Does soy-based infant formula cause ADHD? Update and public policy considerations

References

• Crinella FM. Does soy-based infant formula cause ADHD? Expert Rev. Neurother.3, 89–92 (2003).
   Google Scholar
• Polancyk G, de Lima MS, Horta BL, Biederman J, Rohde LA. The worldwide prevalence of ADHD: a systematic review and metaregression analysis. Am. J. Psychiatry164, 942–948 (2007).
   PubMedGoogle Scholar
• Faraone SV, Sergeant J, Gillberg C, Biederman J. The worldwide prevalence of ADHD: is it an American condition. World Psychiatry2, 104–113 (2003).
   PubMedGoogle Scholar
• Sciutto MJ, Eisenberg M. Evaluating the evidence for and against the overdiagnosis of ADHD. J. Atten. Disord.11, 106–113 (2007).
   PubMedGoogle Scholar
• Milberger S, Biederman J, Faraone SV, Murphy J, Tsuang MT. Attention deficit hyperactivity disorder and comorbid disorders. Am. J. Psychiatry152, 1793–1799 (1995).
   PubMed Web of Science ®Google Scholar
• Wender P. Minimal Brain Dysfunction in Children. Wiley-Interscience, NY, USA (1971).
   Google Scholar
• Levy F. The dopamine theory of attention deficit hyperactivity disorder (ADHD). Aust. NZ J. Psychiatry25, 277–283 (1991).
   PubMed Web of Science ®Google Scholar
• LaHoste GJ, Swanson JM, Wigal SB et al. Dopamine D4 receptor gene polymorphism is associated with attention deficit hyperactivity disorder. Mol. Psychiatry1, 121–124 (1996).
   PubMed Web of Science ®Google Scholar
• Swanson J, Castellanos FX, Murias M, LaHoste G, Kennedy J. Cognitive neuroscience of attention deficit hyperactivity disorder and hyperkinetic disorder. Curr. Opin. Neurobiol.8, 263–271 (1998).
   PubMed Web of Science ®Google Scholar
• Grady D, Moyzis R, Swanson JM. Molecular genetics and attention in ADHD. Clin. Neurosci. Res.5, 265–272 (2005).
   Google Scholar
• MTA Cooperative Group. National Institute of Mental Health multimodal treatment study of ADHD follow-up; 24 month outcomes of treatment strategies for attention-deficit/hyperactivity disorder (ADHD). Pediatrics113, 754–761 (2004).
   PubMed Web of Science ®Google Scholar
• Swanson JM, Elliott BR, Greenhill LL et al. Effects of stimulant medication on growth rates across 3 years in the MTA follow-up. J. Am. Acad. Child Adolesc. Psychiatry46, 1014–1026 (2007).
   Google Scholar
• Chan E. The role of complementary and alternative medicine in attention-deficit hyperactivity disorder. J. Dev. Behav. Pediatr.23, S37–S45 (2002).
   PubMed Web of Science ®Google Scholar
• Sinha D, Efron D. Complementary and alternative medicine use in children with attention deficit hyperactivity disorder. J. Paediatr. Child Health41, 23–26 (2005).
   PubMed Web of Science ®Google Scholar
• Stubblefield TG, Wray JA, Parry TS. Utilization of alternative therapies in attention deficit hyperactivity disorder. J. Paediatr. Child Health35, 450–453 (1999).
   PubMedGoogle Scholar
• Rush B. An enquiry into the influence of physical causes upon the moral faculties. Annual oration. Presented at: Meeting of The American Philosophical Society. PA, USA, 27 February 1786.
   Google Scholar
• Feingold B. Why Your Child is Hyperactive. Random House, NY, USA (1973).
   Google Scholar
• Rucklidge JJ, Johnstone J, Kaplan B. Nutrient supplementation approaches in the treatment of ADHD. Expert Rev. Neurother.9, 461–476 (2009).
   PubMed Web of Science ®Google Scholar
• Gesch CB, Hammond SM, Hampson SE et al. Influence of supplementary vitamins, minerals and essential fatty acids on the antisocial behaviour of young adult prisoners: randomised, placebo-controlled trial. Br. J. Psychiatry181, 22–28 (2002).
   PubMed Web of Science ®Google Scholar
• Zaalberg A, Nijman H, Bulten E et al. Aggressive behavior. Food Behav. Res.36, 117–126 (2010).
   Google Scholar
• Walsh WJ, Glab LB, Haakenson ML. Reduced violent behavior following biochemical therapy. Physiol. Behav.82, 835–839 (2004).
   PubMed Web of Science ®Google Scholar
• Schneider JS, Decamp E, Koser AJ et al. Effects of chronic manganese exposure on cognitive and motor functioning in non-human primates. Brain Res.118, 222–231 (2006).
   Google Scholar
• Schneider JS, Decamp E, Clark K et al. Effects of chronic manganese exposure on working memory in non-human primates. Brain Res.1258, 86–95 (2008).
   PubMedGoogle Scholar
• Aschner M, Guilarte TR, Schneider JS, Zheng W. Manganese: recent advances in understanding its transport and neurotoxicity. Toxicol. Appl. Pharmacol.221, 131–147 (2007).
   PubMed Web of Science ®Google Scholar
• Dorner K, Dziadzka S, Bohn A et al. Longitudinal manganese and copper balances in young infants and preterm infants fed on breast-milk and adapted cow’s milk formulas. Br. J. Nutr.61, 559–572 (1989).
   PubMed Web of Science ®Google Scholar
• Lonnerdal B. Manganese nutrition of infants. In: Manganese in Health and Disease. Klimis-Rvantzis D (Ed.). CRC Press, FL, USA, 175–191 (1994).
   Google Scholar
• Pihl RO, Parks M. Hair element content in learning disabled children. Science198, 204–206 (1977).
   PubMed Web of Science ®Google Scholar
• Marlowe M, Bliss L. Hair element concentrations and young children’s behavior at school and home. J. Orthomol. Med.9, 1–12 (1993).
   Google Scholar
• Cawte J. Psychiatric sequelae of manganese exposure in the adult, foetal and neonatal nervous systems. Aust. NZ J. Psychiatry19, 211–217 (1985).
   PubMed Web of Science ®Google Scholar
• Zhang G, Liu D, He P. Effects of manganese on learning abilities in school children. Chin. J. Prev. Med.29, 156–158 (1995).
   Google Scholar
• Crinella FM, Cordova E, Ericson JE. Head hair levels of manganese in children with attention deficit disorder and aggression. Presented at: 15th Annual Meeting of the International Society for Neurotoxicology. Little Rock, AR, USA, 3 April 1997.
   Google Scholar
• Collip PJ, Chen SY, Maitinsky S. Manganese in infant formulas and learning disability. Ann. Nutrit. Metabol.27, 488–494 (1983).
   PubMedGoogle Scholar
• Prohaska JR. Functions of trace elements in brain metabolism. Physiol. Rev.67, 858–901 (1987).
   PubMed Web of Science ®Google Scholar
• Erikson KM, Dorman DC, Lash LH, Aschner M. Manganese inhalation by rhesus monkeys is associated with brain regional changes in biomarkers of neurotoxicity. Toxicol. Sci.97, 459–466 (2007).
   PubMed Web of Science ®Google Scholar
• Donaldson J, Barbeau A. Metal ions in neurology and psychiatry. Manganese neurotoxicity: possible clues to the etiology of human brain disorders. In: Neurology and Neurobiology. Gabay S, Harris J, Ho BT (Eds). Alan R Liss Inc., NY, USA, 259–285 (1985).
   Google Scholar
• Genro JP, Kielling C, Rohde LA, Hutz MH. Attention-deficit/hyperactivity disorder and the dopaminergic hypotheses. Expert Rev. Neurother.10, 587–601 (2010).
   PubMed Web of Science ®Google Scholar
• Cotzias GC. Manganese in health and disease. Physiol. Rev.38, 503–532 (1958).
   PubMed Web of Science ®Google Scholar
• Iregren A. Psychological test performance in foundry workers exposed to low levels of manganese. Neurotoxicol. Teratol.12, 673–675 (1990).
   PubMed Web of Science ®Google Scholar
• Roels H, Lauwerys R, Buchet JP et al. Epidemiological survey among workers exposed to manganese: effects on lung, central nervous system, and some biological indices. Am. J. Ind. Med.11, 307–327 (1987).
   PubMed Web of Science ®Google Scholar
• Klos KJ, Chandler M, Kumar N et al. Neuropsychological profiles of manganese neurotoxicity. Eur. J. Neurol.13, 1139–1141 (2006).
   PubMed Web of Science ®Google Scholar
• Lucchini RG, Martin CJ, Doney BC. From manganism to manganese-induced parkinsonism: a conceptual model based on the evolution of exposure. Neuromol. Med.11, 311–321 (2009).
   PubMed Web of Science ®Google Scholar
• Duhart HM, Lipe GW, Sobotka T, Slikker W, Ali SF. Pre- and post-natal exposure to manganese chloride on reactive oxygen species (ROS) in difference regions of rat brain. Neurotox. Teratol.16, 326–332 (1994).
   Google Scholar
• Malecki EA, Deveny AG, Beard JL, Connor JR. Transferrin response in normal and iron-deficient mice heterozygotic for hypotransferrinemia: effects on iron and manganese accumulation. Biometals11, 265–276 (1998).
   PubMedGoogle Scholar
• Chandra SV, Shukla GS. Concentrations of striatal catecholamines in rats given manganese chloride through drinking water. J. Neurochem.36, 683–687 (1981).
   PubMed Web of Science ®Google Scholar
• Subhash MN, Padmashree TS. Regional distribution of dopamine B-hydroxylase and monoamine oxidase in the brains of rats exposed to manganese. Fed. Chem. Toxicol.28, 567–570 (1990).
   PubMed Web of Science ®Google Scholar
• Davidson L, Lonnerdal B, Sandstrom B, Kunz C, Keen CL. Identification of transferrin as the major plasma carrier protein for manganese introduced orally or intravenously or after in vitro addition in the rat. J. Nutr.119, 1461–1464 (1989).
   PubMedGoogle Scholar
• Zhang K, Tarazi FI, Davids E, Baldessarini RJ. Plasticity of dopamine D4 receptors in rat forebrain: temporal association with motor hyperactivity following neonatal 6-hydroxydopamine lesioning. Neuropsychopharmacology26, 625–633 (2002).
   PubMed Web of Science ®Google Scholar
• Oner G, Senturk UK. Reversibility of manganese-induced learning defect in rats. Food Chem. Toxicol.33, 559–563 (1995).
   PubMed Web of Science ®Google Scholar
• Gray L, Lackey JW. Multivariate analysis of the effects of manganese on the reproductive physiology and behavior of the male house mouse. J. Toxicol. Environ. Health6, 861–867 (1980).
   PubMed Web of Science ®Google Scholar
• Nachtman JP, Tubben RE, Commissaris RL. Behavioral effects of chronic manganese administration in rats: locomotor activity studies. Neurobehav. Toxicol. Teratol.8, 711–715 (1986).
   PubMedGoogle Scholar
• Ponzoni S, Guimaraes FS, Del Bel EA, Garcia-Cairasco N. Behavioral effects of intranigral microinjections of manganese chloride: interaction with nitric oxide. Prog. Neuro-Psychopharmacol. Biol. Psychiatry24, 307–325 (2000).
   PubMedGoogle Scholar
• Donaldson J. Manganese neurotoxicity: clues to the pathophysiology of brain disorders. Presented at: International Conference on Heavy Metal Toxicity. Irvine, CA, USA, 15 March 2001.
   Google Scholar
• Donaldson J, La Bella FS, Gesser D. Enhanced autooxidation of dopamine as a possible basis of manganese neurotoxicity. Neurotoxicology2, 53–64 (1981).
   PubMed Web of Science ®Google Scholar
• Garcia SL, Gellein K, Syversen T, Aschner M. A manganese-enhanced diet alters brain metals and transporters in the developing rat brain. Toxicol. Sci.92, 516–525 (2006).
   PubMed Web of Science ®Google Scholar
• Hazell AS. Astrocytes and manganese neurotoxicity. Neurochem. Int.41, 271–277 (2001).
   Google Scholar
• Erikson K, Aschner M. Manganese causes differential regulation of glutamate transporter (GLAST) taurine transporter and metallothionein in cultured rat astrocytes. Neurotoxicology23, 595–602 (2001).
   Google Scholar
• Spranger M, Schwab LS, Desiderato S, Bonman E, Krieger D, Fandrey J. Manganese augments nitric oxide synthesis in murine astrocytes: a new pathogenetic mechanism in manganism? Exp. Neurol.149, 277–283 (1998).
   PubMed Web of Science ®Google Scholar
• Boje KM, Orora PK. Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death. Brain Res.587, 250–256 (1992).
   PubMed Web of Science ®Google Scholar
• Chao CC, Hju S, Molitor TW, Shaskan EG, Peterson PK. Activated microglia mediate neuronal cell injury via a nitric oxide mechanism. J. Immunol.149, 2736–2741 (1992).
   PubMed Web of Science ®Google Scholar
• Erikson KM, Dorman DC, Lash LH, Aschner M. Persistent alterations in biomarkers of oxidative stress resulting from combined in utero and neonatal manganese inhalation. Biol. Trace Elem. Res.104, 151–164 (2005).
   PubMed Web of Science ®Google Scholar
• Zheng W, Zhao Q, Slavkovich GV, Aschner M, Graziano J. Alteration of iron homeostasis following chronic exposure to manganese in rats. Brain Res.833, 125–132 (1999).
   PubMed Web of Science ®Google Scholar
• Aschner M, Vrana KE, Zheng W. Manganese uptake and distribution in the central nervous system (CNS). Neurotoxicology20, 173–180 (1999).
   PubMed Web of Science ®Google Scholar
• Eriksson H, Magiste K, Plantin LO et al. Effects of manganese oxide on monkeys as revealed by a combined neurochemical, histological and neurophysiological evaluation. Arch. Toxicol.61, 46–52 (1987).
   PubMed Web of Science ®Google Scholar
• Eriksson H, Gillberg PG, Aquilonius SM, Hedstrom KG, Heilbronn E. Receptor alterations in manganese intoxicated monkeys. Arch. Toxicol.66, 359–364 (1992).
   PubMed Web of Science ®Google Scholar
• Eriksson H, Tedroff J, Thuomas KA et al. Manganese induced brain lesions in Macaca fasicularis as revealed by positron emission tomography and magnetic resonance imaging. Arch. Toxicol.66, 403–407 (1992).
   PubMed Web of Science ®Google Scholar
• Shinotoh H, Snow BJ, Hewitt KA et al. MRI and PET studies of manganese-intoxicated monkeys. Neurology45, 1199–1204 (1995).
   PubMed Web of Science ®Google Scholar
• Van Bogaert L, Dallemagne MJ Approches expérimentales des troubles nerveux du manganisme. J. Psychiatry Neurol.111, 60–89 (1943).
   Google Scholar
• Huang CC, Lu CS, Chu NS et al. Progression after chronic manganese exposure. Neurology43, 1479–1483 (1993).
   PubMed Web of Science ®Google Scholar
• Gwiazda RH, Lee D, Sheridan J, Smith DR. Low cumulative manganese exposure affects striatal GABA but not dopamine. Neurotoxicology95, 1–8 (2002).
   Google Scholar
• Reaney SH, Bench G, Smith DR. Brain accumulation and toxicity of Mn(II) and Mn(III) exposures. Toxicol. Sci.93, 114–124 (2006).
   PubMed Web of Science ®Google Scholar
• Stokinger HE. Manganese. In: Patty’s Industrial Hygiene and Toxicology: Toxicology Vol. 2A (Third Revised Edition). Clayton GD, Clayton FE (Eds). Wiley, NY, USA, 1749–1769 (1987).
   Google Scholar
• Lonnerdal B, Keen CL, Ohtake M, Tamura T. Iron, zinc, copper and manganese in infant formulas. Am. J. Dis. Child.137, 433–437 (1983).
   PubMedGoogle Scholar
• Bell JG, Keen CL, Lonnerdal B. Higher retention of manganese in suckling than in adult rats is not due to maturation differences in manganese uptake by rat small intestine. J. Toxicol. Environ. Health26, 387–398 (1989).
   PubMed Web of Science ®Google Scholar
• Keen CL, Ensuensa JL, Lonnerdal B, Zidenberg-Cherr S. Manganese. In: Encyclopedia of Human Nutrition (2nd Edition). Caballero B, Allen L, Prentice A (Eds). Elsevier/Academic Press, Oxford, UK, 217–225 (2005).
   Google Scholar
• Erikson KM, Thompson K, Aschner J, Aschner M. Manganese neurotoxicity: a focus on the neonate. Pharmacol. Ther.113, 369–377 (2007).
   PubMed Web of Science ®Google Scholar
• American Academy of Pediatrics. Soy protein-based formulas: recommendations for use in infant feeding. Am. J. Pediatr.101, 148–153 (1998).
   PubMed Web of Science ®Google Scholar
• Krachler M, Rossipal E. Concentrations of trace elements in extensively hydrolysed infant formulae and their estimated daily intakes. Ann. Nutr. Metab.44, 68–74 (2000).
   PubMedGoogle Scholar
• Stasny D, Vogel RS, Picciano MF. Manganese intake and serum manganese concentration of human milk-fed and formula-fed infants. Am. J. Clin. Nutr.39, 872–878 (1984).
   PubMedGoogle Scholar
• Ljung K, Vahter M. Time to re-evaluate the guideline value for manganese in drinking water? Environ. Health Perspect.115, 1533–1538 (2007).
   PubMed Web of Science ®Google Scholar
• Tran TT, Chowanadisai W, Crinella FM et al. Effect of manganese supplementation of neonatal rats on tissue mineral accumulation, striatal dopamine levels, and neurodevelopmental status. Neurotoxicology23, 635–643 (2002).
   PubMedGoogle Scholar
• Tran TT, Crinella FM, Chicz-Demet A et al. Effects of neonatal dietary manganese exposure on brain dopamine levels and neurocognitive functions. Neurotoxicology23, 645–651 (2002).
   PubMed Web of Science ®Google Scholar
• Kern C, Stanwood GD, Smith DR. Preweaning manganese exposure causes hyperactivity, disinhibition, and spatial learning and memory deficit associated with altered dopamine receptor and transporter levels. Synapse64, 363–378 (2010).
   PubMedGoogle Scholar
• McDougall SA, Reichel CM, Farley CM. Postnatal manganese exposure alters dopamine transporter function in adult rats: potential impact on nonassociative and associative processes. Neuroscience154, 848–860 (2008).
   PubMed Web of Science ®Google Scholar
• Golub M, Hogrefe CE, Germann SL et al. Neurobehavioral evaluation of rhesus monkey infants fed cow’s milk formula, soy formula, or soy formula with added manganese. Neurotoxicol. Teratol.27, 615–627 (2005).
   PubMedGoogle Scholar
• Barkley RA. Behavioral inhibition, sustained attention, and executive function: constructing a unifying theory of ADHD. Psychol. Bull.121, 65–94 (1997).
   PubMed Web of Science ®Google Scholar
• Gwiazda R, Lucchini R, Smith D. Adequacy and consistency of animal studies to evaluate the neurotoxicity of manganese at chronic low level manganese exposure in humans. J. Toxicol. Environ. Health Part A,70, 594–605 (2007).
   PubMed Web of Science ®Google Scholar
• Integrated Risk Information System (IRIS). Health Risk Assessment of Manganese. Environmental Criteria and Assessment Office, Cincinnati, OH, USA (1993).
   Google Scholar
• Ericson JE, Crinella FM, Clark-Stewart KA et al. Prenatal manganese levels linked to childhood behavioral disinhibition. Neurotoxicol. Teratol.29, 181–187 (2006).
   PubMedGoogle Scholar
• NICHD Early Child Care Research Network. Nonmaternal care and family factors in early development: an overview of the NICHD study of early child care. J. Appl. Develop. Psychol.22, 457–492 (2001).
   Web of Science ®Google Scholar
• Lee KM, Appleton J, Cooke M, Keenan F, Sawicka-Kapusta K. Use of laser ablation-inductively coupled plasma-mass spectrometry to provide element versus time profiles in teeth. Anal. Chim. Acta395, 179–185 (1999).
   Google Scholar
• Lochner F, Appleton J, Keenan F, Cooke M. Multi-element profiled of human deciduous teeth by laser ablation-inductively coupled plasma-mass spectrometry. Anal. Chim. Acta401, 299–306 (1999).
   Web of Science ®Google Scholar
• Mena I. The role of manganese in human disease. Ann. Clin. Lab. Sci.4, 487–491 (1974).
   PubMed Web of Science ®Google Scholar
• Allen LH. Anemia and iron deficiency: effects on pregnancy outcome. Am. J. Clin. Nutr.71, S1280–S1284 (2000).
   PubMed Web of Science ®Google Scholar
• Davidsson L, Cederblad A, Lonnerdal B, Sandstrom B. The effect of individual dietary components on manganese absorption in man. Am. J. Clin. Nutr.54, 1065–1070 (1992).
   Google Scholar
• Golub MS, Hogrefe CE, Germann SL, Capitanio J, Lozoff B. Behavioral consequences of developmental iron deficiency in infant rhesus monkey. Neurotoxicol. Teratol.28, 3–17 (2006).
   PubMed Web of Science ®Google Scholar
• Bouchard M, Laforest F, Vandelac L, Bellinger D, Mergler D. Hair manganese and hyperactive behaviors: pilot study of school-age children exposed through tap water. Environ. Health Perspect.115, 122–127 (2007).
   PubMed Web of Science ®Google Scholar
• US Department of Health and Human Services. Healthy People 2010: Conference Edition. Vols. I and II. US Government Printing Office, Washington, DC, USA (2000).
   Google Scholar
• Li R, Zhao Z, Mokdad A, Barker L, Grummer-Strawn L. Prevalence of breastfeeding in the United States: the 2001 National Immunization Survey. Pediatrics111, 1198–1201 (2003).
   PubMed Web of Science ®Google Scholar
• Ryan AS, Zhou W. Lower breastfeeding rates persist among the special supplemental nutrition program for women, infants and children participants, 1978–2003. Pediatrics117, 1136–1146 (2006).
   PubMed Web of Science ®Google Scholar
• Li R, Rock VJ, Grummer-Strawn L. Changes in public attitudes toward breastfeeding in the United States. 1999–2003. J. Am. Dietetic Assoc.107, 122–127 (2007).
   PubMed Web of Science ®Google Scholar
• Ip S, Chung M, Raman G et al. breastfeeding and maternal and infant health outcomes in developed countries. In: Evidence Report/Technology Assessment No. 153. Agency for Healthcare Research and Quality, Rockville, MD, USA, 1–186 (2007).
   Google Scholar
• Bartick M, Stueibe A, Shealy KR, Walker M, Grummer-Strawn LM. Closing the quality gap: promoting evidence-based breastfeeding care in the hospital. Pediatrics124, 793–802 (2009).
   PubMed Web of Science ®Google Scholar
• Anderson JS, Johnston BM, Remley DT. Breastfeeding and cognitive development: a meta-analysis. Am. J. Clin. Nutr.70, 525–535 (1999).
   PubMed Web of Science ®Google Scholar
• Lucas A, Morley R, Cole TJ, Lister G, Leeson-Payne C. Breast milk and subsequent intelligence quotient in children born preterm. Lancet339, 261–264 (1992).
   PubMed Web of Science ®Google Scholar
• McCann JC, Ames BN. Is docosahexaenoic acid, an n-3 long-chain polyunsaturated fatty acid, required for development of normal brain function? An overview of evidence from cognitive and behavioral tests in humans and animals. Am. J. Clin. Nutr.82, 281–295 (2005).
   PubMed Web of Science ®Google Scholar
• Caspi A, Williams B, Kim-Cohen J et al. Moderation of breastfeeding effects on the IQ by genetic variation in fatty acid metabolism. PNAS104, 18860–18865 (2007).
   PubMed Web of Science ®Google Scholar
• Badger TM, Gilchrist JM, Pivik RT et al. The health implications of soy infant formula. Am. J. Clin. Nutr.89(Suppl.), S1668–S1672 (2009).
   PubMed Web of Science ®Google Scholar
• Jing H, Gilchrist JM, Badger TM, Pivik RT. A longitudinal study of differences in electroencephalographic activity among breastfed, milk-formula-fed and soy formula fed infants during the first year of life. Early Hum. Dev.86, 119–125 (2010).
   PubMed Web of Science ®Google Scholar
• Gillman M. Developmental origins of health and disease. N. Engl. J. Med.353, 1848–1850 (2005).
   PubMed Web of Science ®Google Scholar
• Gluckman PD, Hanson MA. Living with the past: evolution, development, and patterns of disease. Science305, 1733–1736 (2004).
   PubMed Web of Science ®Google Scholar
• Faroane SV, Doyle AE. The nature and heritability of attention deficit/hyperactivity disorder. Child Adolesc. Psychiatr. Clin. N. Am.10, 290–316 (2001).
   Google Scholar
• Larsson H, Lichtenstein P, Larsson JO. Genetic contributions to the development of ADHD subtypes from childhood to adolescence. J. Am. Acad. Child Adolesc. Psychiatry45, 973–981 (2006).
   PubMed Web of Science ®Google Scholar
• Swanson JM, Sunohara GA, Kennedy JL. Association of the dopamine receptor D4 (DRD4) with a refined phenotype of attention deficit hyperactivity disorder (ADHD): a family-based approach. Mol. Psychiatry3, 38–41 (1998).
   PubMed Web of Science ®Google Scholar
• Swanson JM, Posner M, Fusella J, Wasdell M, Sommer T, Fan J. Genes and attention deficit hyperactivity disorder. Curr. Psychiatry Rep.3, 92–100 (2001).
   PubMedGoogle Scholar
• Ornoy A. Growth and neurodevelopmental outcome of children born to mothers with pregestational and gestational diabetes. Ped. Endocrin. Rev.3, 104–113 (2005).
   PubMedGoogle Scholar
• Sutcliffe AG, Derom C. Follow-up of twins: health, behaviour, speech, language outcomes and implications for parents. Early Hum. Dev.82, 379–386 (2006).
   PubMedGoogle Scholar
• Ingelfinger JR. Prematurity and the legacy of intrauterine stress. N. Engl. J. Med.356, 2093–2095 (2007).
   PubMed Web of Science ®Google Scholar
• McLean C, Ferriero D. Mechanisms of hypoxic–ischemic injury in the term infant. Semin. Perinatol.28, 425–432 (2004).
   PubMed Web of Science ®Google Scholar
• Sandman CA, Davis EP. Gestational stress influences cognition and behavior. Future Neurol.5, 675–690 (2010).
   Google Scholar
• Green NS. Risks of birth defects and other adverse outcomes associated with assisted reproductive technology. Pediatrics114, 256–259 (2004).
   PubMedGoogle Scholar
• Hansen M, Kurinczuk JJ, Bower C, Webb S. The risk of major birth defects after intracytoplasmic sperm injection and in vitro fertilization. N. Engl. J. Med.346, 725–730 (2002).
   PubMed Web of Science ®Google Scholar
• Jackson RA, Gibson KA, Wu YW, Croughan MS. Perinatal outcomes in singletons following in vitro fertilization: a meta-analysis. Obstet. Gynecol.103, 551–563 (2004).
   PubMed Web of Science ®Google Scholar
• Stromberg B, Dahlquist G, Ericson A et al. Neurological sequelae in children born after in-vitro fertilisation: a population based study. Lancet359, 461–465 (2002).
   PubMed Web of Science ®Google Scholar
• Dennett DC. Darwin’s Dangerous Idea: Evolution and the Meanings of Life. Allen Lane, London, UK (1995).
   Google Scholar
• McCann D, Barrett A, Cooper A et al. Food additives and hyperactive behaviours in 3-year old and 8/9-year-old children in the community: a randomized, double-blinded, placebo-controlled trial. Lancet370, 1560–1567 (2007).
   PubMed Web of Science ®Google Scholar
• Leno M (Chair). Is there a relationship between elevated manganese levels and violent behavior? California Assembly Committee on Public Safety, Sacramento, CA, USA (2004).
   Google Scholar
• Lien L, Lien N, Heyerdal S, Thoreson M, Bjertness E. Consumption of soft drinks and hyperactivity, mental distress and conduct problems among adolescents in Oslo Norway. Am. J. Public Health96, 1815–1820 (2006).
   PubMed Web of Science ®Google Scholar
• Woolraich ML, Wilson DB, White JW. The effect of sugar on behavior or cognition in children. A meta-analysis. JAMA274, 1617–1621 (1995).
   PubMedGoogle Scholar
• Benton D. Sucrose and behavioral problems. Crit. Rev. Food Sci. Nutr.48, 385–401 (2008).
   PubMed Web of Science ®Google Scholar
• McNemar Q. At random: sense and nonsense. Am. Psychol.15, 553–557 (1960).
   Google Scholar
• Edwards AL. Experimental Design in Psychological Research. Rinehart, NY, USA (1950).
   Google Scholar
• Lozoff B, Klein NK, Nelson EC, McClish DK, Manuel M, Chacon ME. Behavior of infants with iron-deficiency anemia. Child Dev.69, 24–36 (1998).
   PubMed Web of Science ®Google Scholar
• Murphy VA, Rosenberg JM, Smith QR, Rapoport SI. Elevation of brain manganese in calcium deficient rats. Neurotoxicology12, 255–264 (1991).
   PubMedGoogle Scholar
• Rossander-Hulthen L, Brune M, Sandstrom B, Lonnerdal B, Hallberg L. Competitive inhibition of iron absorption by manganese and zinc in humans. Am. J. Clin. Nutr.54, 152–156 (1991).
   PubMed Web of Science ®Google Scholar
• Wedekind KJ, Murphy MR, Baker DH. Manganese turnover in chicks as affected by excess phosphorus consumption. J. Nutr.121, 1035–1041 (1991).
   PubMedGoogle Scholar
• Barkley RA, Smith KM, Fischer M, Bradfor V. An examination of the behavioral and neuropsychological correlates of three ADHD candidate gene polymorphisms (DRD4 7+, DBH TaqI A2, and DAT1 40 BP VNTR) in hyperactive and normal children followed to adulthood. Am. J. Med. Genet. B Neuropsychiatr. Genet.141B, 487–498 (2006).
   PubMed Web of Science ®Google Scholar
• Rozin P. Disorders of food selection. The compromise of pleasure. Ann. NY Acad. Sci.575, 376–386 (2006).
   Google Scholar