1,128
Views
12
CrossRef citations to date
0
Altmetric
Key Paper Evaluation

Contribution of genetic, epigenetic and transcriptomic differences to twin discordance in multiple sclerosis

, &
Pages 1379-1381 | Published online: 09 Jan 2014

References

  • Handel AE, Giovannoni G, Ebers GC, Ramagopalan SV. Environmental factors and their timing in adult-onset multiple sclerosis. Nat. Rev. Neurol.6, 156–166 (2010).
  • Ramagopalan SV, Dyment DA, Ebers GC. Genetic epidemiology: the use of old and new tools for multiple sclerosis. Trends Neurosci.31, 645–652 (2008).
  • Youssoufian H, Pyeritz RE. Mechanisms and consequences of somatic mosaicism in humans. Nat. Rev. Genet.3, 748–758 (2002).
  • Bruder CE, Piotrowski A, Gijsbers AA et al. Phenotypically concordant and discordant monozygotic twins display different DNA copy-number-variation profiles. Am. J. Hum. Genet.82, 763–771 (2008).
  • Feinberg AP. Epigenetics at the epicenter of modern medicine. JAMA299, 1345–1350 (2008).
  • Fraga MF, Ballestar E, Paz MF et al. Epigenetic differences arise during the lifetime of monozygotic twins. Proc. Natl Acad. Sci. USA102, 10604–10609 (2005).
  • Kaminsky ZA, Tang T, Wang SC et al. DNA methylation profiles in monozygotic and dizygotic twins. Nat. Genet.41, 240–245 (2009).
  • Kaplan L, Foster R, Shen Y et al. Monozygotic twins discordant for neurofibromatosis 1. Am. J. Med. Genet. A152A, 601–606 (2010).
  • Weksberg R, Shuman C, Caluseriu O et al. Discordant KCNQ1OT1 imprinting in sets of monozygotic twins discordant for Beckwith–Wiedemann syndrome. Hum. Mol. Genet.11, 1317–1325 (2002).
  • Gilad Y, Pritchard JK, Thornton K. Characterizing natural variation using next-generation sequencing technologies. Trends Genet.25, 463–471 (2009).
  • Baranzini SE, Mudge J, van Velkinburgh JC et al. Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis. Nature464, 1351–1356 (2010).
  • Bentley DR, Balasubramanian S, Swerdlow HP et al. Accurate whole human genome sequencing using reversible terminator chemistry. Nature456, 53–59 (2008).
  • De Jager PL, Rossin E, Pyne S et al. Cytometric profiling in multiple sclerosis uncovers patient population structure and a reduction of CD8low cells. Brain131, 1701–1711 (2008).
  • Friese MA, Fugger L. Pathogenic CD8+ T cells in multiple sclerosis. Ann. Neurol.66, 132–141 (2009).
  • Laird PW. Principles and challenges of genome-wide DNA methylation analysis. Nat. Rev. Genet.11, 191–203 (2010).
  • Kriaucionis S, Heintz N. The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain. Science324, 929–930 (2009).
  • Javierre BM, Fernandez AF, Richter J et al. Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus. Genome Res.20, 170–179 (2010).
  • Nguyen A, Rauch TA, Pfeifer GP, Hu VW. Global methylation profiling of lymphoblastoid cell lines reveals epigenetic contributions to autism spectrum disorders and a novel autism candidate gene, RORA, whose protein product is reduced in autistic brain. FASEB J. DOI: 10.1096/fj.10-154484 (2010) (Epub ahead of print).
  • Kaneda A, Feinberg AP. Loss of imprinting of IGF2: a common epigenetic modifier of intestinal tumor risk. Cancer Res.65, 11236–11240 (2005).
  • Islam T, Gauderman WJ, Cozen W et al. Differential twin concordance for multiple sclerosis by latitude of birthplace. Ann. Neurol.60, 56–64 (2006).
  • Okuda DT. Unanticipated demyelinating pathology of the CNS. Nat. Rev. Neurol.5, 591–597 (2009).
  • Somma P, Ristori G, Battistini L et al. Characterization of CD8+ T cell repertoire in identical twins discordant and concordant for multiple sclerosis. J. Leukoc. Biol.81, 696–710 (2007).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.