294
Views
22
CrossRef citations to date
0
Altmetric
Review

Cost–effectiveness studies in radiation therapy

Pages 567-582 | Published online: 09 Jan 2014

References

  • Cancer Trends Progress Report – 2007 Update. National Cancer Institute, MD, USA (2007).
  • Cancer Facts and Figures – 2008. American Cancer Society, GA, USA (2008).
  • Meropol NJ, Schrag D, Smith TJ et al. American Society of Clinical Oncology guidance statement: the cost of cancer care. J. Clin. Oncol.27(23), 3868–3874 (2009).
  • Warren JL, Yabroff KR, Meekins A, Topor M, Lamont EB, Brown ML. Evaluation of trends in the cost of initial cancer treatment. J. Natl Cancer Inst.100(12), 888–897 (2008).
  • Weinstein MC, Skinner JA. Comparative effectiveness and health care spending – implications for reform. N. Engl. J. Med.362(5), 460–465 (2010).
  • Neumann PJ, Rosen AB, Weinstein MC. Medicare and cost–effectiveness analysis. N. Engl. J. Med.353(14), 1516–1522 (2005).
  • Baker GR. Localization: conventional and CT simulation. Br. J. Radiol.79(Spec. No 1), S36–S49 (2006).
  • Mah D, Chen CC. Image guidance in radiation oncology treatment planning: the role of imaging technologies on the planning process. Semin. Nucl. Med.38(2), 114–118 (2008).
  • Goitein M. Future prospects in planning radiation therapy. Cancer55(9 Suppl.), 2234–2239 (1985).
  • Gunderson LT. Clinical Radiation Oncology. Churchill Livingstone, PA, USA (2000).
  • Mendenhall WM, Amdur RJ, Palta JR. Intensity-modulated radiotherapy in the standard management of head and neck cancer: promises and pitfalls. J. Clin. Oncol.24(17), 2618–2623 (2006).
  • Jereczek-Fossa BA, Krengli M, Orecchia R. Particle beam radiotherapy for head and neck tumors: radiobiological basis and clinical experience. Head Neck28(8), 750–760 (2006).
  • Fukumura A, Tsujii H, Kamada T et al. Carbon-ion radiotherapy: clinical aspects and related dosimetry. Radiat. Prot. Dosimetry137(1–2), 149–155 (2009).
  • Lo SS, Fakiris AJ, Chang EL et al. Stereotactic body radiation therapy: a novel treatment modality. Nat. Rev. Clin. Oncol.7(1), 44–54 (2008).
  • Verellen D, De Ridder M, Tournel K et al. An overview of volumetric imaging technologies and their quality assurance for IGRT. Acta Oncologica (Stockholm, Sweden), 47(7), 1271–1278 (2008).
  • Ben-Josef E, Lawrence TS. Using a bigger hammer: the role of stereotactic body radiotherapy in the management of oligometastases. J. Clin. Oncol.27(10), 1537–1539 (2009).
  • Rusthoven KE, Kavanagh BD, Cardenes H et al. Multi-institutional Phase I/II trial of stereotactic body radiation therapy for liver metastases. J. Clin. Oncol.27(10), 1572–1578 (2009).
  • Heron DE, Ferris RL, Karamouzis M et al. Stereotactic body radiotherapy for recurrent squamous cell carcinoma of the head and neck: results of a Phase I dose-escalation trial. Int. J. Radiat. Oncol. Biol. Phys.75(5), 1493–1500 (2009).
  • Lo SS, Cardenes HR, Teh BS et al. Stereotactic body radiation therapy for nonpulmonary primary tumors. Expert Rev. Anticancer Ther.8(12), 1939–1951 (2008).
  • ProCure. Developing Proton Therapy Centers. ProCure, OK, USA (2009).
  • Van de Werf E, Lievens Y, Verstraete J, Pauwels K, Van den Bogaert W. Time and motion study of radiotherapy delivery: economic burden of increased quality assurance and IMRT. Radiother. Oncol.93(1), 137–140 (2009).
  • Suh WW, Pierce LJ, Vicini FA, Hayman JA. A cost comparison analysis of partial versus whole-breast irradiation after breast-conserving surgery for early-stage breast cancer. Int. J. Radiat. Oncol. Biol. Phys.62(3), 790–796 (2005).
  • Poon I, Pintilie M, Potvin M, McGowan T. The changing costs of radiation treatment for early prostate cancer in Ontario: a comparison between conventional and conformal external beam radiotherapy. Can. J. Urol.11(1), 2125–2132 (2004).
  • Goitein M, Jermann M. The relative costs of proton and x-ray radiation therapy. Clin. Oncol. (R. Coll. Radiol.), 15(1), S37–50 (2003).
  • Peeters A, Grutters JP, Pijls-Johannesma M et al. How costly is particle therapy? Cost analysis of external beam radiotherapy with carbon-ions, protons and photons. Radiother. Oncol.95(1), 45–53 (2010).
  • Gold M, Siegel JE, Russell LB, Weinstein MC. Cost–Effectiveness in Health and Medicine. Oxford University Press, NY, USA (1996).
  • Stiggelbout AM, de Haes JC. Patient preference for cancer therapy: an overview of measurement approaches. J. Clin. Oncol.19(1), 220–230 (2001).
  • Drummond MF, Sculpher M, Torrance GW, O’Brien BJ, Stoddart GL. Methods for the Economic Evaluation of Health Care Programmes. Oxford University Press, Oxford, UK (2005).
  • Pijls-Johannesma M, Pommier P, Lievens Y. Cost–effectiveness of particle therapy: current evidence and future needs. Radiother. Oncol.89(2), 127–134 (2008).
  • Lodge M, Pijls-Johannesma M, Stirk L, Munro AJ, De Ruysscher D, Jefferson T. A systematic literature review of the clinical and cost–effectiveness of hadron therapy in cancer. Radiother. Oncol.83(2), 110–122 (2007).
  • Fisher B, Dignam J, Wolmark N et al. Lumpectomy and radiation therapy for the treatment of intraductal breast cancer: findings from National Surgical Adjuvant Breast and Bowel Project B-17. J. Clin. Oncol.16(2), 441–452 (1998).
  • Clarke M, Collins R, Darby S et al. Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. Lancet366(9503), 2087–2106 (2005).
  • Punglia RS, Morrow M, Winer EP, Harris JR. Local therapy and survival in breast cancer. N. Engl. J. Med.356(23), 2399–2405 (2007).
  • Liljegren G, Karlsson G, Bergh J, Holmberg L. The cost–effectiveness of routine postoperative radiotherapy after sector resection and axillary dissection for breast cancer stage I. Results from a randomized trial. Ann. Oncol.8(8), 757–763 (1997).
  • Hayman JA, Hillner BE, Harris JR, Weeks JC. Cost–effectiveness of routine radiation therapy following conservative surgery for early-stage breast cancer. J. Clin. Oncol.16(3), 1022–1029 (1998).
  • Suh WW, Hillner BE, Pierce LJ, Hayman JA. Cost–effectiveness of radiation therapy following conservative surgery for ductal carcinoma in situ of the breast. Int. J. Radiat. Oncol. Biol. Phys.61(4), 1054–1061 (2005).
  • Lee JH, Glick HA, Hayman JA, Solin LJ. Decision–analytic model and cost–effectiveness evaluation of postmastectomy radiation therapy in high-risk premenopausal breast cancer patients. J. Clin. Oncol.20(11), 2713–2725 (2002).
  • Hayman JA, Hillner BE, Harris JR, Pierce LJ, Weeks JC. Cost–effectiveness of adding an electron-beam boost to tangential radiation therapy in patients with negative margins after conservative surgery for early-stage breast cancer. J. Clin. Oncol.18(2), 287–295 (2000).
  • Sher DJ, Wittenberg E, Suh WW, Taghian AG, Punglia RS. Partial-breast irradiation versus whole-breast irradiation for early-stage breast cancer: a cost–effectiveness analysis. Int. J. Radiat. Oncol. Biol. Phys.74(2), 440–446 (2009).
  • Lundkvist J, Ekman M, Ericsson SR, Isacsson U, Jonsson B, Glimelius B. Economic evaluation of proton radiation therapy in the treatment of breast cancer. Radiother. Oncol.75(2), 179–185 (2005).
  • Kozak KR, Smith BL, Adams J et al. Accelerated partial-breast irradiation using proton beams: initial clinical experience. Int. J. Radiat. Oncol. Biol. Phys.66(3), 691–698 (2006).
  • Pignol JP, Olivotto I, Rakovitch E et al. A multicenter randomized trial of breast intensity-modulated radiation therapy to reduce acute radiation dermatitis. J. Clin. Oncol.26(13), 2085–2092 (2008).
  • D’Amico AV, Whittington R, Malkowicz SB et al. Biochemical outcome after radical prostatectomy, external beam radiation therapy, or interstitial radiation therapy for clinically localized prostate cancer. JAMA280(11), 969–974 (1998).
  • Klotz L, Zhang L, Lam A, Nam R, Mamedov A, Loblaw A. Clinical results of long-term follow-up of a large, active surveillance cohort with localized prostate cancer. J. Clin. Oncol.28(1), 126–131 (2010).
  • Bolla M, de Reijke TM, Van Tienhoven G et al. Duration of androgen suppression in the treatment of prostate cancer. N. Engl. J. Med.360(24), 2516–2527 (2009).
  • Thompson IM, Tangen CM, Paradelo J et al. Adjuvant radiotherapy for pathological T3N0M0 prostate cancer significantly reduces risk of metastases and improves survival: long-term followup of a randomized clinical trial. J. Urol.181(3), 956–962 (2009).
  • Hummel S, Paisley S, Morgan A, Currie E, Brewer N. Clinical and cost–effectiveness of new and emerging technologies for early localised prostate cancer: a systematic review. Health Technol. Assess.7(33), iii, ix–x, 1–157 (2003).
  • Konski A, Watkins-Bruner D, Feigenberg S et al. Using decision analysis to determine the cost–effectiveness of intensity-modulated radiation therapy in the treatment of intermediate risk prostate cancer. Int. J. Radiat. Oncol. Biol. Phys.66(2), 408–415 (2006).
  • Konski A, Speier W, Hanlon A, Beck JR, Pollack A. Is proton beam therapy cost effective in the treatment of adenocarcinoma of the prostate? J. Clin. Oncol.25(24), 3603–3608 (2007).
  • Hoffe SE, Shridhar R, Biagioli MC. Radiation therapy for rectal cancer: current status and future directions. Cancer Control17(1), 25–34 (2010).
  • Cooke EW, Hazard L. Curative radiation therapy for pancreatic malignancies. Surg. Clin. North Am.90(2), 341–354 (2009).
  • Willett CG, Czito BG. Chemoradiotherapy in gastrointestinal malignancies. Clin. Oncol. (R. Coll. Radiol.), 21(7), 543–556 (2009).
  • Meyer J, Willett C, Czito B. Current and emerging treatment strategies for anal cancer. Curr. Oncol. Rep.12(3), 168–174 (2009).
  • Van Den Brink M, Van Den Hout WB, Stiggelbout AM et al. Cost–utility analysis of preoperative radiotherapy in patients with rectal cancer undergoing total mesorectal excision: a study of the Dutch Colorectal Cancer Group. J. Clin. Oncol.22(2), 244–253 (2004).
  • Peeters KC, van de Velde CJ, Leer JW et al. Late side effects of short-course preoperative radiotherapy combined with total mesorectal excision for rectal cancer: increased bowel dysfunction in irradiated patients – a Dutch colorectal cancer group study. J. Clin. Oncol.23(25), 6199–6206 (2005).
  • Bujko K, Nowacki MP, Nasierowska-Guttmejer A, Michalski W, Bebenek M, Kryj M. Long-term results of a randomized trial comparing preoperative short-course radiotherapy with preoperative conventionally fractionated chemoradiation for rectal cancer. Br. J. Surg.93(10), 1215–1223 (2006).
  • Krzyzanowska MK, Earle CC, Kuntz KM, Weeks JC. Using economic analysis to evaluate the potential of multimodality therapy for elderly patients with locally advanced pancreatic cancer. Int. J. Radiat. Oncol. Biol. Phys.67(1), 211–218 (2007).
  • Wenger U, Johnsson E, Bergquist H et al. Health economic evaluation of stent or endoluminal brachytherapy as a palliative strategy in patients with incurable cancer of the oesophagus or gastro-oesophageal junction: results of a randomized clinical trial. Eur. J. Gastroenterol. Hepatol.17(12), 1369–1377 (2005).
  • da Silveira EB, Artifon EL. Cost–effectiveness of palliation of unresectable esophageal cancer. Dig. Dis. Sci.53(12), 3103–3111 (2008).
  • Shenfine J, McNamee P, Steen N, Bond J, Griffin SM. A pragmatic randomised controlled trial of the cost–effectiveness of palliative therapies for patients with inoperable oesophageal cancer. Health Technol. Assess.9(5), iii, 1–121 (2005).
  • Wang SJ, Fuller CD, Choi M, Thomas CR. A cost–effectiveness analysis of adjuvant chemoradiotherapy for resected gastric cancer. Gastrointest. Cancer Res.2(2), 57–63 (2008).
  • Pettersson D, Cedermark B, Holm T et al. Interim analysis of the Stockholm III trial of preoperative radiotherapy regimens for rectal cancer. Br. J. Surg.97(4), 580–587 (2010).
  • Neoptolemos JP, Stocken DD, Friess H et al. A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer. N. Engl. J. Med.350(12), 1200–1210 (2004).
  • Regine WF, Winter KA, Abrams RA et al. Fluorouracil vs gemcitabine chemotherapy before and after fluorouracil-based chemoradiation following resection of pancreatic adenocarcinoma: a randomized controlled trial. JAMA299(9), 1019–1026 (2008).
  • Yovino S, Poppe M, Jabbour S et al. Intensity-modulated radiation therapy significantly improves acute gastrointestinal toxicity in pancreatic and ampullary cancers. Int. J. Radiat. Oncol. Biol. Phys.72(1 Suppl. 1), S254 (2010).
  • Konski A, Kachnic LA. Jury still out on whether advanced technology can improve the outcomes of patients with anal canal cancer. Oncology (Williston Park), 23(12), 1092, 1094, 1096 (2009).
  • Smolle-Juettner FM, Maier A, Lindenmann J, Matzi V, Neubock N. Resection in stage I/II non-small cell lung cancer. Front Radiat. Ther. Oncol.42, 71–77 (2009).
  • Serke M. Adjuvant therapy in early-stage non-small cell lung cancer. Front. Radiat. Ther. Oncol.42, 135–144 (2008).
  • Senan S, Lagerwaard F. Stereotactic radiotherapy for stage I lung cancer: current results and new developments. Cancer Radiother.14(2), 115–118 (2010).
  • Auperin A, Le Pechoux C, Rolland E et al. Meta-analysis of concomitant versus sequential radiochemotherapy in locally advanced non-small-cell lung cancer. J. Clin. Oncol.28(13), 2181–2190 (2009).
  • Albain KS, Swann RS, Rusch VW et al. Radiotherapy plus chemotherapy with or without surgical resection for stage III non-small-cell lung cancer: a Phase III randomised controlled trial. Lancet374(9687), 379–386 (2009).
  • Auperin A, Arriagada R, Pignon JP et al. Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission. Prophylactic Cranial Irradiation Overview Collaborative Group. N. Engl. J. Med.341(7), 476–484 (1999).
  • Pijls-Johannesma M, Grutters JP, Lambin P, Ruysscher DD. Particle therapy in lung cancer: where do we stand? Cancer Treat. Rev.34(3), 259–267 (2008).
  • Ferguson MK. Optimal management when unsuspected N2 nodal disease is identified during thoracotomy for lung cancer: cost–effectiveness analysis. J. Thorac. Cardiovasc. Surg.126(6), 1935–1942 (2003).
  • Tai TH, Yu E, Dickof P et al. Prophylactic cranial irradiation revisited: cost–effectiveness and quality of life in small-cell lung cancer. Int. J. Radiat. Oncol. Biol. Phys.52(1), 68–74 (2002).
  • Coy P, Schaafsma J, Schofield JA. The cost–effectiveness and cost-utility of high-dose palliative radiotherapy for advanced non-small-cell lung cancer. Int. J. Radiat. Oncol. Biol. Phys.48(4), 1025–1033 (2000).
  • van den Hout WB, Kramer GW, Noordijk EM, Leer JW. Cost-utility analysis of short- versus long-course palliative radiotherapy in patients with non-small-cell lung cancer. J. Natl Cancer Inst.98(24), 1786–1794 (2006).
  • Grutters JP, Pijls-Johannesma M, Ruysscher DD et al. The cost–effectiveness of particle therapy in non-small cell lung cancer: exploring decision uncertainty and areas for future research. Cancer Treat Rev.36(6), 468–476 (2010).
  • Zhang X, Li Y, Pan X et al. Intensity-modulated proton therapy reduces the dose to normal tissue compared with intensity-modulated radiation therapy or passive scattering proton therapy and enables individualized radical radiotherapy for extensive stage IIIB non-small-cell lung cancer: a virtual clinical study. Int. J. Radiat. Oncol. Biol. Phys.77(2), 357–366 (2010).
  • Alektiar KM. When and how should adjuvant radiation be used in early endometrial cancer? Semin. Radiat. Oncol.16(3), 158–163 (2006).
  • Barbera L, Thomas G. Management of early and locally advanced cervical cancer. Semin. Oncol.36(2), 155–169 (2009).
  • Chen MF, Tseng CJ, Tseng CC, Kuo YC, Yu CY, Chen WC. Clinical outcome in posthysterectomy cervical cancer patients treated with concurrent cisplatin and intensity-modulated pelvic radiotherapy: comparison with conventional radiotherapy. Int. J. Radiat. Oncol. Biol. Phys.67(5), 1438–1444 (2007).
  • Ng AK, Li S, Neuberg D, Silver B, Weeks J, Mauch P. Factors influencing treatment recommendations in early-stage Hodgkin’s disease: a survey of physicians. Ann. Oncol.15(2), 261–269 (2004).
  • Ng AK, Mauch PM. Role of radiation therapy in localized aggressive lymphoma. J. Clin. Oncol.25(7), 757–759 (2007).
  • Norum J, Angelsen V, Wist E, Olsen JA. Treatment costs in Hodgkin’s disease: a cost–utility analysis. Eur. J. Cancer32A(9), 1510–1517 (1996).
  • Ng AK, Kuntz KM, Mauch PM, Weeks JC. Costs and effectiveness of staging and treatment options in early-stage Hodgkin’s disease. Int. J. Radiat. Oncol. Biol. Phys.50(4), 979–989 (2001).
  • Hutchings M, Barrington SF. PET/CT for therapy response assessment in lymphoma. J. Nucl. Med.50(Suppl. 1), 21S–30S (2009).
  • Gil Z, Fliss DM. Contemporary management of head and neck cancers. Isr. Med. Assoc. J.11(5), 296–300 (2009).
  • Tao Y, Daly-Schveitzer N, Lusinchi A, Bourhis J. Advances in radiotherapy of head and neck cancers. Curr. Opin. Oncol.22(3), 194–199 (2010).
  • Corvo R. Evidence-based radiation oncology in head and neck squamous cell carcinoma. Radiother. Oncol.85(1), 156–170 (2007).
  • Kam MK, Leung SF, Zee B et al. Prospective randomized study of intensity-modulated radiotherapy on salivary gland function in early-stage nasopharyngeal carcinoma patients. J. Clin. Oncol.25(31), 4873–4879 (2007).
  • Widesott L, Pierelli A, Fiorino C et al. Intensity-modulated proton therapy versus helical tomotherapy in nasopharynx cancer: planning comparison and NTCP evaluation. Int. J. Radiat. Oncol. Biol. Phys.72(2), 589–596 (2008).
  • Hoffman KE, Yock TI. Radiation therapy for pediatric central nervous system tumors. J. Child. Neurol.24(11), 1387–1396 (2009).
  • Pollack IF. Brain tumors in children. N. Engl. J. Med.331(22), 1500–1507 (1994).
  • Geyer JR, Sposto R, Jennings M et al. Multiagent chemotherapy and deferred radiotherapy in infants with malignant brain tumors: a report from the Children’s Cancer Group. J. Clin. Oncol.23(30), 7621–7631 (2005).
  • Rutkowski S, Bode U, Deinlein F et al. Treatment of early childhood medulloblastoma by postoperative chemotherapy alone. N. Engl. J. Med.352(10), 978–986 (2005).
  • Lundkvist J, Ekman M, Ericsson SR, Jonsson B, Glimelius B. Cost–effectiveness of proton radiation in the treatment of childhood medulloblastoma. Cancer103(4), 793–801 (2005).
  • Gaspar LE, Mehta MP, Patchell RA et al. The role of whole brain radiation therapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline. J. Neurooncol.96(1), 17–32 (2010).
  • Mehta M, Noyes W, Craig B et al. A cost–effectiveness and cost–utility analysis of radiosurgery vs. resection for single-brain metastases. Int. J. Radiat. Oncol. Biol. Phys.39(2), 445–454 (1997).
  • Hartsell WF, Scott CB, Bruner DW et al. Randomized trial of short- versus long-course radiotherapy for palliation of painful bone metastases. J. Natl Cancer Inst.97(11), 798–804 (2005).
  • Bone Pain Trial Working Party. 8 Gy single fraction radiotherapy for the treatment of metastatic skeletal pain: randomised comparison with a multifraction schedule over 12 months of patient follow-up. Radiother. Oncol.52(2), 111–121 (1999).
  • Ryu S, Jin R, Jin JY et al. Pain control by image-guided radiosurgery for solitary spinal metastasis. J. Pain Symptom Manage.35(3), 292–298 (2008).
  • van den Hout WB, van der Linden YM, Steenland E et al. Single- versus multiple-fraction radiotherapy in patients with painful bone metastases: cost–utility analysis based on a randomized trial. J. Natl Cancer Inst.95(3), 222–229 (2003).
  • Konski A, James J, Hartsell W et al. Economic analysis of radiation therapy oncology group 97–14: multiple versus single fraction radiation treatment of patients with bone metastases. Am. J. Clin. Oncol.32(4), 423–428 (2009).
  • Konski A. Radiotherapy is a cost-effective palliative treatment for patients with bone metastasis from prostate cancer. Int. J. Radiat. Oncol. Biol. Phys.60(5), 1373–1378 (2004).
  • Grutters JP, Kessels AG, Pijls-Johannesma M, De Ruysscher D, Joore MA, Lambin P. Comparison of the effectiveness of radiotherapy with photons, protons and carbon-ions for non-small cell lung cancer: a meta-analysis. Radiother. Oncol.95(1), 32–40 (2010).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.