Antidepressants in the treatment of stroke

References

• Starkstein SE, Mizrahi R, Power BD. Antidepressant therapy in post-stroke depression. Expert Opin. Pharmacother.9,1291–1298 (2008).
   PubMed Web of Science ®Google Scholar
• Yulug B. Neuroprotective treatment strategies for poststroke mood disorders: a minireview on atypical neuroleptic drugs and selective serotonin re-uptake inhibitors. Brain Res. Bull.80,95–99 (2009).
   Google Scholar
• Nakata N, Kato H, Kogure K. Protective effects of serotonin reuptake inhibitors, citalopram and clomipramine, against hippocampal CA1 neuronal damage following transient ischemia in the gerbil. Brain Res.590,48–52 (1992).
   PubMed Web of Science ®Google Scholar
• Kim DH, Li H, Yoo KY, Lee BH, Hwang IK, Won MH. Effects of fluoxetine on ischemic cells and expressions in BDNF and some antioxidants in the gerbil hippocampal CA1 region induced by transient ischemia. Exp. Neurol.204,748–758 (2007).
   PubMed Web of Science ®Google Scholar
• Zhang WH, Wang H, Wang X et al. Nortriptyline protects mitochondria and reduces cerebral ischemia/hypoxia injury. Stroke39,455–462 (2008).
   PubMed Web of Science ®Google Scholar
• Lim CM, Kim SW, Park JY, Kim C, Yoon SH, Lee JK. Fluoxetine affords robust neuroprotection in the postischemic brain via its anti-inflammatory effect. J. Neurosci. Res.87,1037–1045 (2009).
   PubMed Web of Science ®Google Scholar
• Jin K, Minami M, Lan JQ et al. Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat. Proc. Natl Acad. Sci. USA98,4710–4715 (2001).
   PubMed Web of Science ®Google Scholar
• Jin K, Wang X, Xie L et al. Evidence for stroke-induced neurogenesis in the human brain. Proc. Natl Acad. Sci. USA103,13198–13202 (2006).
   PubMed Web of Science ®Google Scholar
• Arvidsson A, Collin T, Kirik D, Kokaia Z, Lindvall O. Neuronal replacement from endogenous precursors in the adult brain after stroke. Nat. Med.8,963–970 (2002).
   PubMed Web of Science ®Google Scholar
• Raber J, Fan Y, Matsumori Y et al. Irradiation attenuates neurogenesis and exacerbates ischemia-induced deficits. Ann. Neurol.55,381–389 (2004).
   PubMed Web of Science ®Google Scholar
• Jin K, Wang X, Xie L, Mao XO, Greenberg DA. Transgenic ablation of doublecortin-expressing cells suppresses adult neurogenesis and worsens stroke outcome in mice. Proc. Natl Acad. Sci. USA107(17),7993–7938 (2010).
   PubMed Web of Science ®Google Scholar
• Manev H, Uz T, Smalheiser NR, Manev R. Antidepressants alter cell proliferation in the adult brain in vivo and in neural cultures in vitro.Eur. J. Pharmacol.411,67–70 (2001).
   PubMed Web of Science ®Google Scholar
• Malberg JE, Eisch AJ, Nestler EJ, Duman RS. Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J. Neurosci.20,9104–9110 (2000).
   PubMed Web of Science ®Google Scholar
• Keilhoff G, Becker A, Grecksch G, Bernstein HG, Wolf G. Cell proliferation is influenced by bulbectomy and normalized by imipramine treatment in a region-specific manner. Neuropsychopharmacology31,1165–1176 (2006).
   PubMedGoogle Scholar
• Hitoshi S, Maruta N, Higashi M, Kumar A, Kato N, Ikenaka K. Antidepressant drugs reverse the loss of adult neural stem cells following chronic stress. J. Neurosci. Res.85,3574–3585 (2007).
   PubMed Web of Science ®Google Scholar
• Lau WM, Qiu G, Helmeste DM, Lee TM, Tang SW, So KF. Corticosteroid decreases subventricular zone cell proliferation, which could be reversed by paroxetine. Restor. Neurol. Neurosci.25,17–23 (2007).
   Google Scholar
• Arias-Carrion O, Verdugo-Diaz L, Feria-Velasco A et al. Neurogenesis in the subventricular zone following transcranial magnetic field stimulation and nigrostriatal lesions. J. Neurosci. Res.78,16–28 (2004).
   PubMed Web of Science ®Google Scholar
• van Praag H, Christie BR, Sejnowski TJ, Gage FH. Running enhances neurogenesis, learning, and long-term potentiation in mice. Proc. Natl Acad. Sci. USA96,13427–13431 (1999).
   PubMed Web of Science ®Google Scholar
• David DJ, Samuels BA, Rainer Q et al. Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression. Neuron62,479–493 (2009).
   PubMed Web of Science ®Google Scholar
• Brezun JM, Daszuta A. Depletion in serotonin decreases neurogenesis in the dentate gyrus and the subventricular zone of adult rats. Neuroscience89,999–1002 (1999).
   PubMed Web of Science ®Google Scholar
• Jha S, Rajendran R, Davda J, Vaidya VA. Selective serotonin depletion does not regulate hippocampal neurogenesis in the adult rat brain: differential effects of p-chlorophenylalanine and 5,7-dihydroxytryptamine. Brain Res.1075,48–59 (2006).
   Google Scholar
• Van Kampen JM, Hagg T, Robertson HA. Induction of neurogenesis in the adult rat subventricular zone and neostriatum following dopamine D3 receptor stimulation. Eur. J. Neurosci.19,2377–2387 (2004).
   PubMed Web of Science ®Google Scholar
• Hoglinger GU, Rizk P, Muriel MP et al. Dopamine depletion impairs precursor cell proliferation in Parkinson disease. Nat. Neurosci.7,726–735 (2004).
   PubMed Web of Science ®Google Scholar
• Baker SA, Baker KA, Hagg T. Dopaminergic nigrostriatal projections regulate neural precursor proliferation in the adult mouse subventricular zone. Eur. J. Neurosci.20,575–579 (2004).
   PubMed Web of Science ®Google Scholar
• Kulkarni VA, Jha S, Vaidya VA. Depletion of norepinephrine decreases the proliferation, but does not influence the survival and differentiation, of granule cell progenitors in the adult rat hippocampus. Eur. J. Neurosci.16,2008–2012 (2002).
   PubMed Web of Science ®Google Scholar
• Yanpallewar SU, Fernandes K, Marathe SV et al. α2-adrenoceptor blockade accelerates the neurogenic, neurotrophic, and behavioral effects of chronic antidepressant treatment. J. Neurosci.30,1096–1109 (2010).
   Google Scholar
• Rizk P, Salazar J, Raisman-Vozari R et al. The a2-adrenoceptor antagonist dexefaroxan enhances hippocampal neurogenesis by increasing the survival and differentiation of new granule cells. Neuropsychopharmacology31,1146–1157 (2006).
   PubMed Web of Science ®Google Scholar
• Jhaveri DJ, Mackay EW, Hamlin AS et al. Norepinephrine directly activates adult hippocampal precursors via b3-adrenergic receptors. J. Neurosci.30,2795–2806 (2010).
   PubMed Web of Science ®Google Scholar
• Hagg T. From neurotransmitters to neurotrophic factors to neurogenesis. Neuroscientist15,20–27 (2009).
   Google Scholar
• Pencea V, Bingaman KD, Wiegand SJ, Luskin MB. Infusion of brain-derived neurotrophic factor into the lateral ventricle of the adult rat leads to new neurons in the parenchyma of the striatum, septum, thalamus, and hypothalamus. J. Neurosci.21,6706–6717 (2001).
   PubMed Web of Science ®Google Scholar
• Benraiss A, Chmielnicki E, Lerner K, Roh D, Goldman SA. Adenoviral brain-derived neurotrophic factor induces both neostriatal and olfactory neuronal recruitment from endogenous progenitor cells in the adult forebrain. J. Neurosci.21,6718–6731 (2001).
   PubMed Web of Science ®Google Scholar
• Wagner JP, Black IB, DiCicco-Bloom E. Stimulation of neonatal and adult brain neurogenesis by subcutaneous injection of basic fibroblast growth factor. J. Neurosci.19,6006–6016 (1999).
   Google Scholar
• Jin K, Zhu Y, Sun Y, Mao XO, Xie L, Greenberg DA. Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo. Proc. Natl Acad. Sci. USA99,11946–11950 (2002).
   PubMed Web of Science ®Google Scholar
• Greenberg DA, Jin K. Growth factors and stroke. NeuroRx3,458–465 (2006).
   Google Scholar
• Nibuya M, Morinobu S, Duman RS. Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. J. Neurosci.15,7539–7547 (1995).
   PubMed Web of Science ®Google Scholar
• Mallei A, Shi B, Mocchetti I. Antidepressant treatments induce the expression of basic fibroblast growth factor in cortical and hippocampal neurons. Mol. Pharmacol.61,1017–1024 (2002).
   PubMed Web of Science ®Google Scholar
• Warner-Schmidt JL, Duman RS. VEGF is an essential mediator of the neurogenic and behavioral actions of antidepressants. Proc. Natl Acad. Sci. USA104,4647–4652 (2007).
   PubMed Web of Science ®Google Scholar
• Choi YS, Cho KO, Kim SY. Fluoxetine does not affect the ischemia-induced increase of neurogenesis in the adult rat dentate gyrus. Arch. Pharm. Res.30,641–645 (2007).
   Google Scholar
• Li WL, Cai HH, Wang B et al. Chronic fluoxetine treatment improves ischemia-induced spatial cognitive deficits through increasing hippocampal neurogenesis after stroke. J. Neurosci. Res.87,112–122 (2009).
   PubMed Web of Science ®Google Scholar
• Schiavon AP, Milani H, Romanini CV et al. Imipramine enhances cell proliferation and decreases neurodegeneration in the hippocampus after transient global cerebral ischemia in rats. Neurosci. Lett.470,43–48 (2010).
   PubMed Web of Science ®Google Scholar
• Goldstein LB. Effects of amphetamines and small related molecules on recovery after stroke in animals and man. Neuropharmacology39,852–859 (2000).
   PubMed Web of Science ®Google Scholar
• Boyeson MG, Harmon RL. Effects of trazodone and desipramine on motor recovery in brain-injured rats. Am. J. Phys. Med. Rehabil.72,286–293 (1993).
   Google Scholar
• Boyeson MG, Harmon RL, Jones JL. Comparative effects of fluoxetine, amitriptyline and serotonin on functional motor recovery after sensorimotor cortex injury. Am. J. Phys. Med. Rehabil.73,76–83 (1994).
   Google Scholar
• Chang YC, Tzeng SF, Yu L et al. Early-life fluoxetine exposure reduced functional deficits after hypoxic-ischemia brain injury in rat pups. Neurobiol. Dis.24,101–113 (2006).
   PubMed Web of Science ®Google Scholar
• Maya Vetencourt JF, Sale A, Viegi A et al. The antidepressant fluoxetine restores plasticity in the adult visual cortex. Science320,385–388 (2008).
   PubMed Web of Science ®Google Scholar
• Ramasubbu R, Robinson RG, Flint AJ, Kosier T, Price TR. Functional impairment associated with acute poststroke depression: the Stroke Data Bank Study. J. Neuropsychiatry Clin. Neurosci.10,26–33 (1998).
   PubMed Web of Science ®Google Scholar
• Dam M, Tonin P, De Boni A et al. Effects of fluoxetine and maprotiline on functional recovery in poststroke hemiplegic patients undergoing rehabilitation therapy. Stroke27,1211–1214 (1996).
   PubMed Web of Science ®Google Scholar
• Miyai I, Reding MJ. Effects of antidepressants on functional recovery following stroke: a double-blind study. J. Neurol. Rehabil.12,5–13 (1998).
   Google Scholar
• Narushima K, Paradiso S, Moser DJ, Jorge R, Robinson RG. Effect of antidepressant therapy on executive function after stroke. Br. J. Psychiatry190,260–265 (2007).
   PubMed Web of Science ®Google Scholar
• Jorge RE, Robinson RG, Arndt S, Starkstein S. Mortality and poststroke depression: a placebo-controlled trial of antidepressants. Am. J. Psychiatry160,1823–1829 (2003).
   PubMed Web of Science ®Google Scholar
• Zittel S, Weiller C, Liepert J. Citalopram improves dexterity in chronic stroke patients. Neurorehabil. Neural Repair22,311–314 (2008).
   PubMed Web of Science ®Google Scholar
• Acler M, Robol E, Fiaschi A, Manganotti P. A double blind placebo RCT to investigate the effects of serotonergic modulation on brain excitability and motor recovery in stroke patients. J. Neurol.256,1152–1158 (2009).
   PubMed Web of Science ®Google Scholar
• Jorge RE, Acion L, Moser D, Adams HP Jr, Robinson RG. Escitalopram and enhancement of cognitive recovery following stroke. Arch. Gen. Psychiatry67,187–196 (2010).
   PubMed Web of Science ®Google Scholar
• Laska AC, von Arbin M, Kahan T, Hellblom A, Murray V. Long-term antidepressant treatment with moclobemide for aphasia in acute stroke patients: a randomised, double-blind, placebo-controlled study. Cerebrovasc. Dis.19,125–132 (2005).
   PubMed Web of Science ®Google Scholar
• Murase N, Duque J, Mazzocchio R, Cohen LG. Influence of interhemispheric interactions on motor function in chronic stroke. Ann. Neurol.55,400–409 (2004).
   PubMed Web of Science ®Google Scholar