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Expert Review of Neurotherapeutics Volume 9, 2009 - Issue 10
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Editorial

Brain tumor treatment increases the number of cancer stem-like cells

Nikki Charles Departments of Cancer Biology and Genetics, and Brain Tumor Center, Memorial Sloan–Kettering Cancer Center, New York, NY 10021, USA. [email protected]
&
Eric C Holland Departments of Neurosurgery and Surgery, and Biology and Genetics, and Brain Tumor Center, Memorial Sloan–Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA. [email protected]
Pages 1447-1449 | Published online: 09 Jan 2014

References

  • Kang MK, Kang SK. Tumorigenesis of chemotherapeutic drug-resistant cancer stem-like cells in brain glioma. Stem Cells Dev.16(5), 837–847 (2007).
  • Liu G, Yuan X, Zeng Z et al. Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma. Mol. Cancer5, 67 (2006).
  • Salmaggi A, Boiardi A, Gelati M et al. Glioblastoma-derived tumorospheres identify a population of tumor stem-like cells with angiogenic potential and enhanced multidrug resistance phenotype. Glia54(8), 850–860 (2006).
  • Bao S, Wu Q, McLendon RE et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature444(7120), 756–760 (2006).
  • Hambardzumyan D, Becher OJ, Rosenblum MK, Pandolfi PP, Manova-Todorova K, Holland EC. PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo.Genes Dev.22(4), 436–448 (2008).
  • Bleau AM, Hambardzumyan D, Ozawa T et al. PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells. Cell Stem Cell4(3), 226–235 (2009).
  • Kitange GJ, Carlson BL, Schroeder MA et al. Induction of MGMT expression is associated with temozolomide resistance in glioblastoma xenografts. Neuro. Oncol.11(3), 281–291 (2009).
  • Shih AH, Holland EC. Notch signaling enhances nestin expression in gliomas. Neoplasia8(12), 1072–1082 (2006).
  • Fan X, Matsui W, Khaki L et al. Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors. Cancer Res.66(15), 7445–7452 (2006).
  • Wang Z, Li Y, Kong D et al. Acquisition of epithelial–mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway. Cancer Res.69(6), 2400–2407 (2009).

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