Recent advances in understanding inflammation and remodeling in the airways in chronic obstructive pulmonary disease

References

• Reid L. Measurement of the bronchial mucous gland layer: a diagnostic yardstick in chronic bronchitis. Thorax 15, 132–141 (1960).
   PubMedGoogle Scholar
• Thurlbeck WM, Angus GE. A distribution curve for chronic bronchitis. Thorax 19, 436–442 (1964).
   PubMedGoogle Scholar
• Dunnill MS. The classification and quantification of emphysema. Proc. R. Soc. Med. 62(10), 1024–1027 (1969).
   PubMedGoogle Scholar
• Hogg JC, Nepszy SJ, Macklem PT, Thurlbeck WM. Elastic properties of the centrilobular emphysematous space. J. Clin. Invest. 48(7), 1306–1312 (1969).
   PubMed Web of Science ®Google Scholar
• Guillemi S, Wright JL, Hogg JC, Wiggs BR, Macklem PT, Paré PD. Density dependence of pulmonary resistance: correlation with small airway pathology. Eur. Respir. J. 8(5), 789–794 (1995).
   PubMedGoogle Scholar
• McDonough JE, Yuan R, Suzuki M et al. Small-airway obstruction and emphysema in chronic obstructive pulmonary disease. N. Engl. J. Med. 365(17), 1567–1575 (2011).
   PubMed Web of Science ®Google Scholar
• Sutherland ER, Martin RJ. Airway inflammation in chronic obstructive pulmonary disease: comparisons with asthma. J. Allergy Clin. Immunol. 112(5), 819–827; quiz 828 (2003).
   PubMed Web of Science ®Google Scholar
• Chung KF, Adcock IM. Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction. Eur. Respir. J. 31(6), 1334–1356 (2008).
   PubMed Web of Science ®Google Scholar
• Saetta M, Turato G, Facchini FM et al. Inflammatory cells in the bronchial glands of smokers with chronic bronchitis. Am. J. Respir. Crit. Care Med. 156(5), 1633–1639 (1997).
   PubMed Web of Science ®Google Scholar
• Baraldo S, Turato G, Badin C et al. Neutrophilic infiltration within the airway smooth muscle in patients with COPD. Thorax 59(4), 308–312 (2004).
   PubMed Web of Science ®Google Scholar
• Stanescu D, Sanna A, Veriter C et al. Airways obstruction, chronic expectoration, and rapid decline of FEV1 in smokers are associated with increased levels of sputum neutrophils. Thorax 51(3), 267–271 (1996).
   PubMed Web of Science ®Google Scholar
• Löfdahl MJ, Roos-Engstrand E, Pourazar J et al. Increased intraepithelial T-cells in stable COPD. Respir. Med. 102(12), 1812–1818 (2008).
   PubMed Web of Science ®Google Scholar
• Hodge G, Reynolds PN, Holmes M, Hodge S. Differential expression of pro-inflammatory cytokines in intra-epithelial T cells between trachea and bronchi distinguishes severity of COPD. Cytokine 60(3), 843–848 (2012).
   PubMed Web of Science ®Google Scholar
• Sohal SS, Reid D, Soltani A et al. Smoking cessation but not inhaled corticosteroids (ICS) can increase histone deacetylase 2 (HDAC2) in COPD (Abstract book). Eur. Respir. J. 36(54), 785S (2010).
   Google Scholar
• Sohal SS, Reid D, Soltani A et al. Reticular basement membrane fragmentation and potential epithelial mesenchymal transition is exaggerated in the airways of smokers with chronic obstructive pulmonary disease. Respirology 15(6), 930–938 (2010).
   PubMed Web of Science ®Google Scholar
• Sohal SS, Reid D, Soltani A et al. Evaluation of epithelial mesenchymal transition in patients with chronic obstructive pulmonary disease. Respir. Res. 12, 130 (2011).
   PubMedGoogle Scholar
• Ito K, Lim S, Caramori G, Chung KF, Barnes PJ, Adcock IM. Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression, and inhibits glucocorticoid actions in alveolar macrophages. FASEB J. 15(6), 1110–1112 (2001).
   PubMedGoogle Scholar
• Bafadhel M, McKenna S, Terry S et al. Blood eosinophils to direct corticosteroid treatment of exacerbations of chronic obstructive pulmonary disease: a randomized placebo-controlled trial. Am. J. Respir. Crit. Care Med. 186(1), 48–55 (2012).
   PubMed Web of Science ®Google Scholar
• Fujimoto K, Kubo K, Yamamoto H, Yamaguchi S, Matsuzawa Y. Eosinophilic inflammation in the airway is related to glucocorticoid reversibility in patients with pulmonary emphysema. Chest 115(3), 697–702 (1999).
   PubMed Web of Science ®Google Scholar
• Chanez P, Vignola AM, O’Shaugnessy T et al. Corticosteroid reversibility in COPD is related to features of asthma. Am. J. Respir. Crit. Care Med. 155(5), 1529–1534 (1997).
   PubMed Web of Science ®Google Scholar
• Pizzichini E, Pizzichini MM, Gibson P et al. Sputum eosinophilia predicts benefit from prednisone in smokers with chronic obstructive bronchitis. Am. J. Respir. Crit. Care Med. 158(5 Pt 1), 1511–1517 (1998).
   PubMed Web of Science ®Google Scholar
• Reid DW, Wen Y, Johns DP, Williams TJ, Ward C, Walters EH. Bronchodilator reversibility, airway eosinophilia and anti-inflammatory effects of inhaled fluticasone in COPD are not related. Respirology 13(6), 799–809 (2008).
   PubMedGoogle Scholar
• Barnes PJ. Immunology of asthma and chronic obstructive pulmonary disease. Nat. Rev. Immunol. 8(3), 183–192 (2008).
   PubMed Web of Science ®Google Scholar
• O’Shaughnessy TC, Ansari TW, Barnes NC, Jeffery PK. Inflammation in bronchial biopsies of subjects with chronic bronchitis: inverse relationship of CD8+ T lymphocytes with FEV1. Am. J. Respir. Crit. Care Med. 155(3), 852–857 (1997).
   PubMed Web of Science ®Google Scholar
• Chrysofakis G, Tzanakis N, Kyriakoy D et al. Perforin expression and cytotoxic activity of sputum CD8+ lymphocytes in patients with COPD. Chest 125(1), 71–76 (2004).
   PubMed Web of Science ®Google Scholar
• Saetta M, Di Stefano A, Turato G et al. CD8+ T-lymphocytes in peripheral airways of smokers with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 157(3 Pt 1), 822–826 (1998).
   PubMed Web of Science ®Google Scholar
• Gosman MM, Willemse BW, Jansen DF et al.; Groningen and Leiden Universities Corticosteroids in Obstructive Lung Disease Study Group. Increased number of B-cells in bronchial biopsies in COPD. Eur. Respir. J. 27(1), 60–64 (2006).
   PubMed Web of Science ®Google Scholar
• Hogg JC, Chu F, Utokaparch S et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N. Engl. J. Med. 350(26), 2645–2653 (2004).
   PubMed Web of Science ®Google Scholar
• Richmond I, Booth H, Ward C, Walters EH. Intrasubject variability in airway inflammation in biopsies in mild to moderate stable asthma. Am. J. Respir. Crit. Care Med. 153(3), 899–903 (1996).
   PubMedGoogle Scholar
• Hogg JC. Pathophysiology of airflow limitation in chronic obstructive pulmonary disease. Lancet 364(9435), 709–721 (2004).
   PubMed Web of Science ®Google Scholar
• Hogg JC, Timens W. The pathology of chronic obstructive pulmonary disease. Annu. Rev. Pathol. 4, 435–459 (2009).
   PubMed Web of Science ®Google Scholar
• van der Strate BW, Postma DS, Brandsma CA et al. Cigarette smoke-induced emphysema: a role for the B cell? Am. J. Respir. Crit. Care Med. 173(7), 751–758 (2006).
   PubMed Web of Science ®Google Scholar
• Demedts IK, Bracke KR, Van Pottelberge G et al. Accumulation of dendritic cells and increased CCL20 levels in the airways of patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 175(10), 998–1005 (2007).
   PubMed Web of Science ®Google Scholar
• Saetta M, Di Stefano A, Maestrelli P et al. Activated T-lymphocytes and macrophages in bronchial mucosa of subjects with chronic bronchitis. Am. Rev. Respir. Dis. 147(2), 301–306 (1993).
   PubMed Web of Science ®Google Scholar
• Fraig M, Shreesha U, Savici D, Katzenstein AL. Respiratory bronchiolitis: a clinicopathologic study in current smokers, ex-smokers, and never-smokers. Am. J. Surg. Pathol. 26(5), 647–653 (2002).
   PubMed Web of Science ®Google Scholar
• Finlay GA, O’Driscoll LR, Russell KJ et al. Matrix metalloproteinase expression and production by alveolar macrophages in emphysema. Am. J. Respir. Crit. Care Med. 156(1), 240–247 (1997).
   PubMed Web of Science ®Google Scholar
• Barnes PJ. Alveolar macrophages as orchestrators of COPD. COPD 1(1), 59–70 (2004).
   PubMedGoogle Scholar
• Brinkman GL. The mast cell in normal human bronchus and lung. J. Ultrastruct. Res. 23(1), 115–123 (1968).
   PubMedGoogle Scholar
• Lamb D, Lumsden A. Intra-epithelial mast cells in human airway epithelium: evidence for smoking-induced changes in their frequency. Thorax 37(5), 334–342 (1982).
   PubMedGoogle Scholar
• Kurmi OP, Lam KB, Ayres JG. Indoor air pollution and the lung in low- and medium-income countries. Eur. Respir. J. 40(1), 239–254 (2012).
   PubMed Web of Science ®Google Scholar
• Marinkovic D, Aleksic-Kovacevic S, Plamenac P. Cellular basis of chronic obstructive pulmonary disease in horses. Int. Rev. Cytol. 257, 213–247 (2007).
   PubMedGoogle Scholar
• Soltani A, Ewe YP, Lim ZS et al. Mast cells in COPD airways: relationship to bronchodilator responsiveness and angiogenesis. Eur. Respir. J. 39(6), 1361–1367 (2012).
   PubMed Web of Science ®Google Scholar
• Siddiqui S, Hollins F, Saha S, Brightling CE. Inflammatory cell microlocalisation and airway dysfunction: cause and effect? Eur. Respir. J. 30(6), 1043–1056 (2007).
   PubMed Web of Science ®Google Scholar
• Gosman MM, Postma DS, Vonk JM et al. Association of mast cells with lung function in chronic obstructive pulmonary disease. Respir. Res. 9, 64 (2008).
   PubMed Web of Science ®Google Scholar
• Slats AM, Janssen K, van Schadewijk A et al. Bronchial inflammation and airway responses to deep inspiration in asthma and chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 176(2), 121–128 (2007).
   PubMedGoogle Scholar
• Ballarin A, Bazzan E, Zenteno RH et al. Mast cell infiltration discriminates between histopathological phenotypes of chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 186(3), 233–239 (2012).
   PubMed Web of Science ®Google Scholar
• Kim WD, Ling SH, Coxson HO et al. The association between small airway obstruction and emphysema phenotypes in COPD. Chest 131(5), 1372–1378 (2007).
   PubMed Web of Science ®Google Scholar
• Andersson CK, Mori M, Bjermer L, Löfdahl CG, Erjefält JS. Alterations in lung mast cell populations in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 181(3), 206–217 (2010).
   PubMed Web of Science ®Google Scholar
• Ward C, Forrest IA, Murphy DM et al. Phenotype of airway epithelial cells suggests epithelial to mesenchymal cell transition in clinically stable lung transplant recipients. Thorax 60(10), 865–871 (2005).
   PubMed Web of Science ®Google Scholar
• Galli SJ, Borregaard N, Wynn TA. Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils. Nat. Immunol. 12(11), 1035–1044 (2011).
   PubMed Web of Science ®Google Scholar
• Persson C, Uller L. Transepithelial exit of leucocytes: inflicting, reflecting or resolving airway inflammation? Thorax 65(12), 1111–1115 (2010).
   PubMedGoogle Scholar
• Gerwin N, Gonzalo JA, Lloyd C et al. Prolonged eosinophil accumulation in allergic lung interstitium of ICAM-2 deficient mice results in extended hyperresponsiveness. Immunity 10(1), 9–19 (1999).
   PubMed Web of Science ®Google Scholar
• Corry DB, Kiss A, Song LZ et al. Overlapping and independent contributions of MMP2 and MMP9 to lung allergic inflammatory cell egression through decreased CC chemokines. FASEB J. 18(9), 995–997 (2004).
   PubMed Web of Science ®Google Scholar
• Jeffery PK. Remodeling in asthma and chronic obstructive lung disease. Am. J. Respir. Crit. Care Med. 164(10 Pt 2), S28–S38 (2001).
   PubMedGoogle Scholar
• Churg A, Tai H, Coulthard T, Wang R, Wright JL. Cigarette smoke drives small airway remodeling by induction of growth factors in the airway wall. Am. J. Respir. Crit. Care Med. 174(12), 1327–1334 (2006).
   PubMed Web of Science ®Google Scholar
• Saetta M, Turato G, Baraldo S et al. Goblet cell hyperplasia and epithelial inflammation in peripheral airways of smokers with both symptoms of chronic bronchitis and chronic airflow limitation. Am. J. Respir. Crit. Care Med. 161(3 Pt 1), 1016–1021 (2000).
   PubMed Web of Science ®Google Scholar
• Bergeron C, Boulet LP. Structural changes in airway diseases: characteristics, mechanisms, consequences, and pharmacologic modulation. Chest 129(4), 1068–1087 (2006).
   PubMed Web of Science ®Google Scholar
• Cosio MG, Hale KA, Niewoehner DE. Morphologic and morphometric effects of prolonged cigarette smoking on the small airways. Am. Rev. Respir. Dis. 122(2), 265–221 (1980).
   PubMed Web of Science ®Google Scholar
• Kim V, Rogers TJ, Criner GJ. New concepts in the pathobiology of chronic obstructive pulmonary disease. Proc. Am. Thorac. Soc. 5(4), 478–485 (2008).
   PubMedGoogle Scholar
• Saha S, Doe C, Mistry V et al. Granulocyte-macrophage colony-stimulating factor expression in induced sputum and bronchial mucosa in asthma and COPD. Thorax 64(8), 671–676 (2009).
   PubMed Web of Science ®Google Scholar
• Kokturk N, Tatlicioglu T, Memis L, Akyurek N, Akyol G. Expression of transforming growth factor β1 in bronchial biopsies in asthma and COPD. J. Asthma 40(8), 887–893 (2003).
   PubMed Web of Science ®Google Scholar
• Kranenburg AR, de Boer WI, Alagappan VK, Sterk PJ, Sharma HS. Enhanced bronchial expression of vascular endothelial growth factor and receptors (Flk-1 and Flt-1) in patients with chronic obstructive pulmonary disease. Thorax 60(2), 106–113 (2005).
   PubMed Web of Science ®Google Scholar
• de Boer WI, Hau CM, van Schadewijk A, Stolk J, van Krieken JH, Hiemstra PS. Expression of epidermal growth factors and their receptors in the bronchial epithelium of subjects with chronic obstructive pulmonary disease. Am. J. Clin. Pathol. 125(2), 184–192 (2006).
   PubMedGoogle Scholar
• Innes AL, Woodruff PG, Ferrando RE et al. Epithelial mucin stores are increased in the large airways of smokers with airflow obstruction. Chest 130(4), 1102–1108 (2006).
   PubMed Web of Science ®Google Scholar
• Thorley AJ, Tetley TD. Pulmonary epithelium, cigarette smoke, and chronic obstructive pulmonary disease. Int. J. Chron. Obstruct. Pulmon. Dis. 2(4), 409–428 (2007).
   PubMedGoogle Scholar
• Chung KF. The role of airway smooth muscle in the pathogenesis of airway wall remodeling in chronic obstructive pulmonary disease. Proc. Am. Thorac. Soc. 2(4), 347–354; discussion 371 (2005).
   PubMedGoogle Scholar
• Baraldo S, Bazzan E, Zanin ME et al. Matrix metalloproteinase-2 protein in lung periphery is related to COPD progression. Chest 132(6), 1733–1740 (2007).
   PubMed Web of Science ®Google Scholar
• Kranenburg AR, Willems-Widyastuti A, Moori WJ et al. Enhanced bronchial expression of extracellular matrix proteins in chronic obstructive pulmonary disease. Am. J. Clin. Pathol. 126(5), 725–735 (2006).
   PubMed Web of Science ®Google Scholar
• Liesker JJ, Ten Hacken NH, Zeinstra-Smith M, Rutgers SR, Postma DS, Timens W. Reticular basement membrane in asthma and COPD: similar thickness, yet different composition. Int. J. Chron. Obstruct. Pulmon. Dis. 4, 127–135 (2009).
   PubMedGoogle Scholar
• Postma DS, Timens W. Remodeling in asthma and chronic obstructive pulmonary disease. Proc. Am. Thorac. Soc. 3(5), 434–439 (2006).
   PubMedGoogle Scholar
• Bosken CH, Wiggs BR, Paré PD, Hogg JC. Small airway dimensions in smokers with obstruction to airflow. Am. Rev. Respir. Dis. 142(3), 563–570 (1990).
   PubMed Web of Science ®Google Scholar
• Jeffery PK. Remodeling and inflammation of bronchi in asthma and chronic obstructive pulmonary disease. Proc. Am. Thorac. Soc. 1(3), 176–183 (2004).
   PubMedGoogle Scholar
• Löfdahl M, Kaarteenaho R, Lappi-Blanco E, Tornling G, Sköld MC. Tenascin-C and α-smooth muscle actin positive cells are increased in the large airways in patients with COPD. Respir. Res. 12, 48 (2011).
   PubMed Web of Science ®Google Scholar
• Yao H, Rahman I. Current concepts on the role of inflammation in COPD and lung cancer. Curr. Opin. Pharmacol. 9(4), 375–383 (2009).
   PubMed Web of Science ®Google Scholar
• Yang IA, Relan V, Wright CM et al. Common pathogenic mechanisms and pathways in the development of COPD and lung cancer. Expert Opin. Ther. Targets 15(4), 439–456 (2011).
   PubMed Web of Science ®Google Scholar
• Feltis BN, Wignarajah D, Zheng L et al. Increased vascular endothelial growth factor and receptors: relationship to angiogenesis in asthma. Am. J. Respir. Crit. Care Med. 173(11), 1201–1207 (2006).
   PubMed Web of Science ®Google Scholar
• McDonald DM. Angiogenesis and remodeling of airway vasculature in chronic inflammation. Am. J. Respir. Crit. Care Med. 164(10 Pt 2), S39–S45 (2001).
   PubMed Web of Science ®Google Scholar
• Siafakas NM, Antoniou KM, Tzortzaki EG. Role of angiogenesis and vascular remodeling in chronic obstructive pulmonary disease. Int. J. Chron. Obstruct. Pulmon. Dis. 2(4), 453–462 (2007).
   PubMedGoogle Scholar
• Liebow AA. Pulmonary emphysema with special reference to vascular changes. Am. Rev. Respir. Dis. 80(1 Pt 2), 67–93 (1959).
   PubMed Web of Science ®Google Scholar
• Calabrese C, Bocchino V, Vatrella A et al. Evidence of angiogenesis in bronchial biopsies of smokers with and without airway obstruction. Respir. Med. 100(8), 1415–1422 (2006).
   PubMed Web of Science ®Google Scholar
• Zanini A, Chetta A, Saetta M et al. Bronchial vascular remodelling in patients with COPD and its relationship with inhaled steroid treatment. Thorax 64(12), 1019–1024 (2009).
   PubMedGoogle Scholar
• Reid LM. Pathology of chronic bronchitis. Lancet 266(6806), 274–278 (1954).
   PubMedGoogle Scholar
• Glynn AA, Michaels L. Bronchial biopsy in chronic bronchitis and asthma. Istanbul Tip. Fak. Mecmuasi 23, 142–153 (1960).
   Google Scholar
• Sommerhoff CP, Nadel JA, Basbaum CB, Caughey GH. Neutrophil elastase and cathepsin G stimulate secretion from cultured bovine airway gland serous cells. J. Clin. Invest. 85(3), 682–689 (1990).
   PubMed Web of Science ®Google Scholar
• Caramori G, Di Gregorio C, Carlstedt I et al. Mucin expression in peripheral airways of patients with chronic obstructive pulmonary disease. Histopathology 45(5), 477–484 (2004).
   PubMed Web of Science ®Google Scholar
• Yoshida T, Tuder RM. Pathobiology of cigarette smoke-induced chronic obstructive pulmonary disease. Physiol. Rev. 87(3), 1047–1082 (2007).
   PubMed Web of Science ®Google Scholar
• O’Donnell RA, Richter A, Ward J et al. Expression of ErbB receptors and mucins in the airways of long term current smokers. Thorax 59(12), 1032–1040 (2004).
   PubMed Web of Science ®Google Scholar
• Chanez P, Bourdin A, Vachier I, Godard P, Bousquet J, Vignola AM. Effects of inhaled corticosteroids on pathology in asthma and chronic obstructive pulmonary disease. Proc. Am. Thorac. Soc. 1(3), 184–190 (2004).
   PubMedGoogle Scholar
• Telenga ED, Kerstjens HA, Postma DS, Ten Hacken NH, van den Berge M. Inhaled corticosteroids in chronic obstructive pulmonary disease: a review. Expert Opin. Pharmacother. 11(3), 405–421 (2010).
   PubMed Web of Science ®Google Scholar
• Walters JA, Gibson PG, Wood-Baker R, Hannay M, Walters EH. Systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease. Coch. Database Syst. Rev. (1), CD001288 (2009).
   Google Scholar
• Barnes PJ. Corticosteroid effects on cell signalling. Eur. Respir. J. 27(2), 413–426 (2006).
   PubMed Web of Science ®Google Scholar
• Pauwels RA, Löfdahl CG, Laitinen LA et al. Long-term treatment with inhaled budesonide in persons with mild chronic obstructive pulmonary disease who continue smoking. European Respiratory Society Study on Chronic Obstructive Pulmonary Disease. N. Engl. J. Med. 340(25), 1948–1953 (1999).
   PubMed Web of Science ®Google Scholar
• Yang IA, Clarke MS, Sim EH, Fong KM. Inhaled corticosteroids for stable chronic obstructive pulmonary disease. Coch. Database Syst. Rev. 7, CD002991 (2012).
   PubMed Web of Science ®Google Scholar
• Vestbo J; TORCH Study Group. The TORCH (towards a revolution in COPD health) survival study protocol. Eur. Respir. J. 24(2), 206–210 (2004).
   PubMed Web of Science ®Google Scholar
• Hattotuwa KL, Gizycki MJ, Ansari TW, Jeffery PK, Barnes NC. The effects of inhaled fluticasone on airway inflammation in chronic obstructive pulmonary disease: a double-blind, placebo-controlled biopsy study. Am. J. Respir. Crit. Care Med. 165(12), 1592–1596 (2002).
   PubMed Web of Science ®Google Scholar
• Gizycki MJ, Hattotuwa KL, Barnes N, Jeffery PK. Effects of fluticasone propionate on inflammatory cells in COPD: an ultrastructural examination of endobronchial biopsy tissue. Thorax 57(9), 799–803 (2002).
   PubMed Web of Science ®Google Scholar
• Lapperre TS, Snoeck-Stroband JB, Gosman MM et al.; Groningen Leiden Universities Corticosteroids in Obstructive Lung Disease Study Group. Effect of fluticasone with and without salmeterol on pulmonary outcomes in chronic obstructive pulmonary disease: a randomized trial. Ann. Intern. Med. 151(8), 517–527 (2009).
   PubMed Web of Science ®Google Scholar
• Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J. Clin. Invest. 119(6), 1420–1428 (2009).
   PubMed Web of Science ®Google Scholar
• Soltani A, Reid DW, Sohal SS et al. Basement membrane and vascular remodelling in smokers and chronic obstructive pulmonary disease: a cross-sectional study. Respir. Res. 11, 105 (2010).
   PubMedGoogle Scholar
• Zeisberg M, Neilson EG. Biomarkers for epithelial-mesenchymal transitions. J. Clin. Invest. 119(6), 1429–1437 (2009).
   PubMed Web of Science ®Google Scholar
• Kalluri R. EMT: when epithelial cells decide to become mesenchymal-like cells. J. Clin. Invest. 119(6), 1417–1419 (2009).
   PubMed Web of Science ®Google Scholar
• Soltani A, Muller HK, Sohal SS et al. Distinctive characteristics of bronchial reticular basement membrane and vessel remodelling in chronic obstructive pulmonary disease (COPD) and in asthma: they are not the same disease. Histopathology 60(6), 964–970 (2012).
   PubMed Web of Science ®Google Scholar
• Bettelheim R, Mitchell D, Gusterson BA. Immunocytochemistry in the identification of vascular invasion in breast cancer. J. Clin. Pathol. 37(4), 364–366 (1984).
   PubMedGoogle Scholar
• Soltani A, Wood-Baker R, Sohal SS, Muller HK, Reid D, Walters EH. Reticular basement membrane vessels are increased in COPD bronchial mucosa by both Factor VIII and collagen IV immunostaining and are hyperpermeable. J. Allergy (Cairo) 2012, 958383 (2012).
   PubMedGoogle Scholar
• Soltani A, Sohal SS, Reid D, Weston S, Wood-Baker R, Walters EH. Vessel-associated transforming growth factor-β1 (TGF-β1) is increased in the bronchial reticular basement membrane in COPD and normal smokers. PLoS ONE 7(6), e39736 (2012).
   PubMedGoogle Scholar
• Kalluri R, Neilson EG. Epithelial–mesenchymal transition and its implications for fibrosis. J. Clin. Invest. 112(12), 1776–1784 (2003).
   PubMed Web of Science ®Google Scholar
• Kalluri R, Zeisberg M. Fibroblasts in cancer. Nat. Rev. Cancer 6(5), 392–401 (2006).
   PubMed Web of Science ®Google Scholar
• Grigoriu BD, Depontieu F, Scherpereel A et al. Endocan expression and relationship with survival in human non-small cell lung cancer. Clin. Cancer Res. 12(15), 4575–4582 (2006).
   PubMed Web of Science ®Google Scholar
• Sarrazin SMC, Delmas D, Lassalle P, Delehedde M. Endocan as a biomarker of endothelial dysfunction in cancer. J. Cancer Sci. Ther. 2(2), 047–052 (2010).
   Google Scholar
• Garber K. Epithelial-to-mesenchymal transition is important to metastasis, but questions remain. J. Natl Cancer Inst. 100(4), 232–233, 239 (2008).
   PubMedGoogle Scholar
• Barnes PJ, Adcock IM. Chronic obstructive pulmonary disease and lung cancer: a lethal association. Am. J. Respir. Crit. Care Med. 184(8), 866–867 (2011).
   PubMed Web of Science ®Google Scholar
• de Torres JP, Marín JM, Casanova C et al. Lung cancer in patients with chronic obstructive pulmonary disease – incidence and predicting factors. Am. J. Respir. Crit. Care Med. 184(8), 913–919 (2011).
   PubMed Web of Science ®Google Scholar
• van Gestel YR, Hoeks SE, Sin DD et al. COPD and cancer mortality: the influence of statins. Thorax 64(11), 963–967 (2009).
   PubMedGoogle Scholar
• Young RP, Hopkins R, Eaton TE. Pharmacological actions of statins: potential utility in COPD. Eur. Respir. Rev. 18(114), 222–232 (2009).
   PubMedGoogle Scholar
• Parimon T, Chien JW, Bryson CL, McDonell MB, Udris EM, Au DH. Inhaled corticosteroids and risk of lung cancer among patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 175(7), 712–719 (2007).
   PubMed Web of Science ®Google Scholar
• Kiri VA, Fabbri LM, Davis KJ, Soriano JB. Inhaled corticosteroids and risk of lung cancer among COPD patients who quit smoking. Respir. Med. 103(1), 85–90 (2009).
   PubMed Web of Science ®Google Scholar
• Calverley PM, Anderson JA, Celli B et al.; TORCH investigators. Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease. N. Engl. J. Med. 356(8), 775–789 (2007).
   PubMed Web of Science ®Google Scholar