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Drug Profile

Cost–effectiveness of lenalidomide in multiple myeloma

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Pages 229-238 | Published online: 09 Jan 2014

References

  • Drayson MT, Augustson BM, Begum G et al. Survival from relapse and the influence of therapy. XIth International Myeloma Workshop Proceedings. Haematologica92(6 Suppl. 2), 173 (2007) (Abstract PO-665).
  • Vacca A, Ribatti D, Presta M et al. Bone marrow neovascularization, plasma cell angiogenic potential, and matrix metalloproteinase-2 secretion parallel progression of human multiple myeloma. Blood93(9), 3064–3073 (1999).
  • D’Amato RJ, Loughnan MS, Flynn E, Folkman J. Thalidomide is an inhibitor of angiogenesis. Proc. Natl Acad. Sci. USA91(9), 4082–4085 (1994).
  • Singhal S, Mehta J, Desikan R et al. Antitumor activity of thalidomide in refractory multiple myeloma. N. Engl. J. Med.341(21), 1565–1571 (1999).
  • Barlogie B, Desikan R, Eddlemon P et al. Extended survival in advanced and refractory multiple myeloma after single-agent thalidomide: identification of prognostic factors in a Phase 2 study of 169 patients. Blood98(2), 492–494 (2001).
  • Schey SA, Cavenagh J, Johnson R, Child JA, Oakervee H, Jones RW. An UK myeloma forum Phase II study of thalidomide; long term follow-up and recommendations for treatment. Leuk. Res.27(10), 909–914 (2003).
  • Glasmacher A, Hahn C, Hoffmann F et al. A systematic review of Phase-II trials of thalidomide monotherapy in patients with relapsed or refractory multiple myeloma. Br. J. Haematol.132(5), 584–593 (2006).
  • Rajkumar SV, Hayman S, Gertz MA et al. Combination therapy with thalidomide plus dexamethasone for newly diagnosed myeloma. J. Clin. Oncol.20(21), 4319–4323 (2002).
  • Rajkumar SV, Gertz MA, Lacy MQ et al. Thalidomide as initial therapy for early-stage myeloma. Leukemia17(4), 775–779 (2003).
  • Weber D, Rankin K, Gavino M, Delasalle K, Alexanian R. Thalidomide alone or with dexamethasone for previously untreated multiple myeloma. J. Clin. Oncol.21(1), 16–19 (2003).
  • Gay F, Hayman S, Lacy M et al. Lenalidomide plus dexamethasone versus thalidomide plus dexamethasone in newly diagnosed multiple myeloma: a comparative analysis of 411 patients. Blood115(7), 1343–1350 (2010).
  • Schey SA, Jones R, Streetly M. A Phase I study of a new immunomodulatory thalidomide analogue CC 4047 (Actimid) in patients with relapsed/refractory multiple myeloma. J. Clin. Oncol.22(16), 3269–3276 (2004).
  • Streetly MJ, Gyertson K, Daniel Y, Zeldis JB, Kazmi M, Schey SA. Alternate day pomalidomide retains anti-myeloma effect with reduced adverse events and evidence of in vivo immunomodulation. Br. J. Haematol.141(1), 41–51 (2008).
  • Lacy MQ, Hayman SR, Gertz MA et al. Pomalidomide (CC4047) plus low-dose dexamethasone as therapy for relapsed multiple myeloma. J. Clin. Oncol.27(30), 5008–5014 (2009).
  • Lioznov M, El-Cheikh J Jr, Hoffmann F et al. Lenalidomide as salvage therapy after allo-SCT for multiple myeloma is effective and leads to an increase of activated NK (NKp44(+)) and T (HLA-DR(+)) cells. Bone Marrow Transplant.45(2), 349–353 (2009).
  • LeBlanc R, Hideshima T, Catley LP et al. Immunomodulatory drug costimulates T cells via the B7-CD28 pathway. Blood103(5), 1787–1790 (2004).
  • Zhu D, Corral LG, Fleming YW, Stein B. Immunomodulatory drugs Revlimid (lenalidomide) and CC-4047 induce apoptosis of both hematological and solid tumor cells through NK cell activation. Cancer Immunol. Immunother.57(12), 1849–1859 (2008).
  • Song W, van der Vliet HJ, Tai YT et al. Generation of antitumor invariant natural killer T cell lines in multiple myeloma and promotion of their functions via lenalidomide: a strategy for immunotherapy. Clin. Cancer Res.14(21), 6955–6962 (2008).
  • Galustian C, Meyer B, Labarthe MC et al. The anti-cancer agents lenalidomide and pomalidomide inhibit the proliferation and function of T regulatory cells. Cancer Immunol. Immunother.58(7), 1033–1045 (2009).
  • Gupta D, Treon SP, Shima Y et al. Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: therapeutic applications. Leukemia15(12), 1950–1961 (2001).
  • Dredge K, Marriott JB, Macdonald CD et al. Novel thalidomide analogues display anti-angiogenic activity independently of immunomodulatory effects. Br. J. Cancer87(10), 1166–1172 (2002).
  • Lentzsch S, LeBlanc R, Podar K et al. Immunomodulatory analogs of thalidomide inhibit growth of Hs Sultan cells and angiogenesis in vivo. Leukemia17(1), 41–44 (2003).
  • Corral LG, Haslett PA, Muller GW et al. Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogues that are potent inhibitors of TNF-α. J. Immunol.163(1), 380–386 (1999).
  • Marriott JB, Clarke IA, Dredge K, Muller G, Stirling D, Dalgleish AG. Thalidomide and its analogues have distinct and opposing effects on TNF-α and TNFR2 during co-stimulation of both CD4(+) and CD8(+) T cells. Clin. Exp. Immunol.130(1), 75–84 (2002).
  • Schafer PH, Gandhi AK, Loveland MA et al. Enhancement of cytokine production and AP-1 transcriptional activity in T cells by thalidomide-related immunomodulatory drugs. J. Pharmacol. Exp. Ther.305(3), 1222–1232 (2003).
  • Galustian C, Labarthe MC, Bartlett JB, Dalgleish AG. Thalidomide-derived immunomodulatory drugs as therapeutic agents. Expert Opin. Biol. Ther.4(12), 1963–1970 (2004).
  • Dredge K, Horsfall R, Robinson SP et al. Orally administered lenalidomide (CC-5013) is anti-angiogenic in vivo and inhibits endothelial cell migration and Akt phosphorylation in vitro. Microvasc. Res.69(1–2), 56–63 (2005).
  • Parman T, Wiley MJ, Wells PG. Free radical-mediated oxidative DNA damage in the mechanism of thalidomide teratogenicity. Nat. Med.5(5), 582–585 (1999).
  • Payvandi F, Wu L, Haley M et al. Immunomodulatory drugs inhibit expression of cyclooxygenase-2 from TNF-α, IL-1β, and LPS-stimulated human PBMC in a partially IL-10-dependent manner. Cell. Immunol.230(2), 81–88 (2004).
  • Escoubet-Lozach L, Lin IL, Jensen-Pergakes K et al. Pomalidomide and lenalidomide induce p21 WAF-1 expression in both lymphoma and multiple myeloma through a LSD1-mediated epigenetic mechanism. Cancer Res.69(18), 7347–7356 (2009).
  • Richardson PG, Schlossman RL, Weller E et al. Immunomodulatory drug CC-5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple myeloma. Blood100(9), 3063–3067 (2002).
  • Zangari MTG, Zeldis J, Eddlemon P, Saghafifar F, Barlogie B. Results of Phase I study of lenalidomide for the treatment of multiple myeloma (MM) patients who relapse after high dose chemotherapy (HDCT). Blood98(775A), (2001) (Abstract 3226).
  • Richardson PG, Blood E, Mitsiades CS et al. A randomized Phase 2 study of lenalidomide therapy for patients with relapsed or relapsed and refractory multiple myeloma. Blood108(10), 3458–3464 (2006).
  • Weber DM, Chen C, Niesvizky R et al. Lenalidomide plus dexamethasone for relapsed multiple myeloma in North America. N. Engl. J. Med.357(21), 2133–2142 (2007).
  • Dimopoulos M, Spencer A, Attal M et al. Lenalidomide plus dexamethasone for relapsed or refractory multiple myeloma. N. Engl. J. Med.357(21), 2123–2132 (2007).
  • Rajkumar SV, Hayman SR, Lacy MQ et al. Combination therapy with lenalidomide plus dexamethasone (Rev/Dex) for newly diagnosed myeloma. Blood106(13), 4050–4053 (2005).
  • Rajkumar SV, Jacobus S, Callander NS et al. Lenalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone as initial therapy for newly diagnosed multiple myeloma: an open-label randomised controlled trial. Lancet Oncol.11(1), 29–37 (2010).
  • Morgan GJ, Schey SA, Wu P et al. Lenalidomide (Revlimid), in combination with cyclophosphamide and dexamethasone (RCD), is an effective and tolerated regimen for myeloma patients. Br. J. Haematol.137(3), 268–269 (2007).
  • Knop S, Gerecke C, Liebisch P et al. Lenalidomide, adriamycin, and dexamethasone (RAD) in patients with relapsed and refractory multiple myeloma: a report from the German Myeloma Study Group DSMM (Deutsche Studiengruppe Multiples Myelom). Blood113(18), 4137–4143 (2009).
  • Baz R, Walker E, Karam MA et al. Lenalidomide and pegylated liposomal doxorubicin-based chemotherapy for relapsed or refractory multiple myeloma: safety and efficacy. Ann. Oncol.17(12), 1766–1771 (2006).
  • Palumbo A, Falco P, Falcone A et al. Melphalan, prednisone, and lenalidomide for newly diagnosed myeloma: kinetics of neutropenia and thrombocytopenia and time-to-event results. Clin. Lymphoma Myeloma9(2), 145–150 (2009).
  • Chauhan D, Singh AV, Ciccarelli B, Richardson PG, Palladino MA, Anderson KC. Combination of novel proteasome inhibitor NPI-0052 and lenalidomide trigger in vitro and in vivo synergistic cytotoxicity in multiple myeloma. Blood115(4), 834–845 (2010).
  • Morgan GJ, Davies FE, Cavenagh JD, Jackson GH. Position statement on the use of bortezomib in multiple myeloma. Int. J. Lab. Hematol.30(1), 1–10 (2008).
  • McCarthy DA, Macey MG, Streetly M, Schey SA, Brown KA. The neutropenia induced by the thalidomide analogue CC-4047 in patients with multiple myeloma is associated with an increased percentage of neutrophils bearing CD64. Int. Immunopharmacol.6(7), 1194–1203 (2006).
  • Aapro MS, Cameron DA, Pettengell R et al. EORTC guidelines for the use of granulocyte-colony stimulating factor to reduce the incidence of chemotherapy-induced febrile neutropenia in adult patients with lymphomas and solid tumours. Eur. J. Cancer42(15), 2433–2453 (2006).
  • Palumbo A, Rajkumar SV, Dimopoulos MA et al. Prevention of thalidomide- and lenalidomide-associated thrombosis in myeloma. Leukemia22(2), 414–423 (2008).
  • Normand C. Measuring outcomes in palliative care: limitations of QALYs and the road to PalYs. J. Pain Symptom Manage.38(1), 27–31 (2009).
  • Higginson IJ, Foley KM. Palliative care: no longer a luxury but a necessity? J. Pain Symptom Manage.38(1), 1–3 (2009).
  • Solano JP, Gomes B, Higginson IJ. A comparison of symptom prevalence in far advanced cancer, AIDS, heart disease, chronic obstructive pulmonary disease and renal disease. J. Pain Symptom Manage.31(1), 58–69 (2006).
  • Higginson IJ, Costantini M. Dying with cancer, living well with advanced cancer. Eur. J. Cancer44(10), 1414–1424 (2008).
  • Koffman J, Morgan M, Edmonds P, Speck P, Higginson IJ. “I know he controls cancer”: the meanings of religion among Black Caribbean and White British patients with advanced cancer. Soc. Sci. Med.67(5), 780–789 (2008).
  • Higginson IJ, Donaldson N. Relationship between three palliative care outcome scales. Health Qual. Life Outcomes2, 68 (2004).
  • Gomes B, Higginson IJ. Where people die (1974–2030): past trends, future projections and implications for care. Palliat. Med.22(1), 33–41 (2008).
  • McCrone P. Capturing the costs of end-of-life care: comparisons of multiple sclerosis, Parkinson’s disease, and dementia. J. Pain Symptom Manage.38(1), 62–67 (2009).
  • British National Formulary (BNF) (55th Edition). BMJ Group and RPS Publishing, London, UK (2009).
  • Bonkowski JJ, Vermeulen LC, Kolesar JM. The clinical utility of lenalidomide in multiple myeloma and myelodysplastic syndromes. J. Oncol. Pharm. Pract. DOI: 0: 1078155209351967v1 (2009) (Epub ahead of print).
  • Douglas HR, Normand CE, Higginson IJ, Goodwin DM. A new approach to eliciting patients’ preferences for palliative day care: the choice experiment method. J. Pain Symptom Manage.29(5), 435–445 (2005).
  • Muhlbacher AC, Lincke HJ, Nubling M. Evaluating patients’ preferences for multiple myeloma therapy, a discrete-choice-experiment. Psychosoc. Med.5, Doc10 (2008).
  • Cocks K, Cohen D, Wisloff F et al. An international field study of the reliability and validity of a disease-specific questionnaire module (the QLQ-MY20) in assessing the quality of life of patients with multiple myeloma. Eur. J. Cancer43(11), 1670–1678 (2007).
  • Kvam AK, Fayers P, Hjermstad M, Gulbrandsen N, Wisloff F. Health-related quality of life assessment in randomised controlled trials in multiple myeloma: a critical review of methodology and impact on treatment recommendations. Eur. J. Haematol.83(4), 279–289 (2009).
  • King MT, Fayers PM. Making quality-of-life results more meaningful for clinicians. Lancet371(9614), 709–710 (2008).
  • Cook R. Introduction: multiple myeloma. J. Manag. Care Pharm.14(7 Suppl.), 4–6 (2008).

Websites

  • Davies Higginson IJ. Better palliative care for older people world health organization (2004) www.euro.who.int/document/e82933.pdf
  • National Institute for Health and Clinical Excellence (NICE). NICE technology appraisal guidance 171. Lenalidomide for the treatment of multiple myeloma in people who have received at least one prior therapy. London, July 2009 www.nice.org.uk/TA171
  • The NCCN Clinical Practice Guidelines in Oncology. Multiple myeloma (Version 1.2010). National Comprehensive Cancer Network, Inc. 2009 www.NCCN.org

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