin. Cancer Res.12, 4545–4552 (2006).
  • Witek ME, Nielsen K, R Walters et al. The putative tumor suppressor Cdx2 is overexpressed by human colorectal adenocarcinomas. Clin. Cancer Res.11, 8549–8556 (2005).
  • Phillips B, Ball C, D Sackett et al.Levels of Evidence. Oxford Centre for Evidence-Based Medicine, Oxford, UK (2009).
  • Chervoneva I, Li Y, Iglewicz B, Waldman S, Hyslop T. Relative quantification based on logistic models for individual polymerase chain reactions. Stat. Med.26, 5596–5611 (2007).
  • Moertel CG, O’Fallon JR, Go VL, O’Connell MJ, Thynne GS. The preoperative carcinoembryonic antigen test in the diagnosis, staging, and prognosis of colorectal cancer. Cancer58, 603–610 (1986).
  • Punt CJ, Buyse M, Kohne CH et al. Endpoints in adjuvant treatment trials. A systematic review of the literature in colon cancer and proposed definitions for future trials. J. Natl Cancer Inst.99, 998–1003 (2007).
  • Le Voyer TE, Sigurdson ER, Hanlon AL et al. Colon cancer survival is associated with increasing number of lymph nodes analyzed. a secondary survey of intergroup trial INT-0089. J. Clin. Oncol.21, 2912–2919 (2003).
  • Swanson RS, Compton CC, Stewart AK, Bland KI. The prognosis of T3N0 colon cancer is dependent on the number of lymph nodes examined. Ann. Surg. Oncol.10, 65–71 (2003).
  • Brown HG, Luckasevic TM, Medich DS, Celebrezze JP, Jones SM. Efficacy of manual dissection of lymph nodes in colon cancer resections. Mod. Pathol.17, 402–406 (2004).
  • Herrera-Ornelas L, Justiniano J, Castillo N, Petrelli NJ, Stulc JP, Mittelman A. Metastases in small lymph nodes from colon cancer. Arch. Surg.122, 1253–1256 (1987).
  • Hitchcock CL, Sampsel J, Young DC, Martin EW Jr, Arnold MW. Limitations with light microscopy in the detection of colorectal cancer cells. Dis. Colon Rectum42, 1046–1052 (1999).
  • Nolan T, Hands RE, Bustin SA. Quantification of mRNA using real-time RT-PCR. Nat. Protoc.1, 1559–1582 (2006).
  • Abati A, Liotta LA. Looking forward in diagnostic pathology. the molecular superhighway. Cancer78, 1–3 (1996).
  • Krishna R, Herman G, Wagner JA. Accelerating drug development using biomarkers. a case study with sitagliptin, a novel DPP4 inhibitor for Type 2 diabetes. AAPS J.10, 401–409 (2008).
  • Lee JW, Devanarayan V, Barrett YC et al. Fit-for-purpose method development and validation for successful biomarker measurement. Pharm. Res.23, 312–328 (2006).
  • Lee JW, Weiner RS, Sailstad JM et al. Method validation and measurement of biomarkers in nonclinical and clinical samples in drug development. a conference report. Pharm. Res.22, 499–511 (2005).
  • Wagner JA. Overview of biomarkers and surrogate endpoints in drug development. Dis. Markers18, 41–46 (2002).
  • Wagner JA. Back to the future. Driving innovation in drug development. Clin. Pharmacol. Ther.83, 199–202 (2008).
  • Wagner JA. Strategic approach to fit-for-purpose biomarkers in drug development. Ann. Rev. Pharmacol. Toxicol.48, 631–651 (2008).
  • Wagner JA, Williams SA, Webster CJ. Biomarkers and surrogate end points for fit-for-purpose development and regulatory evaluation of new drugs. Clin. Pharmacol. Ther.81, 104–107 (2007).
  • Williams SA, Slavin DE, Wagner JA, Webster CJ. A cost–effectiveness approach to the qualification and acceptance of biomarkers. Nat. Rev. Drug Discov.5, 897–902 (2006).

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