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Theme: Demyelinating diseases - Review

Cortical pathology and cognitive impairment in multiple sclerosis

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Pages 425-432 | Published online: 09 Jan 2014

References

  • Charcot JM. Lectures on Diseases of the Nervous System. New Sydenham Society, London, UK (1877).
  • Rao SM, Leo GJ, Ellington L, Nauertz T, Bernardin L, Unverzagt F. Cognitive dysfunction in multiple sclerosis. II. Impact on employment and social functioning. Neurology41(5), 692–696 (1991).
  • Schultheis MT, Garay E, DeLuca J. The influence of cognitive impairment on driving performance in multiple sclerosis. Neurology56, 1089–1094 (2001).
  • Patti F. Cognitive impairment in multiple sclerosis. Mult. Scler.15(1), 2–8 (2009).
  • Rao SM, Leo GJ, Bernardin L, Unverzagt F. Cognitive dysfunction in multiple sclerosis. I. Frequency, patterns, and prediction. Neurology41(5), 685–691 (1991).
  • Amato MP, Zipoli V, Portaccio E. Multiple sclerosis-related cognitive changes: a review of cross-sectional and longitudinal studies. J. Neurol. Sci.245(1–2), 41–46 (2006).
  • Nocentini U, Pasqualetti P, Bonavita S et al. Cognitive dysfunction in patients with relapsing–remitting multiple sclerosis. Mult. Scler.12(1), 77–87 (2006).
  • Chiaravalloti ND, DeLuca J. Cognitive impairment in multiple sclerosis. Lancet Neurol.7(12), 1139–1151 (2008).
  • Winkelmann A, Engel C, Apel A, Zettl UK. Cognitive impairment in multiple sclerosis. J. Neurol.254(2), 35–42 (2007). Erratum in: J. Neurol.255(2), 309–310 (2008).
  • Foong J, Rosewicz L, Chong WK, Thompson AJ, Miller DH, Ron MA. A comparison of neuropsychological deficits in primary and secondary progressive multiple sclerosis. J. Neurol.247(2), 97–101 (2000).
  • Comi G, Filippi M, Martinelli V et al. Brain MRI correlates of cognitive impairment in primary and secondary progressive multiple sclerosis. J. Neurol. Sci.132(2), 222–227 (1995).
  • Huijbregts SC, Kalkers NF, de Sonneville LM, de Groot V, Polman CH. Cognitive impairment and decline in different MS subtypes. J. Neurol. Sci.245, 187–194 (2006).
  • Potagas C, Giogkaraki E, Koutsis G et al. Cognitive impairment in different MS subtypes and clinically isolated syndromes. J. Neurol. Sci.267, 100–106 (2008).
  • Callanan MM, Logsdail SJ, Ron MA, Warrington EK. Cognitive impairment in patients with clinically isolated lesions of the type seen in multiple sclerosis. A psychometric and MRI study. Brain112(Pt 2), 361–374 (1989).
  • Feinstein A, Youl B, Ron M. Acute optic neuritis. A cognitive and magnetic resonance imaging study. Brain115(Pt 5), 1403–1415 (1992).
  • Achiron A, Barak Y. Cognitive impairment in probable multiple sclerosis. J. Neurol. Neurosurg. Psychiatry74(4), 443–446 (2003).
  • Feuillet L, Reuter F, Audoin B et al. Early cognitive impairment in patients with clinically isolated syndrome suggestive of multiple sclerosis. Mult. Scler.13(1), 124–127 (2007).
  • Banwell B, Ghezzi A, Bar-Or A, Mikaeloff Y, Tardieu M. Multiple sclerosis in children: clinical diagnosis, therapeutic strategies, and future directions. Lancet Neurol.6(10), 887–902 (2007).
  • MacAllister WS, Belman AL, Milazzo M et al. Cognitive functioning in children and adolescents with multiple sclerosis. Neurology64(8), 1422–1425 (2005).
  • Banwell BL, Anderson PE. The cognitive burden of multiple sclerosis in children. Neurology64(5), 891–894 (2005).
  • Amato MP, Goretti B, Ghezzi A et al. Cognitive and psychosocial features of childhood and juvenile MS. Neurology70(20), 1891–1897 (2008).
  • Sumowski JF, Wylie GR, Deluca J, Chiaravalloti N. Intellectual enrichment is linked to cerebral efficiency in multiple sclerosis: functional magnetic resonance imaging evidence for cognitive reserve. Brain133, 362–374 (2010).
  • Arnett PA. Longitudinal consistency of the relationship between depression symptoms and cognitive functioning in multiple sclerosis. CNS Spectr.10, 372–382 (2005).
  • Bobholz, JA, Rao, SM. Cognitive dysfunction in multiple sclerosis: a review of recent developments. Curr. Opin. Neurol.16(3), 283–288 (2003).
  • Rogers JM, Panegyres PK. Cognitive impairment in multiple sclerosis: evidence-based analysis and recommendations. J. Clin. Neurosci.14(10), 919–927 (2007).
  • Zakzanis KK. Distinct neurocognitive profiles in multiple sclerosis subtypes. Arch. Clin. Neuropsychol.15(2), 115–136 (2000).
  • Sartori E, Edan G. Assessment of cognitive dysfunction in multiple sclerosis. J. Neurol. Sci.245(1–2), 169–175 (2006).
  • Zipoli V, Goretti B, Hakiki B et al. Cognitive impairment predicts conversion to multiple sclerosis in clinically isolated syndromes. Mult. Scler.16(1), 62–67 (2010).
  • Flavia M, Stampatori C, Zanotti D, Parrinello G, Capra R. Efficacy and specificity of intensive cognitive rehabilitation of attention and executive functions in multiple sclerosis. J. Neurol. Sci.288(1–2), 101–105 (2010).
  • Rovaris M, Filippi M, Minicucci L et al. Cortical/subcortical disease burden and cognitive impairment in patients with multiple sclerosis. Am. J. Neuroradiol.21(2), 402–408 (2000).
  • Rao SM, Leo GJ, Haughton VM, Aubin-Faubert PS, Bernardin L. Correlation of magnetic resonance imaging with neuropsychological testing in multiple sclerosis. Neurology39(2 Pt 1), 161–166 (1989).
  • Benedict RH, Weinstock-Guttman B, Fishman I, Sharma J, Tjoa CW, Bakshi R. Prediction of neuropsychological impairment in multiple sclerosis: comparison of conventional magnetic resonance imaging measures of atrophy and lesion burden. Arch. Neurol.61(2), 226–230 (2004).
  • Swirsky-Sacchetti T, Mitchell DR, Seward J et al. Neuropsychological and structural brain lesions in multiple sclerosis: a regional analysis. Neurology42(7), 1291–1295 (1992).
  • Arnett PA, Rao SM, Bernardin L, Grafman J, Yetkin FZ, Lobeck L. Relationship between frontal lobe lesions and Wisconsin Card Sorting Test performance in patients with multiple sclerosis. Neurology44(3 Pt 1), 420–425 (1994).
  • Foong J, Rozewicz L, Quaghebeur G et al. Executive function in multiple sclerosis. The role of frontal lobe pathology. Brain120(Pt 1), 15–26 (1997).
  • Sperling RA, Guttmann CR, Hohol MJ et al. Regional magnetic resonance imaging lesion burden and cognitive function in multiple sclerosis: a longitudinal study. Arch. Neurol.58(1), 115–121 (2001).
  • Filippi M, Tortorella C, Rovaris M et al. Changes in the normal appearing brain tissue and cognitive impairment in multiple sclerosis. J. Neurol. Neurosurg. Psychiatry68(2), 157–161 (2000).
  • Christodoulou C, Krupp LB, Liang Z et al. Cognitive performance and MR markers of cerebral injury in cognitively impaired MS patients. Neurology60(11), 1793–1798 (2003).
  • Rovaris M, Iannucci G, Falautano M et al. Cognitive dysfunction in patients with mildly disabling relapsing–remitting multiple sclerosis: an exploratory study with diffusion tensor MR imaging. J. Neurol. Sci.195(2), 103–109 (2002).
  • Dineen RA, Vilisaar J, Hlinka J et al. Disconnection as a mechanism for cognitive dysfunction in multiple sclerosis. Brain132(Pt 1), 239–249 (2009).
  • Trapp BD, Peterson J, Ransohoff RM, Rudick R, Mörk S, Bö L. Axonal transection in the lesions of multiple sclerosis. N. Engl. J. Med.338(5), 278–285 (1998).
  • Peterson JW, Bö L, Mörk S, Chang A, Trapp BD. Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions. Ann. Neurol.50(3), 389–400 (2001).
  • Geurts JJ, Pouwels PJ, Uitdehaag BM, Polman CH, Barkhof F, Castelijns JA. Intracortical lesions in multiple sclerosis: improved detection with 3D double inversion-recovery MR imaging. Radiology236(1), 254–260 (2005).
  • De Stefano N, Matthews PM, Filippi M et al. Evidence of early cortical atrophy in MS: relevance to white matter changes and disability. Neurology60(7), 1157–1162 (2003).
  • Sailer M, Fischl B, Salat D et al. Focal thinning of the cerebral cortex in multiple sclerosis. Brain26(Pt 8), 1734–1744 (2003).
  • Dalton CM, Chard DT, Davies GR et al. Early development of multiple sclerosis is associated with progressive grey matter atrophy in patients presenting with clinically isolated syndromes. Brain127(Pt 5), 1101–1107 (2004).
  • Calabrese M, Atzori M, Bernardi V et al. Cortical atrophy is relevant in multiple sclerosis at clinical onset. J. Neurol.254(9), 1212–1220 (2007).
  • Kidd D, Barkhof F, McConnell R, Algra PR, Allen IV, Revesz T. Cortical lesions in multiple sclerosis. Brain122(Pt 1), 17–26 (1999).
  • Kutzelnigg A, Lucchinetti CF, Stadelmann C et al. Cortical demyelination and diffuse white matter injury in multiple sclerosis. Brain128(Pt 11), 2705–2712 (2005).
  • Pomeroy IM, Matthews PM, Frank JA, Jordan EK, Esiri MM. Demyelinated neocortical lesions in marmoset autoimmune encephalomyelitis mimic those in multiple sclerosis. Brain128(Pt 11), 2713–2721 (2005).
  • Geurts JJ, Bo L, Pouwels PJ et al. Cortical lesions in multiple sclerosis: combined postmortem MR imaging and histopathology. Am. J. Neuroradiol.26, 572–577 (2005).
  • Calabrese M, De Stefano N, Atzori M et al. Detection of cortical inflammatory lesions by double inversion recovery magnetic resonance imaging in patients with multiple sclerosis. Arch. Neurol.64(10), 1416–1422 (2007).
  • Calabrese M, Rocca MA, Atzori M et al. Cortical lesions in primary progressive multiple sclerosis: a 2-year longitudinal MR study. Neurology72, 1330–1336 (2009).
  • Calabrese M, Gallo P. Magnetic resonance evidence of cortical onset of multiple sclerosis. Mult. Scler.15(8), 933–941 (2009).
  • Calabrese M, Rocca MA, Atzori M et al. A three-years MRI study of cortical lesions in relapse-onset multiple sclerosis. Ann. Neurol.67(3), 376–383 (2010).
  • Calabrese M, De Stefano N, Atzori M et al. Extensive cortical inflammation is associated with epilepsy in multiple sclerosis. J. Neurol.255(4), 581–586 (2008).
  • Roosendaal SD, Moraal B, Pouwels PJ et al. Accumulation of cortical lesions in MS: relation with cognitive impairment. Mult. Scler.15(6), 708–714 (2009).
  • Calabrese M, Agosta F, Rinaldi F et al. Cortical lesions and atrophy associated with cognitive impairment in relapsing–remitting multiple sclerosis. Arch. Neurol.66(9), 1144–1150 (2009).
  • Rao SM, Cognitive Function Study Group, NMSS. A Manual for the Brief Repeatable Battery of Neuropsychological Tests in Multiple Sclerosis. National Multiple Sclerosis Society, NY, USA (1990).
  • Rinaldi F, Calabrese M, Seppi D, Puthenparampil M, Perini P, Gallo P. Natalizumab prevents the accumulation of cortical lesions in relapsing remitting multiple sclerosis: a preliminary report. Neurol. Sci. DOI: 10.1007/s10072-010-0346-x (2010) (Epub ahead of print).
  • Mattioli F, Stampatori C, Bellomi F, Capra R. Natalizumab efficacy on cognitive impairment in MS. Neurol. Sci. DOI: 10.1007/s10072-010-0351-0 (2010) (Epub ahead of print).
  • Valsasina P, Benedetti B, Rovaris M, Sormani MP, Comi G, Filippi M. Evidence for progressive gray matter loss in patients with relapsing–remitting MS. Neurology65(7), 1126–1128 (2005).
  • Pirko I, Lucchinetti CF, Sriram S, Bakshi R. Gray matter involvement in multiple sclerosis. Neurology68(9), 634–642 (2007).
  • Fisher E, Lee JC, Nakamura K, Rudick RA. Gray matter atrophy in multiple sclerosis: a longitudinal study. Ann. Neurol.64(3), 255–265 (2008).
  • Simon JH, Kinkel RP, Jacobs L, Bub L, Simonian N. A Wallerian degeneration pattern in patients at high risk for MS. Neurology54(5), 1155–1160 (2000).
  • Chard DT, Griffin CM, McLean MA et al. Brain metabolite changes in cortical grey and normal-appearing white matter in clinically early relapsing–remitting multiple sclerosis. Brain125(Pt 10), 2342–2352 (2002).
  • Chard DT, Griffin CM, Rashid W et al. Progressive grey matter atrophy in clinically early relapsing–remitting multiple sclerosis. Mult. Scler.10(4), 387–391 (2004).
  • Charil A, Filippi M. Inflammatory demyelination and neurodegeneration in early multiple sclerosis. J. Neurol Sci.259(1–2), 7–15 (2007).
  • Lanz M, Hahn HK, Hildebrandt H. Brain atrophy and cognitive impairment in multiple sclerosis: a review. J. Neurol.254(Suppl. 2), II43–II48 (2007).
  • Benedict RH, Carone D, Bakshi R. Correlating brain atrophy with cognitive dysfunction, mood disturbances, and personality disorder in multiple sclerosis. J. Neuroimaging14(3 Suppl.), S36–S46 (2004).
  • Lazeron RH, de Sonneville LM, Scheltens P, Polman CH, Barkhof F. Cognitive slowing in multiple sclerosis is strongly associated with brain volume reduction. Mult. Scler.12(4), 760–768 (2006).
  • Sanchez MP, Nieto A, Barroso J, Martin V, Hernandez MA. Brain atrophy as a marker of cognitive impairment in mildly disabling relapsing–remitting multiple sclerosis. Eur. J. Neurol.15(10), 1091–1099 (2008).
  • Benedict RH, Bruce JM, Dwyer MG et al. Neocortical atrophy, third ventricular width, and cognitive dysfunction in multiple sclerosis. Arch. Neurol.63(9), 1301–1306 (2006).
  • Hildebrandt H, Hahn HK, Kraus JA, Schulte-Herbrüggen A, Schwarze B, Schwendemann G. Memory performance in multiple sclerosis patients correlates with central brain atrophy. Mult. Scler.12(4), 428–436 (2006).
  • Amato MP, Bartolozzi ML, Zipoli V et al. Neocortical volume decrease in relapsing remitting MS patients with mild cognitive impairment. Neurology63(1), 89–93 (2004).
  • Sanfilipo MP, Benedict RH, Sharma J, Weinstock-Guttman B, Bakshi R. The relationship between whole brain volume and disability in multiple sclerosis: a comparison of normalized gray vs. white matter with misclassification correction. Neuroimage26(4), 1068–1077 (2005).
  • Sanfilipo MP, Benedict RH, Weinstock-Guttman B, Bakshi R. Gray and white matter brain atrophy and neuropsychological impairment in multiple sclerosis. Neurology66(5), 685–692 (2006).
  • Portaccio E, Amato MP, Bartolozzi ML et al. Neocortical volume decrease in relapsing–remitting multiple sclerosis with mild cognitive impairment. J. Neurol. Sci.245(1–2), 195–199 (2006).
  • Amato MP, Portaccio E, Goretti B et al. Association of neocortical volume changes with cognitive deterioration in relapsing–remitting multiple sclerosis. Arch. Neurol.64(8), 1157–1161 (2007).
  • Rovaris M, Filippi M, Falautano M et al. Relation between MR abnormalities and patterns of cognitive impairment in multiple sclerosis. Neurology50(6), 1601–1618 (1998).
  • Sperling RA, Guttmann CR, Hohol MJ et al. Regional magnetic resonance imaging lesion burden and cognitive function in multiple sclerosis: a longitudinal study. Arch. Neurol.58(1), 115–121 (2001).
  • Locatelli L, Zivadinov R, Grop A, Zorzon M. Frontal parenchymal atrophy measures in multiple sclerosis. Mult. Scler.10(5), 562–568 (2004).
  • Benedict RH, Zivadinov R, Carone D et al. Regional lobar atrophy predicts memory impairment in multiple sclerosis. Am. J. Neuroradiol.26(7), 1824–1831 (2005).
  • Tekok-Kilic A, Benedict RH, Weinstock-Guttman B et al. Independent contributions of cortical gray matter atrophy and ventricle enlargement for predicting neuropsychological impairment in multiple sclerosis. Neuroimage36(4), 1294–1300 (2007).
  • Morgen K, Sammer G, Courtney SM et al. Evidence for a direct association between cortical atrophy and cognitive impairment in relapsing–remitting MS. Neuroimage30(3), 891–898 (2006).
  • Benedict RH, Ramasamy D, Munschauer F, Weinstock-Guttman B, Zivadinov R. Memory impairment in multiple sclerosis: correlation with deep grey matter and mesial temporal atrophy. J. Neurol. Neurosurg. Psychiatry80(2), 201–206 (2009)
  • Deichmann R, Good CD, Josephs O, Ashburner J, Turner R. Optimization of 3-D MP-RAGE sequences for structural brain imaging. Neuroimage12(1), 112–127 (2000).
  • Deichmann R, Schwarzbauer C, Turner R. Optimisation of the 3D MDEFT sequence for anatomical brain imaging: technical implications at 1.5 and 3 T. Neuroimage21(2), 757–767 (2004).
  • Zeng X, Staib LH, Schultz RT, Duncan JS. Segmentation and measurement of the cortex from 3-D MR images using coupled-surfaces propagation. IEEE Trans. Med. Imaging18(10), 927–937 (1999).
  • Fischl B, Dale AM. Measuring the thickness of the human cerebral cortex from magnetic resonance images. Proc. Natl Acad. Sci. USA97(20), 11050–11055 (2000).
  • Jones SE, Buchbinder BR, Aharon I. Three-dimensional mapping of cortical thickness using Laplace’s equation. Hum. Brain Mapp.11(1), 12–32 (2000).
  • MacDonald D, Kabani N, Avis D, Evans AC. Automated 3-D extraction of inner and outer surfaces of cerebral cortex from MRI. Neuroimage12(3), 340–356 (2000).
  • Miller MI, Massie AB, Ratnanather JT, Botteron KN, Csernansky JG. Bayesian construction of geometrically based cortical thickness metrics. Neuroimage12(6), 676–687 (2000).
  • Dale AM, Fischl B, Sereno MI. Cortical surface-based analysis. I. Segmentation and surface reconstruction. Neuroimage9(2), 179–194 (1999).
  • Fischl B, Sereno M, Dale AM. Cortical surface-based analysis. II. Inflation, flattening and a surfacebased coordinate system. Neuroimage9(2), 272–284 (1999).
  • Chen JT, Narayanan S, Collins DL, Smith SM, Matthews PM, Arnold DL. Relating neocortical pathology to disability progression in multiple sclerosis using MRI. Neuroimage23(3), 1168–1175 (2004).
  • Calabrese M, Rinaldi F, Mattisi I et al. Widespread cortical thinning characterizes patients with MS with mild cognitive impairment. Neurology74(4), 321–328 (2010).
  • Filippi M, Rocca MA. Cortical reorganisation in patients with MS. J. Neurol. Neurosurg. Psychiatry75(8), 1087–1089 (2004)
  • Rocca MA, Colombo B, Falini A. Cortical adaptation in patients with MS: a cross-sectional functional MRI study of disease phenotypes. Lancet Neurol.4(10), 618–626 (2005).
  • Calabrese P, Penner IK. Cognitive dysfunctions in multiple sclerosis: a multiple disconnection syndrome’? J. Neurol.254(Suppl. 2), II18–II21 (2007). Erratum in: J. Neurol.255, 309–310 (2008).

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