Mammalian cell transcriptome in response to meningitis-causing pathogens

References

• van de Beek D, de Gans J, Tunkel AR, Wijdicks EF. Community-acquired bacterial meningitis in adults. N. Engl. J. Med.354, 44–53 (2006).
   PubMed Web of Science ®Google Scholar
• Schuchat A, Robinson K, Wenger JD et al. Bacterial meningitis in the United States in 1995. Active Surveillance Team. N. Engl. J. Med.337, 970–976 (1997).
   PubMed Web of Science ®Google Scholar
• Grimwood K, Anderson VA, Bond L et al. Adverse outcomes of bacterial meningitis in school-age survivors. Pediatrics95, 646–656 (1995).
   PubMed Web of Science ®Google Scholar
• Grimwood K, Anderson P, Anderson V, Tan L, Nolan T. Twelve year outcomes following bacterial meningitis, further evidence for persisting effects. Arch. Dis. Child83, 111–116 (2000).
   PubMed Web of Science ®Google Scholar
• Bedford H, de Louvois J, Halket S et al. Meningitis in infancy in England and Wales, follow up at age 5 years. BMJ323, 533–536 (2001).
   PubMed Web of Science ®Google Scholar
• Merkelbach S, Sittinger H, Schweizer I, Muller M. Cognitive outcome after bacterial meningitis. Acta Neurol. Scand.102, 118–123 (2000).
   PubMedGoogle Scholar
• Stuertz K, Schmidt H, Trostdorf F et al. Lower lipoteichoic and teichoic acid CSF concentrations during treatment of pneumococcal meningitis with non-bacteriolytic antibiotics than with ceftriaxone. Scand. J. Infect. Dis.31, 367–370 (1999).
   PubMed Web of Science ®Google Scholar
• Roos KL. Infecions of the Central Nervous System. Scheld WM (Ed.). Lippincott-Raven, PA, USA, 335–402 (1997).
   Google Scholar
• Polfliet MM, Zwijnenburg PJ, van Furth AM et al. Meningeal and perivascular macrophages of the central nervous system play a protective role during bacterial meningitis. J. Immunol.167, 4644–4650 (2001).
   PubMedGoogle Scholar
• Sharief MK, Ciardi M, Thompson EJ. Blood–brain barrier damage in patients with bacterial meningitis, association with tumor necrosis factor-α but not interleukin-1 β. J. Infect. Dis.166, 350–358 (1992).
   PubMed Web of Science ®Google Scholar
• Bjerre A, Brusletto B, Ovstebo R et al. Identification of meningococcal LPS as a major monocyte activator in IL-10 depleted shock plasmas and CSF by blocking the CD14-TLR4 receptor complex. J. Endotoxin Res.9, 155–163 (2003).
   PubMed Web of Science ®Google Scholar
• Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell124, 783–801 (2006).
   PubMed Web of Science ®Google Scholar
• Akira S, Takeda K. Toll-like receptor signalling. Nat. Rev. Immunol.4, 499–511 (2004).
   PubMed Web of Science ®Google Scholar
• Mogensen TH, Paludan SR, Kilian M, Ostergaard L. Live Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis activate the inflammatory response through Toll-like receptors 2, 4, and 9 in species-specific patterns. J. Leukoc. Biol.80, 267–277 (2006).
   PubMed Web of Science ®Google Scholar
• Yoshimura A, Lien E, Ingalls RR et al. Cutting edge, recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2. J. Immunol.163, 1–5 (1999).
   PubMed Web of Science ®Google Scholar
• Dessing MC, Schouten M, Draing C et al. Role played by Toll-like receptors 2 and 4 in lipoteichoic acid-induced lung inflammation and coagulation. J. Infect. Dis.197, 245–252 (2008).
   PubMedGoogle Scholar
• Schroder NW, Morath S, Alexander C et al. Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved. J. Biol. Chem.278, 15587–15594 (2003).
   PubMed Web of Science ®Google Scholar
• Zhu H, Cong JP, Mamtora G, Gingeras T, Shenk T. Cellular gene expression altered by human cytomegalovirus, global monitoring with oligonucleotide arrays. Proc. Natl Acad. Sci. USA95, 14470–14475 (1998).
   PubMed Web of Science ®Google Scholar
• Jenner RG, Young RA. Insights into host responses against pathogens from transcriptional profiling. Nat. Rev. Microbiol.3, 281–294 (2005).
   PubMed Web of Science ®Google Scholar
• Boldrick JC, Alizadeh AA, Diehn M et al. Stereotyped and specific gene expression programs in human innate immune responses to bacteria. Proc. Natl Acad. Sci. USA99, 972–977 (2002).
   PubMed Web of Science ®Google Scholar
• Bryant PA, Venter D, Robins-Browne R, Curtis N. Chips with everything, DNA microarrays in infectious diseases. Lancet Infect. Dis.4, 100–111 (2004).
   PubMed Web of Science ®Google Scholar
• Wells DB, Tighe PJ, Wooldridge KG, Robinson K, Ala’ Aldeen DA. Differential gene expression during meningeal-meningococcal interaction, evidence for self-defense and early release of cytokines and chemokines. Infect. Immun.69, 2718–2722 (2001).
   PubMed Web of Science ®Google Scholar
• Binnicker MJ, Williams RD, Apicella MA. Infection of human urethral epithelium with Neisseria gonorrhoeae elicits an upregulation of host anti-apoptotic factors and protects cells from staurosporine-induced apoptosis. Cell. Microbiol.5, 549–560 (2003).
   PubMedGoogle Scholar
• Schubert-Unkmeir A, Sokolova O, Panzner U, Eigenthaler M, Frosch M. Gene expression pattern in human brain endothelial cells in response to Neisseria meningitidis. Infect. Immun.75, 899–914 (2007).
   PubMed Web of Science ®Google Scholar
• Coimbra RS, Voisin V, de Saizieu AB et al. Gene expression in cortex and hippocampus during acute pneumococcal meningitis. BMC Biol.4, 15 (2006).
   PubMedGoogle Scholar
• Plant L, Asp V, Lovkvist L, Sundqvist J, Jonsson AB. Epithelial cell responses induced upon adherence of pathogenic Neisseria. Cell. Microbiol.6, 663–670 (2004).
   PubMed Web of Science ®Google Scholar
• Bootsma HJ, Egmont-Petersen M, Hermans PW. Analysis of the in vitro transcriptional response of human pharyngeal epithelial cells to adherent Streptococcus pneumoniae, evidence for a distinct response to encapsulated strains. Infect. Immun.75, 5489–5499 (2007).
   PubMedGoogle Scholar
• Jarvis GA. Recognition and control of neisserial infection by antibody and complement. Trends Microbiol.3, 198–201 (1995).
   PubMedGoogle Scholar
• Hammerschmidt S, Birkholz C, Zahringer U et al. Contribution of genes from the capsule gene complex (cps) to lipooligosaccharide biosynthesis and serum resistance in Neisseria meningitidis. Mol. Microbiol.11, 885–896 (1994).
   PubMed Web of Science ®Google Scholar
• Winkelstein JA. Complement and the host’s defense against the pneumococcus. Crit. Rev. Microbiol.11, 187–208 (1984).
   PubMed Web of Science ®Google Scholar
• Brown EJ. Interaction of Gram-positive microorganisms with complement. Curr. Top. Microbiol. Immunol.121, 159–187 (1985).
   PubMed Web of Science ®Google Scholar
• Virji M, Kayhty H, Ferguson DJ et al. The role of pili in the interactions of pathogenic Neisseria with cultured human endothelial cells. Mol. Microbiol.5, 1831–1841 (1991).
   PubMedGoogle Scholar
• Nassif X, Beretti JL, Lowy J et al. Roles of pilin and PilC in adhesion of Neisseria meningitidis to human epithelial and endothelial cells. Proc. Natl Acad. Sci. USA91, 3769–3773 (1994).
   PubMed Web of Science ®Google Scholar
• Linhartova I, Basler M, Ichikawa J et al. Meningococcal adhesion suppresses proapoptotic gene expression and promotes expression of genes supporting early embryonic and cytoprotective signaling of human endothelial cells. FEMS Microbiol. Lett.263, 109–118 (2006).
   PubMed Web of Science ®Google Scholar
• Robinson K, Taraktsoglou M, Rowe KS, Wooldridge KG, Ala’Aldeen DA. Secreted proteins from Neisseria meningitidis mediate differential human gene expression and immune activation. Cell. Microbiol.6, 927–938 (2004).
   PubMed Web of Science ®Google Scholar
• Bonnah RA, Muckenthaler MU, Carlson H et al. Expression of epithelial cell iron-related genes upon infection by Neisseria meningitidis. Cell. Microbiol.6, 473–484 (2004).
   PubMed Web of Science ®Google Scholar
• Zhang H, Su YA, Hu P et al. Signature patterns revealed by microarray analyses of mice infected with influenza virus A and Streptococcus pneumoniae. Microbes Infect.8, 2172–2185 (2006).
   PubMedGoogle Scholar
• Pathan N, Hemingway CA, Alizadeh AA et al. Role of interleukin 6 in myocardial dysfunction of meningococcal septic shock. Lancet363, 203–209 (2004).
   PubMed Web of Science ®Google Scholar
• Zhao B, Bowden RA, Stavchansky SA, Bowman PD. Human endothelial cell response to Gram-negative lipopolysaccharide assessed with cDNA microarrays. Am. J. Physiol. Cell. Physiol.281, C1587–C1595 (2001).
   PubMedGoogle Scholar
• Kullander K, Klein R. Mechanisms and functions of Eph and ephrin signalling. Nat. Rev. Mol. Cell Biol.3, 475–486 (2002).
   PubMed Web of Science ®Google Scholar
• Himanen JP, Nikolov DB. Eph receptors and ephrins. Int. J. Biochem. Cell. Biol.35, 130–134 (2003).
   PubMedGoogle Scholar
• Walker L, Lynch M, Silverman S et al. The notch/jagged pathway inhibits proliferation of human hematopoietic progenitors in vitro. Stem Cells17, 162–171 (1999).
   PubMed Web of Science ®Google Scholar
• Clarke DC, Liu X. Decoding the quantitative nature of TGF-β/Smad signaling. Trends Cell. Biol.18, 430–442 (2008).
   PubMed Web of Science ®Google Scholar
• Silkstone D, Hong H, Alman BA. β-catenin in the race to fracture repair, in it to Wnt. Nat. Clin. Pract. Rheumatol.4, 413–419 (2008).
   PubMedGoogle Scholar
• Mercier JC, Beaufils F, Hartmann JF, Azema D. Hemodynamic patterns of meningococcal shock in children. Crit. Care. Med.16, 27–33 (1988).
   PubMed Web of Science ®Google Scholar
• Klein NJ, Ison CA, Peakman M et al. The influence of capsulation and lipooligosaccharide structure on neutrophil adhesion molecule expression and endothelial injury by Neisseria meningitidis. J. Infect. Dis.173, 172–179 (1996).
   PubMedGoogle Scholar
• de Kleijn ED, Hazelzet JA, Kornelisse RF, de Groot R. Pathophysiology of meningococcal sepsis in children. Eur. J. Pediatr.157, 869–880 (1998).
   PubMedGoogle Scholar
• Holland PC, Thompson D, Hancock S, Hodge D. Calciphylaxis, proteases, and purpura, an alternative hypothesis for the severe shock, rash, and hypocalcemia associated with meningococcal septicemia. Crit. Care Med.30, 2757–2761 (2002).
   PubMed Web of Science ®Google Scholar
• Hoffmann I, Eugene E, Nassif X, Couraud PO, Bourdoulous S. Activation of ErbB2 receptor tyrosine kinase supports invasion of endothelial cells by Neisseria meningitidis. J. Cell. Biol.155, 133–143 (2001).
   PubMedGoogle Scholar
• Unkmeir A, Latsch K, Dietrich G et al. Fibronectin mediates Opc-dependent internalization of Neisseria meningitidis in human brain microvascular endothelial cells. Mol. Microbiol.46, 933–946 (2002).
   PubMed Web of Science ®Google Scholar
• Sokolova O, Heppel N, Jagerhuber R et al. Interaction of Neisseria meningitidis with human brain microvascular endothelial cells, role of MAP- and tyrosine kinases in invasion and inflammatory cytokine release. Cell. Microbiol.6, 1153–1166 (2004).
   PubMedGoogle Scholar
• Merz AJ, So M. Interactions of pathogenic Neisseriae with epithelial cell membranes. Ann. Rev. Cell Dev. Biol.16, 423–457 (2000).
   PubMed Web of Science ®Google Scholar
• Rohde KH, Dyer DW. Mechanisms of iron acquisition by the human pathogens Neisseria meningitidis and Neisseria gonorrhoeae. Front Biosci.8, D1186–D1218 (2003).
   Google Scholar
• Jack RS, Fan X, Bernheiden M et al. Lipopolysaccharide-binding protein is required to combat a murine Gram-negative bacterial infection. Nature389, 742–745 (1997).
   PubMed Web of Science ®Google Scholar
• Cannon JG, Tompkins RG, Gelfand JA et al. Circulating interleukin-1 and tumor necrosis factor in septic shock and experimental endotoxin fever. J. Infect. Dis.161, 79–84 (1990).
   PubMed Web of Science ®Google Scholar
• N ’Guessan PD, Schmeck B, Ayim A et al. Streptococcus pneumoniae R6x induced p38 MAPK and JNK-mediated caspase-dependent apoptosis in human endothelial cells. Thromb. Haemost.94, 295–303 (2005).
   PubMedGoogle Scholar
• N ’Guessan PD, Hippenstiel S, Etouem MO et al. Streptococcus pneumoniae induced p38 MAPK- and NF-κB-dependent COX-2 expression in human lung epithelium. Am. J. Physiol. Lung Cell. Mol. Physiol.290, L1131–L1138 (2006).
   Google Scholar
• Tettelin H, Saunders NJ, Heidelberg J et al. Complete genome sequence of Neisseria meningitidis serogroup B strain MC58. Science287, 1809–1815 (2000).
   PubMed Web of Science ®Google Scholar
• McGuinness BT, Clarke IN, Lambden PR et al. Point mutation in meningococcal por A gene associated with increased endemic disease. Lancet337, 514–517 (1991).
   PubMed Web of Science ®Google Scholar
• Tettelin H, Nelson KE, Paulsen IT et al. Complete genome sequence of a virulent isolate of Streptococcus pneumoniae. Science293, 498–506 (2001).
   PubMed Web of Science ®Google Scholar
• Dopazo J, Mendoza A, Herrero J et al. Annotated draft genomic sequence from a Streptococcus pneumoniae type 19F clinical isolate. Microb. Drug Resist.7, 99–125 (2001).
   PubMedGoogle Scholar
• Rogers PD, Thornton J, Barker KS et al. Pneumolysin-dependent and -independent gene expression identified by cDNA microarray analysis of THP-1 human mononuclear cells stimulated by Streptococcus pneumoniae. Infect. Immun.71, 2087–2094 (2003).
   PubMedGoogle Scholar
• Li-Korotky HS, Swarts JD, Hebda PA, Doyle WJ. Cathepsin gene expression profile in rat acute pneumococcal otitis media. Laryngoscope114, 1032–1036 (2004).
   PubMedGoogle Scholar