463
Views
118
CrossRef citations to date
0
Altmetric
Special Report

Adverse effects of antiepileptic drugs: a brief overview of important issues

, , &
Pages 885-891 | Published online: 09 Jan 2014

References

  • Cramer JA, Fisher R, Ben-Menachem E, French J, Mattson RH. New antiepileptic drugs: comparison of key clinical trials. Epilepsia40, 590–600 (1999).
  • Cramer JA, Ben Menachem E, French J. Review of treatment options for refractory epilepsy: new medications and vagal nerve stimulation. Epilepsy Res.47, 17–25 (2001).
  • Hirsch LJ, Weintraub D, Du Y et al. Correlating lamotrigine serum concentrations with tolerability in patients with epilepsy. Neurology63(6), 1022–1026 (2004).
  • Mattson RH. Medical management of epilepsy in adults. Neurology51, S15–S20 (1998).
  • Mattson RH, Cramer JA, Collins JF et al. Early tolerance to anti-epileptic drug side effects: a controlled trial of 247 patients. In: Tolerance to Beneficial and Adverse Effects of Antiepileptic Drugs. Koella WP (Ed.). Raven Press, NY, USA 149–156 (1986).
  • Mattson RH, Cramer JA, Collins JF et al. Comparison of carbamazepine, phenobarbital, phenytoin and primidone in partial and secondarily generalized tonic clonic seizures. N. Engl. J. Med.313, 145–151 (1985).
  • Cramer JA, Mattson RH, Prevey ML, Ouellette VL. How often is medication taken as prescribed? A novel assessment technique. J. Am. Med. Assoc.261, 3273–3277 (1989).
  • Miura H. Zonisamide monotherapy with once-daily dosing in children with cryptogenic localization-related epilepsies: clinical effects and pharmacokinetic studies. Seizure13, S17–S23 (2004).
  • Reunanen M, Dam M, Yuen AW. A randomised open multicentre comparative trial of lamotrigine and carbamazepine as monotherapy in patients with newly diagnosed or recurrent epilepsy. Epilepsy Res.23, 149–155 (1996).
  • Biton V, Edwards KR, Montouris GD et al. Topiramate titration and tolerability. Ann. Pharmacother.35, 172–179 (2001).
  • Mattson RH. An overview of the new antiepileptic drugs. Neurologist4, S2–S10 (1998).
  • Hermann B, Meador BJ, Gaillard WD, Cramer JA. Cognition across the lifespan: antiepileptic drugs, epilepsy, or both? Epilepsy Behav.17, 1–5 (2010).
  • Vining EPG, Mellits ED, Dorsen MM et al. Psychologic and behavioral effects of antiepileptic drugs in children: a double-blind comparison between phenobarbital and valproic acid. Pediatrics80, 165–174 (1987).
  • Farwell JR, Lee YJ, Hirtz DG, Sulzbacher SI, Ellenberg JH, Nelson KB. Phenobarbital for febrile seizures – effects on intelligence and on seizure recurrence. N. Engl. J. Med.322, 364–369 (1990).
  • Willmore LJ, Wheless JW, Pellock JM. Adverse effects of antiepileptic drugs. In: Pediatric Epilepsy: Diagnosis and Therapy. Pellock JM, Bourgeois BFD, Dodson WE, Nordli DR Jr, Sankar R (Eds). Demos Medical Publishing, LLC, NY, USA 449–559 (2008).
  • Meador KJ, Loring DW, Moore EE et al. Comparative cognitive effects of phenobarbital, phenytoin, and valproate in healthy adults. Neurology45, 1494–1499 (1995).
  • Shorvon SD. Safety of topiramate: adverse events and relationships to dosing. Epilepsia37, S18–S22 (1996).
  • Meador KJ. Effects of topiramate on cognition. J. Neurol. Neurosurg. Psychiatry71, 134–135 (2001).
  • Edwards KR, Kamin M. Efficacy and cognitive side effects of tiagabine and topiramate Neurology48, A39 (1997).
  • Blumer D, Montouris G, Hermann B. Psychiatric morbidity in seizure patients on a neurodiagnostic monitoring unit. J. Neuropsychol. Clin. Neurosci.7, 445–456 (1995).
  • Krishnamoorthy ES, Trimble MR, Sander JW, Kanner AM. Forced normalization at the interface between epilepsy and psychiatry. Epilepsy Behav.3, 303–308 (2002).
  • Cramer JA, De Rue K, Devinsky O, Edrich P, Michael R. Trimble MR. A systematic review of the behavioral effects of levetiracetam in adults with epilepsy, cognitive disorders, or an anxiety disorder in clinical trials. Epilepsy Behav.4, 124–132 (2003).
  • Hirsch LJ, Arif H, Buchsbaum R et al. Effect of age and comedication on levetiracetam pharmacokinetics and tolerability. Epilepsia48, 1351–1359 (2007).
  • Kanner AM, Balabanov A. Depression and epilepsy: how closely related are they? Neurology58, 571–585 (2002).
  • Cramer JA, Brandenburg N, Xiao X. Differentiating anxiety and depression symptoms in patients with partial epilepsy. Epilepsy Behav.6, 563–569 (2005).
  • Schmitz EB, Moriarity J, Costa DC, Ring HA, Ell PJ, Trimble MR. Psychiatric profiles and patterns of cerebral blood flow in focal epilepsy: interactions between depression, obsessionality, and perfusion related to the laterality of the epilepsy. J. Neurol. Neurosurg. Psychiat.62, 458–463 (1997).
  • Parker WA, Shearer CA. Phenytoin hepatotoxicity: a case report and review. Neurology29(2), 175–178 (1979).
  • Besag FM. Behavioural effects of the newer antiepileptic drugs: an update. Expert Opin. Drug Saf.3, 1–8 (2004).
  • Manjula D, David J, Kulkarni C. Prescribing pattern of anti-seizure medications (ASMs): an evaluation of extent of xanthine co-medication. Pol. J. Pharmacol.54, 285–291 (2002).
  • Anderson GD. Children versus adults: pharmacokinetic and adverse effect differences. Epilepsia43, 49–53 (2002).
  • Arif H, Buchsbaum R, Weintraub D et al. Comparison and predictors of rash associated with 15 antiepileptic drugs. Neurology68, 1701–1709 (2007).
  • Man CB, Kwan P, Baum L et al. Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese. Epilepsia48, 1015–1018 (2007).
  • Cheng SH, Kwan P, Ng NK, Ng MH. New testing approach in HLA genotyping helps overcome barriers in effective clinical practice. Clin. Chem.55(8), 1568–1572 (2009).
  • Moore TJ, Weiss SR, Kaplan S, Blaisdell CJ. Reported adverse drug events in infants and children under 2 years of age. Pediatrics110, E53–E57 (2002).
  • Mathis LL, Iyasu S. Safety monitoring of drugs granted exclusivity under the Best Pharmaceuticals for Children Act: what the FDA has learned. Clin. Pharmacol. Ther.82, 133–134 (2007).
  • Johann-Liang R, Wyeth J, Chen M, Cope JU. Pediatric drug surveillance and the Food and Drug Administration’s adverse event reporting system: an overview of reports, 2003–2007. Pharmacoepidemiol. Drug Saf.18, 24–27 (2009).
  • Perucca E, Meador KJ. Adverse effects of antiepileptic drugs. Acta Neurol. Scand.112, 30–35 (2005).
  • Zaccara G, Franciotta D, Perucca E. Idiosyncratic adverse reactions to antiepileptic drugs. Epilepsia48, 1223–1244 (2007).
  • McSherry E. Acidosis and growth in nonuremic renal disease. Kidney Int.14, 349–354 (1978).
  • Camfield P, Camfield C. Monitoring for adverse effects of antiepileptic drugs. Epilepsia47, 31–34 (2006).
  • Mattson RH, Cramer JA, McCutchen CB; The VA Epilepsy Cooperative Study Group. Barbiturate related connective tissue disorders. Arch. Intern. Med.149, 911–914 (1989).
  • Mintzer S, Skidmore CT, Abidin CJ et al. Effects of antiepileptic drugs on lipids, homocysteine, and C-reactive protein. Ann. Neurol.65, 448–456 (2009).
  • Ben-Menachem E. Weight issues for people with epilepsy – a review. Epilepsia48, 42–45 (2007).
  • Sharpe C, Wolfson T, Trauner DA. Weight gain in children treated with valproate. J. Child Neurol.24, 338–341 (2009).
  • Bootsma HP, Ricker L, Hekster YA et al. The impact of side effects on long-term retention in three new antiepileptic drugs. Seizure18, 327–331 (2009).

Website

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.