Neurodegeneration in schizophrenia

References

• Bullmore ET, O’Connell P, Frangou S, Murray RM. Schizophrenia as a developmental disorder of neural network integrity: the dysplastic net hypothesis. In: Neurodevelopment and Adult Psychopathology. Keshaven MS, Murray RM (Eds). Cambridge University Press, Cambridge, UK 253–266 (1997).
   Google Scholar
• Sawa A, Snyder SH. Schizophrenia: diverse approaches to a complex disease. Science296, 692–695 (2002).
   PubMed Web of Science ®Google Scholar
• Rapaport MH, Delrahim KK, Bresee CJ, Maddux RE, Ahmadpour O, Dolnak D. Celecoxib augmentation of continuously ill patients with schizophrenia. Biol. Psychiatry57, 1594–1596 (2005).
   PubMed Web of Science ®Google Scholar
• Cannon M, Caspi A, Moffitt TE. Evidence for early, specific, pan-development impairment in schizophreniform disorder: results from a longitudinal birth cohort. Arch. Gen. Psychiatr.59, 449–456 (2002).
   PubMed Web of Science ®Google Scholar
• Cannon M, Murray RM, Jones P. Obstetric complications and schizophrenia: past, present and future. Am. J. Psychiatry159, 1080–1092 (2002).
   PubMed Web of Science ®Google Scholar
• Geddes JR, Verdoux H, Takei N. Schizophrenia and complications of pregnancy and labour: an individual patient data meta-analysis. Schizophr. Bull.25, 413–423 (1999).
   PubMed Web of Science ®Google Scholar
• Levinson DF, Mowry BJ. Genetics of schizophrenia. In: Genetic Influences on Neural and Behavioral Functions. Pfaff DW, Berrettini WH, Joh TH, Maxson SC (Eds). CRC Press, FL, USA, 47–82 (2000).
   Google Scholar
• Lipska BK, Weinberger DR. A neurodevelopmental model of schizophrenia: neonatal disconnection of the hippocampus. Neurotoxicity Res.4, 469–475 (2002).
   PubMed Web of Science ®Google Scholar
• Bachevalier J, Alvarado MC, Malkova L. Memory and socioemotional behavior in monkeys after hippocampal damage incurred in infancy or in adulthood. Biol. Psychiatry46, 329–339 (1999).
   PubMed Web of Science ®Google Scholar
• Decker MJ, Rye DB. Neonatal intermittent hypoxia impairs dopamine signaling and executive functioning. Sleep Breath.6, 205–207 (2002).
   PubMedGoogle Scholar
• Heijman BT, Tobi EW, Stein AD et al. Persistent epigenetic differences associated with prenatal exposure to famine in humans. Proc. Natl Acad. Sci. USA105, 17046–17049 (2008).
   PubMed Web of Science ®Google Scholar
• Hulshoff Pol HE, Hoek HW, Susser E et al. Prenatal exposure to famine and brain morphology in schizophrenia. Am. J. Psychiatry157, 1170–1172 (2000).
   PubMed Web of Science ®Google Scholar
• Sperner-Unterweger B. Immunological aetiology of major psychiatric disorders: evidence and therapeutic implications. Drugs65, 1493–1520 (2005).
   PubMed Web of Science ®Google Scholar
• St Clair D, Xu M, Wang P et al. Rates of adult schizophrenia following prenatal exposure to the Chinese famine of 1959–1961. JAMA294, 557–562 (2005).
   PubMed Web of Science ®Google Scholar
• Susser ES, Lin SP. Schizophrenia after prenatal exposure to the Dutch Hunger Winter of 1944–1945. Arch. Gen. Psychiatry49, 983–988 (1992).
   PubMed Web of Science ®Google Scholar
• Arnold SE. Cellular and molecular neuropathology of the parahippocampal region in schizophrenia. Ann. NY Acad. Sci.911, 275–292 (2000).
   PubMed Web of Science ®Google Scholar
• Gold JM, Weinberger DR. Cognitive deficits and the neurobiology of schizophrenia. Curr. Opin. Neurobiol.5, 225–230 (1995).
   PubMed Web of Science ®Google Scholar
• Kalus P, Slotboom J, Gallinat J et al. New evidence for involvement of the entorhinal region in schizophrenia: a combined MRI volumetric and DTI study. Neuroimage24, 1122–1129 (2005).
   PubMed Web of Science ®Google Scholar
• Le Pen G, Gourevitch R, Hazane F, Hoareau C, Jay TM, Krebs MO. Peripubertal maturation after developmental disturbance: a model for psychosis onset in the rat. Neuroscience143, 395–405 (2006).
   PubMed Web of Science ®Google Scholar
• Abi-Dargham A, Gil R, Krystal J. Increased striatal dopamine transmission in schizophrenia: confirmation in a second cohort. Am. J. Psychiatry155, 761–767 (1998).
   PubMed Web of Science ®Google Scholar
• Talamini LM, Koch T, Luiten PGM, Koolhaas JM, Korf J. Interruptions of early cortical development affect limbic association areas and social behavior in rats: possible relevance for neurodevelopmental disorders. Brain Res.847, 105–120 (1999).
   PubMed Web of Science ®Google Scholar
• Weinberger DR. Neurodevelopmental perspectives on schizophrenia. In: Psychopharmacology: The Fourth Generation of Progress. Bloom FE, Kupfer DJ (Eds). Raven Press, NY, USA 1171–1183 (1995).
   Google Scholar
• Moghaddam B. Targeting metabotropic glutamate receptors for treatment of the cognitive symptoms of schizophrenia. Psychopharmacology174, 39–44 (2004).
   PubMed Web of Science ®Google Scholar
• Olney JW, Farber NB. Glutamate receptor dysfunction and schizophrenia. Arch. Gen. Psychiatry52, 998–1007 (1995).
   PubMed Web of Science ®Google Scholar
• Tamminga C. Glutamatergic aspects of schizophrenia. Br. J. PsychiatrySuppl.37, 12–15 (1999).
   Google Scholar
• Forbes NF, Carrick LA, McIntosh AM, Lawrie SM. Working memory in schizophrenia: a meta-analysis. Psychol. Med.23, 1–17 (2008).
   Google Scholar
• Karilampi U, Helldin L, Hjärthag F, Norlander T, Archer T. Verbal learning in schizopsychotic outpatients and healthy volunteers as a function of cognitive performance. Arch. Clin. Neuropsychol.22, 161–174 (2007).
   PubMed Web of Science ®Google Scholar
• Owashi T, Iwanami A, Nakagome K, Higuchi T, Kamijima K. Thought disorder and executive dysfunction in patients with schizophrenia. Int. J. Neurosci.119, 105–123 (2009)
   PubMed Web of Science ®Google Scholar
• Segarra N, Bernardo M, Valdes M et al. Cerebellar deficits in schizophrenia are associated with executive dysfunction. Neuroreport19, 1513–1517 (2008).
   PubMed Web of Science ®Google Scholar
• Lewis DA, Moghaddam B. Cognitive dysfunction in schizophrenia: convergence of g-aminobutyric acid and glutamate alterations. Arch. Neurol.63, 1372–1376 (2006).
   PubMed Web of Science ®Google Scholar
• Abi-Saab WM, D’Souza DC, Moghaddam B, Krystal JH. The NMDA antagonist model for schizophrenia: promise and pitfalls. Pharmacopsychiatry31(Suppl. 2), 104–109 (1998).
   PubMed Web of Science ®Google Scholar
• Krystal JH, Anand A, Moghaddam B. Effects of NMDA receptor antagonists: implications for the pathophysiology of schizophrenia. Arch. Gen. Psychiatry59, 663–664 (2002).
   PubMed Web of Science ®Google Scholar
• Stefani MR, Moghaddam B. Distinct contributions of glutamate receptor subtypes to cognitive set-shifting abilities in the rat. Ann. NY Acad. Sci.1003, 464–467 (2003).
   PubMed Web of Science ®Google Scholar
• Kobori N, Dash PK. Reversal of brain injury-induced prefrontal glutamic acid decarboxylase expression and working memory deficts by D1 antagonism. J. Neurosci.26, 4236–4246 (2006).
   PubMed Web of Science ®Google Scholar
• Williams GV, Castner SA. Under the curve: critical issues for elucidating D1 receptor function in working memory. Neuroscience139, 263–276 (2006).
   PubMed Web of Science ®Google Scholar
• Dikranian K, Ishimaru MJ, Tenkova T et al. Apoptosis in the in vivo mammalian forebrain. Neurobiol. Dis.8, 359–379 (2001).
   PubMed Web of Science ®Google Scholar
• Ishimaru MJ, Ikonomidou C, Tenkova TI et al. Distinguishing excitotoxic from apoptotic neurodegeneration in the developing rat brain. J. Comp. Neurol.408, 461–476 (1999).
   PubMed Web of Science ®Google Scholar
• Gwag BJ, Koh JY, Demaro JA, Ying HS, Jacquin M, Choi DW. Slowly triggered excitotoxicity occurs by necrosis in cortical cultures. Neuroscience77, 393–401 (1997).
   PubMed Web of Science ®Google Scholar
• Olney JW, Wozniak DF, Jevtovic-Todorovic V, Farber NB, Bittigau P, Ikonomidou C. Glutamate and GABA receptor dysfunction in the fetal alcohol syndrome. Neurotox. Res.4, 315–325 (2002).
   PubMed Web of Science ®Google Scholar
• Olney JW, Tenkova T, Dikranian K, Qin YQ, Labruyere J, Ikonomidou C. Ethanol-induced apoptotic neurodegeneration in the developing C57BL/6 mouse brain. Brain Res. Devel. Brain Res.133, 115–126 (2002).
   PubMedGoogle Scholar
• Bubeníková-Valesová V, Horácek J, Vrajová M, Höschl C. Models of schizophrenia in humans and animals based on inhibition of NMDA receptors. Neurosci. Biobehav. Rev.32, 1014–1023 (2008).
   PubMed Web of Science ®Google Scholar
• Jarskog LF, Glantz LA, Gilmore JH. Apoptotic mechanisms in the pathophysiology of schizophrenia. Prog. Neuropsychopharmacol. Biol. Psychiatry29, 846–858 (2005).
   PubMed Web of Science ®Google Scholar
• Mattson MP, Duan W. “Apoptotic” biochemical cascades in synaptic compartments: roles in adaptive plasticity and neurodegenerative disorders. J. Neurosci. Res.58, 152–166 (1999).
   PubMed Web of Science ®Google Scholar
• Jarskog LF, Gilmore JH, Selinger ES, Lieberman JA. Cortical bcl-2 protein expression and apoptotic regulation in schizophrenia. Biol. Psychiatry48, 641–650 (2000).
   PubMed Web of Science ®Google Scholar
• Jarskog LF, Selinger ES, Lieberman JA, Gilmore JH. Apoptotic proteins in the temporal cortex in schizophrenia: high Bax/Bcl-2 ratio without caspase-3 activation. Am. J. Psychiatry161, 109–115 (2004).
   PubMed Web of Science ®Google Scholar
• Miyaoka T. Clinical potential of minocycline for schizophrenia. CNS Neurol. Disord. Drug Targets7, 376–381 (2008)
   PubMed Web of Science ®Google Scholar
• Butts BD, Houde C, Mehmet H. Maturation-dependent sensitivity of oligodendrocyte lineage cells to apoptosis: implications for normal development and disease.Cell Death Differ.15, 1178–1186 (2008).
   PubMed Web of Science ®Google Scholar
• Beauregard M, Bachevalier J. Neonatal insult to the hippocampal region and schizophrenia: a review and a putative animal model. Can. J. Psychiatry41, 446–456 (1996).
   PubMed Web of Science ®Google Scholar
• Bertolino A, Nawroz S, Mattay VS et al. Regionally specific pattern neurochemical pathology in schizophrenia as assessed by multislice proton magnetic resonance spectroscopic imaging. Am. J. Psychiat.153, 1554–1563 (1996).
   PubMed Web of Science ®Google Scholar
• Bertolino A, Breier A, Callicott JH et al. The relationship between dorsolateral prefrontal neuronal N-acetylaspartate and evoked release of striatal dopamine in schizophrenia. Neuropsychopharmacology22, 125–132 (2000).
   PubMed Web of Science ®Google Scholar
• Black MD, Lister S, Hitchcock JM, Giersbergen P, Sorensen SM. Neonatal lesion model of schizophrenia in rats: sex differences and persistence of effects into maturity. Drug Dev. Res.43, 206–213 (1998).
   Web of Science ®Google Scholar
• Chambers RA, Moore J, McEnvoy JP, Levin ED. Cognitive effects of neonatal hippocampal lesions in a rat model of schizophrenia. Neuropsychopharmacology15, 587–594 (1996).
   PubMed Web of Science ®Google Scholar
• Lillrank SM, Lipska BK, Weinberger DR. Neurodevelopmental animal models of schizophrenia. Clin. Neurosci.3, 98–104 (1995).
   PubMedGoogle Scholar
• Lipska BK, Jaskiw GE, Weinberger DR. Postpubertal emergence of hyperresponsiveness to stress and to amphetamine after neonatal hippocampal damage: a potential animal model of schizophrenia. Neuropsychopharmacology9, 67–75 (1993).
   PubMed Web of Science ®Google Scholar
• Lipska BK, Al-Amin HA, Weinberger DR. Excitotoxic lesions of the rat medial prefrontal cortex: effects on abnormal behaviors associated with neonatal hippocampal damage. Neuropsychopharmacology19, 451–464 (1998).
   PubMed Web of Science ®Google Scholar
• Wan RQ, Corbett R. Enhancement of postsynaptic sensitivity to dopaminergic agonists induced by neonatal hippocampal lesions. Neuropsychopharmacology16, 259–268 (1997).
   PubMed Web of Science ®Google Scholar
• Weinberger DR. Cell biology of the hippocampal formation in schizophrenia. Biol. Psychiatry45, 395–402 (1999).
   PubMed Web of Science ®Google Scholar
• Eastwood SL, Harrison PJ. Hippocampal and cortical growth-associated protein-43 messenger RNA in schizophrenia. Neuroscience86, 437–448 (1998).
   PubMed Web of Science ®Google Scholar
• Falkai P, Bogerts B. Cell loss in the hippocampus of schizophrenics. Eur. Arch. Psychiat. Neurol.Sci.236, 154–161 (1986)
   PubMedGoogle Scholar
• Suddath RL, Christisin GW, Torrey EF, Casanova M, Weinberger DR. Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia. N. Engl. J. Med.322, 789–794 (1990).
   PubMed Web of Science ®Google Scholar
• Akbarian S, Bunney WE, Potkin SG et al. Altered distribution of nicotinamideadenine dinucleotide phosphate diaphorase cells in front lobe of schizophrenics implies disturbances of cortical development. Arch. Gen. Psychiatr.50, 169–177 (1993).
   PubMed Web of Science ®Google Scholar
• Arnold SE, Hyman BT, Vanhoesen GW, Damasio AR. Some cutoarchitectural abnormalities of the entorhinal cortex in schizophrenia. Arch. Gen. Psychiatr.48, 625–632 (1991).
   PubMed Web of Science ®Google Scholar
• Jakob H, Beckman H. Prenatal developmental disturbances in the limbic allocortex in schizophrenics. J. Neural Transm.65, 303–326 (1986).
   PubMed Web of Science ®Google Scholar
• Csernansky JG, Bardgett ME. Limbic-cortical neuronal damage and the pathophysiology in schizophrenia. Schizophr. Bull.24, 231–248 (1998).
   PubMed Web of Science ®Google Scholar
• Raedler TJ, Knable MB, Weinberger DR. Schizophrenia as a developmental disorder of the cerebral cortex. Curr. Opin. Neurobiol.8, 157–161 (1998).
   PubMed Web of Science ®Google Scholar
• Jones P, Done DJ. From birth to onset: a neurodevelopmental perspective of schizophrenia in two national birth cohorts. In: Neurodevelopment and Adult Psychopathology. Keshaven MS, Murray RM (Eds). Cambridge University Press, Cambridge, UK 119–136 (1997).
   Google Scholar
• Mednick SA, Machon RA, Huttunen MO, Bonett D. Adult schizophrenia following prenatal exposure to an influenza epidemic. Arch. Gen. Psychiatr.45, 189–192 (1988).
   PubMed Web of Science ®Google Scholar
• Beninger RJ, Jhamandas A, Aujla H et al. Neonatal exposure to the glutamate receptor antagonist MK-801: effects on locomotor activity and pre-pulse inhibition before and after sexual maturity in rats. Neurotoxicity Res.4, 477–488 (2002).
   PubMed Web of Science ®Google Scholar
• Moore H, Giracello D, Grace AA, Geyer MA. Sensory gating deficits in rats with early disruption of limbic cortical development. Relevance to schizophrenia. Soc. Neurosci. Abstr.25, 1580 (1999).
   Google Scholar
• Talamini LM, Koch T, Ter Horst GJ, Korf J. Methylazoxymethanol acetate-induced abnormalities in the entorhinal cortex of the rat: parallels with morphological findings in schizophrenia. Brain Res.789, 293–306 (1999).
   Web of Science ®Google Scholar
• Archer T, Palomo P, Fredriksson A. Neonatal 6-hydroxydopamine-induced hypo/hyperactivity: blockade by dopamine reuptake inhibitors and effect of acute D-amphetamine. Neurotoxicity Res.4, 247–266 (2002).
   PubMed Web of Science ®Google Scholar
• Braff DL, Geyer MA. Sensorimotor gating and schizophrenia: human and animal model studies. Arch. Gen. Psychiatry47, 181–188 (1990).
   PubMed Web of Science ®Google Scholar
• Braff DL Information processing and attentional dysfunctions in schizophrenia. Schizophr. Bull.19, 233–259 (1993).
   PubMed Web of Science ®Google Scholar
• Perry W, Braff DL. Information processing deficits and thought disorder in schizophrenia. Am. J. Psychiatr.151, 363–367 (1994).
   PubMed Web of Science ®Google Scholar
• Geyer MA. The family of sensorimotor gating disorders: comorbidities or diagnostic overlaps. Neurotox. Res.10, 211–220 (2006).
   PubMed Web of Science ®Google Scholar
• Powell SB, Geyer MA. Developmental markers of psychiatric disorders as identified by sensorimotor gating. Neurotox. Res.4, 489–502 (2002).
   PubMed Web of Science ®Google Scholar
• Van den Buuse M, Garner B, Koch M. Neurodevelopmental animal models of schizophrenia: effects on prepulse inhibition. Curr. Mol. Med.3, 459–471 (2003).
   PubMed Web of Science ®Google Scholar
• Tseng KY, Chambers RA, Lipska BK. The neonatal ventral hippocampal lesion as a heuristic neurodevelopmental model of schizophrenia. Behav. Brain Res.204, 295–305 (2009).
   PubMed Web of Science ®Google Scholar
• Tseng KY, Lewis BL, Lipska BK, O’Donnell P. Post-pubertal disruption of medial prefrontal cortical dopamine–glutamate interactions in a developmental animal model of schizophrenia. Biol. Psychiatry62, 730–738 (2007).
   PubMed Web of Science ®Google Scholar
• Lipska BK, Jaskiw GE, Chrapusta S, Karoum F, Weinberger DR. Ibotenic acid lesion of the ventral hippocampus differentially affects dopamine and its metabolites in the nucleus accumbens and prefrontal cortex in the rat. Brain Res.585, 1–6 (1992).
   PubMed Web of Science ®Google Scholar
• Lipska BK, Swerdlow NR, Geyer MA, Jaskiw GE, Braff DL, Weinberger DR. Neonatal excitotoxic lesions hippocampal damage in rats causes post pubertal changes in prepulse inhibition of startle and its disruption by apomorphine. Psychopharmacology122, 35–43 (1995).
   PubMed Web of Science ®Google Scholar
• Lipska BK, Kolb B, Halim N, Weinberger DR. Synaptic abnormalities in prefrontal cortex and nucleus accumbens of adult rats with neonatal hippocampal damage. Schizophr. Res.49, 47 (2001).
   Web of Science ®Google Scholar
• O’Donnell P, Lewis BL, Weinberger DR, Lipska BK. Neonatal hippocampal damage alters electrophysiological properties of prefrontal cortical neurons an adult rats. Cereb. Cortex12, 975–982 (2002).
   PubMed Web of Science ®Google Scholar
• Lipska BK, Weinberger DR. Subchronic treatment with haloperidol and clozapine in rats with neonatal excitotoxic hippocampal damage. Neuropsychopharmacology10, 199–205 (1994).
   PubMed Web of Science ®Google Scholar
• Lillrank SM, Lipska BK, Kolachana BS, Weinberger DR. Attenuated extracellular dopamine levels after stress and amphetamine in the nucleus accumbens of rats with neonatal ventral hippocampal damage. J. Neural Transm.106, 183–196 (1999).
   PubMed Web of Science ®Google Scholar
• Brans RG, van Haren NE, van Baal GC, Schnack HG, Kahn RS, Hulshoff Pol HE. Heritability of changes in brain volume over time in twin pairs discordant for schizophrenia. Arch. Gen. Psychiatry65, 1259–1268 (2008).
   PubMed Web of Science ®Google Scholar
• Shenton ME, Gerig G, McCarley RW, Szekely G, Kikinis R. Amygdala-hippocampal shape differences in schizophrenia: the application of 3D shape models to volumetric MR data. Psychiatry Res.115, 15–35 (2002).
   PubMed Web of Science ®Google Scholar
• Archer T, Fredriksson A, Sundström E et al. Prenatal methylazoxymethanol treatment potentiates D-amphetamine- and methylphenidate-induced motor activity in male and female rats. Pharmacol. Toxicol.63, 233–239 (1988).
   PubMedGoogle Scholar
• Flagstad P, Glenthoj BY, Didriksen M. Cognitive deficits caused by late gestational disruption of neurogenesis in rats: a preclinical model of schizophrenia. Neuropsychopharmacolgy30, 250–260 (2005).
   PubMed Web of Science ®Google Scholar
• Mohammed AK, Jonsson G, Söderberg U, Archer T. Impaired selective attention in methylazoxymethanol-induced microencephalic rats. Pharmacol. Biochem. Behav.24, 975–981 (1986).
   PubMed Web of Science ®Google Scholar
• Mohammed AK, Jonsson G, Sundström E, Minor BG, Söderberg U, Archer T. Selective attention and place navigation in rats treated prenatally with methylazoxymethanol. Brain Res. Dev. Brain Res.30, 145–155 (1986).
   Google Scholar
• Kostrzewa RM, Kostrzewa JP, Kostrzewa RA, Nowak P, Brus R. Pharmacological models of ADHD. J. Neural Transm.115, 287–298 (2008).
   PubMed Web of Science ®Google Scholar
• Lodge DJ, Grace AA. Hippocampal dysfunction and disruption of dopamine system regulation in an animal model of schizophrenia. Neurotox. Res14, 97–104. (2008).
   PubMed Web of Science ®Google Scholar
• Moore H, Jentsch JD, Ghajarnia M, Geyer MA, Grace AA. A neurobehavioral systems analysis of adult rats exposed to methylazoxymethanol acetate on E17: implications for the neuropathology of schizophrenia. Biol. Psychiatry60, 253–264 (2006).
   PubMed Web of Science ®Google Scholar
• Lavin A Moore HM, Grace AA. Prenatal disruption of neocortical development alters prefrontal cortical neuron responses to dopamine in adult rats. Neuropsychopharmacology30, 1426–1435 (2005).
   PubMed Web of Science ®Google Scholar
• Chen S, Hillman DE. Selective ablation of neurons by methylazoxymethanol during pre- and postnatal brain development. Exp. Neurol.94, 103–119 (1986).
   PubMed Web of Science ®Google Scholar
• Gourevitch R, Rocher C, Le Pen G, Krebs MO, Jay TM. Working memory deficits in adult rats after prenatal disruption of neurogenesis. Behav. Pharmacol.15, 287–292 (2004).
   PubMed Web of Science ®Google Scholar
• Virgili M, Vandi M, Contestabile A. Ischemic and excitotoxic damage to brain slices from normal and microencephalic rats. Neurosci. Lett.233, 53–57 (1997).
   PubMed Web of Science ®Google Scholar
• Ferguson SA, Holson RR. Methylazoxymethanol-induced microencephaly in the brown Norway strain: behavior and brain weight. Int. J. Dev. Neurosci.15, 75–86 (1997).
   PubMedGoogle Scholar
• Flagstad P, Mork A, Glenthoj BY, van Beek J, Michael-Titus AT, Didriksen M. Disruption of neurogenesis on gestation day 17 in the rat causes behavioral changes relevant to positive and negative schizophrenia symptoms and alters amphetamine-induced dopamine release in nucleus accumbens. Neuropsychopharmacology29, 2052–2064 (2004).
   PubMed Web of Science ®Google Scholar
• Fiore M, Aloe L, Westenbroek C, Amendola T, Antonelli A, Korf J. Bromodeoxyuridine and methylazoxymethanol exposure during brain development affects behavior in rats: consideration for a role of nerve growth factor and brain derived neurotrophic factor. Neurosci. Lett.309, 113–116 (2001)
   PubMed Web of Science ®Google Scholar
• Fiore M, Korf J, Antonelli A, Talamini L, Aloe L. Long-lasting effects of prenatal MAM treatment on water maze performance in rats: associations with altered brain development and neurotrophin levels. Neurotoxicol. Teratol.24, 179–191 (2002).
   PubMed Web of Science ®Google Scholar
• Lee MH, Rabe A. Premature decline in Morris water maze performance of aging microencephalic rats. Neurotoxicol. Teratol.14, 383–392 (1992).
   PubMed Web of Science ®Google Scholar
• Shimizu J, Tamaru M, Katsukura T, Matsutani T, Nagata Y. Effects of fetal treatment with methylazoxymethanol acetate on radial maze performance in rats. Neurosci. Res.11, 209–214 (1991).
   PubMed Web of Science ®Google Scholar
• Leng A, Jongen-Relo AL, Pothuizen HH, Feldon J. Effects of prenatal methylazoxymethanol acetate (MAM) treatment in rats on water maze performance. Behav. Brain Res.161, 291–298 (2005).
   PubMed Web of Science ®Google Scholar
• Grace AA, Moore H. Regulation of information flow in the nucleus accumbens: a model for the pathophysiology of schizophrenia. In: Origins and Development of Schizophrenia: Advances in Experimental Psychopathology. Lenzenweger MF, Dworkin RH (Eds). American Psychological Association Press, DC, USA 123–157 (1998).
   Google Scholar
• Jongen-Relo AL, Leng A, Luber M, Pothuizen HH, Weber L, Feldon J. The prenatal methylazoxymethanol acetate treatment: a neurodevelopmental animal model for schizophrenia. Behav. Brain Res.149, 159–181 (2004).
   PubMed Web of Science ®Google Scholar
• Featherstone RE, Rizos Z, Nobrega JN, Kapur S, Fletcher PJ. Gestational methylazoxymethanol acetate treatment impairs select cognitive functions: parallels to schizophrenia.Neuropsychopharmacology32, 483–492 (2007).
   PubMed Web of Science ®Google Scholar
• Goto Y, Grace AA. Alterations in medial prefrontal cortical activity and plasticity in rats with disruption of cortical development. Biol. Psychiatry60, 1259–1267 (2006).
   PubMed Web of Science ®Google Scholar
• Castro PA, Cooper EC, Lowenstein DH, Baraban SC. Hippocampal heterotopias lack of functional Kv4.2 potassium channels in the methylazoxymethanol model of cortical malformations and epilepsy. J. Neurosci.21, 6626–6634 (2001).
   PubMed Web of Science ®Google Scholar
• Ferrer I, Pozas E, Marti M, Blanco R, Planas AM. Methylazoxymethanol acetate-induced apoptosis in the external granule cell layer of the developing cerebellum of the rat is associated with strong c-jun expression and formation of high molecular weight c-jun complexes. J. Neuropathol. Exp. Neurol.56, 1–9 (1997).
   PubMed Web of Science ®Google Scholar
• Lafarga M, Lerga A, Andres MA, Polanco JL, Calle E, Berciano MT. Apoptosis induced by methylazoxymethanol in developing rat cerebellum: organization of the cell nucleus and its relationship to DNA and rRNA degradation. Cell Tissue Res.289, 25–38 (1997).
   PubMed Web of Science ®Google Scholar
• Ciani E, Frenquelli M, Contestabile A. Developmental expression of the cell cycle and apoptosis controlling gene, Lot1, in the rat cerebellum and in cultures of cerebellar granule cells. Brain Res. Dev. Brain Res.142, 193–202 (2003).
   PubMedGoogle Scholar
• Fan QY, Ramakrisna S, Marchi N, Fazio V, Hallene K, Janigro D. Combined effects of prenatal inhibition of vasculogenesis and neurogenesid on rat brain development. Neurobiol. Dis.32, 499–509 (2008).
   PubMed Web of Science ®Google Scholar
• Ferrer I, Puig B, Goutan E, Gombau L, Muñoz-Cánoves P. Methylazoximethanol acetate-induced cell death in the granule cell layer of the developing mouse cerebellum is associated with caspase-3 activation, but does not depend on the tissue-type plasminogen activator. Neurosci. Lett.299, 77–80 (2001).
   PubMed Web of Science ®Google Scholar
• Hugon J, Esclaire F, Lesort M, Kisby G, Spencer P. Toxic neuronal apoptosis and modifications of tau and APP gene and protein expressions. Drug. Metab. Rev.31, 635–647 (1999).
   PubMed Web of Science ®Google Scholar
• Kisby GE, Olivas A, Standley M et al. Genotoxicants target distinct molecular networks in neonatal neurons. Environ. Health Perspect.114, 1703–1712 (2006).
   PubMed Web of Science ®Google Scholar
• Rice D, Barone S Jr. Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models. Environ. Health Perspect.108(Suppl. 3), 511–533 (2000).
   PubMed Web of Science ®Google Scholar
• Maekawa M, Takashima N, Matsumata M et al. Arachidonic acid drives postnatal neurogenesis and elicits a beneficial effect on prepulse inhibition, a biological trait of psychiatric illness. PLos One4, 5085–5095 (2009).
   Web of Science ®Google Scholar
• Ko HG, Jang DJ, Son J et al. Effect of ablated hippocampal neurogenesis on the formation and extinction of contextual fear memory. Mol. Brain2(1), 1 (2009).
   PubMedGoogle Scholar
• Brunskill EW, Ehrman LA, Williams MT et al. Abnormal neurodevelopment, neurosignalling and behavior in Npas-deficient mice. Eur. J. Neurosci.22, 1265–1276 (2005).
   PubMed Web of Science ®Google Scholar
• Kamnasaran D, Muir WJ, Ferguson-Smith MA, Cox DW. Disruption of the neuronal PAS3 gene in a family affected with schizophrenia. J. Med. Genet.40, 325–332 (2003).
   PubMed Web of Science ®Google Scholar
• Geist MA, Volbracht C, Podhorna J, Falsig J, Leist M. Wide spectrum modulation by KP-544 in models relevant for neuronal survival. Neuroreport18, 571–575 (2007).
   PubMed Web of Science ®Google Scholar
• Ellenbroek BA, van den Kroonenberg PT, Cools AR. The effects of an early stressful life event on sensorimotor gating in adult rats. Schizophr. Res.30, 251–260 (1998).
   PubMed Web of Science ®Google Scholar
• Furukawa T, Mizukawa R, Hirai T, Fujihara S, Kitamura T, Takahashi K. Childhood parental loss and schizophrenia: evidence against pathogenic but for some pathoplastic effects. Psychiatry Res.81, 353–362 (1998).
   PubMed Web of Science ®Google Scholar
• Millstein RA, Ralph RJ, Yang RJ, Holmes A. Effects of repeated maternal separation on prepulse inhibition of startle across inbred mouse strains. Genes Brain Behav.5, 346–354 (2006).
   PubMed Web of Science ®Google Scholar
• Mäki P, Veijola J, Joukamaa M et al. Maternal separation at birth and schizophrenia – a long-term follow-up of the Finnish Christmas Seal Home Children. Schizophr. Res.60, 13–19 (2003).
   PubMed Web of Science ®Google Scholar
• Dean B. Is schizophrenia the price of human central nervous system complexity? Aust. NZ J. Psychiatry43, 13–24 (2009).
   PubMed Web of Science ®Google Scholar
• Kasof GM, Mahanty NK, Pozzo Miller LD et al. Spontaneous and evoked glutamate signalling influences Fos-lacZ expression and pyramidal cell death in hippocampal slice cultures from transgenic rats. Brain Res. Mol. Brain Res.34, 197–208 (1995).
   PubMedGoogle Scholar
• Kasof GM, Mandelzys A, Maika SD, Hammer RE, Curran T, Morgan JI. Kainic acid-induced neuronal death is associated with DNA damage and a unique immediate-early gene response in c-fos-lacZ transgenic rats. J. Neurosci.15, 4238–4249 (1995).
   PubMed Web of Science ®Google Scholar
• Morgan JI, Curran T. Stimulus-transcription coupling in the nervous system – involvement of inducible protoonco-genes Fos and Jun. Ann. Rev. Neurosci.14, 421–451 (1991).
   PubMed Web of Science ®Google Scholar
• Morgan JI, Curran T. Immediate-early genes: ten years on. Trends Neurosci.18, 66–67 (1995).
   PubMed Web of Science ®Google Scholar
• Sheng M, Greenberg ME. The regulation and function of c-fos and other immediate early genes in the nervous system. Neuron4, 477–485 (1990).
   PubMed Web of Science ®Google Scholar
• Akbari EM, Budin R, Parada M, Fleming AS. The effects of early isolation on sexual behavior and c-fos expression in naïve male Long-Evans rats. Dev. Psychobiol.50, 298–306 (2008).
   PubMed Web of Science ®Google Scholar
• Morales T, Aguilar L, Ramos E, Mena F, Morgan C. Fos expression induced by milk ingestion in the caudal brainstem of neonatal rats. Brain Res.1241, 76–83 (2008).
   PubMed Web of Science ®Google Scholar
• Shi L, Liu Y, Mao C, Zeng F, Meyer K, Xu Z. A new approach for exploring functional development of fetal brain pathways. Dev. Psychobiol.51, 384–388 (2009).
   PubMed Web of Science ®Google Scholar
• Doucet JP, Nakabeppu Y, Bedard PJ et al. Chronic alterations in dopaminergic neurotransmission produce a persistent elevation of delta FosB-like protein(s) in both rodent and primate striatum. Eur. J. Neurosci.8, 365–381 (1996).
   PubMed Web of Science ®Google Scholar
• Hiroi N, Brown JR, Haile CN, Ye H, Greenberg ME, Nestler EJ. FosB mutant mice: loss of chronic cocaine induction of Fos-related proteins and heightened sensitivity to cocaine’s psychomotor and rewarding effects. Proc. Natl Acad. Sci. USA94, 10397–10402 (1997).
   PubMed Web of Science ®Google Scholar
• Kim Y, Teylan MA, Baron M, Sands A, Nairn AC, Greengard P. Methylphenidate-induced dendritic spine formation and DeltaFosB expression in nucleus accumbens. Proc. Natl Acad. Sci. USA106, 2915–2920 (2009).
   PubMed Web of Science ®Google Scholar
• Powell KJ, Binder TL, Hori S et al. Neonatal ventral hippocampal lesions produce an elevation of δFosB-like protein(s) in the rodent neocortex. Neuropsychopharmacolgy31, 700–711 (2006).
   PubMed Web of Science ®Google Scholar
• Green TA, Alibhai IN, Unterberg S et al. Induction of activating transcription factors (ATFs) ATF2, ATF3, and ATF4 in the nucleus accumbens and their regulation of emotional behavior. J. Neurosci.28, 2025–2032 (2008).
   PubMed Web of Science ®Google Scholar
• Nestler EJ. Review. Transcriptional mechanisms of addiction: role of δFosB. Philos. Trans. R. Soc. Lond. B Biol. Sci.363, 3245–3255 (2008).
   PubMed Web of Science ®Google Scholar
• Wallace DL, Vialou V, Rios L et al. The influence of δFosB in the nucleus accumbens on natural reward-related behavior. J. Neurosci.28, 10272–10277 (2008).
   PubMed Web of Science ®Google Scholar
• Winstanley CA. The orbitofrontal cortex, impulsivity, and addiction: probing orbitofrontal dysfunction at the neural, neurochemical, and molecular level. Ann. NY Acad. Sci.1121, 639–655 (2007).
   PubMed Web of Science ®Google Scholar
• Nikulina EM, Arrillaga-Romany I, Miczek KA, Hammer RP Jr. Long-lasting alteration in mesocorticolimbic structures after repeated social defeat stress in rats: time course of µ-opioid receptor mRNA and FosB/δFosB immunoreactivity. Eur. J. Neurosci.27, 2272–2284 (2008).
   PubMed Web of Science ®Google Scholar
• Wallace DL, Han MH, Graham DL et al. CREB regulation of nucleus accumbens excitability mediates social isolation-induced behavioral deficits. Nat. Neurosci.12, 200–209 (2009).
   PubMed Web of Science ®Google Scholar
• Moghaddam B, Jackson M. Effect of stress on prefrontal cortex function. Neurotox. Res.6, 73–78 (2004).
   PubMed Web of Science ®Google Scholar
• Scornaiencki R, Cantrup R, Rushlow WJ, Rajakumar N. Prefrontal cortical D1 dopamine receptors modulate subcortical D2 dopamine receptor-mediated stress responsiveness. Int. J. Neuropsychopharmacol.11, 1–14 (2009).
   Google Scholar
• Inglis FM, Moghaddam B. Dopaminergic innervation of the amygdala is highly responsive to stress. J. Neurochem.72, 1088–1094 (1999).
   PubMed Web of Science ®Google Scholar
• King S, Mancini-Marïe A, Brunet A, Walker E, Meaney MJ, Laplante DP. Prenatal maternal stress from a natural disaster predicts dermatoglyphic asymmetry in humans. Dev. Psychopathol.21, 343–353 (2009).
   PubMed Web of Science ®Google Scholar
• Wong AH, Lipska BK, Likhodi O et al. Cortical gene expression in the neonatal ventral-hippocampal lesion rat model. Schizophr. Res.77, 261–270 (2005).
   PubMed Web of Science ®Google Scholar
• Pearlson GD, Folley BS. Endophenotypes, dimensions, risks: is psychosis analogous to common inherited medical illnesses? Clin. EEG Neurosci.39, 73–77 (2008).
   PubMed Web of Science ®Google Scholar
• Wang Y, Paramasivam M, Thomas A et al. DYX1C1 functions in neuronal migration in developing neocortex. Neuroscience143, 515–522 (2006).
   PubMed Web of Science ®Google Scholar
• Schwab SG, Knapp M, Mondabon S et al. Support for association of schizophrenia with genetic variation in the 6p22.3 gene, dysbindin, in sib-pair families with linkage and in an additional sample of triad families. Am. J. Hum. Genet.72, 185–190 (2003).
   PubMed Web of Science ®Google Scholar
• Schwab SG, Knapp M, Sklar P et al. Evidence for association of DNA sequence variants in the phosphatidylinositol-4-phosphate 5-kinase IIα gene (PIP5K2A) with schizophrenia. Mol. Psychiatry11, 837–846 (2006).
   PubMed Web of Science ®Google Scholar
• Abou Jamra R, Schmael C, Cichon S, Rietschel M, Schumacher J, Nothen MM. The G72/G30 gene locus in psychiatric disorders: a challenge to diagnostic boundaries? Schizophr. Bull.32, 599–608 (2006).
   PubMed Web of Science ®Google Scholar
• Li D, Collier DA, He L. Meta-analysis shows strong positive association of the neureglin 1 (NRG1) gene with schizophrenia. Hum. Mol. Genet.15, 1995–2002 (2006).
   PubMed Web of Science ®Google Scholar
• Anton ES, Ghashghaei HT, Weber JL et al. Receptor tyrosine kinase ErbB4 modulates neuroblast migration and placement in the adult forebrain. Nat. Neurosci.7, 1319–1328 (2004)
   PubMed Web of Science ®Google Scholar
• Ghashghaei HT, Lai C, Anton ES. Neuronal migration in the adult brain: are we there yet? Nat. Rev. Neurosci.8, 141–151 (2007).
   PubMed Web of Science ®Google Scholar
• Ghashghaei HT, Weber J, Pevny L et al. The role of neuregulin–ErbB4 interactions on the proliferation and organization of cells in the subventricular zone. Proc. Natl Acad. Sci. USA103, 1930–1935 (2006).
   PubMed Web of Science ®Google Scholar
• Nave KA, Salzer JL. Axonal regulation of myelination by neuregulin 1. Curr. Opin. Neurobiol.16, 492–500 (2006).
   PubMed Web of Science ®Google Scholar
• Wratten NS, Memoli H, Huang Y et al. Identification of a schizophrenia-associated functional noncoding variant in NOS1AP. Am. J. Psychiatry166, 434–441 (2009).
   PubMed Web of Science ®Google Scholar
• Krug A, Markov V, Leube D et al. Genetic variation in the schizophrenia-risk gene neureglin 1 correlates with personality traits in healthy individuals. Eur. Psychiatry23, 344–349 (2008).
   PubMed Web of Science ®Google Scholar
• Craddock N, O’Donovan MC, Owen MJ. Phenotypic and genetic complexity of psychosis. Invited Commentary on schizophrenia: a common disease caused by multiple rare alleles. Br. J. Psychiatry190, 200–203 (2007).
   PubMed Web of Science ®Google Scholar
• Pickard BS, Thomson PA, Christoforou A et al. The PDE4B gene confers sex-specific protection against schizophrenia. Psychiatry Genet.17, 129–133 (2007).
   PubMed Web of Science ®Google Scholar
• Numata S, Ueno SI, Iga JI et al. Positive association of the PDE4B (phosphodiesterase 4B) gene with schizophrenia in a Japanese population. J. Psychiatry43(1), 7–12 (2008).
   Google Scholar
• Blackwood DH, Thiagarajah T, Malloy MP, Pickard BS, Muir WJ. Chromosome abnormalities, mental retardation and the search for genes in bipolar disorder and schizophrenia. Neurotox. Res.14, 113–120 (2008).
   PubMed Web of Science ®Google Scholar
• Pickard BS, Malloy MP, Porteous DJ, Blackwood DH, Muir WJ. Disruption of a brain transcription factor, NPAS3, is associated with schizophrenia and learning disability. Am. J. Med. Genet. B Neuropsychiatr. Genet.136, 26–32 (2005).
   Google Scholar
• Pickard BS, Malloy MP, Christoforou A. Cytogenetic and genetic evidence support a role for the kainite-type glutamate receptor gene, GRIK4, in schizophrenia and bipolar disorder. Mol. Psychiatry11, 847–857 (2006).
   PubMed Web of Science ®Google Scholar
• Caluseriu O, Mirza G, Ragoussis J, Chow EW, MacCrimmon D, Bassett AS. Schizophrenia in an adult with 6p25 deletion syndrome. Am. J. Med. Genet. A140, 1208–1213 (2006).
   PubMedGoogle Scholar
• Pickard BS, Christoforou A, Thomson PA. Interacting haplotypes at the NPAS3 locus alter risk of schizophrenia and bipolar disorder. Mol. Psychiatry14, 874–884 (2008).
   PubMed Web of Science ®Google Scholar
• Radulescu A. A multi-etiology model of systemic degeneration in schizophrenia. J. Theor. Biol.259(2), 269–279 (2009).
   PubMed Web of Science ®Google Scholar
• Fatemi SH, Folsom TD. The neurodevelopmental hypothesis of schizophrenia, revisited. Schizophr. Bull.35, 528–548 (2009).
   PubMed Web of Science ®Google Scholar
• Sweet RA, Henteleff RA, Zhang W, Sampson AR, Lewis DA. Reduced dendritic spine density in auditory cortex of subjects with schizophrenia. Neuropsychopharmacology34, 374–389 (2009).
   PubMed Web of Science ®Google Scholar
• Wedenoja J, Luokola A, Tuulio-Henriksson A et al. Replication of linkage on chromosome 7q22 and association of the regional Reelin gene with working memory in schizophrenia families. Mol. Psychiatry13, 673–684 (2008).
   PubMed Web of Science ®Google Scholar
• Weinberger DR, McClure RK. Neurotoxicity, neuroplasticity, and magnetic resonance imaging morphology: what is happening in the schizophrenic brain? Arch. Gen. Psychiatry59, 553–558 (2002).
   PubMed Web of Science ®Google Scholar
• Yuan J, Yanker BA. Apoptosis in the nervous system. Nature407, 802–809 (2000).
   PubMed Web of Science ®Google Scholar
• Lieberman JA. Is schizophrenia a neurodegenerative disorder? A clinical and neurobiological perspective. Biol. Psychiatry46, 729–739 (1999)
   PubMed Web of Science ®Google Scholar
• Lieberman JA. Neuroprotection: a new strategy in the treatment of schizophrenia. Neurobiological basis of neurodegeneration and neuroprotection. CNS Spectr.12(10 Suppl. 18), 4–6 (2007).
   PubMedGoogle Scholar
• Yasui-Furukori N, Saito M, Nakagami T et al. Clinical response to risperidone in relation to plasma drug concentrations in acutely exacerbated schizophrenic patients. J. Psychopharmacol. DOI: 10.1177/0269881109104849 (2009) (Epub ahead of print).
   PubMedGoogle Scholar
• Lynch D, Laws KR, McKenna PJ. Cognitive behavioural therapy for major psychiatric disorder: does it really work? A meta-analytical review of well-controlled trials. Psychol Med.29, 1–16 (2009).
   Google Scholar
• Gil Sanz D, Diego Lorenzo M, Bengochea Seco R et al. Efficacy of a social cognition training program for schizophrenic patients: a pilot study. Span. J. Psychol.12, 184–191 (2009).
   PubMed Web of Science ®Google Scholar
• von Hausswolff-Juhlin Y, Bjartveit M, Lindström E, Jones P. Schizophrenia and physical health problems. Acta Psychiatr. Scand. Suppl.438, 15–21 (2009).
   PubMedGoogle Scholar
• Acil AA, Dogan S, Dogan O. The effects of physical exercises to mental state and quality of life in patients with schizophrenia. J. Psychiatr. Ment. Health Nurs.15, 808–815 (2008).
   PubMed Web of Science ®Google Scholar
• Ho B-C, Andreasen NC, Nopoulus P, Arndt S, Magnotta V, Flaum M. Progressive structural brain abnormalities and their relationship in clinical outcome. A longitudinal magnetic resonance imaging study early in schizophrenia. Arch. Gen. Psychiatry60, 585–594 (2003).
   PubMed Web of Science ®Google Scholar