212
Views
5
CrossRef citations to date
0
Altmetric
Drug Profile

OROS methylphenidate for the treatment of adults with attention-deficit/hyperactivity disorder

, , , &
Pages 1121-1131 | Published online: 09 Jan 2014

References

  • Faraone SV, Biederman J. What is the prevalence of adult ADHD? Results of a population screen of 966 adults. J. Atten. Disord.9(2), 384–391 (2005).
  • Biederman J, Faraone SV. Attention-deficit hyperactivity disorder. Lancet366(9481), 237–248 (2005).
  • Adler LA, Chua HC. Management of ADHD in adults. J. Clin. Psychiatry63(Suppl. 12), 29–35 (2002).
  • American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) . Text Revision. Washington DA (Eds). The American Psychiatric Association, WA, USA (2000).
  • Kooij JJ, Buitelaar JK, van den Oord EJ, Furer JW, Rijnders CA, Hodiamont PP. Internal and external validity of attention-deficit hyperactivity disorder in a population-based sample of adults. Psychol. Med.35(6), 817–827 (2005).
  • Kessler RC, Adler L, Barkley R. The prevalence and correlates of adult ADHD in the United States: results from the national comorbidity survey replication. Am. J. Psychiatry163(4), 716–723 (2006).
  • Lamberg L. ADHD often undiagnosed in adults: appropriate treatment may benefit work, family, social life. JAMA290(12), 1565–1567 (2003).
  • Murphy K, Barkley RA. Attention deficit hyperactivity disorder adults: comorbidities and adaptive impairments. Compr. Psychiatry37(6), 393–401 (1996).
  • Barkley RA. Major life activity and health outcomes associated with attention-deficit/hyperactivity disorder. J. Clin. Psychiatry63(Suppl. 12), 10–15 (2002).
  • Biederman J, Faraone SV. The effects of attention-deficit/hyperactivity disorder on employment and household income. Med. Gen. Med.8(3), 12 (2006).
  • Biederman J, Petty CR, Fried R et al. Educational and occupational underattainment in adults with attention-deficit/hyperactivity disorder: a controlled study. J. Clin. Psychiatry69(8), 1217–1222 (2008).
  • Biederman J. Impact of comorbidity in adults with attention-deficit/hyperactivity disorder. J. Clin. Psychiatry65(Suppl. 3), 3–7 (2004).
  • Adler L, Cohen J. Diagnosis and evaluation of adults with attention-deficit/hyperactivity disorder. Psychiatr. Clin. North Am.27(2), 187–201 (2004).
  • National Institute for Health and Clinical Excellence. NICE Clinical Guideline 72. Attention deficit hyperacitivity disorder. Diagnosis and management of ADHD in children, young people and adults (2008).
  • Wilens TE, Spencer TJ, Biederman J. A review of the pharmacotherapy of adults with attention-deficit/hyperactivity disorder. J. Atten. Disord.5(4), 189–202 (2002).
  • Faraone SV, Spencer T, Aleardi M, Pagano C, Biederman J. Meta-analysis of the efficacy of methylphenidate for treating adult attention-deficit/hyperactivity disorder. J. Clin. Psychopharmacol.24(1), 24–29 (2004).
  • Stein MA, Blondis TA, Schnitzler ER et al. Methylphenidate dosing: twice daily versus three times daily. Pediatrics98(4 Pt 1), 748–756 (1996).
  • Pelham WE Jr, McBurnett K, Harper GW et al. Methylphenidate and baseball playing in ADHD children: who’s on first? J. Consult. Clin. Psychol.58(1), 130–133 (1990).
  • Darredeau C, Barrett SP, Jardin B, Pihl RO. Patterns and predictors of medication compliance, diversion, and misuse in adult prescribed methylphenidate users. Hum. Psychopharmacol.22(8), 529–536 (2007).
  • Sumnall HR, Woolfall K, Cole J, Mackridge A, McVeigh J. NICE guidance on ADHD. Diversion and abuse of methylphenidate in light of new guidance. BMJ337, A2287 (2008).
  • Wilens TE, Adler LA, Adams J et al. Misuse and diversion of stimulants prescribed for ADHD: a systematic review of the literature. J. Am. Acad. Child Adolesc. Psychiatry47(1), 21–31 (2008).
  • Kaiser NM, Hoza B, Hurt EA. Multimodal treatment for childhood attention-deficit/hyperactivity disorder. Expert Rev. Neurother.8(10), 1573–1583 (2008).
  • Rollini M, Baud P. Pharmacological treatment of attention-deficit/hyperactivity disorder in adults. Rev. Med. Suisse4(165), 1638–1643 (2008).
  • Benner-Davis S, Heaton PC. Attention deficit and hyperactivity disorder: controversies of diagnosis and safety of pharmacological and nonpharmacological treatment. Curr. Drug Saf.2(1), 33–42 (2007).
  • Faraone SV, Biederman J, Spencer TJ, Aleardi M. Comparing the efficacy of medications for ADHD using meta-analysis. MedGenMed8(4), 4 (2006).
  • Zabik JE, Levine RM, Maickel RP. Drug interactions with brain biogenic amines and the effects of amphetamine isomers on locomotor activity. Pharmacol. Biochem. Behav.8(4), 429–435 (1978).
  • Swanson J, Gupta S, Lam A et al. Development of a new once-a-day formulation of methylphenidate for the treatment of attention-deficit/hyperactivity disorder: proof-of-concept and proof-of-product studies. Arch. Gen. Psychiatry60(2), 204–211 (2003).
  • Patrick KS, González MA, Straughn AB, Markowitz JS. New methylphenidate formulations for the treatment of attention-deficit/hyperactivity disorder. Expert Opin. Drug Deliv.2(1), 121–143 (2005).
  • Faraj BA, Israili ZH, Perel JM et al. Metabolism and disposition of methylphenidate-14C: studies in man and animals. J. Pharmacol. Exp. Ther.191(3), 535–547 (1974).
  • Chan YM, Soldin SJ, Swanson JM, Deber CM, Thiessen JJ, Macleod S. Gas chromatographic/mass spectrometric analysis of methylphenidate (ritalin) in serum. Clin. Biochem.13(6), 266–272 (1980).
  • Patrick KS, Ellington KR, Breese GR. Distribution of methylphenidate and p-hydroxymethylphenidate in rats. J. Pharmacol. Exp. Ther.231(1), 61–65 (1984).
  • Modi NB, Wang B, Hu WT, Gupta SK. Effect of food on the pharmacokinetics of osmotic controlled-release methylphenidate HCl in healthy subjects. Biopharm. Drug Dispos.21(1), 23–31 (2000).
  • Rochdi M, González MA, Dirksen SJ. Dose-proportional pharmacokinetics of a methylphenidate extended-release capsule. Int. J. Clin. Pharmacol. Ther.42(5), 285–292 (2004).
  • Modi NB, Wang B, Noveck RJ, Gupta SK. Dose-proportional and stereospecific pharmacokinetics of methylphenidate delivered using an osmotic, controlled-release oral delivery system. J. Clin. Pharmacol.40(10), 1141–1149 (2000).
  • Pelham WE, Gnagy EM, Burrows-Maclean L et al. Once-a-day Concerta methylphenidate versus three-times-daily methylphenidate in laboratory and natural settings. Pediatrics107(6), E105 (2001).
  • Swanson JM, Volkow ND. Serum and brain concentrations of methylphenidate: implications for use and abuse. Neurosci. Biobehav. Rev.27(7), 615–621 (2003).
  • Auiler JF, Liu K, Lynch JM, Gelotte CK. Effect of food on early drug exposure from extended-release stimulants: results from the Concerta, Adderall Food Evaluation (CAFE) study. Curr. Med. Res. Opin.18(5), 311–316 (2002).
  • Markowitz JS, Straughn AB, Patrick KS et al. Pharmacokinetics of methylphenidate after oral administration of two modified-release formulations in healthy adults. Clin. Pharmacokinet.42(4), 393–401 (2003).
  • Gonz ález MA, Pentikis HS, Anderl N et al. Methylphenidate bioavailability from two extended-release formulations. Int. J. Clin. Pharmacol. Ther.40(4), 175–184 (2002).
  • Greenhill LL. Pharmacologic treatment of attention deficit hyperactivity disorder. Psychiatr. Clin. North Am. (1), 1–27 (1992).
  • Gatley SJ, Volkow ND, Gifford AN et al. Dopamine-transporter occupancy after intravenous doses of cocaine and methylphenidate in mice and humans. Psychopharmacology (Berl.)146(1), 93–100 (1999).
  • Volkow ND, Wang GJ, Fowler JS et al. Dopamine transporter occupancies in the human brain induced by therapeutic doses of oral methylphenidate. Am. J. Psychiatry155(10), 1325–1331 (1998).
  • Volkow ND, Fowler JS, Wang G, Ding Y, Gatley SJ. Mechanism of action of methylphenidate: insights from PET imaging studies. J. Atten. Disord.6(Suppl. 1), S31–S43 (2002).
  • Patrick KS, Caldwell RW, Ferris RM, Breese GR. Pharmacology of the enantiomers of threo-methylphenidate. J. Pharmacol. Exp. Ther.241(1), 152–158 (1987).
  • Volkow ND, Wang GJ, Fowler JS et al. “Nonhedonic” food motivation in humans involves dopamine in the dorsal striatum and methylphenidate amplifies this effect. Synapse44(3), 175–180 (2002).
  • Solanto MV. Neuropsychopharmacological mechanisms of stimulant drug action in attention-deficit hyperactivity disorder: a review and integration. Behav. Brain Res.94(1), 127–152 (1998).
  • Seeman P, Madras B. Methylphenidate elevates resting dopamine which lowers the impulse-triggered release of dopamine: a hypothesis. Behav. Brain Res.130(1–2), 79–83 (2002).
  • Wachtel H, Kandel ER. A direct synaptic connection mediating both excitation and inhibition. Science158(805), 1206–1208 (1967).
  • Chuang TT, Iacovelli L, Sallese M, De Blasi A. G protein-coupled receptors: heterologous regulation of homologous desensitization and its implications. Trends Pharmacol. Sci.17(11), 416–421 (1996).
  • Biederman J, Mick E, Surman C et al. A randomized, placebo-controlled trial of OROS methylphenidate in adults with attention-deficit/hyperactivity disorder. Biol. Psychiatry.59(9), 829–835 (2006).
  • Biederman J, Mick EO, Surman C et al. Comparative acute efficacy and tolerability of OROS and immediate release formulations of methylphenidate in the treatment of adults with attention-deficit/hyperactivity disorder. BMC Psychiatry7, 49 (2007).
  • Medori R, Ramos-Quiroga JA, Casas M et al. A randomized, placebo-controlled trial of three fixed dosages of prolonged-release OROS methylphenidate in adults with attention-deficit/hyperactivity disorder. Biol. Psychiatry63(10), 981–989 (2008).
  • Reimherr FW, Williams ED, Strong RE, Mestas R, Soni P, Marchant BK. A double-blind, placebo-controlled, crossover study of osmotic release oral system methylphenidate in adults with ADHD with assessment of oppositional and emotional dimensions of the disorder. J. Clin. Psychiatry68(1), 93–101 (2007).
  • Biederman J, Mick E, Spencer T et al. An open-label trial of OROS methylphenidate in adults with late-onset ADHD. CNS Spectr.11(5), 390–396 (2006).
  • Fallu A, Richard C, Prinzo R, Binder C. Does OROS-methylphenidate improve core symptoms and deficits in executive function? results of an open-label trial in adults with attention deficit hyperactivity disorder. Curr. Med. Res. Opin.22(12), 2557–2566 (2006).
  • Ramos-Quiroga JA, Bosch R, Castells X et al. Effect of switching drug formulations from immediate-release to extended-release OROS methylphenidate : a chart review of Spanish adults with attention-deficit hyperactivity disorder. CNS Drugs22(7), 603–611 (2008).
  • Spencer T, Biederman J, Wilens T et al. A large, double-blind, randomized clinical trial of methylphenidate in the treatment of adults with attention-deficit/hyperactivity disorder. Biol. Psychiatry57(5), 456–463 (2005).
  • Sobanski E. Psychiatric comorbidity in adults with attention-deficit/hyperactivity disorder (ADHD). Eur. Arch. Psychiatry Clin. Neurosci.256(Suppl. 1), I26–I31 (2006).
  • Ramos-Quiroga JA, Bosch R, Casas M. El TDAH en la edad adulta. In: El Alumno con TDAH. Guía Pràctica Para Educadores. Mena B, Nicolau R, Salat L, Tort P, Romero B (Eds). Ediciones Mayo, Barcelona, Spain 43–46 (2006).
  • Ramos-Quiroga JA, Bosch-Munso R, Castells-Cervello X, Nogueira-Morais M, Garcia-Gimenez E, Casas-Brugue M. Attention deficit hyperactivity disorder in adults: a clinical and therapeutic characterization. Rev. Neurol.42, 600–606 (2006).
  • Bekker EM, Overtoom CC, Kooij JJ, Buitelaar JK, Verbaten MN, Kenemans JL. Disentangling deficits in adults with attention-deficit/hyperactivity disorder. Arch. Gen. Psychiatry62(10), 1129–1136 (2005).
  • Aron AR, Dowson JH, Sahakian BJ, Robbins TW. Methylphenidate improves response inhibition in adults with attention-deficit/hyperactivity disorder. Biol. Psychiatry54(12), 1465–1468 (2003).
  • Parasrampuria DA, Schoedel KA, Schuller R et al. Assessment of pharmacokinetics and pharmacodynamic effects related to abuse potential of a unique oral osmotic-controlled extended-release methylphenidate formulation in humans. J. Clin. Pharmacol.47(12), 1476–1488 (2007).
  • Bayes M, Ramos JA, Cormand B et al. Large-scale genotyping in research into autism spectrum disorders and attention deficit hyperactivity disorder. Rev. Neurol.40(Suppl. 1), S187–S190 (2005).
  • Ribases M, Hervas A, Ramos-Quiroga JA et al. Association study of 10 genes encoding neurotrophic factors and their receptors in adult and child attention-deficit/hyperactivity disorder: contribution of ciliary neurotrophic factor receptors, neurotrophic factor receptor 3, and neurotrophic tyrosine kinase receptor 2. Biol. Psychiatry63(10), 935–945 (2008).
  • Ramos-Quiroga JA, Ribases-Haro M, Bosch-Munso R, Cormand-Rifa B, Casas M. Genetic advances in attention deficit hyperactivity disorder. Rev. Neurol.44(Suppl. 3), S51–S52 (2007).
  • Castellanos FX, Lee PP, Sharp W et al. Developmental trajectories of brain volume abnormalities in children and adolescents with attention-deficit/hyperactivity disorder. JAMA288, 1740–1748 (2002).
  • Seidman LJ, Valera EM, Makris N. Structural brain imaging of attention-deficit/hyperactivity disorder. Biol. Psychiatry57(11), 1263–1272 (2005).
  • Bush G, Frazier JA, Rauch SL et al. Anterior cingulate cortex dysfunction in attention-deficit/hyperactivity disorder revealed by fMRI and the Counting Stroop. Biol. Psychiatry.45, 1542–1552 (1999).
  • Bush G, Valera EM, Seidman LJ. Functional neuroimaging of attention-deficit/hyperactivity disorder: a review and suggested future directions. Biol. Psychiatry.57(11), 1273–1284 (2005).
  • Valera EM, Faraone SV, Biederman J, Poldrack RA, Seidman LJ. Functional neuroanatomy of working memory in adults with attention-deficit/hyperactivity disorder. Biol. Psychiatry57(5), 439–447 (2005).
  • Rommelse NN, Altink ME, Martin NC et al. Neuropsychological measures probably facilitate heritability research of ADHD. Arch. Clin. Neuropsychol.23(5), 579–591 (2008).
  • Wodka EL, Mostofsky SH, Prahme C et al. Process examination of executive function in ADHD: sex and subtype effects. Clin. Neuropsychol.22(5), 826–841 (2008).
  • Dresel S, Krause J, Krause KH et al. Attention deficit hyperactivity disorder: binding of [99mTc]TRODAT-1 to the dopamine transporter before and after methylphenidate treatment. Eur. J. Nucl. Med.27, 1518–1524 (2000).
  • Krause KH, Dresel SH, Krause J, Kung HF, Tatsch K. Increased striatal dopamine transporter in adult patients with attention deficit hyperactivity disorder: effects of methylphenidate as measured by single photon emission computed tomography. Neurosci. Lett.285, 107–110 (2000).
  • Volkow ND, Wang GJ, Fowler JS, Ding YS. Imaging the effects of methylphenidate on brain dopamine: new model on its therapeutic actions for attention-deficit/hyperactivity disorder. Biol. Psychiatry57, 1410–1415 (2005).
  • Ribases M, Ramos-Quiroga JA, Hervas A et al. Exploration of 19 serotoninergic candidate genes in adults and children with attention-deficit/hyperactivity disorder identifies association for 5HT2A, DDC and MAOB. Mol. Psychiatry.14(1), 71–85 (2009).

Website

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.