Neurotrophins in lung health and disease

References

• Levi-Montalcini R. The saga of the nerve growth factor. Neuroreport9, R71–R83 (1998).
   Google Scholar
• Hennigan A, O’Callaghan RM, Kelly AM. Neurotrophins and their receptors: roles in plasticity, neurodegeneration and neuroprotection. Biochem. Soc. Trans.35(Pt 2), 424–427 (2007).
   PubMed Web of Science ®Google Scholar
• Reichardt LF. Neurotrophin-regulated signalling pathways. Philos. Trans. R. Soc. Lond. B Biol. Sci.361, 1545–1564 (2006).
   PubMed Web of Science ®Google Scholar
• Lu B, Pang PT, Woo NH. The yin and yang of neurotrophin action. Nat. Rev. Neurosci.6, 603–614 (2005).
   PubMed Web of Science ®Google Scholar
• Blum R, Konnerth A. Neurotrophin-mediated rapid signaling in the central nervous system: mechanisms and functions. Physiology20, 70–78 (2005).
   PubMed Web of Science ®Google Scholar
• Teng KK, Hempstead BL. Neurotrophins and their receptors: signaling trios in complex biological systems. Cell. Mol. Life Sci.61, 35–48 (2004).
   PubMed Web of Science ®Google Scholar
• Chao MV, Rajagopal R, Lee FS. Neurotrophin signalling in health and disease. Clin. Sci. (Lond.)110, 167–173 (2006).
   PubMed Web of Science ®Google Scholar
• Lykissas MG, Batistatou AK, Charalabopoulos KA, Beris AE. The role of neurotrophins in axonal growth, guidance, and regeneration. Curr. Neurovasc. Res.4, 143–151 (2007).
   PubMed Web of Science ®Google Scholar
• Kalb R. The protean actions of neurotrophins and their receptors on the life and death of neurons. Trends Neurosci.28, 5–11 (2005).
   PubMed Web of Science ®Google Scholar
• Saragovi HU, Hamel E, Di Polo A. A neurotrophic rationale for the therapy of neurodegenerative disorders. Curr. Alzheimer Res.6, 419–423 (2009).
   Google Scholar
• Schulte-Herbruggen O, Jockers-Scherubl MC, Hellweg R. Neurotrophins: from pathophysiology to treatment in Alzheimer’s disease. Curr. Alzheimer Res.5, 38–44 (2008).
   PubMed Web of Science ®Google Scholar
• Thiele CJ, Li Z, McKee AE. On Trk – the TrkB signal transduction pathway is an increasingly important target in cancer biology. Clin. Cancer Res.15, 5962–5967 (2009).
   PubMed Web of Science ®Google Scholar
• Blesch A, Tuszynski MH. Spontaneous and neurotrophin-induced axonal plasticity after spinal cord injury. Prog. Brain Res.137, 415–423 (2002).
   PubMed Web of Science ®Google Scholar
• Dwivedi Y. Brain-derived neurotrophic factor: role in depression and suicide. Neuropsychiatr. Dis. Treat.5, 433–449 (2009).
   PubMed Web of Science ®Google Scholar
• Skaper SD. The biology of neurotrophins, signalling pathways, and functional peptide mimetics of neurotrophins and their receptors. CNS Neurol. Disord. Drug Targets7, 46–62 (2008).
   PubMed Web of Science ®Google Scholar
• Lessmann V, Brigadski T. Mechanisms, locations, and kinetics of synaptic BDNF secretion: an update. Neurosci. Res.65, 11–22 (2009).
   PubMed Web of Science ®Google Scholar
• Lessmann V, Gottmann K, Malcangio M. Neurotrophin secretion: current facts and future prospects. Prog. Neurobiol.69, 341–374 (2003).
   PubMed Web of Science ®Google Scholar
• McDonald NQ, Chao MV. Structural determinants of neurotrophin action. J. Biol. Chem.270, 19669–19672 (1995).
   PubMed Web of Science ®Google Scholar
• Robinson RC, Radziejewski C, Stuart DI, Jones EY. Structure of the brain-derived neurotrophic factor/neurotrophin 3 heterodimer. Biochemistry34, 4139–4146 (1995).
   PubMed Web of Science ®Google Scholar
• Butte MJ, Hwang PK, Mobley WC, Fletterick RJ. Crystal structure of neurotrophin-3 homodimer shows distinct regions are used to bind its receptors. Biochemistry37, 16846–16852 (1998).
   PubMedGoogle Scholar
• Barker PA. p75NTR is positively promiscuous: novel partners and new insights. Neuron42, 529–533 (2004).
   PubMed Web of Science ®Google Scholar
• Blochl A, Blochl R. A cell-biological model of p75NTR signaling. J. Neurochem.102, 289–305 (2007).
   PubMed Web of Science ®Google Scholar
• Chen Y, Zeng J, Cen L et al. Multiple roles of the p75 neurotrophin receptor in the nervous system. J. Int. Med. Res.37, 281–288 (2009).
   PubMed Web of Science ®Google Scholar
• Conover JC, Yancopoulos GD. Neurotrophin regulation of the developing nervous system: analyses of knockout mice. Rev. Neurosci.8, 13–27 (1997).
   PubMedGoogle Scholar
• Yamashita T, Fujitani M, Hata K, Mimura F, Yamagishi S. Diverse functions of the p75 neurotrophin receptor. Anat. Sci. Int.80, 37–41 (2005).
   Google Scholar
• Underwood CK, Coulson EJ. The p75 neurotrophin receptor. Int. J. Biochem. Cell Biol.40, 1664–1668 (2008).
   PubMedGoogle Scholar
• Kovalchuk Y, Holthoff K, Konnerth A. Neurotrophin action on a rapid timescale. Curr. Opin. Neurobiol.14, 558–563 (2004).
   Google Scholar
• Carvalho AL, Caldeira MV, Santos SD, Duarte CB. Role of the brain-derived neurotrophic factor at glutamatergic synapses. Br. J. Pharmacol.153(Suppl. 1), S310–S324 (2008).
   PubMed Web of Science ®Google Scholar
• Rose CR, Blum R, Kafitz KW, Kovalchuk Y, Konnerth A. From modulator to mediator: rapid effects of BDNF on ion channels. Bioessays26, 1185–1194 (2004).
   Google Scholar
• Nockher WA, Renz H. Neurotrophins in clinical diagnostics: pathophysiology and laboratory investigation. Clin. Chim. Acta352, 49–74 (2005).
   PubMed Web of Science ®Google Scholar
• Sariola H. The neurotrophic factors in non-neuronal tissues. Cell. Mol. Life Sci.58, 1061–1066 (2001).
   Google Scholar
• Luther JA, Birren SJ. Neurotrophins and target interactions in the development and regulation of sympathetic neuron electrical and synaptic properties. Auton. Neurosci.151, 46–60 (2009).
   PubMedGoogle Scholar
• Ernsberger U. Role of neurotrophin signalling in the differentiation of neurons from dorsal root ganglia and sympathetic ganglia. Cell Tissue Res.336, 349–384 (2009).
   PubMed Web of Science ®Google Scholar
• Mantilla CB, Zhan WZ, Sieck GC. Neurotrophins improve neuromuscular transmission in the adult rat diaphragm. Muscle Nerve29, 381–386 (2004).
   Google Scholar
• Raap U, Kapp A. Neuroimmunological findings in allergic skin diseases. Curr. Opin. Allergy Clin. Immunol.5, 419–424 (2005).
   PubMedGoogle Scholar
• Schiller LR. New and emerging treatment options for chronic constipation. Rev. Gastroenterol. Disord.4(Suppl. 2), S43–S51 (2004).
   PubMedGoogle Scholar
• Caporali A, Emanueli C. Cardiovascular actions of neurotrophins. Physiol. Rev.89, 279–308 (2009).
   PubMed Web of Science ®Google Scholar
• Ricci A, Graziano P, Bronzetti E et al. Increased pulmonary neurotrophin protein expression in idiopathic interstitial pneumonias. Sarcoidosis Vasc. Diffuse Lung Dis.24, 13–23 (2007).
   PubMedGoogle Scholar
• Ricci A, Felici L, Mariotta S et al. Neurotrophin and neurotrophin receptor protein expression in the human lung. Am. J. Respir. Cell Mol. Biol.30, 12–19 (2004).
   PubMed Web of Science ®Google Scholar
• Virchow JC, Julius P, Lommatzsch M et al. Neurotrophins are increased in bronchoalveolar lavage fluid after segmental allergen provocation. Am. J. Respir. Crit. Care Med.158, 2002–2005 (1998).
   PubMed Web of Science ®Google Scholar
• Rochlitzer S, Nassenstein C, Braun A. The contribution of neurotrophins to the pathogenesis of allergic asthma. Biochem. Soc. Trans.34(Pt 4), 594–599 (2006).
   Google Scholar
• Raap U, Braunstahl GJ. The role of neurotrophins in the pathophysiology of allergic rhinitis. Curr. Opin. Allergy Clin. Immunol.10, 8–13 (2010).
   PubMed Web of Science ®Google Scholar
• Nockher WA, Renz H. Neurotrophins and asthma: novel insight into neuroimmune interaction. J. Allergy Clin. Immunol.117, 67–71 (2006).
   PubMed Web of Science ®Google Scholar
• Nockher WA, Renz H. Neurotrophins in allergic diseases: from neuronal growth factors to intercellular signaling molecules. J. Allergy Clin. Immunol.117, 583–589 (2006).
   PubMed Web of Science ®Google Scholar
• Kobayashi H, Gleich GJ, Butterfield JH, Kita H. Human eosinophils produce neurotrophins and secrete nerve growth factor on immunologic stimuli. Blood99, 2214–2220 (2002).
   PubMed Web of Science ®Google Scholar
• Noga O, Englmann C, Hanf G et al. The production, storage and release of the neurotrophins nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 by human peripheral eosinophils in allergics and non-allergics. Clin. Exp. Allergy33, 649–654 (2003).
   PubMed Web of Science ®Google Scholar
• Toyoda M, Nakamura M, Makino T, Morohashi M. Localization and content of nerve growth factor in peripheral blood eosinophils of atopic dermatitis patients. Clin. Exp. Allergy33, 950–955 (2003).
   Google Scholar
• Noga O, Englmann C, Hanf G et al. Activation of the specific neurotrophin receptors TrkA, TrkB and TrkC influences the function of eosinophils. Clin. Exp. Allergy32, 1348–1354 (2002).
   PubMed Web of Science ®Google Scholar
• Hamada A, Watanabe N, Ohtomo H, Matsuda H. Nerve growth factor enhances survival and cytotoxic activity of human eosinophils. Br. J. Haematol.93, 299–302 (1996).
   PubMed Web of Science ®Google Scholar
• Raap U, Fokkens W, Bruder M et al. Modulation of neurotrophin and neurotrophin receptor expression in nasal mucosa after nasal allergen provocation in allergic rhinitis. Allergy63, 468–475 (2008).
   PubMedGoogle Scholar
• Piedimonte G. Contribution of neuroimmune mechanisms to airway inflammation and remodeling during and after respiratory syncytial virus infection. Pediatr. Infect. Dis. J.22(2 Suppl.), S66–S74 (2003).
   PubMed Web of Science ®Google Scholar
• Noga O, Peiser M, Altenahr M et al. Differential activation of dendritic cells by nerve growth factor and brain-derived neurotrophic factor. Clin. Exp. Allergy37, 1701–1708 (2007).
   Google Scholar
• Noga O, Peiser M, Altenahr M et al. Selective induction of nerve growth factor and brain-derived neurotrophic factor by LPS and allergen in dendritic cells. Clin. Exp. Allergy38, 473–479 (2008).
   Google Scholar
• Hikawa S, Kobayashi H, Hikawa N et al. Expression of neurotrophins and their receptors in peripheral lung cells of mice. Histochem. Cell Biol.118, 51–58 (2002).
   Google Scholar
• Santambrogio L, Benedetti M, Chao MV et al. Nerve growth factor production by lymphocytes. J. Immunol.153, 4488–4495 (1994).
   PubMedGoogle Scholar
• Lambiase A, Bracci-Laudiero L, Bonini S et al. Human CD4+ T cell clones produce and release nerve growth factor and express high-affinity nerve growth factor receptors. J. Allergy Clin. Immunol.100, 408–414 (1997).
   PubMed Web of Science ®Google Scholar
• Kerschensteiner M, Gallmeier E, Behrens L et al. Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation? J. Exp. Med.189, 865–870 (1999).
   PubMed Web of Science ®Google Scholar
• Crystal RG, Randell SH, Engelhardt JF, Voynow J, Sunday ME. Airway epithelial cells: current concepts and challenges. Proc. Am. Thorac. Soc.5, 772–777 (2008).
   PubMedGoogle Scholar
• Othumpangat S, Gibson LF, Samsell L, Piedimonte G. NGF is an essential survival factor for bronchial epithelial cells during respiratory syncytial virus infection. PLoS One4, e6444 (2009).
   PubMed Web of Science ®Google Scholar
• Hahn C, Islamian AP, Renz H, Nockher WA. Airway epithelial cells produce neurotrophins and promote the survival of eosinophils during allergic airway inflammation. J. Allergy Clin. Immunol.117, 787–794 (2006).
   PubMed Web of Science ®Google Scholar
• Lommatzsch M, Braun A, Renz H. Neurotrophins in allergic airway dysfunction: what the mouse model is teaching us. Ann. NY Acad. Sci.992, 241–249 (2003).
   PubMed Web of Science ®Google Scholar
• Fox AJ, Patel HJ, Barnes PJ, Belvisi MG. Release of nerve growth factor by human pulmonary epithelial cells: role in airway inflammatory diseases. Eur. J. Pharmacol.424, 159–162 (2001).
   PubMed Web of Science ®Google Scholar
• Sonar SS, Schwinge D, Kilic A et al. Nerve growth factor enhances Clara cell proliferation after lung injury. Eur. Respir. J. DOI: 10.1183/09031936.00165508 (2010) (Epub ahead of print).
   Google Scholar
• Meuchel L, Townsend E, Thompson M, Pabelick C, Prakash Y. Effect of neurotrophins on NO generation in airway epithelial cells. Presented at: International Conference of the American Thoracic Society. New Orleans, LA, USA, 14–19 May 2010 (Abstract).
   Google Scholar
• Prakash YS, Iyanoye A, Ay B, Mantilla CB, Pabelick CM. Neurotrophin effects on intracellular Ca2+ and force in airway smooth muscle. Am. J. Physiol. Lung Cell. Mol. Physiol.291, L447–L456 (2006).
   PubMed Web of Science ®Google Scholar
• Prakash YS, Thompson MA, Pabelick CM. Brain-derived neurotrophic factor in TNF-α modulation of Ca2+ in human airway smooth muscle. Am. J. Respir. Cell Mol. Biol.41, 603–611 (2009).
   PubMed Web of Science ®Google Scholar
• Kraemer R, Nguyen H, March KL, Hempstead B. NGF activates similar intracellular signaling pathways in vascular smooth muscle cells as PDGF-BB but elicits different biological responses. Arterioscler. Thromb. Vasc. Biol.19, 1041–1050 (1999).
   Google Scholar
• Wang S, Bray P, McCaffrey T et al. p75(NTR) mediates neurotrophin-induced apoptosis of vascular smooth muscle cells. Am. J. Pathol.157, 1247–1258 (2000).
   PubMed Web of Science ®Google Scholar
• Kemi C, Grunewald J, Eklund A, Hoglund CO. Differential regulation of neurotrophin expression in human bronchial smooth muscle cells. Respir. Res.7, 18 (2006).
   Google Scholar
• Hamid Q, Tulic M. Immunobiology of asthma. Annu. Rev. Physiol.71, 489–507 (2009).
   PubMed Web of Science ®Google Scholar
• Brightling C, Berry M, Amrani Y. Targeting TNF-α: a novel therapeutic approach for asthma. J. Allergy Clin. Immunol.121, 5–10; quiz 11–12 (2008).
   PubMed Web of Science ®Google Scholar
• Racke K, Matthiesen S. The airway cholinergic system: physiology and pharmacology. Pulm. Pharmacol. Ther.17, 181–198 (2004).
   PubMed Web of Science ®Google Scholar
• Canning BJ. Reflex regulation of airway smooth muscle tone. J. Appl. Physiol.101, 971–985 (2006).
   PubMed Web of Science ®Google Scholar
• Verhein KC, Fryer AD, Jacoby DB. Neural control of airway inflammation. Curr. Allergy Asthma Rep.9, 484–490 (2009).
   PubMed Web of Science ®Google Scholar
• Groneberg DA, Harrison S, Dinh QT, Geppetti P, Fischer A. Tachykinins in the respiratory tract. Curr. Drug Targets7, 1005–1010 (2006).
   Google Scholar
• Frossard N, Freund V, Advenier C. Nerve growth factor and its receptors in asthma and inflammation. Eur. J. Pharmacol.500, 453–465 (2004).
   PubMed Web of Science ®Google Scholar
• Freund-Michel V, Frossard N. The nerve growth factor and its receptors in airway inflammatory diseases. Pharmacol. Ther.117, 52–76 (2008).
   PubMed Web of Science ®Google Scholar
• Hoyle GW, Graham RM, Finkelstein JB et al. Hyperinnervation of the airways in transgenic mice overexpressing nerve growth factor. Am. J. Respir. Cell Mol. Biol.18, 149–157 (1998).
   PubMed Web of Science ®Google Scholar
• Braun A, Lommatzsch M, Neuhaus-Steinmetz U et al. Brain-derived neurotrophic factor (BDNF) contributes to neuronal dysfunction in a model of allergic airway inflammation. Br. J. Pharmacol.141, 431–440 (2004).
   PubMedGoogle Scholar
• Xu M, Remillard CV, Sachs BD et al. p75 neurotrophin receptor regulates agonist-induced pulmonary vasoconstriction. Am. J. Physiol. Heart Circ. Physiol.295, H1529–H1538 (2008).
   Google Scholar
• Nico B, Mangieri D, Benagiano V, Crivellato E, Ribatti D. Nerve growth factor as an angiogenic factor. Microvasc. Res.75, 135–141 (2008).
   PubMed Web of Science ®Google Scholar
• Campos X, Munoz Y, Selman A et al. Nerve growth factor and its high-affinity receptor TrkA participate in the control of vascular endothelial growth factor expression in epithelial ovarian cancer. Gynecol. Oncol.104, 168–175 (2007).
   Google Scholar
• Ejiri J, Inoue N, Kobayashi S et al. Possible role of brain-derived neurotrophic factor in the pathogenesis of coronary artery disease. Circulation112, 2114–2120 (2005).
   PubMed Web of Science ®Google Scholar
• Ricci A, Greco S, Amenta F et al. Neurotrophins and neurotrophin receptors in human pulmonary arteries. J. Vasc. Res.37, 355–363 (2000).
   Google Scholar
• Meuchel L, Thompson M, Pabelick C, Prakash Y. Neurotrophins induce NO generation in pulmonary artery endothelial cells. Presented at: Experimental Biology 2010. Anaheim, CA, USA, 24–28 April 2010 (Abstract).
   Google Scholar
• Ricci A, Bronzetti E, Mannino F et al. Elevated neurotrophin and neurotrophin receptor expression in spontaneously hypertensive rat lungs. Growth Factors22, 195–205 (2004).
   Web of Science ®Google Scholar
• Lommatzsch M, Quarcoo D, Schulte-Herbruggen O et al. Neurotrophins in murine viscera: a dynamic pattern from birth to adulthood. Int. J. Dev. Neurosci.23, 495–500 (2005).
   PubMed Web of Science ®Google Scholar
• Garcia-Suarez O, Perez-Pinera P, Laura R et al. TrkB is necessary for the normal development of the lung. Respir. Physiol. Neurobiol.167, 281–291 (2009).
   PubMedGoogle Scholar
• Lommatzsch M, Braun A, Mannsfeldt A et al. Abundant production of brain-derived neurotrophic factor by adult visceral epithelia. Implications for paracrine and target-derived neurotrophic functions. Am. J. Pathol.155, 1183–1193 (1999).
   PubMed Web of Science ®Google Scholar
• Chen X, Ye H, Kuruvilla R et al. A chemical-genetic approach to studying neurotrophin signaling. Neuron46, 13–21 (2005).
   Google Scholar
• Hack M, Taylor HG, Drotar D et al. Chronic conditions, functional limitations, and special health care needs of school-aged children born with extremely low-birth-weight in the 1990s. JAMA294, 318–325 (2005).
   PubMed Web of Science ®Google Scholar
• Yao Q, Zaidi SI, Haxhiu MA, Martin RJ. Neonatal lung and airway injury: a role for neurotrophins. Semin. Perinatol.30, 156–162 (2006).
   Web of Science ®Google Scholar
• Yao Q, Haxhiu MA, Zaidi SI et al. Hyperoxia enhances brain-derived neurotrophic factor and tyrosine kinase B receptor expression in peribronchial smooth muscle of neonatal rats. Am. J. Physiol. Lung Cell Mol. Physiol.289, L307–L314 (2005).
   Google Scholar
• Tortorolo L, Langer A, Polidori G et al. Neurotrophin overexpression in lower airways of infants with respiratory syncytial virus infection. Am. J. Respir. Crit. Care Med.172, 233–237 (2005).
   PubMed Web of Science ®Google Scholar
• Zaidi SI, Jafri A, Doggett T, Haxhiu MA. Airway-related vagal preganglionic neurons express brain-derived neurotrophic factor and TrkB receptors: implications for neuronal plasticity. Brain Res.1044, 133–143 (2005).
   Google Scholar
• Sopi RB, Martin RJ, Haxhiu MA et al. Role of brain-derived neurotrophic factor in hyperoxia-induced enhancement of contractility and impairment of relaxation in lung parenchyma. Am. J. Physiol. Lung Cell Mol. Physiol.295, L348–L355 (2008).
   Google Scholar
• Nassenstein C, Braun A, Nockher WA, Renz H. Neurotrophin effects on eosinophils in allergic inflammation. Curr. Allergy Asthma Rep.5, 204–211 (2005).
   Google Scholar
• Nassenstein C, Mohring UH, Luttmann W, Virchow JC Jr, Braun A. Differential expression of the neurotrophin receptors p75NTR, TrkA, TrkB and TrkC in human peripheral blood mononuclear cells. Exp. Toxicol. Pathol.57(Suppl. 2), 55–63 (2006).
   Google Scholar
• Abram M, Wegmann M, Fokuhl V et al. Nerve growth factor and neurotrophin-3 mediate survival of pulmonary plasma cells during the allergic airway inflammation. J. Immunol.182, 4705–4712 (2009).
   PubMedGoogle Scholar
• Bennedich Kahn L, Gustafsson LE, Olgart Hoglund C. Brain-derived neurotrophic factor enhances histamine-induced airway responses and changes levels of exhaled nitric oxide in guinea pigs in vivo. Eur. J. Pharmacol.595, 78–83 (2008).
   Google Scholar
• Dagnell C, Kemi C, Klominek J et al. Effects of neurotrophins on human bronchial smooth muscle cell migration and matrix metalloproteinase-9 secretion. Transl. Res.150, 303–310 (2007).
   PubMedGoogle Scholar
• Nassenstein C, Dawbarn D, Pollock K et al. Pulmonary distribution, regulation, and functional role of Trk receptors in a murine model of asthma. J. Allergy Clin. Immunol.118, 597–605 (2006).
   PubMedGoogle Scholar
• Renz H, Kerzel S, Nockher WA. The role of neurotrophins in bronchial asthma: contribution of the pan-neurotrophin receptor p75. Prog. Brain Res.146, 325–333 (2004).
   Google Scholar
• Braun A, Lommatzsch M, Lewin GR, Virchow JC, Renz H. Neurotrophins: a link between airway inflammation and airway smooth muscle contractility in asthma? Int. Arch. Allergy Immunol.118, 163–165 (1999).
   PubMed Web of Science ®Google Scholar
• Micera A, Vigneti E, Pickholtz D et al. Nerve growth factor displays stimulatory effects on human skin and lung fibroblasts, demonstrating a direct role for this factor in tissue repair. Proc. Natl Acad. Sci. USA98, 6162–6167 (2001).
   PubMed Web of Science ®Google Scholar
• Bahat-Stroomza M, Barhum Y, Levy YS et al. Induction of adult human bone marrow mesenchymal stromal cells into functional astrocyte-like cells: potential for restorative treatment in Parkinson’s disease. J. Mol. Neurosci.39, 199–210 (2009).
   Google Scholar
• Dekkers BG, Maarsingh H, Meurs H, Gosens R. Airway structural components drive airway smooth muscle remodeling in asthma. Proc. Am. Thorac. Soc.6, 683–692 (2009).
   PubMedGoogle Scholar
• Bai TR. Evidence for airway remodeling in chronic asthma. Curr. Opin. Allergy Clin. Immunol.10, 82–86 (2010).
   Google Scholar
• Lagente V, Boichot E. Role of matrix metalloproteinases in the inflammatory process of respiratory diseases. J. Mol. Cell. Cardiol.48(3), 440–444 (2009).
   Google Scholar
• Fujimaki H, Win-Shwe TT, Yamamoto S, Nakajima D, Goto S. The expression of nerve growth factor in mice lung following low-level toluene exposure. Toxicol. Lett.191, 240–245 (2009).
   PubMed Web of Science ®Google Scholar
• Win-Shwe TT, Yamamoto S, Nakajima D et al. Modulation of neurological related allergic reaction in mice exposed to low-level toluene. Toxicol. Appl. Pharmacol.222, 17–24 (2007).
   PubMedGoogle Scholar
• Fujimaki H, Yamamoto S, Win-Shwe TT et al. Effect of long-term exposure to low-level toluene on airway inflammatory response in mice. Toxicol. Lett.168, 132–139 (2007).
   PubMed Web of Science ®Google Scholar
• Kimata H. Passive smoking elevates neurotrophin levels in tears. Hum. Exp. Toxicol.23, 215–217 (2004).
   PubMed Web of Science ®Google Scholar
• Urrego F, Scuri M, Auais A, Mohtasham L, Piedimonte G. Combined effects of chronic nicotine and acute virus exposure on neurotrophin expression in rat lung. Pediatr. Pulmonol.44, 1075–1084 (2009).
   Google Scholar
• McSharry CP, Fraser I, Chaudhuri R et al. Nerve growth factor in serum and lymphocyte culture in pigeon fanciers’ acute hypersensitivity pneumonitis. Chest130, 37–42 (2006).
   Google Scholar
• Olgart C, Frossard N. Human lung fibroblasts secrete nerve growth factor: effect of inflammatory cytokines and glucocorticoids. Eur. Respir. J.18, 115–121 (2001).
   PubMed Web of Science ®Google Scholar
• Antonelli A, Lapucci G, Vigneti E, Bonini S, Aloe L. Human lung fibroblast response to NGF, IL-1β, and dexamethsone. Lung183, 337–351 (2005).
   PubMed Web of Science ®Google Scholar
• Kruttgen A, Schneider I, Weis J. The dark side of the NGF family: neurotrophins in neoplasias. Brain Pathol.16, 304–310 (2006).
   PubMed Web of Science ®Google Scholar
• Ricci A, Greco S, Mariotta S et al. Neurotrophins and neurotrophin receptors in human lung cancer. Am. J. Respir. Cell Mol. Biol.25, 439–446 (2001).
   PubMedGoogle Scholar
• Ricci A, Graziano P, Mariotta S et al. Neurotrophin system expression in human pulmonary carcinoid tumors. Growth Factors23, 303–312 (2005).
   PubMed Web of Science ®Google Scholar
• Perez-Pinera P, Hernandez T, Garcia-Suarez O et al. The Trk tyrosine kinase inhibitor K252a regulates growth of lung adenocarcinomas. Mol. Cell Biochem.295, 19–26 (2007).
   PubMedGoogle Scholar
• Missale C, Codignola A, Sigala S et al. Nerve growth factor abrogates the tumorigenicity of human small cell lung cancer cell lines. Proc. Natl Acad. Sci. USA95, 5366–5371 (1998).
   PubMed Web of Science ®Google Scholar
• Bandtlow C, Dechant G. From cell death to neuronal regeneration, effects of the p75 neurotrophin receptor depend on interactions with partner subunits. Sci. STKE (235), pe24 (2004).
   Google Scholar
• Lomen-Hoerth C, Shooter EM. Widespread neurotrophin receptor expression in the immune system and other nonneuronal rat tissues. J. Neurochem.64, 1780–1789 (1995).
   PubMed Web of Science ®Google Scholar
• Goss JR. The therapeutic potential of gene transfer for the treatment of peripheral neuropathies. Expert Rev. Mol. Med.9, 1–20 (2007).
   Google Scholar
• Webster NJ, Pirrung MC. Small molecule activators of the Trk receptors for neuroprotection. BMC Neurosci.9(Suppl. 2), S1 (2008).
   Google Scholar
• Longo FM, Massa SM. Small molecule modulation of p75 neurotrophin receptor functions. CNS Neurol. Disord. Drug Targets7, 63–70 (2008).
   Google Scholar
• Nockher WA, Renz H. Neurotrophins in inflammatory lung diseases: modulators of cell differentiation and neuroimmune interactions. Cytokine Growth Factor Rev.14, 559–578 (2003).
   Web of Science ®Google Scholar
• Hoyle GW. Neurotrophins and lung disease. Cytokine Growth Factor Rev.14, 551–558 (2003).
   Web of Science ®Google Scholar
• Nassenstein C, Kerzel S, Braun A. Neurotrophins and neurotrophin receptors in allergic asthma. Prog. Brain Res.146, 347–367 (2004).
   PubMed Web of Science ®Google Scholar