152
Views
14
CrossRef citations to date
0
Altmetric
Drug Profile

Onabotulinum toxin A for the treatment of neurogenic detrusor overactivity due to spinal cord injury or multiple sclerosis

&
Pages 763-775 | Published online: 09 Jan 2014

References

  • Hanchanale VS, Rao AR, Martin FL, Matanhelia SS. The unusual history and the urological applications of botulinum neurotoxin. Urol. Int. 85(2), 125–130 (2010).
  • Kopera D. Botulinum toxin historical aspects: from food poisoning to pharmaceutical. Int. J. Dermatol. 50(8), 976–980 (2011).
  • Negro A, Martelletti P. Chronic migraine plus medication overuse headache: two entities or not? J. Headache Pain 12(6), 593–601 (2011).
  • Dressler D, Benecke R. Pharmacology of therapeutic botulinum toxin preparations. Disabil. Rehabil. 29(23), 1761–1768 (2007).
  • Schurch B, Hodler J, Rodic B. Botulinum A toxin as a treatment of detrusor-sphincter dyssynergia in patients with spinal cord injury: MRI controlled transperineal injections. J. Neurol. Neurosurg. Psychiatr. 63(4), 474–476 (1997).
  • Jackson AB, Dijkers M, Devivo MJ, Poczatek RB. A demographic profile of new traumatic spinal cord injuries: change and stability over 30 years. Arch. Phys. Med. Rehabil. 85(11), 1740–1748 (2004).
  • van den Berg ME, Castellote JM, Mahillo-Fernandez I, de Pedro-Cuesta J. Incidence of spinal cord injury worldwide: a systematic review. Neuroepidemiology 34(3), 184–192; discussion 192 (2010).
  • Wyndaele M, Wyndaele JJ. Incidence, prevalence and epidemiology of spinal cord injury: what learns a worldwide literature survey? Spinal Cord 44(9), 523–529 (2006).
  • Kaplan SA, Chancellor MB, Blaivas JG. Bladder and sphincter behavior in patients with spinal cord lesions. J. Urol. 146(1), 113–117 (1991).
  • Anderson KD. Targeting recovery: priorities of the spinal cord-injured population. J. Neurotrauma 21(10), 1371–1383 (2004).
  • David BT, Steward O. Deficits in bladder function following spinal cord injury vary depending on the level of the injury. Exp. Neurol. 226(1), 128–135 (2010).
  • de Groat WC, Yoshimura N. Changes in afferent activity after spinal cord injury. Neurourol. Urodyn. 29(1), 63–76 (2010).
  • Blackmer J. Rehabilitation medicine: 1. Autonomic dysreflexia. CMAJ 169(9), 931–935 (2003).
  • Lindan R, Joiner E, Freehafer AA, Hazel C. Incidence and clinical features of autonomic dysreflexia in patients with spinal cord injury. Paraplegia 18(5), 285–292 (1980).
  • Karlsson AK. Autonomic dysfunction in spinal cord injury: clinical presentation of symptoms and signs. Prog. Brain Res. 152, 1–8 (2006).
  • Pugliatti M, Rosati G, Carton H et al. The epidemiology of multiple sclerosis in Europe. Eur. J. Neurol. 13(7), 700–722 (2006).
  • Trapp BD, Peterson J, Ransohoff RM, Rudick R, Mörk S, Bö L. Axonal transection in the lesions of multiple sclerosis. N. Engl. J. Med. 338(5), 278–285 (1998).
  • Rosati G. The prevalence of multiple sclerosis in the world: an update. Neurol. Sci. 22(2), 117–139 (2001).
  • Araki I, Matsui M, Ozawa K, Takeda M, Kuno S. Relationship of bladder dysfunction to lesion site in multiple sclerosis. J. Urol. 169(4), 1384–1387 (2003).
  • Giannantoni A, Scivoletto G, Di Stasi SM, Grasso MG, Vespasiani G, Castellano V. Urological dysfunctions and upper urinary tract involvement in multiple sclerosis patients. Neurourol. Urodyn. 17(2), 89–98 (1998).
  • Koldewijn EL, Hommes OR, Lemmens WA, Debruyne FM, van Kerrebroeck PE. Relationship between lower urinary tract abnormalities and disease-related parameters in multiple sclerosis. J. Urol. 154(1), 169–173 (1995).
  • Mehnert U, Birzele J, Reuter K, Schurch B. The effect of botulinum toxin type a on overactive bladder symptoms in patients with multiple sclerosis: a pilot study. J. Urol. 184(3), 1011–1016 (2010).
  • Mahajan ST, Patel PB, Marrie RA. Under treatment of overactive bladder symptoms in patients with multiple sclerosis: an ancillary analysis of the NARCOMS Patient Registry. J. Urol. 183(4), 1432–1437 (2010).
  • Marrie RA, Horwitz RI, Cutter G, Tyry T, Vollmer T. Association between comorbidity and clinical characteristics of MS. Acta Neurol. Scand. 124(2), 135–141 (2011).
  • Jackson S. The patient with an overactive bladder – symptoms and quality-of-life issues. Urology 50(6A Suppl.), 18–22; discussion 23 (1997).
  • de Sèze M, Ruffion A, Denys P, Joseph PA, Perrouin-Verbe B; GENULF. The neurogenic bladder in multiple sclerosis: review of the literature and proposal of management guidelines. Mult. Scler. 13(7), 915–928 (2007).
  • Chiaravalloti ND, DeLuca J. Cognitive impairment in multiple sclerosis. Lancet Neurol. 7(12), 1139–1151 (2008).
  • Freund P, Weiskopf N, Ward NS et al. Disability, atrophy and cortical reorganization following spinal cord injury. Brain 134(Pt 6), 1610–1622 (2011).
  • Riccabona M, Koen M, Schindler M et al. Botulinum-A toxin injection into the detrusor: a safe alternative in the treatment of children with myelomeningocele with detrusor hyperreflexia. J. Urol. 171(2 Pt 1), 845–848; discussion 848 (2004).
  • Mahfouz W, Corcos J. Management of detrusor external sphincter dyssynergia in neurogenic bladder. Eur. J. Phys. Rehabil. Med. 47(4), 639–650 (2011).
  • Chen G, Liao L. Injections of botulinum toxin A into the detrusor to treat neurogenic detrusor overactivity secondary to spinal cord injury. Int. Urol. Nephrol. 43(3), 655–662 (2011).
  • Sexton CC, Notte SM, Maroulis C et al. Persistence and adherence in the treatment of overactive bladder syndrome with anticholinergic therapy: a systematic review of the literature. Int. J. Clin. Pract. 65(5), 567–585 (2011).
  • Yeaw J, Benner JS, Walt JG, Sian S, Smith DB. Comparing adherence and persistence across 6 chronic medication classes. J. Manag. Care Pharm. 15(9), 728–740 (2009).
  • Cameron AP, Clemens JQ, Latini JM, McGuire EJ. Combination drug therapy improves compliance of the neurogenic bladder. J. Urol. 182(3), 1062–1067 (2009).
  • Wein AJ. Voiding function and dysfunction, bladder physiology and pharmacology, and female urology: reply. J. Urol. 178(1), 353 (2007).
  • Yamaguchi O, Nishizawa O, Takeda M et al.; Neurogenic Bladder Society. Clinical guidelines for overactive bladder. Int. J. Urol. 16(2), 126–142 (2009).
  • Bushman W, Steers WD, Meythaler JM. Voiding dysfunction in patients with spastic paraplegia: urodynamic evaluation and response to continuous intrathecal baclofen. Neurourol. Urodyn. 12(2), 163–170 (1993).
  • Bakke A, Malt UF. Social functioning and general well-being in patients treated with clean intermittent catheterization. J. Psychosom. Res. 37(4), 371–380 (1993).
  • Kessler TM, Ryu G, Burkhard FC. Clean intermittent self-catheterization: a burden for the patient? Neurourol. Urodyn. 28(1), 18–21 (2009).
  • Lindehall B, Abrahamsson K, Hjälmås K, Jodal U, Olsson I, Sillén U. Complications of clean intermittent catheterization in boys and young males with neurogenic bladder dysfunction. J. Urol. 172(4 Pt 2), 1686–1688 (2004).
  • Groah SL, Weitzenkamp DA, Lammertse DP, Whiteneck GG, Lezotte DC, Hamman RF. Excess risk of bladder cancer in spinal cord injury: evidence for an association between indwelling catheter use and bladder cancer. Arch. Phys. Med. Rehabil. 83(3), 346–351 (2002).
  • Greenwell TJ, Venn SN, Mundy AR. Augmentation cystoplasty. BJU Int. 88(6), 511–525 (2001).
  • Harper M, Popat RB, Dasgupta R, Fowler CJ, Dasgupta P. A minimally invasive technique for outpatient local anaesthetic administration of intradetrusor botulinum toxin in intractable detrusor overactivity. BJU Int. 92(3), 325–326 (2003).
  • Abdel-Meguid TA. Botulinum toxin-A injections into neurogenic overactive bladder – to include or exclude the trigone? A prospective, randomized, controlled trial. J. Urol. 184(6), 2423–2428 (2010).
  • Mascarenhas F, Cocuzza M, Gomes CM, Leão N. Trigonal injection of botulinum toxin-A does not cause vesicoureteral reflux in neurogenic patients. Neurourol. Urodyn. 27(4), 311–314 (2008).
  • Apostolidis A, Dasgupta P, Denys P et al.; European Consensus Panel. Recommendations on the use of botulinum toxin in the treatment of lower urinary tract disorders and pelvic floor dysfunctions: a European consensus report. Eur. Urol. 55(1), 100–119 (2009).
  • Mangera A, Andersson KE, Apostolidis A et al. Contemporary management of lower urinary tract disease with botulinum toxin A: a systematic review of botox (onabotulinumtoxinA) and dysport (abobotulinumtoxinA). Eur. Urol. 60(4), 784–795 (2011).
  • Wöllner J, Kessler TM. Botulinum toxin injections into the detrusor. BJU Int. 108(9), 1528–1537 (2011).
  • Jahn R. Neuroscience. A neuronal receptor for botulinum toxin. Science 312(5773), 540–541 (2006).
  • Chancellor MB, Fowler CJ, Apostolidis A et al. Drug insight: biological effects of botulinum toxin A in the lower urinary tract. Nat. Clin. Pract. Urol. 5(6), 319–328 (2008).
  • Hanna-Mitchell AT, Birder LA. New insights into the pharmacology of the bladder. Curr. Opin. Urol. 18(4), 347–352 (2008).
  • Kanai A, Wyndaele JJ, Andersson KE et al. Researching bladder afferents – determining the effects of b(3)-adrenergic receptor agonists and botulinum toxin type-A. Neurourol. Urodyn. 30(5), 684–691 (2011).
  • Smith CP, Gangitano DA, Munoz A et al. Botulinum toxin type A normalizes alterations in urothelial ATP and NO release induced by chronic spinal cord injury. Neurochem. Int. 52(6), 1068–1075 (2008).
  • Schurch B, de Sèze M, Denys P et al.; Botox Detrusor Hyperreflexia Study Team. Botulinum toxin type a is a safe and effective treatment for neurogenic urinary incontinence: results of a single treatment, randomized, placebo controlled 6-month study. J. Urol. 174(1), 196–200 (2005).
  • Cruz F, Herschorn S, Aliotta P et al. Efficacy and safety of onabotulinum toxin A in patients with urinary incontinence due to neurogenic detrusor overactivity: a randomised, double-blind, placebo-controlled trial. Eur. Urol. 60(4), 742–750 (2011).
  • Ginsberg D, Gousse A, Keppenne V et al. Phase 3 efficacy and tolerability study of onabotulinum toxin A for urinary incontinence from neurogenic detrusor overactivity. J. Urol. 187(6), 2131–2139 (2012).
  • Schulte-Baukloh H, Michael T, Schobert J, Stolze T, Knispel HH. Efficacy of botulinum – a toxin in children with detrusor hyperreflexia due to myelomeningocele: preliminary results. Urology 59(3), 325–327; discussion 327 (2002).
  • Kessler TM, Danuser H, Schumacher M, Studer UE, Burkhard FC. Botulinum A toxin injections into the detrusor: an effective treatment in idiopathic and neurogenic detrusor overactivity? Neurourol. Urodyn. 24(3), 231–236 (2005).
  • Reitz A, Schurch B. Botulinum toxin type B injection for management of type A resistant neurogenic detrusor overactivity. J. Urol. 171(2 Pt 1), 804–805 (2004).
  • Pannek J, Göcking K, Bersch U. Long-term effects of repeated intradetrusor botulinum neurotoxin A injections on detrusor function in patients with neurogenic bladder dysfunction. BJU Int. 104(9), 1246–1250 (2009).
  • Reitz A, Denys P, Fermanian C, Schurch B, Comperat E, Chartier-Kastler E. Do repeat intradetrusor botulinum toxin type a injections yield valuable results? Clinical and urodynamic results after five injections in patients with neurogenic detrusor overactivity. Eur. Urol. 52(6), 1729–1735 (2007).
  • Mouttalib S, Khan S, Castel-Lacanal E et al. Risk of urinary tract infection after detrusor botulinum toxin A injections for refractory neurogenic detrusor overactivity in patients with no antibiotic treatment. BJU Int. 106(11), 1677–1680 (2010).
  • Bootsma AM, Laguna Pes MP, Geerlings SE, Goossens A. Antibiotic prophylaxis in urologic procedures: a systematic review. Eur. Urol. 54(6), 1270–1286 (2008).
  • Gamé X, Castel-Lacanal E, Bentaleb Y et al. Botulinum toxin A detrusor injections in patients with neurogenic detrusor overactivity significantly decrease the incidence of symptomatic urinary tract infections. Eur. Urol. 53(3), 613–618 (2008).
  • Courtois F, Caremel R, Charvier K, Ruffion A, Journel NM. Botox treatment and its impact on ejaculation and fertility in men with spinal cord injury. J. Sex. Med. 7, 431 (2010).
  • Bakheit AM, Liptrot A, Newton R, Pickett AM. The effect of total cumulative dose, number of treatment cycles, interval between injections, and length of treatment on the frequency of occurrence of antibodies to botulinum toxin type A in the treatment of muscle spasticity. Int. J. Rehabil. Res. 35(1), 36–39 (2012).
  • Naumann M, Carruthers A, Carruthers J et al. Meta-analysis of neutralizing antibody conversion with onabotulinumtoxinA (BOTOX®) across multiple indications. Mov. Disord. 25(13), 2211–2218 (2010).
  • Reitz A, Stöhrer M, Kramer G et al. European experience of 200 cases treated with botulinum-A toxin injections into the detrusor muscle for urinary incontinence due to neurogenic detrusor overactivity. Eur. Urol. 45(4), 510–515 (2004).
  • De Laet K, Wyndaele JJ. Adverse events after botulinum A toxin injection for neurogenic voiding disorders. Spinal Cord 43(7), 397–399 (2005).
  • Dykstra DD, Sidi AA. Treatment of detrusor-sphincter dyssynergia with botulinum A toxin: a double-blind study. Arch. Phys. Med. Rehabil. 71(1), 24–26 (1990).
  • Schurch B, Hauri D, Rodic B, Curt A, Meyer M, Rossier AB. Botulinum-A toxin as a treatment of detrusor-sphincter dyssynergia: a prospective study in 24 spinal cord injury patients. J. Urol. 155(3), 1023–1029 (1996).
  • Patti F. Cognitive impairment in multiple sclerosis. Mult. Scler. 15(1), 2–8 (2009).
  • Vahter L, Zopp I, Kreegipuu M, Kool P, Talvik T, Gross-Paju K. Clean intermittent self-catheterization in persons with multiple sclerosis: the influence of cognitive dysfunction. Mult. Scler. 15(3), 379–384 (2009).
  • Asayama K, Kihara K, Shidoh T, Shigaki M, Ikeda T. The functional limitations of tetraplegic hands for intermittent clean self-catheterisation. Paraplegia 33(1), 30–33 (1995).
  • Kiyono Y, Hashizume C, Ohtsuka K, Igawa Y. Improvement of urological-management abilities in individuals with tetraplegia by reconstructive hand surgery. Spinal Cord 38(9), 541–545 (2000).
  • Hori S, Patki P, Attar KH, Ismail S, Vasconcelos JC, Shah PJ. Patients’ perspective of botulinum toxin-A as a long-term treatment option for neurogenic detrusor overactivity secondary to spinal cord injury. BJU Int. 104(2), 216–220 (2009).
  • Khan S, Game X, Kalsi V et al. Long-term effect on quality of life of repeat detrusor injections of botulinum neurotoxin-A for detrusor overactivity in patients with multiple sclerosis. J. Urol. 185(4), 1344–1349 (2011).
  • Kuo HC. Prostate botulinum A toxin injection – an alternative treatment for benign prostatic obstruction in poor surgical candidates. Urology 65(4), 670–674 (2005).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.