Advanced search
Publication Cover
Expert Review of Neurotherapeutics Volume 12, 2012 - Issue 6
Submit an article Journal homepage
764
Views
6
CrossRef citations to date
0
Altmetric
Editorial

Ironing out neurodegeneration: is iron intake important during the teenage years?

Paul M Thompson Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095, USA and Department of Psychiatry & Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, UCLA School of Medicine, Los Angeles, CA 90095, USA. [email protected]
&
Neda Jahanshad Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095, USA and Medical Imaging Informatics Group, Department of Radiological Sciences, UCLA School of Medicine, Los Angeles, CA 90095, USA
Pages 629-631 | Published online: 09 Jan 2014

References

  • Sullivan JL. Iron and the genetics of cardiovascular disease. Circulation 100(12), 1260–1263 (1999).
  • Jahanshad N, Kohannim O, Hibar DP et al. Brain structure in healthy adults is related to serum transferrin and the H63D polymorphism in the HFE gene. Proc. Natl Acad. Sci. USA 109(14), e851–e859 (2012).
  • Pardridge WM, Eisenberg J, Yang J. Human blood–brain barrier transferrin receptor. Metab. Clin. Exp. 36(9), 892–895 (1987).
  • Todorich B, Pasquini JM, Garcia CI, Paez PM, Connor JR. Oligodendrocytes and myelination: the role of iron. Glia 57(5), 467–478 (2009).
  • Beard JL, Connor JR, Jones BC. Iron in the brain. Nutr. Rev. 51(6), 157–170 (1993).
  • Halterman JS, Kaczorowski JM, Aligne CA, Auinger P, Szilagyi PG. Iron deficiency and cognitive achievement among school-aged children and adolescents in the United States. Pediatrics 107(6), 1381–1386 (2001).
  • Benton D, Roberts G. Effect of vitamin and mineral supplementation on intelligence of a sample of schoolchildren. Lancet 1(8578), 140–143 (1988).
  • Stoltzfus RJ, Kvalsvig JD, Chwaya HM et al. Effects of iron supplementation and anthelmintic treatment on motor and language development of preschool children in Zanzibar: double blind, placebo controlled study. BMJ 323(7326), 1389–1393 (2001).
  • Ke Y, Ming Qian Z. Iron misregulation in the brain: a primary cause of neurodegenerative disorders. Lancet Neurol. 2(4), 246–253 (2003).
  • Stern Y, Gurland B, Tatemichi TK, Tang MX, Wilder D, Mayeux R. Influence of education and occupation on the incidence of Alzheimer’s disease. JAMA 271(13), 1004–1010 (1994).
  • Bartzokis G. Age-related myelin breakdown: a developmental model of cognitive decline and Alzheimer’s disease. Neurobiol. Aging 25(1), 5–18; author reply 49 (2004).
  • Connor JR, Menzies SL. Relationship of iron to oligodendrocytes and myelination. Glia 17(2), 83–93 (1996).
  • He X, Lu X, Hu J et al. H63D polymorphism in the hemochromatosis gene is associated with sporadic amyotrophic lateral sclerosis in China. Eur. J. Neurol. 18(2), 359–361 (2011).
  • Giambattistelli F, Bucossi S, Salustri C et al. Effects of hemochromatosis and transferrin gene mutations on iron dyshomeostasis, liver dysfunction and on the risk of Alzheimer’s disease. Neurobiol. Aging doi:10.1016/j.neurobiolaging.2011.03.005 (2011) (Epub ahead of print).
  • Lin M, Zhao L, Fan J et al. Association between HFE polymorphisms and susceptibility to Alzheimer’s disease: a meta-analysis of 22 studies including 4,365 cases and 8,652 controls. Mol. Biol. Rep. 39(3): 3089–3095 (2012).
  • Carlson ES, Magid R, Petryk A, Georgieff MK. Iron deficiency alters expression of genes implicated in Alzheimer disease pathogenesis. Brain Res. 1237, 75–83 (2008).
  • Braskie MN, Jahanshad N, Stein JL et al. Common Alzheimer’s disease risk variant within the CLU gene affects white matter microstructure in young adults. J. Neurosci. 31(18), 6764–6770 (2011).
  • Kohannim O, Jahanshad N, Braskie MN et al. Predicting white matter integrity from multiple common genetic variants. Neuropsychopharmacology doi:10.1038/npp.2012.49 (2012) (In Press).
  • Rajagopalan P, Hua X, Toga AW, Jack CR Jr, Weiner MW, Thompson PM. Homocysteine effects on brain volumes mapped in 732 elderly individuals. Neuroreport 22(8), 391–395 (2011).
  • Aisen PS, Schneider LS, Sano M et al.; Alzheimer Disease Cooperative Study. High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial. JAMA 300(15), 1774–1783 (2008).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.