Fear reduction in patients with chronic pain: a learning theory perspective

References

• Turk DC, Okifuji A. Pain terms and taxonomies. In: Bonica’s Management of Pain. Loeser JD, Butler SH, Chapman CR, Turk DC (Eds). Lippincott Williams & Wilkins, NY, USA, 18–25 (2001).
   Google Scholar
• Breivik H, Collett B, Ventafridda V, Cohen R, Gallacher D. Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment. Eur. J. Pain10(4), 287–333 (2006).
   PubMed Web of Science ®Google Scholar
• Tsang A, Von Korff M, Lee S et al. Common chronic pain conditions in developed and developing countries: gender and age differences and comorbidity with depression-anxiety disorders. J. Pain9(10), 883–891 (2008).
   PubMed Web of Science ®Google Scholar
• Nelson DV, Novy DM. Self-report differentiation of anxiety and depression in chronic pain. J. Pers. Assess.69(2), 392–407 (1997).
   PubMed Web of Science ®Google Scholar
• Goossens MEJB. Economic aspects of chronic musculoskeletal pain. In: New Avenues for the Prevention of Chronic Musculoskeletal Pain and Disability. Linton, SJ (Ed.). Elsevier Science, Amsterdam, The Netherlands (2002).
   Google Scholar
• Pizzi LT, Carter CT, Howell JB, Vallow SM, Crawford AG, Frank ED. Work loss, healthcare utilization, and costs among US employees with chronic pain. Disease Management Health Outcomes13(3), 201–208 (2005).
   Google Scholar
• Linton SJ, Ryberg M. A cognitive–behavioral group intervention as prevention for persistent neck and back pain in a non-patient population: a randomized controlled trial. Pain90(1), 83–90 (2001).
   PubMed Web of Science ®Google Scholar
• van Leeuwen MT, Blyth FM, March LM, Nicholas MK, Cousins MJ. Chronic pain and reduced work effectiveness: the hidden cost to Australian employers. Eur. J. Pain10(2), 161–166 (2006).
   PubMed Web of Science ®Google Scholar
• Gatchel RJ, Okifuji A. Evidence-based scientific data documenting the treatment and cost-effectiveness of comprehensive pain programs for chronic nonmalignant pain. J. Pain7(11), 779–793 (2006).
   PubMed Web of Science ®Google Scholar
• Waddell G. The biopsychosocial model. In: The Back Pain Revolution. Waddell G (Ed.). Churchill Livingston, Edinburgh, Scotland, 265–282 (2004).
   Google Scholar
• Nederhand MJ, Hermens HJ, Ijzerman MJ, Groothuis KG, Turk DC. The effect of fear of movement on muscle activation in posttraumatic neck pain disability. Clin. J. Pain22(6), 519–525 (2006).
   PubMed Web of Science ®Google Scholar
• Wilmink J, Patijn J. MR imaging of alar ligament in whiplash-associated disorders: an observer study. Neuroradiology43(10), 859–863 (2001).
   PubMedGoogle Scholar
• Lethem J, Slade PD, Troup JD, Bentley G. Outline of a fear-avoidance model of exaggerated pain perception. Behav. Res. Ther.21(4), 401–408 (1983).
   PubMed Web of Science ®Google Scholar
• Norton PJ, Asmundson GJ. Amending the fear-avoidance model of chronic pain: what is the role of physiological arousal? Behav. Ther.34(1), 17–30 (2003).
   Web of Science ®Google Scholar
• Sullivan MJL, Bishop SR, Pivik J. The Pain Catastrophizing Scale: development and validation. Psychol. Assess.7(4), 524–532 (1995).
   Web of Science ®Google Scholar
• Vlaeyen JW, Linton SJ. Fear-avoidance and its consequences in chronic musculoskeletal pain: a state of the art. Pain85(3), 317–332 (2000).
   PubMed Web of Science ®Google Scholar
• Vangronsveld K, Peters M, Goossens M, Linton SJ, Vlaeyen J. Applying the fear-avoidance model to the chronic whiplash syndrome. Pain131(3), 258–261 (2007).
   PubMedGoogle Scholar
• Leeuw M, Goossens M, Linton SJ, Crombez G, Boersma K, Vlaeyen J. The fear-avoidance model of musculoskeletal pain: current state of scientific evidence. J. Behav. Med.30(1), 77–94 (2007).
   PubMed Web of Science ®Google Scholar
• Swinkels-Meewisse IE, Roelofs J, Oostendorp RA, Verbeek AL, Vlaeyen JW. Acute low back pain: pain-related fear and pain catastrophizing influence physical performance and perceived disability. Pain120(1), 36–43 (2006).
   PubMed Web of Science ®Google Scholar
• Crombez G, Vlaeyen JW, Heuts PH, Lysens R. Pain-related fear is more disabling than pain itself: evidence on the role of pain-related fear in chronic back pain disability. Pain80(1), 329–339 (1999).
   PubMed Web of Science ®Google Scholar
• Vlaeyen JW, Kole-Snijders AM, Boeren RG, van Eek H. Fear of movement/(re)injury in chronic low back pain and its relation to behavioral performance. Pain62(3), 363–372 (1995).
   PubMed Web of Science ®Google Scholar
• Sieben JM, Vlaeyen JW, Portegijs PJ et al. A longitudinal study on the predictive validity of the fear-avoidance model in low back pain. Pain117(1–2), 162–170 (2005).
   PubMed Web of Science ®Google Scholar
• Picavet HS, Vlaeyen JW, Schouten JS. Pain catastrophizing and kinesiophobia: predictors of chronic low back pain. Am. J. Epidemiol.156(11), 1028–1034 (2002).
   PubMed Web of Science ®Google Scholar
• Pincus T, Vogel S, Burton KA, Santos R, Field AP. Fear avoidance and prognosis in back pain. Arth. Rheum.54(12), 3999–4010 (2006).
   PubMed Web of Science ®Google Scholar
• Lakke SE, Soer R, Takken T, Reneman MF. Risk and prognostic factors for non-specific musculoskeletal pain: a synthesis of evidence from systematic reviews classified into ICF dimensions. Pain147(1–3), 153–164 (2009).
   PubMed Web of Science ®Google Scholar
• Foster NE, Thomas E, Bishop A, Dunn KM, Main CJ. Distinctiveness of psychological obstacles to recovery in low back pain patients in primary care. Pain148(3), 398–406 (2010).
   PubMed Web of Science ®Google Scholar
• Gheldof ELM, Crombez G, van den Bussche E et al. Pain-related fear predicts disability, but not pain severity: a path analytic approach of the fear-avoidance model. Eur. J. Pain14(8), 870.e1–9 (2010).
   Google Scholar
• Wall PD. On the relation of injury to pain; the John J. Bonica Lecture. Pain6(3), 253–264 (1979).
   PubMed Web of Science ®Google Scholar
• Jarvik J, Hollingworth W, Heagerty P, Haynor D, Deyo R. The longitudinal assessment of imaging and disability of the back (LAIDBack) study: baseline data. Spine26(10), 1158–1166 (2001).
   PubMed Web of Science ®Google Scholar
• van Tulder MW, Assendelft WJJ, Koes BW, Bouter LM. Spinal radiographic findings and nonspecific low back pain: a systematic review of observational studies. Spine22(4), 427–434 (1997).
   PubMed Web of Science ®Google Scholar
• Goubert L, Crombez G, van Damme S. The role of neuroticism, pain catastrophizing and pain-related fear in vigilance to pain: a structural equations approach. Pain107(3), 234–241 (2004).
   PubMed Web of Science ®Google Scholar
• Esteve MR, Camacho L. Anxiety sensitivity, body vigilance and fear of pain. Behav. Res. Ther.46(6), 715–727 (2008).
   PubMed Web of Science ®Google Scholar
• Roelofs J, Peters ML, McCracken LM, Vlaeyen JW. The pain vigilance and awareness questionnaire (PVAQ): further psychometric evaluation in fibromyalgia and other chronic pain syndromes. Pain101(3), 299–306 (2003).
   PubMed Web of Science ®Google Scholar
• Stewart SH, Asmundson GJ. Anxiety sensitivity and its impact on pain experiences and conditions: a state of the art. Cogn. Behav. Ther.35(4), 185–188 (2006).
   PubMedGoogle Scholar
• Severeijns R, Vlaeyen JW, van den Hout MA, Weber WE. Pain catastrophizing predicts pain intensity, disability, and psychological distress independent of the level of physical impairment. Clin. J. Pain17(2), 165–172 (2001).
   PubMed Web of Science ®Google Scholar
• Severeijns R, van den Hout MA, Vlaeyen JW, Picavet HS. Pain catastrophizing and general health status in a large Dutch community sample. Pain99(1–2), 367–376 (2002).
   PubMed Web of Science ®Google Scholar
• Vancleef LM, Peters ML, Gilissen SM, De Jong PJ. Understanding the role of injury/illness sensitivity and anxiety sensitivity in (automatic) pain processing: an examination using the extrinsic affective Simon task. J. Pain8(7), 563–572 (2007).
   PubMedGoogle Scholar
• Quinn JJ, Fanselow MS, Craske MG, Hermans D, Vansteenwegen D. Defenses and memories: functional neural circuitry of fear and conditional responding. In: Fear and Learning: From Basic Processes to Clinical Implications. American Psychological Association, DC, USA, 55–74 (2006).
   Google Scholar
• Crombez G, van Damme S, Eccleston C. Hypervigilance to pain: an experimental and clinical analysis. Pain116(1–2), 4–7 (2005).
   PubMed Web of Science ®Google Scholar
• de Gier M, Peters ML, Vlaeyen JW. Fear of pain, physical performance, and attentional processes in patients with fibromyalgia. Pain104(1–2), 121–130 (2003).
   PubMed Web of Science ®Google Scholar
• Goubert L, Crombez G, Peters ML. Pain-related fear and avoidance: a conditioning perspective. In: Understanding and Treating Fear of Pain. Asmundson GJG, Vlaeyen JWS, Crombez G (Eds). University Press, Oxford, UK, 25–50 (2004).
   Google Scholar
• Salkovskis PM. The Cognitive Approach to Anxiety: Threat Beliefs, Safety-Seeking Behavior, and the Special Case of Health Anxiety and Obsessions. Guilford Press, NY, USA (1996).
   Google Scholar
• Salkovskis PM, Clark DM, Gelder MG. Cognition-behaviour links in the persistence of panic. Behav. Res. Ther.34(5–6), 453–458 (1996).
   PubMed Web of Science ®Google Scholar
• Tang NK, Salkovskis PM, Poplavskaya E, Wright KJ, Hanna M, Hester J. Increased use of safety-seeking behaviors in chronic back pain patients with high health anxiety. Behav. Res. Ther.45(12), 2821–2835 (2007).
   PubMed Web of Science ®Google Scholar
• Hermans D, Craske MG, Mineka S, Lovibond PF. Extinction in human fear conditioning. Biol. Psychiatry60(4), 361–368 (2006).
   PubMed Web of Science ®Google Scholar
• Bouton ME, Mineka S, Barlow DH. A modern learning theory perspective on the etiology of panic disorder. Psychol. Rev.108(1), 4–32 (2001).
   PubMed Web of Science ®Google Scholar
• Lovibond PF, Mitchell CJ, Minard E, Brady A, Menzies RG. Safety behaviours preserve threat beliefs: protection from extinction of human fear conditioning by an avoidance response. Behav. Res. Ther.47(8), 716–720 (2009).
   PubMed Web of Science ®Google Scholar
• Ash LM, Modic MT, Obuchowski NA, Ross JS, Brant-Zawadzki MN, Groof PN. Effects of diagnostic information, per se, on patient outcomes in acute radiculopathy and low back pain. Am. J. Neuroradiol.29(6), 1098–1103 (2008).
   PubMed Web of Science ®Google Scholar
• Houben RM, Ostelo RW, Vlaeyen JW, Wolters PM, Peters M, Stomp-van den Berg SG. Health care providers‘ orientations towards common low back pain predict perceived harmfulness of physical activities and recommendations regarding return to normal activity. Eur. J. Pain9(2), 173–183 (2005).
   PubMed Web of Science ®Google Scholar
• Rainville J, Bagnall D, Phalen L. Health care providers’ attitudes and beliefs about functional impairments and chronic back pain. Clin. J. Pain11(4), 287–295 (1995).
   PubMed Web of Science ®Google Scholar
• Vlaeyen JW, Linton SJ. Are we ‘fear-avoidant?’ Pain124(3), 240–241 (2006).
   PubMed Web of Science ®Google Scholar
• Bishop A, Foster NE, Thomas E, Hay EM. How does the self-reported clinical management of patients with low back pain relate to the attitudes and beliefs of health care practitioners? A survey of UK general practitioners and physiotherapists. Pain135(1), 187–195 (2008).
   PubMed Web of Science ®Google Scholar
• Olsson A, Phelps EA. Learned fear of ‘unseen’ faces after Pavlovian, observational, and instructed fear. Psychol. Sci.15(12), 822–828 (2004).
   PubMed Web of Science ®Google Scholar
• Waddell G, Newton M, Henderson I, Somerville D. A Fear-Avoidance Beliefs Questionnaire (FABQ) and the role of fear-avoidance beliefs in chronic low back pain and disability. Pain52(2), 157–168 (1993).
   PubMed Web of Science ®Google Scholar
• McCracken LM, Zayfert C, Gross RT. 
The Pain Anxiety Symptoms Scale: development and validation of a scale to measure fear of pain. Pain50(1), 67–73 (1992).
   PubMed Web of Science ®Google Scholar
• Kori S, Miller R, Todd D. Kinesiophobia: a new view on chronic pain behavior. Pain Manag.35–43 (1990).
   Google Scholar
• Roelofs J, Sluiter JK, Frings-Dresen MHW et al. Fear of movement and (re)injury in chronic musculoskeletal pain: evidence for an invariant two-factor model of the Tampa Scale for Kinesiophobia across pain diagnoses and Dutch, Swedish, and Canadian samples. Pain131(1–2), 181–190 (2007).
   PubMed Web of Science ®Google Scholar
• Lee KC, Chiu TTW, Lam TH. Psychometric properties of the Fear-Avoidance Beliefs Questionnaire in patients with neck pain. Clin. Rehab.20(10), 909–920 (2006).
   PubMedGoogle Scholar
• Roelofs J, McCracken LM, Peters ML, Crombez G, van Breukelen GJP, Vlaeyen JW. Psychometric evaluation of the Pain Anxiety Symptoms Scale (PASS) in chronic pain patients. J. Behav. Med.27(2), 167–183 (2004).
   PubMed Web of Science ®Google Scholar
• Goubert L, Crombez G, Van Damme S, Vlaeyen JWS, Bijttebier P, Roelofs J. Confirmatory factor analysis of the Tampa Scale for Kinesiophobia: invariant two-factor model across low back pain patients and fibromyalgia patients. Clin. J. Pain20(2), 103–110 (2004).
   PubMed Web of Science ®Google Scholar
• Roelofs J, Goubert L, Peters ML, Vlaeyen JW, Crombez G. The Tampa Scale for Kinesiophobia: further examination of psychometric properties in patients with chronic low back pain and fibromyalgia. Eur. J. Pain8(5), 495–502 (2004).
   PubMed Web of Science ®Google Scholar
• Leeuw M, Goossens MEJB, van Breukelen GJP, Boersma K, Vlaeyen JW. Measuring perceived harmfulness of physical activities in patients with chronic low back pain: the Photograph Series of Daily Activities-short electronic version. J. Pain8(11), 840–849 (2007).
   PubMed Web of Science ®Google Scholar
• Turk DC, Robinson JP, Sherman JJ, Burwinkle T, Swanson K. Assessing fear in patients with cervical pain: development and validation of the Pictorial Fear of Activity Scale-Cervical (PFActS-C). Pain139(1), 55–62 (2008).
   PubMedGoogle Scholar
• Vlaeyen JW, de Jong JR, Sieben JM, Crombez G. Graded exposure in vivo for pain-related fear. In: Psychological Approaches to Pain Management: a Practitioner’s Handbook. Turk DC, Gatchel RJ (Eds). Guilford Press, NY, USA, 210–233 (2002).
   Google Scholar
• Leeuw M, Peters ML, Wiers RW, Vlaeyen JW. Measuring fear of movement/(re)injury in chronic low back pain using implicit measures. Cogn. Behav. Ther.36(1), 52–64 (2007).
   PubMedGoogle Scholar
• Bouton ME, Swartzentruber D. Sources of relapse after extinction in Pavlovian and instrumental learning. Clin. Psychol. Rev.11(2), 123–140 (1991).
   Web of Science ®Google Scholar
• Crombez G, Eccleston C, Vlaeyen JW et al. Exposure to physical movement in low back pain patients: restricted effects of generalization. Health Psychol.21(6), 573–578 (2002).
   PubMed Web of Science ®Google Scholar
• Hofmann SG. Cognitive processes during fear acquisition and extinction in animals and humans: implications for exposure therapy of anxiety disorders. Clin. Psychol. Rev.28(2), 199–210 (2008).
   PubMed Web of Science ®Google Scholar
• Bouton ME. Context, ambiguity, and unlearning: sources of relapse after behavioral extinction. Biol. Psychiatry52(10), 976–986 (2002).
   PubMed Web of Science ®Google Scholar
• Mineka S, Zinbarg R. A contemporary learning theory perspective on the etiology of anxiety disorders: it’s not what you thought it was. Am. Psychol.61(1), 10–26 (2006).
   PubMed Web of Science ®Google Scholar
• de Jong JR, Vlaeyen JW, Onghena P, Cuijpers C, den Hollander M, Ruijgrok J. Reduction of pain-related fear in complex regional pain syndrome type I: the application of graded exposure in vivo. Pain116(3), 264–275 (2005).
   PubMed Web of Science ®Google Scholar
• Vlaeyen JWS, de Jong JR, Leeuw M, Crombez G. Fear reduction in chronic pain; Graded exposure in vivo with behavioral experiments. In: Understanding and Treating Fear of Pain. Asmundson GJG, Vlaeyen JWS, Crombez G (Eds). University Press, Oxford, UK, 313–343 (2004).
   Google Scholar
• de Jong JR, Vlaeyen JW, Onghena P, Goossens ME, Geilen M, Mulder H. Fear of movement/(re)injury in chronic low back pain: education or exposure in vivo as mediator to fear reduction? Clin. J. Pain21(1), 9–17 (2005).
   PubMed Web of Science ®Google Scholar
• Burton KA, Waddell G, Tillotson MK, Summerton N. Information and advice to patients with back pain can have a positive effect. A randomized controlled trial of a novel educational booklet in primary care. Spine24(23), 2484–2491 (1999).
   PubMed Web of Science ®Google Scholar
• Moore JE, Von Korff M, Cherkin D, Saunders K, Lorig K. A randomized trial of a cognitive-behavioral program for enhancing back pain self care in a primary care setting. Pain88, 145–153 (2000).
   PubMed Web of Science ®Google Scholar
• Colloca L, Benedetti F. Placebo analgesia induced by social observational learning. Pain144(1–2), 28–34 (2009).
   PubMed Web of Science ®Google Scholar
• Boersma K, Linton SJ, Overmeer T, Jansson M, Vlaeyen JW, de Jong JR. Lowering fear-avoidance and enhancing function through exposure in vivo. A multiple baseline study across six patients with back pain. Pain108(1), 8–16 (2004).
   PubMed Web of Science ®Google Scholar
• Linton SJ, Overmeer T, Janson M, Vlaeyen JW, de Jong JR. Graded in-vivo exposure treatment for fear-avoidant pain patients with functional disability: a case study. Cogn. Behav. Ther.31(2), 49–58 (2002).
   Google Scholar
• Lohnberg JA. A review of outcome studies on cognitive-behavioral therapy for reducing fear-avoidance beliefs among individuals with chronic pain. J. Clin. Psychol. Med. Settings14(2), 113–122 (2007).
   Web of Science ®Google Scholar
• Vlaeyen JWS, de Jong JR, Geilen M, Heuts PH, van Breukelen GJ. The treatment of fear of movement/(re)injury in chronic low back pain: further evidence on the effectiveness of exposure in vivo. Clin. J. Pain18(4), 251–261 (2002).
   PubMed Web of Science ®Google Scholar
• Vlaeyen JW, de Jong JR, Geilen M, Heuts PH, van Breukelen GJ. Graded exposure in vivo in the treatment of pain-related fear: a replicated single-case experimental design in four patients with chronic low back pain. Behav. Res. Ther.39(2), 151–166 (2001).
   PubMed Web of Science ®Google Scholar
• Vlaeyen JW, de Jong JR, Onghena P, Kerckhoffs-Hanssen M, Kole-Snijders AMJ. Can pain-related fear be reduced? The application of cognitive-behavioural exposure in vivo. Pain Res. Manag.7(3), 144–153 (2002).
   PubMedGoogle Scholar
• Bailey KM, Carleton RN, Vlaeyen JW, Asmundson GJ. Treatments addressing pain-related fear and anxiety in patients with chronic musculoskeletal pain: a preliminary review. Cogn. Behav. Ther.39(1), 46–63 (2010).
   PubMedGoogle Scholar
• Macedo LG, Smeets RJ, Maher CG, Latimer J, McAuley JH. Graded activity and graded exposure for persistent non-specific low back pain: a systematic review. Phys. Ther.90(6), 860–879 (2010).
   PubMed Web of Science ®Google Scholar
• Woods MP, Asmundson GJ. Evaluating the efficacy of graded in vivo exposure for the treatment of fear in patients with chronic back pain: a randomized controlled clinical trial. Pain136(3), 271–280 (2008).
   PubMed Web of Science ®Google Scholar
• Linton SJ, Boersma K, Jansson M, Overmeer T, Lindblom K, Vlaeyen JW. A randomized controlled trial of exposure in vivo for patients with spinal pain reporting fear of work-related activities. Eur. J. Pain12(6), 722–730 (2008).
   PubMed Web of Science ®Google Scholar
• Leeuw M, Goossens MEJB, van Breukelen GJ et al. Exposure in vivo versus operant graded activity in chronic low back pain patients: results of a randomized controlled trial. Pain138(1), 192–207 (2008).
   PubMed Web of Science ®Google Scholar
• de Jong JR, Vangronsveld K, Peters ML et al. Reduction of pain-related fear and disability in post-traumatic neck pain: a replicated single-case experimental study of exposure in vivo. J. Pain9(12), 1123–1134 (2008).
   PubMed Web of Science ®Google Scholar
• ter Kuile MM, Bulte I, Weijenborg PT, Beekman A, Melles R, Onghena P. Therapist-aided exposure for women with lifelong vaginismus: a replicated single-case design. J. Consult. Clin. Psychol.77(1), 149–159 (2009).
   PubMed Web of Science ®Google Scholar
• Sieben JM, Portegijs PJ, Vlaeyen JW, Knottnerus JA. Pain-related fear at the start of a new low back pain episode. Eur. J. Pain9(6), 635–641 (2005).
   PubMedGoogle Scholar
• Smeets RJEM, Vlaeyen JWS, Kester AD, Knottnerus JA. Reduction of pain catastrophizing mediates the outcome of both physical and cognitive-behavioral treatment in chronic low back pain. J. Pain7(4), 261–271 (2006).
   PubMed Web of Science ®Google Scholar
• McCracken LM, Keogh E. Acceptance, mindfulness, and values-based action may counteract fear and avoidance of emotions in chronic pain: an analysis of anxiety sensitivity. J. Pain10(4), 408–415 (2009).
   PubMed Web of Science ®Google Scholar
• McCracken LM, Vowles KE, Eccleston C. Acceptance-based treatment for persons with complex, long standing chronic pain: a preliminary analysis of treatment outcome in comparison to a waiting phase. Behav. Res. Ther.43(10), 1335–1346 (2005).
   PubMed Web of Science ®Google Scholar
• Wicksell RK, Ahlqvist J, Bring A, Melin L, Olsson GL. Can exposure and acceptance strategies improve functioning and life satisfaction in people with chronic pain and whiplash-associated disorders (WAD)? A randomized controlled trial. Cogn. Behav. Ther.37(3), 1–14 (2008).
   PubMedGoogle Scholar
• Hofmann SG, Asmundson GJ. Acceptance and mindfulness-based therapy: new wave or old hat? Clin. Psychol. Rev.28(1), 1–16 (2008).
   PubMed Web of Science ®Google Scholar
• Wicksell RK, Melin L, Lekander M, Olsson GL. Evaluating the effectiveness of exposure and acceptance strategies to improve functioning and quality of life in longstanding pediatric pain – a randomized controlled trial. Pain141(3), 248–257 (2009).
   PubMed Web of Science ®Google Scholar
• Linton SJ. Applying dialectical behavior therapy to chronic pain: a case study. Scand. J. Pain1(1), 50–54 (2010).
   PubMedGoogle Scholar
• Hayes SC. Acceptance and commitment therapy, relational frame theory, and the third wave of behavioral and cognitive therapies. Behav. Ther.35(4), 639–665 (2004).
   Web of Science ®Google Scholar
• Olsson A, Phelps EA. Social learning of fear. Nat. Neurosci.10(9), 1095–1102 (2007).
   PubMed Web of Science ®Google Scholar
• Bliokas VV, Cartmill TK, Nagy BJ. Does systematic graded exposure in vivo enhance outcomes in multidisciplinary chronic pain management groups? Clin. J. Pain23(4), 361–374 (2007).
   PubMed Web of Science ®Google Scholar
• Dahl JC, Nilsson A. Evaluation of randomized preventive behavioural medicine work site intervention for public health workers at risk for developing chronic pain. Eur. J. Pain5(4), 421–432 (2001).
   PubMedGoogle Scholar
• Bouton ME. Context, ambiguity, and classical conditioning. Curr. Dir. Psychol. Sci.3(2), 49–53 (1994).
   Web of Science ®Google Scholar
• Goubert L, Crombez G, Danneels L. The reluctance to generalize corrective experiences in chronic low back pain patients: a questionnaire study of dysfunctional cognitions. Behav. Res. Ther.43(8), 1055–1067 (2005).
   PubMed Web of Science ®Google Scholar
• Goubert L, Francken G, Crombez G, Vansteenwegen D, Lysens R. Exposure to physical movement in chronic back pain patients: no evidence for generalization across different movements. Behav. Res. Ther.40(4), 415–429 (2002).
   PubMed Web of Science ®Google Scholar
• Trost Z, France CR, Thomas JS. Exposure to movement in chronic back pain: evidence of successful generalization across a reaching task. Pain137(1), 26–33 (2008).
   PubMed Web of Science ®Google Scholar
• Rachman S, Radomsky AS, Shafran R. Safety behaviour: a reconsideration. Behav. Res. Ther.46(2), 163–173 (2008).
   PubMed Web of Science ®Google Scholar
• Salkovskis PM, Clark DM, Hackmann A, Wells A, Gelder MG. An experimental investigation of the role of safety-seeking behaviours in the maintenance of panic disorder with agoraphobia. Behav. Res. Ther.37(6), 559–574 (1999).
   PubMed Web of Science ®Google Scholar
• Powers MB, Smits JAJ, Telch MJ. Disentangling the effects of safety-behavior utilization and safety-behavior availability during exposure-based treatment: 
a placebo-controlled trial. J. Consult. Clin. Psychol.72(3), 448–454 (2004).
   PubMed Web of Science ®Google Scholar
• Lovibond PF. Cognitive processes in extinction. Learn. Memory11(5), 495–500 (2004).
   PubMed Web of Science ®Google Scholar
• Vervliet B, Vansteenwegen D, Hermans D, Eelen P. Concurrent excitors limit the extinction of conditioned fear in humans. Behav. Res. Ther.45(2), 375–383 (2007).
   PubMed Web of Science ®Google Scholar
• Lovibond PF, Davis NR, O’Flaherty AS. Protection from extinction in human fear conditioning. Behav. Res. Ther.38(10), 967–983 (2000).
   PubMed Web of Science ®Google Scholar
• Flink IK, Boersma K, Linton SJ. Catastrophizing moderates the effect of exposure in vivo for back pain patients with pain-related fear. Eur. J. Pain DOI: 10.1016/j.ejpain.2010.02.003 (2010) (Epub ahead of print).
   Google Scholar
• Seminowicz DA, Davis KD. Cortical responses to pain in healthy individuals depends on pain catastrophizing. Pain120(3), 297–306 (2006).
   PubMed Web of Science ®Google Scholar
• Craske MG, Kircanski K, Zelikowsky M, Mystkowski J, Chowdhury N, Baker A. Optimizing inhibitory learning during exposure therapy. Behav. Res. Ther.46(1), 5–27 (2008).
   PubMed Web of Science ®Google Scholar
• Sinha S, Papp LA, Gorman JM. How study of respiratory physiology aided our understanding of abnormal brain function in panic disorder. J. Affect. Disorders61(3), 191–200 (2000).
   PubMed Web of Science ®Google Scholar
• Flink IK, Nicholas MK, Boersma K, Linton SJ. Reducing the threat value of chronic pain: a preliminary replicated single-case study of interoceptive exposure versus distraction in six individuals with chronic back pain. Behav. Res. Ther.47(8), 721–728 (2009).
   PubMedGoogle Scholar
• van Damme S, Crombez G, Eccleston C. Coping with pain: a motivational perspective. Pain139(1), 1–4 (2008).
   PubMed Web of Science ®Google Scholar
• Vlaeyen JW, Crombez G, Linton SJ. The fear-avoidance model of pain: we are not there yet. Comment on Wideman et al. “A prospective sequential analysis of the fear-avoidance model of pain” [Pain, 2009] and Nicholas “First things first: reduction in catastrophizing before fear of movement” [Pain, 2009]. Pain146(1–2), 222–222 (2009).
   PubMed Web of Science ®Google Scholar
• Karoly P, Okun MA, Ruehlman LS, Pugliese JA. The impact of goal cognition and pain severity on disability and depression in adults with chronic pain: an examination of direct effects and mediated effects via pain-induced fear. Cognitive Ther. Res.32(3), 418–433 (2008).
   Web of Science ®Google Scholar
• Christiansen S, Oettingen G, Dahme B, Klinger R. A short goal-pursuit intervention to improve physical capacity: a randomized clinical trial in chronic back pain patients. Pain149(3), 444–452 (2010).
   PubMed Web of Science ®Google Scholar
• Schrooten MG, Vlaeyen JW. Becoming active again? Further thoughts on goal pursuit in chronic pain. Pain149(3), 422–423 (2010).
   PubMed Web of Science ®Google Scholar