The physical basis of ventilator-induced lung injury

References

• Bernard GR, Artigas A, Brigham KL et al. The American–European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am. J. Respir. Crit. Care Med.149(3 Pt 1), 818–824 (1994).
   PubMed Web of Science ®Google Scholar
• Ashbaugh DG, Bigelow DB, Petty TL, Levine BE. Acute respiratory distress in adults. Lancet2(7511), 319–323 (1967).
   PubMed Web of Science ®Google Scholar
• Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N. Engl. J. Med.342(18), 1301–1308 (2000).
   PubMed Web of Science ®Google Scholar
• Brower RG, Lanken PN, MacIntyre N et al. Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. N. Engl. J. Med.351(4), 327–336 (2004).
   PubMed Web of Science ®Google Scholar
• Steinberg KP, Hudson LD, Goodman RB et al. Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome. N. Engl. J. Med.354(16), 1671–1684 (2006).
   PubMed Web of Science ®Google Scholar
• Phua J, Badia JR, Adhikari NK et al. Has mortality from acute respiratory distress syndrome decreased over time? A systematic review. Am. J. Respir. Crit. Care Med.179(3), 220–227 (2009).
   PubMed Web of Science ®Google Scholar
• Zambon M, Vincent JL. Mortality rates for patients with acute lung injury/ARDS have decreased over time. Chest133(5), 1120–1127 (2008).
   PubMed Web of Science ®Google Scholar
• Greenfield LJ, Ebert PA, Benson DW. Effect of positive pressure ventilation on surface tension properties of lung extracts. Anesthesiology25, 312–316 (1964).
   Google Scholar
• Dreyfuss D, Saumon G. Ventilator-induced lung injury: lessons from experimental studies. Am. J. Respir. Crit. Care Med.157(1), 294–323 (1998).
   PubMed Web of Science ®Google Scholar
• Vlahakis NE, Hubmayr RD. Response of alveolar cells to mechanical stress. Curr. Opin. Crit. Care9(1), 2–8 (2003).
   PubMedGoogle Scholar
• Vlahakis NE, Hubmayr RD. Cellular stress failure in ventilator-injured lungs. Am. J. Respir. Crit. Care Med.171(12), 1328–1342 (2005).
   PubMed Web of Science ®Google Scholar
• Gattinoni L, Pesenti A, Torresin A et al. Adult respiratory distress syndrome profiles by computed tomography. J. Thorac. Imag.3, 25–30 (1986).
   Google Scholar
• Maunder RJ, Shuman WP, McHugh JW, Marglin SI, Butler J. Preservation of normal lung regions in the adult respiratory distress syndrome. Analysis by computed tomography. JAMA255(18), 2463–2465 (1986).
   PubMed Web of Science ®Google Scholar
• Gattinoni L, Pesenti A. ARDS: the non-homogeneous lung; facts and hypothesis. Intensive Crit. Care Dig.6, 1–4 (1987).
   Google Scholar
• Gattinoni L, Pesenti A. The concept of ‘baby lung’. Intensive Care Med.31(6), 776–784 (2005).
   PubMed Web of Science ®Google Scholar
• Gattinoni L, Pesenti A, Avalli L, Rossi F, Bombino M. Pressure–volume curve of total respiratory system in acute respiratory failure. Computed tomographic scan study. Am. Rev. Resp. Dis.136(3), 730–736 (1987).
   PubMed Web of Science ®Google Scholar
• Dreyfuss D, Soler P, Basset G, Saumon G. High inflation pressure pulmonary edema. Respective effects of high airway pressure, high tidal volume, and positive end-expiratory pressure. Am. Rev. Resp. Dis.137(5), 1159–1164 (1988).
   PubMed Web of Science ®Google Scholar
• Gattinoni L, Caironi P, Pelosi P, Goodman LR. What has computed tomography taught us about the acute respiratory distress syndrome? Am. J. Respir. Crit. Care Med.164(9), 1701–1711 (2001).
   PubMed Web of Science ®Google Scholar
• Bone RC. The ARDS lung. New insights from computed tomography. JAMA269(16), 2134–2135 (1993).
   PubMed Web of Science ®Google Scholar
• Hubmayr RD. Perspective on lung injury and recruitment: a skeptical look at the opening and collapse story. Am. J. Respir. Crit. Care Med.165(12), 1647–1653 (2002).
   PubMed Web of Science ®Google Scholar
• Martynowicz MA, Minor TA, Walters BJ, Hubmayr RD. Regional expansion of oleic acid-injured lungs. Am. J. Respir. Crit. Care Med.160(1), 250–258 (1999).
   Google Scholar
• Smith JC, Stamenovic D. Surface forces in lungs. I. Alveolar surface tension-lung volume relationships. J. Appl. Physiol.60(4), 1341–1350 (1986).
   PubMed Web of Science ®Google Scholar
• Stamenovic D, Smith JC. Surface forces in lungs. III. Alveolar surface tension and elastic properties of lung parenchyma. J. Appl. Physiol.60(4), 1358–1362 (1986).
   Google Scholar
• Stamenovic D, Smith JC. Surface forces in lungs. II. Microstructural mechanics and lung stability. J. Appl. Physiol.60(4), 1351–1357 (1986).
   Google Scholar
• Wilson TA, Anafi RC, Hubmayr RD. Mechanics of edematous lungs. J. Appl. Physiol.90(6), 2088–2093 (2001).
   Google Scholar
• Hubmayr RD. Another look at the opening and collapse story. Crit. Care Med.37(9), 2667–2668 (2009).
   PubMed Web of Science ®Google Scholar
• Mertens M, Tabuchi A, Meissner S et al. Alveolar dynamics in acute lung injury: heterogeneous distension rather than cyclic opening and collapse. Crit. Care Med.37(9), 2604–2611 (2009).
   PubMed Web of Science ®Google Scholar
• Artigas A, Bernard GR, Carlet J et al. The American–European Consensus Conference on ARDS, part 2: Ventilatory, pharmacologic, supportive therapy, study design strategies, and issues related to recovery and remodeling. Acute respiratory distress syndrome. Am. J. Respir. Crit. Care Med.157(4 Pt 1), 1332–1347 (1998).
   PubMed Web of Science ®Google Scholar
• Spragg RG, Lewis JF. Pathology of the surfactant system of the mature lung: second San Diego conference. Am. J. Respir. Crit. Care Med.163(1), 280–282 (2001).
   Google Scholar
• Cook CD, Mead J, Schreiner GL, Frank NR, Craig JM. Pulmonary mechanics during induced pulmonary edema in anesthetized dogs. J. Appl. Physiol.14(2), 177–186 (1959).
   PubMed Web of Science ®Google Scholar
• Delaunois L, Sergysels R, Martin RR. Acute effects on airways mechanics of pulmonary edema induced by intravenous oleic acid in dogs. Bull. Eur. Physiopathol. Respir.16(1), 47–55 (1980).
   Google Scholar
• Frazer DG, Stengel PW, Weber KC. The effect of pulmonary edema on gas trapping in excised rat lungs. Resp. Physiol.38(3), 325–333 (1979).
   PubMedGoogle Scholar
• Chung KF, Keyes SJ, Morgan BM, Jones PW, Snashall PD. Mechanisms of airway narrowing in acute pulmonary oedema in dogs: influence of the vagus and lung volume. Clin. Sci. (Lond.)65(3), 289–296 (1983).
   Google Scholar
• Derks CM, D’Hollander AA, Jacobovitz-Derks D. Gas exchange and respiratory mechanics in moderate and severe pulmonary oedema in dogs. Bull. Eur. Physiopathol. Respir.17(2), 163–177 (1981).
   Google Scholar
• Esbenshade AM, Newman JH, Lams PM, Jolles H, Brigham KL. Respiratory failure after endotoxin infusion in sheep: lung mechanics and lung fluid balance. J. Appl. Physiol.53(4), 967–976 (1982).
   PubMed Web of Science ®Google Scholar
• Mead J, Takishima T, Leith D. Stress distribution in lungs: a model of pulmonary elasticity. J. Appl. Physiol.28(5), 596–608 (1970).
   PubMed Web of Science ®Google Scholar
• Bachofen H, Schurch S, Michel RP, Weibel ER. Experimental hydrostatic pulmonary edema in rabbit lungs. Morphology. Am. Rev. Resp. Dis.147(4), 989–996 (1993).
   PubMed Web of Science ®Google Scholar
• Bilek AM, Dee KC, Gaver DP 3rd. Mechanisms of surface-tension-induced epithelial cell damage in a model of pulmonary airway reopening. J. Appl. Physiol.94(2), 770–783 (2003).
   Google Scholar
• Gaver DP 3rd, Kute SM. A theoretical model study of the influence of fluid stresses on a cell adhering to a microchannel wall. Biophys. J.75(2), 721–733 (1998).
   PubMed Web of Science ®Google Scholar
• Huh D, Fujioka H, Tung YC et al. Acoustically detectable cellular-level lung injury induced by fluid mechanical stresses in microfluidic airway systems. Proc. Natl Acad. Sci. USA104(48), 18886–18891 (2007).
   PubMed Web of Science ®Google Scholar
• Fung Y. Biomechanics: Mechanical Properties of Living Tissues. Springer-Verlag, New York, USA (1981).
   Google Scholar
• Rodarte JR, Hubmayr RD, Stamenovic D, Walters BJ. Regional lung strain in dogs during deflation from total lung capacity. J. Appl. Physiol.58(1), 164–172 (1985).
   Google Scholar
• Chiumello D, Carlesso E, Cadringher P et al. Lung stress and strain during mechanical ventilation for acute respiratory distress syndrome. Am. J. Respir. Crit. Care Med.178(4), 346–355 (2008).
   PubMed Web of Science ®Google Scholar
• Waters CM, Sporn PH, Liu M, Fredberg JJ. Cellular biomechanics in the lung. Am. J. Physiol.283(3), L503–L509 (2002).
   PubMed Web of Science ®Google Scholar
• Agostoni E. Mechanics of the pleural space. In: Handbook of Physiology. Geiger S (Ed.). American Physiological Society, MD, USA, 531–559 (1986).
   Google Scholar
• D’Angelo E, Michelini S, Agostoni E. Partition of factors contributing to the vertical gradient of transpulmonary pressure. Respir. Physiol.12(1), 90–101 (1971).
   Google Scholar
• Rodarte J, Fung Y. Distribution of stresses within the lung. In: Handbook of Physiology. Section 3: Respiratory System. Fishman A (Ed.). Williams and Wilkins Co., MD, USA, 233–246 (1986).
   Google Scholar
• Wilson TA. Solid mechanics. In: Handbook of Physiology. Section 3: Respiratory System. Fishman A (Ed.). Williams and Wilkins Co., MD, USA, 35–40 (1986).
   Google Scholar
• Albert RK, Hubmayr RD. The prone position eliminates compression of the lungs by the heart. Am. J. Respir. Crit. Care Med.161(5), 1660–1665 (2000).
   PubMed Web of Science ®Google Scholar
• Bar-Yishay E, Hyatt RE, Rodarte JR. Effect of heart weight on distribution of lung surface pressures in vertical dogs. J. Appl. Physiol.61(2), 712–718 (1986).
   PubMed Web of Science ®Google Scholar
• Agostoni E, D’Angelo E, Bonanni MV. The effect of the abdomen on the vertical gradient of pleural surface pressure. Respir. Physiol.8(3), 332–346 (1970).
   PubMedGoogle Scholar
• Chang H, Lai-Fook SJ, Domino KB et al. Spatial distribution of ventilation and perfusion in anesthetized dogs in lateral postures. J. Appl. Physiol.92(2), 745–762 (2002).
   PubMed Web of Science ®Google Scholar
• Hubmayr RD, Rodarte JR, Walters BJ, Tonelli FM. Regional ventilation during spontaneous breathing and mechanical ventilation in dogs. J. Appl. Physiol.63(6), 2467–2475 (1987).
   Google Scholar
• Weibel ER, Gil J. Structure–function relationships at the alveolar level. In: Bioengineering Aspects of the Lung. West JB (Ed.). Dekker, NY, USA, 1–81 (1977).
   Google Scholar
• Wilson TA, Bachofen H. A model for mechanical structure of the alveolar duct. J. Appl. Physiol.52(4), 1064–1070 (1982).
   PubMed Web of Science ®Google Scholar
• Suki B, Ito S, Stamenovic D, Lutchen KR, Ingenito EP. Biomechanics of the lung parenchyma: critical roles of collagen and mechanical forces. J. Appl. Physiol.98(5), 1892–1899 (2005).
   PubMed Web of Science ®Google Scholar
• Ingber D. Integrins as mechanochemical transducers. Curr. Opin. Cell Biol.3(5), 841–848 (1991).
   PubMed Web of Science ®Google Scholar
• Misof K, Rapp G, Fratzl P. A new molecular model for collagen elasticity based on synchrotron X-ray scattering evidence. Biophys. J.72(3), 1376–1381 (1997).
   PubMed Web of Science ®Google Scholar
• Bachofen H, Schurch S. Alveolar surface forces and lung architecture. Comp. Biochem. Physiol.129(1), 183–193 (2001).
   Google Scholar
• Tschumperlin DJ, Margulies SS. Alveolar epithelial surface area–volume relationship in isolated rat lungs. J. Appl. Physiol.86(6), 2026–2033 (1999).
   PubMedGoogle Scholar
• Puybasset L, Cluzel P, Gusman P et al. Regional distribution of gas and tissue in acute respiratory distress syndrome. I. Consequences for lung morphology. CT Scan ARDS Study Group. Intensive Care Med.26(7), 857–869 (2000).
   PubMed Web of Science ®Google Scholar
• Puybasset L, Gusman P, Muller JC et al. Regional distribution of gas and tissue in acute respiratory distress syndrome. III. Consequences for the effects of positive end-expiratory pressure. CT Scan ARDS Study Group. Adult Respiratory Distress Syndrome. Intensive Care Med.26(9), 1215–1227 (2000).
   PubMed Web of Science ®Google Scholar
• Caironi P, Cressoni M, Chiumello D et al. Lung opening and closing during ventilation of acute respiratory distress syndrome. Am. J. Respir. Crit. Care Med.181, 578–586, (2010).
   PubMed Web of Science ®Google Scholar
• Gattinoni L, Caironi P, Cressoni M et al. Lung recruitment in patients with the acute respiratory distress syndrome. N. Engl. J. Med.354(17), 1775–1786 (2006).
   PubMed Web of Science ®Google Scholar
• Nieszkowska A, Lu Q, Vieira S et al. Incidence and regional distribution of lung overinflation during mechanical ventilation with positive end-expiratory pressure. Crit. Care Med.32(7), 1496–1503 (2004).
   PubMed Web of Science ®Google Scholar
• Lichtenstein D, Meziere G, Biderman P, Gepner A, Barre O. The comet-tail artifact. An ultrasound sign of alveolar-interstitial syndrome. Am. J. Respir. Crit. Care Med.156(5), 1640–1646 (1997).
   PubMed Web of Science ®Google Scholar
• Bouhemad B, Liu ZH, Arbelot C et al. Ultrasound assessment of antibiotic-induced pulmonary reaeration in ventilator-associated pneumonia. Crit. Care Med.38(1), 84–92 (2010).
   PubMed Web of Science ®Google Scholar
• Deans KJ, Minneci PC, Cui X et al. Mechanical ventilation in ARDS: one size does not fit all. Crit. Care Med.33(5), 1141–1143 (2005).
   PubMed Web of Science ®Google Scholar
• Brochard L. Respiratory pressure–volume curves. In: Principles and Practice of Intensive Care Monitoring. Tobin M (Ed.). McGraw-Hill, NY, USA, 597–616 (1997).
   Google Scholar
• Crotti S, Mascheroni D, Caironi P et al. Recruitment and derecruitment during acute respiratory failure: a clinical study. Am. J. Respir. Crit. Care Med.164(1), 131–140 (2001).
   PubMed Web of Science ®Google Scholar
• Pelosi P, Goldner M, McKibben A et al. Recruitment and derecruitment during acute respiratory failure: an experimental study. Am. J. Respir. Crit. Care Med.164(1), 122–130 (2001).
   PubMed Web of Science ®Google Scholar
• Slutsky AS. Mechanical ventilation. American College of Chest Physicians’ Consensus Conference. Chest104(6), 1833–1859 (1993).
   PubMed Web of Science ®Google Scholar
• Gattinoni L, Chiumello D, Carlesso E, Valenza F. Bench-to-bedside review: chest wall elastance in acute lung injury/acute respiratory distress syndrome patients. Crit. Care8(5), 350–355 (2004).
   PubMed Web of Science ®Google Scholar
• Hess DR, Bigatello LM. The chest wall in acute lung injury/acute respiratory distress syndrome. Curr. Opin. Crit. Care14(1), 94–102 (2008).
   Google Scholar
• Talmor D, Sarge T, O’Donnell CR et al. Esophageal and transpulmonary pressures in acute respiratory failure. Crit. Care Med.34(5), 1389–1394 (2006).
   PubMed Web of Science ®Google Scholar
• Loring SH, O’Donnell CR, Behazin N et al. Esophageal pressures in acute lung injury-do they represent artifact or useful information about transpulmonary pressure, chest wall mechanics, and lung stress? J. Appl. Physiol.108(3), 515–522 (2010).
   PubMed Web of Science ®Google Scholar
• Talmor D, Sarge T, Malhotra A et al. Mechanical ventilation guided by esophageal pressure in acute lung injury. N. Engl. J. Med.359(20), 2095–2104 (2008).
   PubMed Web of Science ®Google Scholar
• Hager DN, Krishnan JA, Hayden DL, Brower RG. Tidal volume reduction in patients with acute lung injury when plateau pressures are not high. Am. J. Respir. Crit. Care Med.172(10), 1241–1245 (2005).
   PubMed Web of Science ®Google Scholar
• Brower RG, Hubmayr RD, Slutsky AS. Lung stress and strain in acute respiratory distress syndrome: good ideas for clinical management? Am. J. Respir. Crit. Care Med.178(4), 323–324 (2008).
   Google Scholar
• Maisch S, Boehm SH, Weismann D et al. Determination of functional residual capacity by oxygen washin-washout: a validation study. Intensive Care Med.33(5), 912–916 (2007).
   PubMed Web of Science ®Google Scholar
• Olegard C, Sondergaard S, Palsson J, Lundin S, Stenqvist O. Validation and clinical feasibility of nitrogen washin/washout functional residual capacity measurements in children. Acta Anaesthesiol. Scand.54(3), 370–376 (2010).
   Google Scholar
• Webb HH, Tierney DF. Experimental pulmonary edema due to intermittent positive pressure ventilation with high inflation pressures. Protection by positive end-expiratory pressure. Am. Rev. Resp. Dis.110(5), 556–565 (1974).
   PubMed Web of Science ®Google Scholar
• Gibson GJ, Pride NB. Lung distensibility. The static pressure–volume curve of the lungs and its use in clinical assessment. Br. J. Dis. Chest70(3), 143–184 (1976).
   PubMedGoogle Scholar
• Hager DN, Brower RG. Customizing lung-protective mechanical ventilation strategies. Crit. Care Med.34(5), 1554–1555 (2006).
   Google Scholar
• Milic-Emili J, Mead J, Turner JM. Topography of esophageal pressure as a function of posture in man. J. Appl. Physiol.19, 212–216 (1964).
   PubMed Web of Science ®Google Scholar
• Milic-Emili J, Mead J, Turner JM, Glauser EM. Improved technique for estimating pleural pressure from esophageal balloons. J. Appl. Physiol.19, 207–211 (1964).
   PubMed Web of Science ®Google Scholar
• Washko GR, O’Donnell CR, Loring SH. Volume-related and volume-independent effects of posture on esophageal and transpulmonary pressures in healthy subjects. J. Appl. Physiol.100(3), 753–758 (2006).
   Google Scholar
• Hubmayr RD. Is there a place for esophageal manometry in the care of patients with injured lungs? J. Appl. Physiol.108, 481–482 (2010).
   Google Scholar
• Sarge T, Talmor D. Targeting transpulmonary pressure to prevent ventilator induced lung injury. Minerva Anestesiol.75(5), 293–299 (2009).
   Google Scholar
• McGee KP, Hubmayr RD, Levin D, Ehman RL. Feasibility of quantifying the mechanical properties of lung parenchyma in a small-animal model using 1H magnetic resonance elastography (MRE). J. Magn. Reson. Imaging29(4), 838–845 (2009).
   Google Scholar
• McGee KP, Hubmayr RD, Ehman RL. MR elastography of the lung with hyperpolarized 3He. Magn. Reson. Med.59(1), 14–18 (2008).
   Google Scholar
• Goss BC, McGee KP, Ehman EC, Manduca A, Ehman RL. Magnetic resonance elastography of the lung: technical feasibility. Magn. Reson. Med.56(5), 1060–1066 (2006).
   Google Scholar
• Zhang X, Qiang B, Hubmayr R et al. Preliminary study of human lung elasticity with the noninvasive surface wave technique. Presented at: UFFC Meeting 2010. CA, USA, 2–4 June 2010.
   Google Scholar
• Bachofen H, Gerber U, Schurch S. Effects of fixatives on function of pulmonary surfactant. J. Appl. Physiol.93(3), 911–916 (2002).
   Google Scholar
• Oldmixon EH, Hoppin FG Jr. Alveolar septal folding and lung inflation history. J. Appl. Physiol.71(6), 2369–2379 (1991).
   Google Scholar
• Wirtz HR, Dobbs LG. The effects of mechanical forces on lung functions. Respir. Physiol.119(1), 1–17 (2000).
   PubMedGoogle Scholar
• Perlman CE, Bhattacharya J. Alveolar expansion imaged by optical sectioning microscopy. J. Appl. Physiol.103(3), 1037–1044 (2007).
   PubMedGoogle Scholar
• Carney DE, Bredenberg CE, Schiller HJ et al. The mechanism of lung volume change during mechanical ventilation. Am. J. Respir. Crit. Care Med.160(5 Pt 1), 1697–1702 (1999).
   Web of Science ®Google Scholar
• Schiller HJ, Steinberg J, Halter J et al. Alveolar inflation during generation of a quasi-static pressure/volume curve in the acutely injured lung. Crit. Care Med.31(4), 1126–1133 (2003).
   Google Scholar
• Halter JM, Steinberg JM, Schiller HJ et al. Positive end-expiratory pressure after a recruitment maneuver prevents both alveolar collapse and recruitment/derecruitment. Am. J. Respir. Crit. Care Med.167(12), 1620–1626 (2003).
   PubMed Web of Science ®Google Scholar
• Steinberg J, Schiller HJ, Halter JM et al. Tidal volume increases do not affect alveolar mechanics in normal lung but cause alveolar overdistension and exacerbate alveolar instability after surfactant deactivation. Crit. Care Med.30(12), 2675–2683 (2002).
   Google Scholar
• Schiller HJ, McCann UG 2nd, Carney DE et al. Altered alveolar mechanics in the acutely injured lung. Crit. Care Med.29(5), 1049–1055 (2001).
   Google Scholar
• Pavone LA, Albert S, Carney D et al. Injurious mechanical ventilation in the normal lung causes a progressive pathologic change in dynamic alveolar mechanics. Crit. Care11(3), R64 (2007).
   PubMed Web of Science ®Google Scholar
• Azeloglu EU, Bhattacharya J, Costa KD. Atomic force microscope elastography reveals phenotypic differences in alveolar cell stiffness. J. Appl. Physiol.105(2), 652–661 (2008).
   PubMed Web of Science ®Google Scholar
• Berrios JC, Schroeder MA, Hubmayr RD. Mechanical properties of alveolar epithelial cells in culture. J. Appl. Physiol.91(1), 65–73 (2001).
   Google Scholar
• Banes AJ, Tsuzaki M, Yamamoto J et al. Mechanoreception at the cellular level: the detection, interpretation, and diversity of responses to mechanical signals. Biochem. Cell. Biol.73(7–8), 349–365 (1995).
   PubMed Web of Science ®Google Scholar
• Dreyfuss D, Saumon G. Role of tidal volume, FRC, and end-inspiratory volume in the development of pulmonary edema following mechanical ventilation. Am. Rev. Resp. Dis.148(5), 1194–1203 (1993).
   PubMed Web of Science ®Google Scholar
• Egan EA. Lung inflation, lung solute permeability, and alveolar edema. J. Appl. Physiol.53(1), 121–125 (1982).
   Google Scholar
• Gajic O, Lee J, Doerr CH et al. Ventilator-induced cell wounding and repair in the intact lung. Am. J. Respir. Crit. Care Med.167(8), 1057–1063 (2003).
   Google Scholar
• Yoshigi M, Clark EB, Yost HJ. Quantification of stretch-induced cytoskeletal remodeling in vascular endothelial cells by image processing. Cytometry A55(2), 109–118 (2003).
   Google Scholar
• Wang N, Ingber DE. Control of cytoskeletal mechanics by extracellular matrix, cell shape, and mechanical tension. Biophys. J.66(6), 2181–2189 (1994).
   PubMedGoogle Scholar
• Heidemann SR, Wirtz D. Towards a regional approach to cell mechanics. Trends Cell Biol.14(4), 160–166 (2004).
   Google Scholar
• Ko KS, McCulloch CA. Partners in protection: interdependence of cytoskeleton and plasma membrane in adaptations to applied forces. J. Membr. Biol.174(2), 85–95 (2000).
   PubMed Web of Science ®Google Scholar
• Vlahakis NE, Schroeder MA, Pagano RE, Hubmayr RD. Role of deformation-induced lipid trafficking in the prevention of plasma membrane stress failure. Am. J. Respir. Crit. Care Med.166(9), 1282–1289 (2002).
   Google Scholar
• Vlahakis NE, Schroeder MA, Pagano RE, Hubmayr RD. Deformation-induced lipid trafficking in alveolar epithelial cells. Am. J. Physiol.280(5), L938–L946 (2001).
   Google Scholar
• Oeckler RA, Hubmayr RD. Cell wounding and repair in ventilator injured lungs. Respir. Physiol. Neurobiol.163(1–3), 44–53 (2008).
   Google Scholar
• Chakrabarti S, Kobayashi KS, Flavell RA et al. Impaired membrane resealing and autoimmune myositis in synaptotagmin VII-deficient mice. J. Cell Biol.162(4), 543–549 (2003).
   PubMedGoogle Scholar
• Tremblay L, Valenza F, Ribeiro SP, Li J, Slutsky AS. Injurious ventilatory strategies increase cytokines and c-fos m-RNA expression in an isolated rat lung model. J. Clin. Invest.99(5), 944–952 (1997).
   PubMed Web of Science ®Google Scholar
• Pugin J. Molecular mechanisms of lung cell activation induced by cyclic stretch. Crit. Care Med.31(4 Suppl.), S200–S206 (2003).
   PubMed Web of Science ®Google Scholar
• Dos Santos CC, Slutsky AS. Invited review: mechanisms of ventilator-induced lung injury: a perspective. J. Appl. Physiol.89(4), 1645–1655 (2000).
   PubMed Web of Science ®Google Scholar
• West JB, Tsukimoto K, Mathieu-Costello O, Prediletto R. Stress failure in pulmonary capillaries. J. Appl. Physiol.70(4), 1731–1742 (1991).
   PubMed Web of Science ®Google Scholar
• Tsukimoto K, Mathieu-Costello O, Prediletto R, Elliott AR, West JB. Ultrastructural appearances of pulmonary capillaries at high transmural pressures. J. Appl. Physiol.71(2), 573–582 (1991).
   PubMed Web of Science ®Google Scholar
• Berg JT, Fu Z, Breen EC et al. High lung inflation increases mRNA levels of ECM components and growth factors in lung parenchyma. J. Appl. Physiol.83(1), 120–128 (1997).
   Google Scholar
• Pugin J, Dunn I, Jolliet P et al. Activation of human macrophages by mechanical ventilation in vitro. Am. J. Physiol.275(6 Pt 1), L1040–L1050 (1998).
   PubMed Web of Science ®Google Scholar
• Vlahakis NE, Schroeder MA, Limper AH, Hubmayr RD. Stretch induces cytokine release by alveolar epithelial cells in vitro. Am. J. Physiol.277(1 Pt 1), L167–L173 (1999).
   PubMed Web of Science ®Google Scholar
• Li LF, Ouyang B, Choukroun G et al. Stretch-induced IL-8 depends on c-Jun NH2-terminal and nuclear factor-κB-inducing kinases. Am. J. Physiol.285(2), L464–L475 (2003).
   Web of Science ®Google Scholar
• D’Angelo E, Pecchiari M, Della Valle P, Koutsoukou A, Milic-Emili J. Effects of mechanical ventilation at low lung volume on respiratory mechanics and nitric oxide exhalation in normal rabbits. J. Appl. Physiol.99(2), 433–444 (2005).
   PubMed Web of Science ®Google Scholar
• Matute-Bello G, Frevert CW, Martin TR. Animal models of acute lung injury. Am. J. Physiol.295(3), L379–L399 (2008).
   PubMed Web of Science ®Google Scholar
• Hubmayr RD. Ventilator-induced lung injury without biotrauma? J. Appl. Physiol.99(2), 384–385 (2005).
   Google Scholar
• Brower RG, Shanholtz CB, Fessler HE et al. Prospective, randomized, controlled clinical trial comparing traditional versus reduced tidal volume ventilation in acute respiratory distress syndrome patients. Crit. Care Med.27(8), 1492–1498 (1999).
   PubMed Web of Science ®Google Scholar
• Stewart TE, Meade MO, Cook DJ et al. Evaluation of a ventilation strategy to prevent barotrauma in patients at high risk for acute respiratory distress syndrome. Pressure- and Volume-Limited Ventilation Strategy Group. N. Engl. J. Med.338(6), 355–361 (1998).
   PubMed Web of Science ®Google Scholar
• Amato MB, Barbas CS, Medeiros DM et al. Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome. N. Engl. J. Med.338(6), 347–354 (1998).
   PubMed Web of Science ®Google Scholar
• Gajic O, Dara SI, Mendez JL et al. Ventilator-associated lung injury in patients without acute lung injury at the onset of mechanical ventilation. Crit. Care Med.32(9), 1817–1824 (2004).
   PubMed Web of Science ®Google Scholar
• Wolthuis EK, Choi G, Dessing MC et al. Mechanical ventilation with lower tidal volumes and positive end-expiratory pressure prevents pulmonary inflammation in patients without preexisting lung injury. Anesthesiology108(1), 46–54 (2008).
   PubMed Web of Science ®Google Scholar
• Determann RM, Wolthuis EK, Choi G et al. Lung epithelial injury markers are not influenced by use of lower tidal volumes during elective surgery in patients without preexisting lung injury. Am. J. Physiol.294(2), L344–L350 (2008).
   Google Scholar
• Schultz MJ, Haitsma JJ, Slutsky AS, Gajic O. What tidal volumes should be used in patients without acute lung injury? Anesthesiology106(6), 1226–1231 (2007).
   PubMed Web of Science ®Google Scholar
• Kavanagh BP, Laffey JG. Hypercapnia: permissive and therapeutic. Minerva Anestesiol.72(6), 567–576 (2006).
   PubMed Web of Science ®Google Scholar
• Laffey JG, Engelberts D, Kavanagh BP. Buffering hypercapnic acidosis worsens acute lung injury. Am. J. Respir. Crit. Care Med.161(1), 141–146 (2000).
   PubMed Web of Science ®Google Scholar
• Laffey JG, Kavanagh BP. Carbon dioxide and the critically ill – too little of a good thing? Lancet354(9186), 1283–1286 (1999).
   PubMed Web of Science ®Google Scholar
• Mascheroni D, Kolobow T, Fumagalli R et al. Acute respiratory failure following pharmacologically induced hyperventilation: an experimental animal study. Intensive Care Med.15(1), 8–14 (1988).
   PubMed Web of Science ®Google Scholar
• Meade MO, Cook DJ, Guyatt GH et al. Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. JAMA299(6), 637–645 (2008).
   PubMed Web of Science ®Google Scholar
• Terragni PP, Rosboch G, Tealdi A et al. Tidal hyperinflation during low tidal volume ventilation in acute respiratory distress syndrome. Am. J. Respir. Crit. Care Med.175(2), 160–166 (2007).
   PubMed Web of Science ®Google Scholar
• Grasso S, Fanelli V, Cafarelli A et al. Effects of high versus low positive end-expiratory pressures in acute respiratory distress syndrome. Am. J. Respir. Crit. Care Med.171(9), 1002–1008 (2005).
   PubMed Web of Science ®Google Scholar
• Mercat A, Richard JC, Vielle B et al. Positive end-expiratory pressure setting in adults with acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. JAMA299(6), 646–655 (2008).
   PubMed Web of Science ®Google Scholar
• Grasso S, Stripoli T, De Michele M et al. ARDSnet ventilatory protocol and alveolar hyperinflation: role of positive end-expiratory pressure. Am. J. Respir. Crit. Care Med.176(8), 761–767 (2007).
   PubMed Web of Science ®Google Scholar