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Review

Controversies in the treatment of chronic rhinosinusitis

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Pages 463-477 | Published online: 09 Jan 2014

References

  • Melen I. Chronic sinusitis: clinical and pathophysiological aspects. Acta Otolaryngol.515, 45–48 (1994).
  • Kaliner MA, Osguthorpe JD, Fireman P et al. Sinusitis: bench to bedside – current findings, future directions. J. Allergy Clin. Immunol.99, S829–S848 (1997).
  • Fokkens W, Lund V, Mullol J; European Position Paper on Rhinosinusitis and Nasal Polyps Group. EP3OS 2007: European position paper on rhinosinusitis and nasal polyps 2007. A summary for otorhinolaryngologists. Rhinology45, 97–101 (2007).
  • Fokkens W, Lund V, Mullol J; European Position Paper on Rhinosinusitis and Nasal Polyps Group. European position paper on rhinosinusitis and nasal polyps 2007. Rhinology(Suppl. 20), 1–136 (2007).
  • Roca-Ferrer J, Mullol J, Lopez E et al. Effect of topical anti-inflammatory drugs on epithelial cell-induced eosinophil survival and GM-CSF secretion. Eur. Respir. J.10, 1489–1495 (1997).
  • Pujols L, Mullol J, Pérez M et al. Expression of the human glucocorticoid receptor α and β isoforms in human respiratory epithelial cells and their regulation by dexamethasone. Am. J. Respir. Cell. Mol. Biol.24, 49–57 (2001).
  • Schmid M, Gode U, Schafer D et al. Arachidonic acid metabolism in nasal tissue and peripheral blood cells in aspirin intolerant asthmatics. Acta Otolaryngol.119, 277–280 (1999).
  • Picado C, Fernandez-Morata JC, Juan M et al. Cyclooxygenase-2 mRNA is downexpressed in nasal polyps from aspirin-sensitive asthmatics. Am. J. Respir. Crit. Care Med.160, 291–296 (1999).
  • Alobid I, Benítez P, Bernal-Sprekelsen M et al. The impact of asthma and aspirin sensitivity on quality of life of patients with nasal polyposis. Qual. Life Res.14, 789–793 (2005).
  • Alobid I, Benitez P, Bernal-Sprekelsen M et al. Nasal polyposis and its impact on quality of life. Comparison between the effects of medical and surgical treatments. Allergy125, 215–219 (2005).
  • Szczeklik A, Nizankowska E, Duplaga M. Natural history of aspirin-induced asthma. AIANE Investigators. European Network on Aspirin-Induced Asthma. Eur. Respir. J.16, 432–436 (2000).
  • Guilemany JM, Angrill J, Alobid I et al. United airways again: high prevalence of rhinosinusitis and nasal polyps in bronchiectasis. Allergy64, 790–797 (2009).
  • Guilemany JM, Angrill J, Alobid I et al. United airways: the impact of chronic rhinosinusitis and nasal polyps in bronchiectasic patient’s quality of life. Allergy64, 1524–1529 (2009).
  • Guilemany JM, Alobid I, Angrill J et al. The impact of bronchiectasis associated to sinonasal disease on quality of life. Respir. Med.100, 1997–2003 (2006).
  • Hens G, Vanaudenaerde BM, Bullens DM et al. Sinonasal pathology in nonallergic asthma and COPD: ‘united airway disease’ beyond the scope of allergy. Allergy63, 261–267 (2008).
  • Hurst JR, Wilkinson TM, Donaldson GC, Wedzicha JA. Upper airway symptoms and quality of life in chronic obstructive pulmonary disease (COPD). Respir. Med.98, 767–770 (2004).
  • Hens G, Hellings PW. The nose: gatekeeper and trigger of bronchial disease. Rhinology44, 179–187 (2006).
  • McCusker C, Chicoine M, Hamid D, Mazer B. Site-specific sensitization in a murine model of allergic rhinitis: role of the upper airway in the lower airway disease. J. Allergy Clin. Immunol.110, 891–898 (2002).
  • Togias A. Rhinitis and asthma: evidence for respiratory system integration. J. Allergy Clin. Immunol.111, 1171–1183 (2003).
  • Meltzer EO, Hamilos DL, Hadley JA et al. Rhinosinusitis: establishing definitions for clinical research and patient care. J. Allergy Clin. Immunol.114(Suppl. 6), S155–S212 (2004).
  • Mullol J, Xaubet A, Lopez E et al. Comparative study of the effects of different glucocorticosteroids on eosinophil survival primed by cultured epithelial cell supernatants obtained from nasal mucosa and nasal polyps. Thorax50, 270–274 (1995).
  • Mullol J, Lopez E, Roca-Ferrer J et al. Effects of topical anti-inflammatory drugs on eosinophil survival primed by epithelial cells. Additive effect of glucocorticoids and nedocromil sodium. Clin. Exp. Allergy27, 1432–1441 (1997).
  • Mullol J, Roca-Ferrer J, Xaubet A et al. Inhibition of GM-CSF secretion by topical corticosteroids and nedocromil sodium. A comparison study using nasal polyp epithelial cells. Respir. Med.94, 428–431 (2000).
  • Xaubet A, Mullol J, Roca-Ferrer J et al. Effect of budesonide and nedocromil sodium on IL-6 and IL-8 release from human nasal mucosa and polyp epithelial cells. Respir. Med.95, 408–414 (2001).
  • Parikh A, Scadding GK, Darby Y et al. Topical corticosteroids in chronic rhinosinusitis: a randomized, double-blind, placebo-controlled trial using fluticasone propionate aqueous nasal spray. Rhinology39, 75–79 (2001).
  • Lavigne F, Cameron L, Renzi PM et al. Intrasinus administration of topical budesonide to allergic patients with chronic rhinosinusitis following surgery. Laryngoscope112, 858–864 (2002).
  • Cuenant G, Stipon JP, Plante-Longchamp G et al. Efficacy of endonasal neomycin-tixocortol pivalate irrigation in the treatment of chronic allergic and bacterial sinusitis. ORL J. Otorhinolaryngol. Relat. Spec.48, 226–232 (1986).
  • Sykes DA, Wilson R, Chan KL et al. Relative importance of antibiotic and improved clearance in topical treatment of chronic mucopurulent rhinosinusitis. A controlled study. Lancet2, 359–360 (1986).
  • Lund VJ, Black JH, Szabo LZ et al. Efficacy and tolerability of budesonide aqueous nasal spray in chronic rhinosinusitis patients. Rhinology42, 57–62 (2004).
  • Schenkel EJ, Skoner DP, Bronsky EA et al. Absence of growth retardation in children with perennial allergic rhinitis after one year of treatment with mometasone furoate aqueous nasal spray. Pediatrics105, E22 (2000).
  • Skoner D. Update of growth effects of inhaled and intranasal corticosteroids. Curr. Opin. Allergy Clin. Immunol.2, 7–10 (2002).
  • Cave A, Arlett P, Lee E. Inhaled and nasal corticosteroids: factors affecting the risks of systemic adverse effects. Pharmacol. Ther.83, 153–179 (1999).
  • Holm AF, Fokkens WJ, Godthelp T et al. A 1-year placebo-controlled study of intranasal fluticasone propionate aqueous nasal spray in patients with perennial allergic rhinitis: a safety and biopsy study. Clin. Otolaryngol.23, 69–73 (1998).
  • McNally PA, White MV, Kaliner MA. Sinusitis in an allergist’s office: analysis of 200 consecutive cases. Allergy Asthma Proc.18, 169–175 (1997).
  • Subramanian HN, Schechtman KB, Hamilos DL. A retrospective analysis of treatment outcomes and time to relapse after intensive medical treatment for chronic sinusitis. Am. J. Rhinol.16, 303–312 (2002).
  • Legent F, Bordure P, Beauvillain C, Berche P. A double-blind comparison of ciprofloxacin and amoxycillin/clavulanic acid in the treatment of chronic sinusitis. Chemotherapy40, 8–15 (1994).
  • Namyslowski G, Misiolek M, Czecior E et al. Comparison of the efficacy and tolerability of amoxycillin/clavulanic acid 875 mg b.i.d. with cefuroxime 500 mg b.i.d. in the treatment of chronic and acute exacerbation of chronic sinusitis in adults. J. Chemother.14, 508–517 (2002).
  • Suzuki H, Shimomura A, Ikeda K et al. Inhibitory effect of macrolides on interleukin-8 secretion from cultured human nasal epithelial cells. Laryngoscope107, 1661–1666 (1997).
  • Miyanohara T, Ushikai M, Matsune S et al. Effects of clarithromycin on cultured human nasal epithelial cells and fibroblasts. Laryngoscope110, 126–131 (2000).
  • Cervin A. The anti-inflammatory effect of erythromycin and its derivatives, with special reference to nasal polyposis and chronic sinusitis. Acta Otolaryngol.121, 83–92 (2001).
  • Hashiba M, Baba S. Efficacy of long-term administration of clarithromycin in the treatment of intractable chronic sinusitis. Acta Otolaryngol. Suppl.525, 73–78 (1996).
  • Gandhi A, Brodsky L, Ballow M. Benefits of antibiotic prophylaxis in children with chronic sinusitis: assessment of outcome predictors. Allergy Proc.14, 37–43 (1993).
  • Ragab SM, Lund VJ, Scadding G. Evaluation of the medical and surgical treatment of chronic rhinosinusitis: a prospective, randomised, controlled trial. Laryngoscope114, 923–930 (2004).
  • Wallwork B, Coman W, Mackay-Sim A et al. A double-blind, randomized, placebo-controlled trial of macrolide in the treatment of chronic rhinosinusitis. Laryngoscope116, 189–193 (2006).
  • Soler ZM, Smith TL. What is the role of long-term macrolide therapy in the treatment of recalcitrant chronic rhinosinusitis? Laryngoscope119, 2083–2084 (2009).
  • Parnes SM. The role of leukotriene inhibitors in patients with paranasal sinus disease. Curr. Opin. Otolaryngol. Head Neck Surg.11, 184–191 (2003).
  • Otten FW. Conservative treatment of chronic maxillary sinusitis in children. Long-term follow-up. Acta Otorhinolaryngol. Belg.51, 173–175 (1997).
  • Graf P, Enerdal J, Hallen H. Ten days’ use of oxymetazoline nasal spray with or without benzalkonium chloride in patients with vasomotor rhinitis. Arch. Otolaryngol. Head Neck Surg.125, 1128–1132 (1999).
  • Van Bever HP, Bosmans J, Stevens WJ. Nebulization treatment with saline compared to bromhexine in treating chronic sinusitis in asthmatic children. Allergy42, 33–36 (1987).
  • Szmeja Z, Golusinski W, Mielcarek-Kuchta D et al. [Use of mucolytic preparations (Mucosolvan) in selected diseases of the upper respiratory tract. Part II]. Otolaryngol. Pol.51, 480–486 (1997).
  • Bhattacharyya Nl. The economic burden and symptom manifestations of chronic rhinosinusitis. Am. J. Rhinol.17, 27–32 (2003).
  • Ponikau JU, Sherris DA, Kern EB et al. The diagnosis and incidence of allergic fungal sinusitis. Mayo Clin. Proc.74, 877–884 (1999).
  • Ponikau JU, Sherris DA, Kita H et al. Intranasal antifungal treatment in 51 patients with chronic rhinosinusitis. J. Allergy Clin. Immunol.110, 862–866 (2002).
  • Ponikau JU, Sherris DA, Weaver A et al. Treatment of chronic rhinosinusitis with intranasal amphotericin B: a randomized, placebo-controlled, double-blind pilot trial. J. Allergy Clin. Immunol.115, 125–131 (2005).
  • Weschta M, Rimek D, Formanek M et al. Topical antifungal treatment of chronic rhinosinusitis with nasal polyps: a randomized, double-blind clinical trial. J. Allergy Clin. Immunol.113, 1122–1128 (2004).
  • Ebbens FA, Scadding GK, Badia L et al. Amphotericin B nasal lavages: not a solution for patients with chronic rhinosinusitis. J. Allergy Clin. Immunol.118, 1149–1156 (2006).
  • Kennedy DW, Kuhn FA, Hamilos DL et al. Treatment of chronic rhinosinusitis with high dose oral terbinafine: a double blind, placebo-controlled study. Laryngoscope115, 1793–1799 (2005).
  • Heintz B, Schlenter WW, Kirsten R et al. Clinical efficacy of Broncho-Vaxom in adult patients with chronic purulent sinusitis – a multi-centric, placebo-controlled, double-blind study. Int. J. Clin. Pharmacol. Ther. Toxicol.27, 530–534 (1989).
  • Bachmann G, Hommel G, Michel O. Effect of irrigation of the nose with isotonic salt solution on adult patients with chronic paranasal sinus disease. Eur. Arch. Otorhinolaryngol.257, 537–541 (2000).
  • Taccariello M, Parikh A, Darby Y et al. Nasal douching as a valuable adjunct in the management of chronic rhinosinusitis. Rhinology37, 29–32 (1999).
  • Rabago D, Zgierska A, Mundt M et al. Efficacy of daily hypertonic saline nasal irrigation among patients with sinusitis: a randomized controlled trial. J. Fam. Pract.51, 1049–1055 (2002).
  • Shoseyov D, Bibi H, Shai P et al. Treatment with hypertonic saline versus normal saline nasal wash of pediatric chronic sinusitis. J. Allergy Clin. Immunol.101, 602–605 (1998).
  • Friedman M, Vidyasagar R, Joseph N. A randomized, prospective, double-blind study on the efficacy of Dead Sea salt nasal irrigations. Laryngoscope116, 878–882 (2006).
  • Pinto JM, Elwany S, Baroody FM et al. Effects of saline sprays on symptoms after endoscopic sinus surgery. Am. J. Rhinol.20, 191–196 (2006).
  • Pang YT, Willatt DJ. Do antral washouts have a place in the current management of chronic sinusitis? J. Laryngol. Otol.110, 926–928 (1996).
  • Weaver EM. Association between gastroesophageal reflux and sinusitis, otitis media, and laryngeal malignancy: a systematic review of the evidence. Am. J. Med.115, 81–89 (2003).
  • Blanc PD, Trupin L, Earnest G, Katz PP, Yelin EH, Eisner MD. Alternative therapies among adults with a reported diagnosis of asthma or rhinosinusitis: data from a population-based survey. Chest120, 1461–1467 (2001).
  • Hopkins C, Browne JP, Slack R et al. Complications of surgery for nasal polyposis and chronic rhinosinusitis: the results of a national audit in England and Wales. Laryngoscope116, 1494–1499 (2006).
  • Deal RT, Kountakis SE. Significance of nasal polyps in chronic rhinosinusitis: symptoms and surgical outcomes. Laryngoscope114, 1932–1935 (2004).
  • Giger R, Dulguerov P, Quinodoz D et al. Chronic panrhinosinusitis without nasal polyps: long-term outcome after functional endoscopic sinus surgery. Otolaryngol. Head Neck Surg.131, 534–541 (2004).
  • Senior BA, Kennedy DW, Tanabodee J, Kroger H, Hassab M, Lanza DC. Long-term impact of functional endoscopic sinus surgery on asthma. Otolaryngol. Head Neck Surg.121, 66–68 (1999).
  • Dejima K, Hama T, Miyazaki M et al. A clinical study of endoscopic sinus surgery for sinusitis in patients with bronchial asthma. Int. Arch. Allergy Immunol.138, 97–104 (2005).
  • Dhong HJ, Jung YS, Chung SK, Choi DC. Effect of endoscopic sinus surgery on asthmatic patients with chronic rhinosinusitis. Otolaryngol. Head Neck Surg.124, 99–104 (2001).
  • Dinis PB, Gomes A. Sinusitis and asthma: how do they interrelate in sinus surgery? Am. J. Rhinol.11, 421–428 (1997).
  • Amar YG, Frenkiel S, Sobol SE. Outcome analysis of endoscopic sinus surgery for chronic sinusitis in patients having Samter’s triad. J. Otolaryngol.29, 7–12 (2000).
  • Mehanna H, Mills J, Kelly B, McGarry GW. Benefit from endoscopic sinus surgery. Clin. Otolaryngol.27, 464–471 (2002).
  • Kountakis SE, Bradley DT. Effect of asthma on sinus computed tomography grade and symptom scores in patients undergoing revision functional endoscopic sinus surgery. Am. J. Rhinol.17, 215–219 (2003).
  • Mygind N, Pedersen CB, Prytz S et al. Treatment of nasal polyps with intranasal beclomethasone dipropionate aerosol. Clin. Allergy5, 159–164 (1975).
  • Deuschl H, Drettner B. Nasal polyps treated by beclomethasone nasal aerosol. Rhinology15, 17–23 (1977).
  • Holopainen E, Grahne B, Malmberg H et al. Budesonide in the treatment of nasal polyposis. Eur. J. Respir. Dis. Suppl.122, 221–228 (1982).
  • Tos M, Svendstrup F, Arndal H et al. Efficacy of an aqueous and a powder formulation of nasal budesonide compared in patients with nasal polyps. Am. J. Rhinol.12, 183–189 (1998).
  • Vendelo Johansen L, Illum P, Kristensen S et al. The effect of budesonide (Rhinocort) in the treatment of small and medium-sized nasal polyps. Clin. Otolaryngol.18, 524–527 (1993).
  • Lildholdt T, Rundcrantz H, Lindqvist N. Efficacy of topical corticosteroid powder for nasal polyps: a double-blind, placebo-controlled study of budesonide. Clin. Otolaryngol.20, 26–30 (1995).
  • Holmberg K, Juliusson S, Balder B et al. Fluticasone propionate aqueous nasal spray in the treatment of nasal polyposis. Ann. Allergy Asthma Immunol.78, 270–276 (1997).
  • Lund VJ, Flood J, Sykes AP et al. Effect of fluticasone in severe polyposis. Arch. Otolaryngol. Head Neck Surg.124, 513–518 (1998).
  • Keith P, Nieminen J, Hollingworth K et al. Efficacy and tolerability of fluticasone propionate nasal drops 400 microgram once daily compared with placebo for the treatment of bilateral polyposis in adults. Clin. Exp. Allergy30, 1460–1468 (2000).
  • Penttila M, Poulsen P, Hollingworth K et al. Dose-related efficacy and tolerability of fluticasone propionate nasal drops 400 microg once daily and twice daily in the treatment of bilateral nasal polyposis: a placebo-controlled randomized study in adult patients. Clin. Exp. Allergy30, 94–102 (2000).
  • Aukema AAC, Mulder PGH, Fokkens WJ. Treatment of nasal polyposis and chronic rhinosinusitis with fluticasone propionate nasal drops reduces need for sinus surgery. J. Allergy Clin. Immunol.115, 1017–1023 (2005).
  • Small CB, Hernandez J, Reyes A et al. Efficacy and safety of mometasone furoate nasal spray in nasal polyposis. J. Allergy Clin. Immunol.116, 1275–1281 (2005).
  • Stjärne P, Mosges R, Jorissen M et al. A randomized controlled trial of mometasone furoate nasal spray for the treatment of nasal polyposis. Arch. Otolaryngol. Head Neck Surg.132, 179–185 (2006).
  • Stjärne P, Blomgren K, Caye-Thomasen P et al. The efficacy and safety of once-daily mometasone furoate nasal spray in nasal polyposis: a randomized, double-blind, placebo-controlled study. Acta Otolaryngol.126, 606–612 (2006).
  • Lildholdt T, Fogstrup J, Gammelgaard N et al. Surgical versus medical treatment of nasal polyps. Acta Otolaryngol.105, 140–143 (1988).
  • Van Camp C, Clement PA. Results of oral steroid treatment in nasal polyposis. Rhinology32, 5–9 (1994).
  • Damm M, Jungehulsing M, Eckel HE et al. Effects of systemic steroid treatment in chronic polypoid rhinosinusitis evaluated with magnetic resonance imaging. Otolaryngol. Head Neck Surg.120, 517–523 (1999).
  • Benitez P, Alobid I, De Haro J et al. A short course of oral prednisone followed by intranasal budesonide is an effective treatment of severe nasal polyps. Laryngoscope116, 770–775 (2006).
  • Hissaria P, Smith W, Wormald PJ et al. Short course of systemic corticosteroids in sinonasal polyposis: a double-blind, randomized, placebo-controlled trial with evaluation of outcome measures. J. Allergy Clin. Immunol.118, 128–133 (2006).
  • Becker SS, Rasamny JK, Han JK et al. Steroid injection for sinonasal polyps: the University of Virginia experience. Am. J. Rhinol.21, 64–69 (2007).
  • Shalek P, Petras P, Klement V, Hahn A. Short-term antibiotics treatment in patients with nasal polyps and enterotoxins producing Staphylococcus aureus strains. Eur. Arch. Otorhinolaryngol.266, 1909–1913 (2009).
  • Van Cauwenberge P, Van Zele T, Bachert C. Chronic rhinosinusitis and nasal polyposis: the etiopathogenesis revealed? Verh. K. Acad. Geneeskd. Belg.70, 305–322 (2008).
  • Elbez M, De Pressigny M, Halimi P et al. Does the use of nasal vasoconstrictor agents change tomodensitometric images of nasosinusal polyposis? Ann. Otolaryngol. Chir. Cervicofac.110, 277–280 (1993).
  • Johansson L, Oberg D, Melen I et al. Do topical nasal decongestants affect polyps? Acta Otolaryngol.126, 288–290 (2006).
  • Haye R, Aanesen JP, Burtin B et al. The effect of cetirizine on symptoms and signs of nasal polyposis. J. Laryngol. Otol.112, 1042–1046 (1998).
  • Ricchetti A, Landis BN, Maffioli A et al. Effect of anti-fungal nasal lavage with amphotericin B on nasal polyposis. J. Laryngol. Otol.116, 261–263 (2002).
  • Parnes SM, Chuma AV. Acute effects of antileukotrienes on sinonasal polyposis and sinusitis. Ear Nose Throat J.79, 18–20 (2000).
  • Corradini C, Del Ninno M, Buonomo A et al. Amphotericin B and lysine acetylsalicylate in the combined treatment of nasal polyposis associated with mycotic infection. J. Investig. Allergol. Clin. Immunol.16, 188–193 (2006).
  • Ulualp SO, Sterman BM, Toohill RJ. Antileukotriene therapy for the relief of sinus symptoms in aspirin triad disease. Ear Nose Throat J.78, 604–606 (1999).
  • Ragab S, Parikh A, Darby YC, Scadding GK. An open audit of montelukast, a leukotriene receptor antagonist, in nasal polyposis associated with asthma. Clin. Exp. Allergy.31, 1385–1391 (2001).
  • Mostafa BE, Abdel HH, Mohammed HE et al. Role of leukotriene inhibitors in the postoperative management of nasal polyps. ORL J. Otorhinolaryngol. Relat. Spec.67, 148–153 (2005).
  • Stevenson DD. Aspirin desensitization in patients with AERD. Clin. Rev. Allergy Immunol.24, 159–168 (2003).
  • Nucera E, Schiavino D, Milani A et al. Effects of lysine-acetylsalicylate (LAS) treatment in nasal polyposis: two controlled long term prospective follow up studies. Thorax55, 75–78 (2000).
  • Scadding GK, Hassab M, Darby YC et al. Intranasal lysine aspirin in recurrent nasal polyposis. Clin. Otolaryngol.20, 561–563 (1995).
  • Parikh AA, Scadding GK. Intranasal lysine-aspirin in aspirin-sensitive nasal polyposis: a controlled trial. Laryngoscope115, 1385–1390 (2005).
  • Ogata N, Darby Y, Scadding G. Intranasal lysine-aspirin administration decreases polyp volume in patients with aspirin-intolerant asthma. J. Laryngol. Otol.121, 1156–1160 (2007).
  • Dalziel K, Stein K, Round A et al. Systematic review of endoscopic sinus surgery for nasal polyps. Health Technol. Assess.7, 1–159 (2003).
  • Alobid I, Benítez P, Bernal-Sprekelsen M et al. Nasal polyposis and its impact on quality of life: comparison between the effects of medical and surgical treatments. Allergy60, 452–458 (2005).
  • Batra PS, Kern RC, Tripathi A et al. Outcome analysis of endoscopic sinus surgery in patients with nasal polyps and asthma. Laryngoscope113, 1703–1706 (2003).
  • Ehnhage A, Olsson P, Kölbeck KG et al.; NAFS Study Group. Functional endoscopic sinus surgery improved asthma symptoms as well as PEFR and olfaction in patients with nasal polyposis. Allergy64, 762–769 (2009).
  • Grundmann SA, Hemfort PB, Luger TA, Brehler R. Anti-IgE (omalizumab): a new therapeutic approach for chronic rhinosinusitis. J. Allergy Clin. Immunol.121, 257–258 (2008).
  • Gevaert P, Lang-Loidolt D, Lackner A et al. Nasal IL-5 levels determine the response to anti-IL-5 treatment in patients with nasal polyps. J. Allergy Clin. Immunol.118, 1133–1141 (2006).
  • Mullol J, Obando A, Pujols L, Alobid I. Corticosteroid treatment in chronic rhinosinusitis: the possibilities and the limits. Immunol. Allergy Clin. North Am.29, 657–668 (2009).
  • Shekelle PG, Woolf SH, Eccles M, Grimshaw J. Clinical guidelines: developing guidelines. BMJ318(7183), 593–596 (1999).

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