Predicting and preventing stroke after transient ischemic attack

References

• A classification and outline of cerebrovascular diseases II. Stroke6(5), 564–616 (1975).
   PubMedGoogle Scholar
• Koudstaal PJ, Gerritsma JG, van Gijn J. Clinical disagreement on the diagnosis of transient ischemic attack: is the patient or the doctor to blame? Stroke20(2), 300–301 (1989).
   PubMed Web of Science ®Google Scholar
• Albers GW, Caplan LR, Easton JD et al. Transient ischemic attack: proposal for a new definition. N. Engl. J. Med.347(21), 1713–1716 (2002).
   PubMed Web of Science ®Google Scholar
• Engelter ST, Provenzale JM, Petrella JR, Alberts MJ. Diffusion MR imaging and transient ischemic attacks. Stroke30(12), 2762–2763 (1999).
   PubMedGoogle Scholar
• Crisostomo RA, Garcia MM, Tong DC. Detection of diffusion-weighted MRI abnormalities in patients with transient ischemic attack: correlation with clinical characteristics. Stroke34(4), 932–937 (2003).
   PubMed Web of Science ®Google Scholar
• Redgrave JN, Coutts SB, Schulz UG, Briley D, Rothwell PM. Systematic review of associations between the presence of acute ischemic lesions on diffusion-weighted imaging and clinical predictors of early stroke risk after transient ischemic attack. Stroke38(5), 1482–1488 (2007).
   PubMedGoogle Scholar
• Kidwell CS, Alger JR, Di Salle F et al. Diffusion MRI in patients with transient ischemic attacks. Stroke30(6), 1174–1180 (1999).
   PubMed Web of Science ®Google Scholar
• Levy DE. How transient are transient ischemic attacks? Neurology38(5), 674–677 (1988).
   PubMed Web of Science ®Google Scholar
• Marler JR, Tilley BC, Lu M et al. Early stroke treatment associated with better outcome: the NINDS rt-PA stroke study. Neurology55(11), 1649–1655 (2000).
   PubMed Web of Science ®Google Scholar
• Hollander M, Koudstaal PJ, Bots ML et al. Incidence, risk, and case fatality of first ever stroke in the elderly population. the Rotterdam Study. J. Neurol. Neurosurg. Psychiatr.74(3), 317–321 (2003).
   PubMed Web of Science ®Google Scholar
• Bos MJ, van Rijn MJ, Witteman JC et al. Incidence and prognosis of transient neurological attacks. JAMA298(24), 2877–2885 (2007).
   PubMedGoogle Scholar
• van Swieten JC, Kappelle LJ, Algra A et al. Hypodensity of the cerebral white matter in patients with transient ischemic attack or minor stroke: influence on the rate of subsequent stroke. Dutch TIA trial study group. Ann. Neurol.32(2), 177–183 (1992).
   PubMed Web of Science ®Google Scholar
• Sempere AP, Duarte J, Cabezas C, Claveria LE. Incidence of transient ischemic attacks and minor ischemic strokes in Segovia, Spain. Stroke27(4), 667–671 (1996).
   PubMed Web of Science ®Google Scholar
• Ricci S, Celani MG, Guercini G et al. First-year results of a community-based study of stroke incidence in Umbria, Italy. Stroke20(7), 853–857 (1989).
   PubMedGoogle Scholar
• Bejot Y, Rouaud O, Benatru I et al. Trends in the incidence of transient ischemic attacks, premorbid risk factors and the use of preventive treatments in the population of Dijon, France from 1985 to 2004. Cerebrovasc. Dis.23(2–3), 126–131 (2007).
   PubMed Web of Science ®Google Scholar
• Feigin VL, Shishkin SV, Tzirkin GM et al. A population-based study of transient ischemic attack incidence in Novosibirsk, Russia, 1987–1988 and 1996–1997. Stroke31(1), 9–13 (2000).
   PubMedGoogle Scholar
• Rothwell PM, Coull AJ, Giles MF et al. Change in stroke incidence, mortality, case-fatality, severity, and risk factors in Oxfordshire, UK from 1981 to 2004 (Oxford Vascular Study). Lancet363(9425), 1925–1933 (2004).
   PubMed Web of Science ®Google Scholar
• Brown RD Jr, Petty GW, O’Fallon WM, Wiebers DO, Whisnant JP. Incidence of transient ischemic attack in Rochester, Minnesota, 1985–1989. Stroke29(10), 2109–2113 (1998).
   PubMedGoogle Scholar
• Kleindorfer D, Panagos P, Pancioli A et al. Incidence and short-term prognosis of transient ischemic attack in a population-based study. Stroke36(4), 720–723 (2005).
   PubMed Web of Science ®Google Scholar
• Giles MF, Rothwell PM. Substantial underestimation of the need for outpatient services for TIA and minor stroke. Age Ageing36(6), 676–680 (2007).
   PubMed Web of Science ®Google Scholar
• Hankey GJ, Slattery JM, Warlow CP. The prognosis of hospital-referred transient ischaemic attacks. J. Neurol. Neurosurg. Psychiatr.54(9), 793–802 (1991).
   PubMed Web of Science ®Google Scholar
• Farrell B, Godwin J, Richards S, Warlow C. The United Kingdom transient ischaemic attack (UK-TIA) aspirin trial: final results. J. Neurol. Neurosurg. Psychiatr.54(12), 1044–1054 (1991).
   PubMed Web of Science ®Google Scholar
• The Dutch TIA trial: protective effects of low-dose aspirin and atenolol in patients with transient ischemic attacks or nondisabling stroke. the Dutch TIA Study Group. Stroke19(4), 512–517 (1988).
   PubMed Web of Science ®Google Scholar
• Rothwell PM, Warlow CP. Timing of TIAs preceding stroke: time window for prevention is very short. Neurology64(5), 817–820 (2005).
   PubMed Web of Science ®Google Scholar
• Johnston SC, Gress DR, Browner WS, Sidney S. Short-term prognosis after emergency department diagnosis of TIA. JAMA284(22), 2901–2906 (2000).
   PubMed Web of Science ®Google Scholar
• Daffertshofer M, Mielke O, Pullwitt A, Felsenstein M, Hennerici M. Transient ischemic attacks are more than “ministrokes”. Stroke35(11), 2453–2458 (2004).
   PubMed Web of Science ®Google Scholar
• Coull AJ, Lovett JK, Rothwell PM. Population based study of early risk of stroke after transient ischaemic attack or minor stroke: implications for public education and organisation of services. BMJ328(7435), 326 (2004).
   PubMed Web of Science ®Google Scholar
• Lovett JK, Dennis MS, Sandercock PA et al. Very early risk of stroke after a first transient ischemic attack. Stroke34(8), E138–E140 (2003).
   PubMed Web of Science ®Google Scholar
• Correia M, Silva MR, Magalhaes R, Guimaraes L, Silva MC. Transient ischemic attacks in rural and urban northern Portugal: incidence and short-term prognosis. Stroke37(1), 50–55 (2006).
   PubMedGoogle Scholar
• Giles MF, Rothwell PM. Risk of stroke early after transient ischaemic attack: a systematic review and meta-analysis. Lancet Neurol.6(12), 1063–1072 (2007).
   PubMed Web of Science ®Google Scholar
• Wu CM, McLaughlin K, Lorenzetti DL et al. Early risk of stroke after transient ischemic attack: a systematic review and meta-analysis. Arch. Intern. Med.167(22), 2417–2422 (2007).
   PubMed Web of Science ®Google Scholar
• Rothwell PM, Giles MF, Flossmann E et al. A simple score (ABCD) to identify individuals at high early risk of stroke after transient ischaemic attack. Lancet366(9479), 29–36 (2005).
   PubMed Web of Science ®Google Scholar
• Johnston SC, Rothwell PM, Nguyen-Huynh MN et al. Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack. Lancet369(9558), 283–292 (2007).
   PubMed Web of Science ®Google Scholar
• Douglas VC, Johnston CM, Elkins J et al. Head computed tomography findings predict short-term stroke risk after transient ischemic attack. Stroke34(12), 2894–2898 (2003).
   PubMedGoogle Scholar
• Sciolla R, Melis F. Rapid identification of high-risk transient ischemic attacks: prospective validation of the ABCD score. Stroke39(2), 297–302 (2008).
   PubMed Web of Science ®Google Scholar
• Oppenheim C, Lamy C, Touze E et al. Do transient ischemic attacks with diffusion-weighted imaging abnormalities correspond to brain infarctions? AJNR Am. J. Neuroradiol.27(8), 1782–1787 (2006).
   PubMed Web of Science ®Google Scholar
• Purroy F, Montaner J, Rovira A et al. Higher risk of further vascular events among transient ischemic attack patients with diffusion-weighted imaging acute ischemic lesions. Stroke35(10), 2313–2319 (2004).
   PubMed Web of Science ®Google Scholar
• Coutts SB, Simon JE, Eliasziw M et al. Triaging transient ischemic attack and minor stroke patients using acute magnetic resonance imaging. Ann. Neurol.57(6), 848–854 (2005).
   PubMed Web of Science ®Google Scholar
• Sylaja PN, Coutts SB, Subramaniam S et al. Acute ischemic lesions of varying ages predict risk of ischemic events in stroke/TIA patients. Neurology68(6), 415–419 (2007).
   PubMed Web of Science ®Google Scholar
• Wen HM, Lam WW, Rainer T et al. Multiple acute cerebral infarcts on diffusion-weighted imaging and risk of recurrent stroke. Neurology63(7), 1317–1319 (2004).
   PubMed Web of Science ®Google Scholar
• Valton L, Larrue V, le Traon AP, Massabuau P, Geraud G. Microembolic signals and risk of early recurrence in patients with stroke or transient ischemic attack. Stroke29(10), 2125–2128 (1998).
   PubMed Web of Science ®Google Scholar
• Molloy J, Markus HS. Asymptomatic embolization predicts stroke and TIA risk in patients with carotid artery stenosis. Stroke30(7), 1440–1443 (1999).
   PubMed Web of Science ®Google Scholar
• Lovett JK, Coull AJ, Rothwell PM. Early risk of recurrence by subtype of ischemic stroke in population-based incidence studies. Neurology62(4), 569–573 (2004).
   PubMed Web of Science ®Google Scholar
• Ois A, Gomis M, Rodriguez-Campello A et al. Factors associated with a high risk of recurrence in patients with transient ischemic attack or minor stroke. Stroke39(6), 1717–1721 (2008).
   PubMed Web of Science ®Google Scholar
• Jensen MB, Chacon MR, Sattin JA, Aleu A, Lyden PD. The promise and potential pitfalls of serum biomarkers for ischemic stroke and transient ischemic attack. Neurologist14(4), 243–246 (2008).
   PubMed Web of Science ®Google Scholar
• Di Angelantonio E, De Castro S, Toni D et al. Determinants of plasma levels of brain natriuretic peptide after acute ischemic stroke or TIA. J. Neurol. Sci.260(1–2), 139–142 (2007).
   PubMedGoogle Scholar
• Dambinova SA, Khounteev GA, Skoromets AA. Multiple panel of biomarkers for TIA/stroke evaluation. Stroke33(5), 1181–1182 (2002).
   PubMedGoogle Scholar
• Jefferson AL, Massaro JM, Wolf PA et al. Inflammatory biomarkers are associated with total brain volume: the Framingham Heart Study. Neurology68(13), 1032–1038 (2007).
   PubMed Web of Science ®Google Scholar
• Bos MJ, Schipper CM, Koudstaal PJ et al. High serum C-reactive protein level is not an independent predictor for stroke: the Rotterdam Study. Circulation114(15), 1591–1598 (2006).
   PubMed Web of Science ®Google Scholar
• Flex A, Gaetani E, Papaleo P et al. Proinflammatory genetic profiles in subjects with history of ischemic stroke. Stroke35(10), 2270–2275 (2004).
   PubMed Web of Science ®Google Scholar
• Ikram MA, Seshadri S, Bis JC et al. Genomewide association studies of stroke. N. Engl. J. Med.360(17), 1718–1728 (2009).
   PubMed Web of Science ®Google Scholar
• Albers GW. A review of published TIA treatment recommendations. Neurology62(8 Suppl. 6), S26–S28 (2004).
   PubMedGoogle Scholar
• Guidelines for management of ischaemic stroke and transient ischaemic attack 2008. Cerebrovasc. Dis. 25(5), 457–507 (2008).
   PubMed Web of Science ®Google Scholar
• Rothwell PM, Giles MF, Chandratheva A et al. Effect of urgent treatment of transient ischaemic attack and minor stroke on early recurrent stroke (EXPRESS study): a prospective population-based sequential comparison. Lancet370(9596), 1432–1442 (2007).
   PubMed Web of Science ®Google Scholar
• Lavallee PC, Meseguer E, Abboud H et al. A transient ischaemic attack clinic with round-the-clock access (SOS-TIA): feasibility and effects. Lancet Neurol.6(11), 953–960 (2007).
   PubMed Web of Science ®Google Scholar
• Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ324(7329), 71–86 (2002).
   PubMed Web of Science ®Google Scholar
• Algra A, van Gijn J. Aspirin at any dose above 30 mg offers only modest protection after cerebral ischaemia. J. Neurol. Neurosurg. Psychiatr.60(2), 197–199 (1996).
   PubMed Web of Science ®Google Scholar
• A comparison of two doses of aspirin (30 mg vs. 283 mg a day) in patients after a transient ischemic attack or minor ischemic stroke:the Dutch TIA Trial Study Group. N. Engl. J. Med.325(18), 1261–1266 (1991).
   PubMed Web of Science ®Google Scholar
• Campbell CL, Smyth S, Montalescot G, Steinhubl SR. Aspirin dose for the prevention of cardiovascular disease: a systematic review. JAMA297(18), 2018–2024 (2007).
   PubMed Web of Science ®Google Scholar
• Bhatt DL, Fox KA, Hacke W et al. Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events. N. Engl. J. Med.354(16), 1706–1717 (2006).
   PubMed Web of Science ®Google Scholar
• Diener HC, Bogousslavsky J, Brass LM et al. Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial. Lancet364(9431), 331–337 (2004).
   PubMed Web of Science ®Google Scholar
• Halkes PH, van Gijn J, Kappelle LJ, Koudstaal PJ, Algra A. Aspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial origin (ESPRIT): randomised controlled trial. Lancet367(9523), 1665–1673 (2006).
   PubMed Web of Science ®Google Scholar
• Armstrong PW, Fu Y, Chang WC et al. Acute coronary syndromes in the GUSTO-IIb trial: prognostic insights and impact of recurrent ischemia. the GUSTO-IIb investigators. Circulation98(18), 1860–1868 (1998).
   PubMed Web of Science ®Google Scholar
• Sacco RL, Diener HC, Yusuf S et al. Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke. N. Engl. J. Med.359(12), 1238–1251 (2008).
   PubMed Web of Science ®Google Scholar
• Cheng Y, Austin SC, Rocca B et al. Role of prostacyclin in the cardiovascular response to thromboxane A2. Science296(5567), 539–541 (2002).
   PubMed Web of Science ®Google Scholar
• Bousser MG, Amarenco P, Chamorro A et al. Rationale and design of a randomized, double-blind, parallel-group study of terutroban 30 mg/day versus aspirin 100 mg/day in stroke patients: the prevention of cerebrovascular and cardiovascular events of ischemic origin with terutroban in patients with a history of ischemic stroke or transient ischemic attack (PERFORM) study. Cerebrovasc. Dis.27(5), 509–518 (2009).
   PubMed Web of Science ®Google Scholar
• Gorog DA, Sweeny JM, Fuster V. Antiplatelet drug ‘resistance’. part 2: laboratory resistance to antiplatelet drugs-fact or artifact? Nat. Rev. Cardiol.6(5), 365–373 (2009).
   PubMed Web of Science ®Google Scholar
• Sweeny JM, Gorog DA, Fuster V. Antiplatelet drug ‘resistance’. part 1: mechanisms and clinical measurements. Nat. Rev. Cardiol.6(4), 273–282 (2009).
   PubMed Web of Science ®Google Scholar
• Anderson JL, Adams CD, Antman EM et al. ACC/AHA 2007 guidelines for the management of patients with unstable angina/non ST-elevation myocardial infarction: a report of the American college of cardiology/american heart association task force on practice guidelines (writing committee to revise the 2002 guidelines for the management of patients with unstable angina/non ST-elevation myocardial infarction): developed in collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons: endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine. Circulation116(7), E148–E304 (2007).
   PubMed Web of Science ®Google Scholar
• Secondary prevention in non-rheumatic atrial fibrillation after transient ischaemic attack or minor stroke. EAFT (European Atrial Fibrillation Trial) Study Group. Lancet342(8882), 1255–1262 (1993).
   PubMed Web of Science ®Google Scholar
• Optimal oral anticoagulant therapy in patients with nonrheumatic atrial fibrillation and recent cerebral ischemia: The European Atrial Fibrillation Trial Study Group. N. Engl. J. Med.333(1), 5–10 (1995).
   PubMed Web of Science ®Google Scholar
• Hart RG, Pearce LA, Koudstaal PJ. Transient ischemic attacks in patients with atrial fibrillation: implications for secondary prevention: the European Atrial Fibrillation Trial and Stroke Prevention in Atrial Fibrillation III trial. Stroke35(4), 948–951 (2004).
   PubMed Web of Science ®Google Scholar
• van Walraven C, Hart RG, Connolly S et al. Effect of age on stroke prevention therapy in patients with atrial fibrillation: the atrial fibrillation investigators. Stroke40(4), 1410–1416 (2009).
   PubMed Web of Science ®Google Scholar
• A randomized trial of anticoagulants versus aspirin after cerebral ischemia of presumed arterial origin. The Stroke Prevention in Reversible Ischemia Trial (SPIRIT) Study Group. Ann. Neurol.42(6), 857–865 (1997).
   PubMed Web of Science ®Google Scholar
• Saxena R, Lewis S, Berge E, Sandercock PA, Koudstaal PJ. Risk of early death and recurrent stroke and effect of heparin in 3169 patients with acute ischemic stroke and atrial fibrillation in the International Stroke Trial. Stroke32(10), 2333–2337 (2001).
   PubMed Web of Science ®Google Scholar
• Lippi G, Franchini M, Favaloro EJ. Pharmacogenetics of vitamin K antagonists: useful or hype? Clin. Chem. Lab. Med.47(5), 503–515 (2009).
   PubMedGoogle Scholar
• Yusuf S, Sleight P, Pogue J et al. Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N. Engl. J. Med.342(3), 145–153 (2000).
   PubMed Web of Science ®Google Scholar
• Bosch J, Yusuf S, Pogue J et al. Use of ramipril in preventing stroke: double blind randomised trial. BMJ324(7339), 699–702 (2002).
   PubMed Web of Science ®Google Scholar
• Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6,105 individuals with previous stroke or transient ischaemic attack. Lancet358(9287), 1033–1041 (2001).
   PubMed Web of Science ®Google Scholar
• Rashid P, Leonardi-Bee J, Bath P. Blood pressure reduction and secondary prevention of stroke and other vascular events: a systematic review. Stroke34(11), 2741–2748 (2003).
   PubMed Web of Science ®Google Scholar
• Amarenco P, Bogousslavsky J, Callahan A 3rd et al. High-dose atorvastatin after stroke or transient ischemic attack. N. Engl. J. Med.355(6), 549–559 (2006).
   PubMed Web of Science ®Google Scholar
• Amarenco P, Labreuche J, Lavallee P, Touboul PJ. Statins in stroke prevention and carotid atherosclerosis: systematic review and up-to-date meta-analysis. Stroke35(12), 2902–2909 (2004).
   PubMed Web of Science ®Google Scholar
• Baigent C, Keech A, Kearney PM et al. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins. Lancet366(9493), 1267–1278 (2005).
   PubMed Web of Science ®Google Scholar
• Fuentes B, Martinez-Sanchez P, Diez-Tejedor E. Lipid-lowering drugs in ischemic stroke prevention and their influence on acute stroke outcome. Cerebrovasc. Dis.27(Suppl. 1), 126–133 (2009).
   PubMedGoogle Scholar
• Barnett HJ, Taylor DW, Eliasziw M et al. Benefit of carotid endarterectomy in patients with symptomatic moderate or severe stenosis: North American Symptomatic Carotid Endarterectomy Trial collaborators. N. Engl. J. Med.339(20), 1415–1425 (1998).
   PubMed Web of Science ®Google Scholar
• Randomised trial of endarterectomy for recently symptomatic carotid stenosis: final results of the MRC European Carotid Surgery Trial (ECST). Lancet351(9113), 1379–1387 (1998).
   PubMed Web of Science ®Google Scholar
• Rothwell PM, Eliasziw M, Gutnikov SA et al. Analysis of pooled data from the randomised controlled trials of endarterectomy for symptomatic carotid stenosis. Lancet361(9352), 107–116 (2003).
   PubMed Web of Science ®Google Scholar
• Rothwell PM, Eliasziw M, Gutnikov SA, Warlow CP, Barnett HJ. Endarterectomy for symptomatic carotid stenosis in relation to clinical subgroups and timing of surgery. Lancet363(9413), 915–924 (2004).
   PubMed Web of Science ®Google Scholar
• Fisher M, Paganini-Hill A, Martin A et al. Carotid plaque pathology: thrombosis, ulceration, and stroke pathogenesis. Stroke36(2), 253–257 (2005).
   PubMed Web of Science ®Google Scholar
• Rothwell PM, Gibson R, Warlow CP. Interrelation between plaque surface morphology and degree of stenosis on carotid angiograms and the risk of ischemic stroke in patients with symptomatic carotid stenosis.: on behalf of the European Carotid Surgery Trialists’ Collaborative Group. Stroke31(3), 615–621 (2000).
   PubMed Web of Science ®Google Scholar
• Eliasziw M, Streifler JY, Fox AJ et al. Significance of plaque ulceration in symptomatic patients with high-grade carotid stenosis. North American Symptomatic Carotid Endarterectomy Trial. Stroke25(2), 304–308 (1994).
   PubMed Web of Science ®Google Scholar
• Endovascular versus surgical treatment in patients with carotid stenosis in the carotid and vertebral artery transluminal angioplasty study (CAVATAS): a randomised trial. Lancet357(9270), 1729–1737 (2001).
   PubMed Web of Science ®Google Scholar
• Ringleb PA, Allenberg J, Bruckmann H et al. 30 day results from the SPACE trial of stent-protected angioplasty versus carotid endarterectomy in symptomatic patients: a randomised non-inferiority trial. Lancet368(9543), 1239–1247 (2006).
   PubMed Web of Science ®Google Scholar
• Featherstone RL, Brown MM, Coward LJ. International carotid stenting study: protocol for a randomised clinical trial comparing carotid stenting with endarterectomy in symptomatic carotid artery stenosis. Cerebrovasc. Dis.18(1), 69–74 (2004).
   PubMed Web of Science ®Google Scholar
• Hobson RW 2nd. CREST (Carotid Revascularization Endarterectomy versus Stent Trial): background, design, and current status. Semin. Vasc. Surg.13(2), 139–143 (2000).
   PubMedGoogle Scholar
• Thaler DE, Saver JL. Cryptogenic stroke and patent foramen ovale. Curr. Opin. Cardiol.23(6), 537–544 (2008).
   PubMedGoogle Scholar
• Stokes J 3rd, Kannel WB, Wolf PA, Cupples LA, D’Agostino RB. The relative importance of selected risk factors for various manifestations of cardiovascular disease among men and women from 35 to 64 years old: 30 years of follow-up in the Framingham Study. Circulation75(6 Pt 2), V65–V73 (1987).
   PubMed Web of Science ®Google Scholar
• Wilcox R, Bousser MG, Betteridge DJ et al. Effects of pioglitazone in patients with type 2 diabetes with or without previous stroke: results from PROactive (PROspective pioglitAzone clinical trial in macrovascular events 04). Stroke38(3), 865–873 (2007).
   PubMed Web of Science ®Google Scholar
• Urabe T, Watada H, Okuma Y et al. Prevalence of abnormal glucose metabolism and insulin resistance among subtypes of ischemic stroke in Japanese patients. Stroke40(4), 1289–1295 (2009).
   PubMed Web of Science ®Google Scholar
• Gray CS, Scott JF, French JM, Alberti KG, O’Connell JE. Prevalence and prediction of unrecognised diabetes mellitus and impaired glucose tolerance following acute stroke. Age Ageing33(1), 71–77 (2004).
   PubMed Web of Science ®Google Scholar
• Ivey FM, Ryan AS, Hafer-Macko CE et al. High prevalence of abnormal glucose metabolism and poor sensitivity of fasting plasma glucose in the chronic phase of stroke. Cerebrovasc. Dis.22(5–6), 368–371 (2006).
   PubMed Web of Science ®Google Scholar
• Vermeer SE, Hollander M, van Dijk EJ et al. Silent brain infarcts and white matter lesions increase stroke risk in the general population: the Rotterdam Scan Study. Stroke34(5), 1126–1129 (2003).
   PubMed Web of Science ®Google Scholar
• Kernan WN, Viscoli CM, Brass LM et al. The stroke prognosis instrument II (SPI-II): a clinical prediction instrument for patients with transient ischemia and nondisabling ischemic stroke. Stroke31(2), 456–462 (2000).
   PubMed Web of Science ®Google Scholar
• Lee IM, Hennekens CH, Berger K, Buring JE, Manson JE. Exercise and risk of stroke in male physicians. Stroke30(1), 1–6 (1999).
   PubMed Web of Science ®Google Scholar
• Robbins AS, Manson JE, Lee IM, Satterfield S, Hennekens CH. Cigarette smoking and stroke in a cohort of U.S. male physicians. Ann. Intern. Med.120(6), 458–462 (1994).
   PubMed Web of Science ®Google Scholar
• Chiuve SE, Rexrode KM, Spiegelman D et al. Primary prevention of stroke by healthy lifestyle. Circulation118(9), 947–954 (2008).
   PubMed Web of Science ®Google Scholar
• Giles MF. Risk of stroke and lifestyle. BMJ338, B14 (2009).
   PubMedGoogle Scholar
• Myint PK, Luben RN, Wareham NJ, Bingham SA, Khaw KT. Combined effect of health behaviours and risk of first ever stroke in 20,040 men and women over 11 years’ follow-up in Norfolk cohort of European Prospective Investigation of Cancer (EPIC Norfolk): prospective population study. BMJ338, B349 (2009).
   PubMedGoogle Scholar
• Lindstrom J, Ilanne-Parikka P, Peltonen M et al. Sustained reduction in the incidence of Type 2 diabetes by lifestyle intervention: follow-up of the Finnish diabetes prevention study. Lancet368(9548), 1673–1679 (2006).
   PubMed Web of Science ®Google Scholar
• Maasland L, van Oostenbrugge R, Franke C et al. Patients enrolled in large randomized clinical trials of antiplatelet treatment for prevention after TIA or ischemic stroke are not representative of patients in clinical practice: the Netherlands stroke survey. Stroke DOI: STROKEAHA.109.551812v1 (2009) (Epub ahead of print).
   PubMedGoogle Scholar
• Rothwell PM. External validity of randomised controlled trials: “to whom do the results of this trial apply?” Lancet365(9453), 82–93 (2005).
   PubMed Web of Science ®Google Scholar