131
Views
12
CrossRef citations to date
0
Altmetric
Theme: Epilepsy - Review

Investigating psychotropic properties of antiepileptic drugs

Pages 639-646 | Published online: 09 Jan 2014

References

  • Bialer M. Why are antiepileptic drugs used for nonepileptic conditions? Epilepsia 53(Suppl. 7), 26–33 (2012).
  • Johannessen Landmark C. Antiepileptic drugs in non-epilepsy disorders: relations between mechanisms of action and clinical efficacy. CNS Drugs 22(1), 27–47 (2008).
  • Mula M, Sander JW. Negative effects of antiepileptic drugs on mood in patients with epilepsy. Drug Saf. 30(7), 555–567 (2007).
  • Chris Sackellares J, Jacqueline Kwong W, Vuong A, Hammer AE, Barrett PS. Lamotrigine monotherapy improves health-related quality of life in epilepsy: a double-blind comparison with valproate. Epilepsy Behav. 3(4), 376–382 (2002).
  • Lin JJ, Mula M, Hermann BP. Uncovering the neurobehavioural comorbidities of epilepsy over the lifespan. Lancet 380(9848), 1180–1192 (2012).
  • Sanacora G, Saricicek A. GABAergic contributions to the pathophysiology of depression and the mechanism of antidepressant action. CNS Neurol. Disord. Drug Targets 6(2), 127–140 (2007).
  • Comai S, Tau M, Gobbi G. The psychopharmacology of aggressive behavior: a translational approach: part 1: neurobiology. J. Clin. Psychopharmacol. 32(1), 83–94 (2012).
  • Mula M, Monaco F. Antiepileptic drugs and psychopathology of epilepsy: an update. Epileptic Disord. 11(1), 1–9 (2009).
  • Mula M. New antiepileptic drugs: molecular targets. Cent. Nerv. Syst. Agents Med. Chem. 9(2), 79–86 (2009).
  • Rogawski MA, Löscher W. The neurobiology of antiepileptic drugs. Nat. Rev. Neurosci. 5(7), 553–564 (2004).
  • Mula M. GABAergic drugs in the treatment of epilepsy: modern or outmoded? Future Med. Chem. 3(2), 177–182 (2011).
  • Farrant M, Nusser Z. Variations on an inhibitory theme: phasic and tonic activation of GABA(A) receptors. Nat. Rev. Neurosci. 6(3), 215–229 (2005).
  • Carta MG, Bhat KM, Preti A. GABAergic neuroactive steroids: a new frontier in bipolar disorders? Behav. Brain Funct. 8, 61 (2012).
  • Marx CE, Stevens RD, Shampine LJ et al. Neuroactive steroids are altered in schizophrenia and bipolar disorder: relevance to pathophysiology and therapeutics. Neuropsychopharmacology 31(6), 1249–1263 (2006).
  • Pieribone VA, Tsai J, Soufflet C et al. Clinical evaluation of ganaxolone in pediatric and adolescent patients with refractory epilepsy. Epilepsia 48(10), 1870–1874 (2007).
  • Bialer M, Johannessen SI, Levy RH, Perucca E, Tomson T, White HS. Progress report on new antiepileptic drugs: a summary of the Tenth Eilat Conference (EILAT X). Epilepsy Res. 92(2–3), 89–124 (2010).
  • Hu AQ, Wang ZM, Lan DM et al. Inhibition of evoked glutamate release by neurosteroid allopregnanolone via inhibition of l-type calcium channels in rat medial prefrontal cortex. Neuropsychopharmacology 32(7), 1477–1489 (2007).
  • Mula M. Recent and future antiepileptic drugs and their impact on cognition: what can we expect? Expert Rev. Neurother. 12(6), 667–671 (2012).
  • Bialer M, Johannessen SI, Levy RH, Perucca E, Tomson T, White HS. Progress report on new antiepileptic drugs: a summary of the Eleventh Eilat Conference (EILAT XI). Epilepsy Res. 103(1), 2–30 (2013).
  • No authors listed. Gamma-aminobutyric acid (GABA), monograph. Altern. Med. Rev. 12(3), 274–279 (2007).
  • Altamura CA, Mauri MC, Ferrara A, Moro AR, D’Andrea G, Zamberlan F. Plasma and platelet excitatory amino acids in psychiatric disorders. Am. J. Psychiatry 150(11), 1731–1733 (1993).
  • Mauri MC, Ferrara A, Boscati L et al. Plasma and platelet amino acid concentrations in patients affected by major depression and under fluvoxamine treatment. Neuropsychobiology 37(3), 124–129 (1998).
  • Sheline YI. Hippocampal atrophy in major depression: a result of depression-induced neurotoxicity? Mol. Psychiatry 1(4), 298–299 (1996).
  • Sapolsky RM. Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. Arch. Gen. Psychiatry 57(10), 925–935 (2000).
  • Kendell SF, Krystal JH, Sanacora G. GABA and glutamate systems as therapeutic targets in depression and mood disorders. Expert Opin. Ther. Targets 9(1), 153–168 (2005).
  • Meldrum BS, Rogawski MA. Molecular targets for antiepileptic drug development. Neurotherapeutics 4(1), 18–61 (2007).
  • Lee CY, Fu WM, Chen CC, Su MJ, Liou HH. Lamotrigine inhibits postsynaptic AMPA receptor and glutamate release in the dentate gyrus. Epilepsia 49(5), 888–897 (2008).
  • Gibbs JW 3rd, Sombati S, DeLorenzo RJ, Coulter DA. Cellular actions of topiramate: blockade of kainate-evoked inward currents in cultured hippocampal neurons. Epilepsia 41(Suppl. 1), S10–S16 (2000).
  • Meldrum BS. Lamotrigine – a novel approach. Seizure 3(Suppl. A), 41–45 (1994).
  • Cunningham MO, Jones RS. The anticonvulsant, lamotrigine decreases spontaneous glutamate release but increases spontaneous GABA release in the rat entorhinal cortex in vitro. Neuropharmacology 39(11), 2139–2146 (2000).
  • Wang SJ, Sihra TS, Gean PW. Lamotrigine inhibition of glutamate release from isolated cerebrocortical nerve terminals (synaptosomes) by suppression of voltage-activated calcium channel activity. Neuroreport 12(10), 2255–2258 (2001).
  • Gay PE, Mecham GF, Coskey JS, Sadler T, Thompson JA. Behavioral effects of felbamate in childhood epileptic encephalopathy (Lennox–Gastaut syndrome). Psychol. Rep. 77(3 Pt 2), 1208–1210 (1995).
  • Ketter TA, Post RM, Theodore WH. Positive and negative psychiatric effects of antiepileptic drugs in patients with seizure disorders. Neurology 53(5 Suppl. 2), S53–S67 (1999).
  • Frye MA. Clinical practice. Bipolar disorder – a focus on depression. N. Engl. J. Med. 364(1), 51–59 (2011).
  • Schindler F, Anghelescu IG. Lithium versus lamotrigine augmentation in treatment resistant unipolar depression: a randomized, open-label study. Int. Clin. Psychopharmacol. 22(3), 179–182 (2007).
  • Ettinger AB, Kustra RP, Hammer AE. Effect of lamotrigine on depressive symptoms in adult patients with epilepsy. Epilepsy Behav. 10(1), 148–154 (2007).
  • Tritt K, Nickel C, Lahmann C et al. Lamotrigine treatment of aggression in female borderline-patients: a randomized, double-blind, placebo-controlled study. J. Psychopharmacol. (Oxford) 19(3), 287–291 (2005).
  • Reich DB, Zanarini MC, Bieri KA. A preliminary study of lamotrigine in the treatment of affective instability in borderline personality disorder. Int. Clin. Psychopharmacol. 24(5), 270–275 (2009).
  • Perucca P, Mula M. Antiepileptic drug effects on mood and behavior: molecular targets. Epilepsy Behav. 26(3), 440–449 (2013).
  • Mula M, Trimble MR, Lhatoo SD, Sander JW. Topiramate and psychiatric adverse events in patients with epilepsy. Epilepsia 44(5), 659–663 (2003).
  • Nickel C, Lahmann C, Tritt K et al. Topiramate in treatment of depressive and anger symptoms in female depressive patients: a randomized, double-blind, placebo-controlled study. J. Affect. Disord. 87(2–3), 243–252 (2005).
  • Nickel MK, Nickel C, Mitterlehner FO et al. Topiramate treatment of aggression in female borderline personality disorder patients: a double-blind, placebo-controlled study. J. Clin. Psychiatry 65(11), 1515–1519 (2004).
  • Nickel MK, Nickel C, Kaplan P et al. Treatment of aggression with topiramate in male borderline patients: a double-blind, placebo-controlled study. Biol. Psychiatry 57(5), 495–499 (2005).
  • Leombruni P, Lavagnino L, Fassino S. Treatment of obese patients with binge eating disorder using topiramate: a review. Neuropsychiatr. Dis. Treat. 5, 385–392 (2009).
  • Mula M, Pini S, Cassano GB. The role of anticonvulsant drugs in anxiety disorders: a critical review of the evidence. J. Clin. Psychopharmacol. 27(3), 263–272 (2007).
  • Delbello MP, Findling RL, Kushner S et al. A pilot controlled trial of topiramate for mania in children and adolescents with bipolar disorder. J. Am. Acad. Child Adolesc. Psychiatry 44(6), 539–547 (2005).
  • Roy Chengappa KN, Schwarzman LK, Hulihan JF, Xiang J, Rosenthal NR; Clinical Affairs Product Support Study-168 Investigators. Adjunctive topiramate therapy in patients receiving a mood stabilizer for bipolar I disorder: a randomized, placebo-controlled trial. J. Clin. Psychiatry 67(11), 1698–1706 (2006).
  • Lindley SE, Carlson EB, Hill K. A randomized, double-blind, placebo-controlled trial of augmentation topiramate for chronic combat-related posttraumatic stress disorder. J. Clin. Psychopharmacol. 27(6), 677–681 (2007).
  • Tucker P, Trautman RP, Wyatt DB et al. Efficacy and safety of topiramate monotherapy in civilian posttraumatic stress disorder: a randomized, double-blind, placebo-controlled study. J. Clin. Psychiatry 68(2), 201–206 (2007).
  • Mula M, Cavanna AE, Monaco F. Psychopharmacology of topiramate: from epilepsy to bipolar disorder. Neuropsychiatr. Dis. Treat. 2(4), 475–488 (2006).
  • French JA, Krauss GL, Biton V et al. Adjunctive perampanel for refractory partial-onset seizures: randomized Phase III study 304. Neurology 79(6), 589–596 (2012).
  • Krauss GL, Serratosa JM, Villanueva V et al. Randomized Phase III study 306: adjunctive perampanel for refractory partial-onset seizures. Neurology 78(18), 1408–1415 (2012).
  • Rektor I, Krauss GL, Bar M et al. Perampanel Study 207: long-term open-label evaluation in patients with epilepsy. Acta Neurol. Scand. 126(4), 263–269 (2012).
  • Krauss GL, Perucca E, Ben-Menachem E et al. Perampanel, a selective, noncompetitive a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist, as adjunctive therapy for refractory partial-onset seizures: interim results from Phase III, extension study 307. Epilepsia 54(1), 126–134 (2013).
  • French JA, Krauss GL, Steinhoff BJ et al. Evaluation of adjunctive perampanel in patients with refractory partial-onset seizures: results of randomized global Phase III study 305. Epilepsia 54(1), 117–125 (2013).
  • El-Mallakh RS, Huff MO. Mood stabilizers and ion regulation. Harv. Rev. Psychiatry 9(1), 23–32 (2001).
  • Mogilnicka E, Czyrak A, Maj J. Dihydropyridine calcium channel antagonists reduce immobility in the mouse behavioral despair test; antidepressants facilitate nifedipine action. Eur. J. Pharmacol. 138(3), 413–416 (1987).
  • Galeotti N, Bartolini A, Ghelardini C. Blockade of intracellular calcium release induces an antidepressant-like effect in the mouse forced swimming test. Neuropharmacology 50(3), 309–316 (2006).
  • Quintero JE, Dooley DJ, Pomerleau F, Huettl P, Gerhardt GA. Amperometric measurement of glutamate release modulation by gabapentin and pregabalin in rat neocortical slices: role of voltage-sensitive Ca2+ a2d-1 subunit. J. Pharmacol. Exp. Ther. 338(1), 240–245 (2011).
  • Dooley DJ, Mieske CA, Borosky SA. Inhibition of K(+)-evoked glutamate release from rat neocortical and hippocampal slices by gabapentin. Neurosci. Lett. 280(2), 107–110 (2000).
  • Farber NB, Jiang XP, Heinkel C, Nemmers B. Antiepileptic drugs and agents that inhibit voltage-gated sodium channels prevent NMDA antagonist neurotoxicity. Mol. Psychiatry 7(7), 726–733 (2002).
  • Cipriani A, Barbui C, Salanti G et al. Comparative efficacy and acceptability of antimanic drugs in acute mania: a multiple-treatments meta-analysis. Lancet 378(9799), 1306–1315 (2011).
  • Mula M, Monaco F. Phenytoin and other hydantoins: clinical efficacy and use in psychiatric disorders. In: Antiepileptic Drugs (5th Edition). Levy R, Mattson R, Meldrum B, Perucca E (Eds). Lippincott William & Wilkins, Baltimore, MD, USA, 600–604 (2002).
  • Rosa AR, Fountoulakis K, Siamouli M, Gonda X, Vieta E. Is anticonvulsant treatment of mania a class effect? Data from randomized clinical trials. CNS Neurosci. Ther. 17(3), 167–177 (2011).
  • Fornaro M, Martino M, Dalmasso B et al. An open pilot study of zonisamide augmentation in major depressive patients not responding to a low dose trial with duloxetine: preliminary results on tolerability and clinical effects. Ann. Gen. Psychiatry 10(1), 23 (2011).
  • Dauphinais D, Knable M, Rosenthal J, Polanski M, Rosenthal N. Zonisamide for bipolar disorder, mania or mixed states: a randomized, double blind, placebo-controlled adjunctive trial. Psychopharmacol. Bull. 44(1), 5–17 (2011).
  • Stahl SM. Mechanism of action of α2δ ligands: voltage sensitive calcium channel (VSCC) modulators. J. Clin. Psychiatry 65(8), 1033–1034 (2004).
  • Micó JA, Prieto R. Elucidating the mechanism of action of pregabalin: a(2)d as a therapeutic target in anxiety. CNS Drugs 26(8), 637–648 (2012).
  • Montgomery S, Chatamra K, Pauer L, Whalen E, Baldinetti F. Efficacy and safety of pregabalin in elderly people with generalised anxiety disorder. Br. J. Psychiatry 193(5), 389–394 (2008).
  • Kasper S, Herman B, Nivoli G et al. Efficacy of pregabalin and venlafaxine-XR in generalized anxiety disorder: results of a double-blind, placebo-controlled 8-week trial. Int. Clin. Psychopharmacol. 24(2), 87–96 (2009).
  • Feltner DE, Liu-Dumaw M, Schweizer E, Bielski R. Efficacy of pregabalin in generalized social anxiety disorder: results of a double-blind, placebo-controlled, fixed-dose study. Int. Clin. Psychopharmacol. 26(4), 213–220 (2011).
  • Greist JH, Liu-Dumaw M, Schweizer E, Feltner D. Efficacy of pregabalin in preventing relapse in patients with generalized social anxiety disorder: results of a double-blind, placebo-controlled 26-week study. Int. Clin. Psychopharmacol. 26(5), 243–251 (2011).
  • Englisch S, Esser A, Enning F, Hohmann S, Schanz H, Zink M. Augmentation with pregabalin in schizophrenia. J. Clin. Psychopharmacol. 30(4), 437–440 (2010).
  • Showraki M. Pregabalin in the treatment of depression. J. Psychopharmacol. (Oxford) 21(8), 883–884 (2007).
  • Vieta E, Manuel Goikolea J, Martínez-Arán A et al. A double-blind, randomized, placebo-controlled, prophylaxis study of adjunctive gabapentin for bipolar disorder. J. Clin. Psychiatry 67(3), 473–477 (2006).
  • Schifano F, D’Offizi S, Piccione M et al. Is there a recreational misuse potential for pregabalin? Analysis of anecdotal online reports in comparison with related gabapentin and clonazepam data. Psychother. Psychosom. 80(2), 118–122 (2011).
  • Rogawski MA. KCNQ2/KCNQ3 K+ channels and the molecular pathogenesis of epilepsy: implications for therapy. Trends Neurosci. 23(9), 393–398 (2000).
  • Kobayashi T, Hirai H, Iino M et al. Inhibitory effects of the antiepileptic drug ethosuximide on G protein-activated inwardly rectifying K+ channels. Neuropharmacology 56(2), 499–506 (2009).
  • Dooley DJ, Donovan CM, Pugsley TA. Stimulus-dependent modulation of [(3)H]norepinephrine release from rat neocortical slices by gabapentin and pregabalin. J. Pharmacol. Exp. Ther. 295(3), 1086–1093 (2000).
  • Danielsson BR, Lansdell K, Patmore L, Tomson T. Effects of the antiepileptic drugs lamotrigine, topiramate and gabapentin on hERG potassium currents. Epilepsy Res. 63(1), 17–25 (2005).
  • Madeja M, Margineanu DG, Gorji A et al. Reduction of voltage-operated potassium currents by levetiracetam: a novel antiepileptic mechanism of action? Neuropharmacology 45(5), 661–671 (2003).
  • Deeks ED. Retigabine (ezogabine): in partial-onset seizures in adults with epilepsy. CNS Drugs 25(10), 887–900 (2011).
  • Czuczwar SJ, Patsalos PN. The new generation of GABA enhancers. Potential in the treatment of epilepsy. CNS Drugs 15(5), 339–350 (2001).
  • Barrese V, Miceli F, Soldovieri MV et al. Neuronal potassium channel openers in the management of epilepsy: role and potential of retigabine. Clin. Pharmacol. 2, 225–236 (2010).
  • Dencker D, Husum H. Antimanic efficacy of retigabine in a proposed mouse model of bipolar disorder. Behav. Brain Res. 207(1), 78–83 (2010).
  • Korsgaard MP, Hartz BP, Brown WD, Ahring PK, Strøbaek D, Mirza NR. Anxiolytic effects of Maxipost (BMS-204352) and retigabine via activation of neuronal Kv7 channels. J. Pharmacol. Exp. Ther. 314(1), 282–292 (2005).
  • Porter RJ, Partiot A, Sachdeo R, Nohria V, Alves WM; 205 Study Group. Randomized, multicenter, dose-ranging trial of retigabine for partial-onset seizures. Neurology 68(15), 1197–1204 (2007).
  • Brodie MJ, Lerche H, Gil-Nagel A et al.; RESTORE 2 Study Group. Efficacy and safety of adjunctive ezogabine (retigabine) in refractory partial epilepsy. Neurology 75(20), 1817–1824 (2010).
  • French JA, Abou-Khalil BW, Leroy RF et al.; RESTORE 1/Study 301 Investigators. Randomized, double-blind, placebo-controlled trial of ezogabine (retigabine) in partial epilepsy. Neurology 76(18), 1555–1563 (2011).
  • Potiga. Precribing information. GlaxoSmithKline, Research Triangle Park, NC, USA, 29 June 2012.
  • Hilfiker S, Pieribone VA, Czernik AJ, Kao HT, Augustine GJ, Greengard P. Synapsins as regulators of neurotransmitter release. Philos. Trans. R. Soc. Lond. B, Biol. Sci. 354(1381), 269–279 (1999).
  • Custer KL, Austin NS, Sullivan JM, Bajjalieh SM. Synaptic vesicle protein 2 enhances release probability at quiescent synapses. J. Neurosci. 26(4), 1303–1313 (2006).
  • Lynch BA, Lambeng N, Nocka K et al. The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam. Proc. Natl Acad. Sci. USA 101(26), 9861–9866 (2004).
  • Muralidharan A, Bhagwagar Z. Potential of levetiracetam in mood disorders: a preliminary review. CNS Drugs 20(12), 969–979 (2006).
  • Zhang W, Connor KM, Davidson JR. Levetiracetam in social phobia: a placebo controlled pilot study. J. Psychopharmacol. (Oxford) 19(5), 551–553 (2005).
  • Saricicek A, Maloney K, Muralidharan A et al. Levetiracetam in the management of bipolar depression: a randomized, double-blind, placebo-controlled trial. J. Clin. Psychiatry 72(6), 744–750 (2011).
  • Stein MB, Ravindran LN, Simon NM et al. Levetiracetam in generalized social anxiety disorder: a double-blind, randomized controlled trial. J. Clin. Psychiatry 71(5), 627–631 (2010).
  • Mattes JA. Levetiracetam in patients with impulsive aggression: a double-blind, placebo-controlled trial. J. Clin. Psychiatry 69(2), 310–315 (2008).
  • Mula M, Trimble MR, Yuen A, Liu RS, Sander JW. Psychiatric adverse events during levetiracetam therapy. Neurology 61(5), 704–706 (2003).
  • White JR, Walczak TS, Leppik IE et al. Discontinuation of levetiracetam because of behavioral side effects: a case–control study. Neurology 61(9), 1218–1221 (2003).
  • Helmstaedter C, Mihov Y, Toliat MR et al. Genetic variation in dopaminergic activity is associated with the risk for psychiatric side effects of levetiracetam. Epilepsia 54(1), 36–44 (2013).
  • Post RM, Silberstein SD. Shared mechanisms in affective illness, epilepsy, and migraine. Neurology 44(10 Suppl. 7), S37–S47 (1994).
  • Kanner AM. Depression and epilepsy: a bidirectional relation? Epilepsia 52(Suppl. 1), 21–27 (2011).
  • Machado-Vieira R, Kapczinski F, Soares JC. Perspectives for the development of animal models of bipolar disorder. Prog. Neuropsychopharmacol. Biol. Psychiatry 28(2), 209–224 (2004).
  • Amann B, Grunze H. Neurochemical underpinnings in bipolar disorder and epilepsy. Epilepsia 46(Suppl. 4), 26–30 (2005).
  • Hafeman DM, Chang KD, Garrett AS, Sanders EM, Phillips ML. Effects of medication on neuroimaging findings in bipolar disorder: an updated review. Bipolar Disord. 14(4), 375–410 (2012).
  • Post RM, Weiss SR. A speculative model of affective illness cyclicity based on patterns of drug tolerance observed in amygdala-kindled seizures. Mol. Neurobiol. 13(1), 33–60 (1996).
  • Potschka H, Feuerstein TJ, Löscher W. Gabapentin-lactam, a close analogue of the anticonvulsant gabapentin, exerts convulsant activity in amygdala kindled rats. Naunyn Schmiedebergs Arch. Pharmacol. 361(2), 200–205 (2000).
  • Mula M. Topiramate and cognitive impairment: evidence and clinical implications. Ther. Adv. Drug Saf. 3(6), 279–289 (2012).
  • Bersudsky Y, Applebaum J, Gaiduk Y et al. Valnoctamide as a valproate substitute with low teratogenic potential in mania: a double-blind, controlled, add-on clinical trial. Bipolar Disord. 12(4), 376–382 (2010).
  • Zullino DF, Khazaal Y, Hättenschwiler J, Borgeat F, Besson J. Anticonvulsant drugs in the treatment of substance withdrawal. Drugs Today 40(7), 603–619 (2004).
  • Denis C, Fatseas M, Lavie E, Auriacombe M. Pharmacological interventions for benzodiazepine mono-dependence management in outpatient settings. Cochrane Database Syst. Rev. 3, CD005194 (2006).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.