918
Views
63
CrossRef citations to date
0
Altmetric
Review

Antibody-profiling technologies for studying humoral responses to infectious agents

, , , &
Pages 567-578 | Published online: 09 Jan 2014

References

  • McKevitt M, Brinkman MB, McLoughlin M et al. Genome scale identification of Treponema pallidum antigens. Infect. Immun.73(7), 4445–4450 (2005).
  • Brinkman MB, McKevitt M, McLoughlin M et al. Reactivity of antibodies from syphilis patients to a protein array representing the Treponema pallidum proteome. J. Clin. Microbiol.44(3), 888–891 (2006).
  • Brinkman MB, McGill MA, Pettersson J et al. A novel Treponema pallidum antigen, TP0136, is an outer membrane protein that binds human fibronectin. Infect. Immun.76(5), 1848–1857 (2008).
  • Neuman de Vegvar HE, Amara RR, Steinman L, Utz PJ, Robinson HL, Robinson WH. Microarray profiling of antibody responses against simian–human immunodeficiency virus: postchallenge convergence of reactivities independent of host histocompatibility type and vaccine regimen. J. Virol.77(20), 11125–11138 (2003).
  • Zhu H, Hu S, Jona G et al. Severe acute respiratory syndrome diagnostics using a coronavirus protein microarray. Proc. Natl Acad. Sci. USA103(11), 4011–4016 (2006).
  • Davies DH, Liang X, Hernandez JE et al. Profiling the humoral immune response to infection by using proteome microarrays: high-throughput vaccine and diagnostic antigen discovery. Proc. Natl Acad. Sci. USA102(3), 547–552 (2005).
  • Davies DH, McCausland MM, Valdez C et al. Vaccinia virus H3L envelope protein is a major target of neutralizing antibodies in humans and elicits protection against lethal challenge in mice. J. Virol.79(18), 11724–11733 (2005).
  • Davies DH, Molina DM, Wrammert J et al. Proteome-wide analysis of the serological response to vaccinia and smallpox. Proteomics7(10), 1678–1686 (2007).
  • Eyles JE, Unal B, Hartley MG et al. Immunodominant Francisella tularensisantigens identified using proteome microarray. Proteomics7(13), 2172–2183 (2007).
  • Sundaresh S, Randall A, Unal B et al. From protein microarrays to diagnostic antigen discovery: a study of the pathogen Francisella tularensis. Bioinformatics23(13), i508–i518 (2007).
  • Molina DM, Pal S, Kayala MA et al. Identification of immunodominant antigens of Chlamydia trachomatis using proteome microarrays. Vaccine28(17), 3014–3024 (2009).
  • Doolan DL, Mu Y, Unal B et al. Profiling humoral immune responses to P. falciparum infection with protein microarrays. Proteomics8(22), 4680–4694 (2008).
  • Regis DP, Dobano C, Quinones-Olson P et al. Transcriptionally active PCR for antigen identification and vaccine development: in vitro genome-wide screening and in vivo immunogenicity. Mol. Biochem. Parasitol.158(1), 32–45 (2008).
  • Beare PA, Chen C, Bouman T et al. Candidate antigens for Q fever serodiagnosis revealed by immunoscreening of a Coxiella burnetiiprotein microarray. Clin. Vaccine Immunol.15(12), 1771–1779 (2008).
  • Felgner PL, Kayala MA, Vigil A et al. A Burkholderia pseudomallei protein microarray reveals serodiagnostic and cross-reactive antigens. Proc. Natl Acad. Sci. USA106(32), 13499–13504 (2009).
  • Tsuboi T, Takeo S, Iriko H et al. Wheat germ cell-free system-based production of malaria proteins for discovery of novel vaccine candidates. Infect. Immun.76(4), 1702–1708 (2008).
  • Barbour AG, Jasinskas A, Kayala MA et al. A genome-wide proteome array reveals a limited set of immunogens in natural infections of humans and white-footed mice with Borrelia burgdorferi. Infect. Immun.76(8), 3374–3389 (2008).
  • Ramachandran N, Hainsworth E, Bhullar B et al. Self-assembling protein microarrays. Science305(5680), 86–90 (2004).
  • Montor WR, Huang J, Hu Y et al. Genome-wide study of Pseudomonas aeruginosa outer membrane protein immunogenicity using self-assembling protein microarrays. Infect. Immun.77(11), 4877–4886 (2009).
  • Keasey SL, Schmid KE, Lee MS et al. Extensive antibody cross-reactivity among infectious Gram-negative bacteria revealed by proteome microarray analysis. Mol. Cell. Proteomics8(5), 924–935 (2009).
  • Pickering JW, Martins TB, Greer RW et al. A multiplexed fluorescent microsphere immunoassay for antibodies to pneumococcal capsular polysaccharides. Am. J. Clin. Pathol.117(4), 589–596 (2002).
  • Pickering JW, Martins TB, Schroder MC, Hill HR. Comparison of a multiplex flow cytometric assay with enzyme-linked immunosorbent assay for auantitation of antibodies to tetanus, diphtheria, and Haemophilusinfluenzae type b. Clin. Diagn. Lab. Immunol.9(4), 872–876 (2002).
  • Dias D, Van Doren J, Schlottmann S et al. Optimization and validation of a multiplexed luminex assay to quantify antibodies to neutralizing epitopes on human papillomaviruses 6, 11, 16, and 18. Clin. Diagn. Lab. Immunol.12(8), 959–969 (2005).
  • Opalka D, Lachman CE, MacMullen SA et al. Simultaneous quantitation of antibodies to neutralizing epitopes on virus-like particles for human papillomavirus types 6, 11, 16, and 18 by a multiplexed luminex assay. Clin. Diagn. Lab. Immunol.10(1), 108–115 (2003).
  • Prince HE, Lape-Nixon M, Matud J. Evaluation of a tetraplex microsphere assay for Bordetella pertussis antibodies. Clin. Vaccine Immunol.13(2), 266–270 (2006).
  • Wong J, Sibani S, Lokko NN, LaBaer J, Anderson KS. Rapid detection of antibodies in sera using multiplexed self-assembling bead arrays. J. Immunol. Methods350(1–2), 171–182 (2009).
  • Waterboer T, Sehr P, Pawlita M. Suppression of non-specific binding in serological Luminex assays. J. Immunol. Methods309(1–2), 200–204 (2006).
  • Pickering JW, Larson MT, Martins TB, Copple SS, Hill HR. Elimination of false-positive results in a luminex assay for pneumococcal antibodies. Clin. Vaccine Immunol.17(1), 185–189 (2010).
  • Liu E, Eisenbarth GS. Accepting clocks that tell time poorly: fluid-phase versus standard ELISA autoantibody assays. Clin. Immunol.125(2), 120–126 (2007).
  • Li M, Yu L, Tiberti C et al. A report on the International Transglutaminase Autoantibody Workshop for Celiac Disease. Am. J. Gastroenterol.104(1), 154–163 (2009).
  • Burbelo PD, Ching KH, Klimavicz CM, Iadarola MJ. Antibody profiling by luciferase immunoprecipitation systems (LIPS). J. Vis. Exp.7(32), 1549 (2009).
  • Burbelo PD, Goldman R, Mattson TL. A simplified immunoprecipitation method for quantitatively measuring antibody responses in clinical sera samples by using mammalian-produced Renilla luciferase-antigen fusion proteins. BMC Biotechnol.5, 22 (2005).
  • Sashihara J, Burbelo PD, Savoldo B, Pierson TC, Cohen JI. Human antibody titers to Epstein–Barr virus (EBV) gp350 correlate with neutralization of infectivity better than antibody titers to EBV gp42 using a rapid flow cytometry-based EBV neutralization assay. Virology391(2), 249–256 (2009).
  • Burbelo PD, Ramanathan R, Klion AD, Iadarola MJ, Nutman TB. Rapid, novel, specific, high-throughput assay for diagnosis of Loa loa infection. J. Clin. Microbiol.46(7), 2298–2304 (2008).
  • Ramanathan R, Burbelo PD, Groot S, Iadarola MJ, Neva FA, Nutman TB. A luciferase immunoprecipitation systems assay enhances the sensitivity and specificity of diagnosis of Strongyloides stercoralis infection. J. Infect. Dis.198(3), 444–451 (2008).
  • Burbelo PD, Hirai H, Issa AT et al. Comparison of radioimmunoprecipitation with luciferase immunoprecipitation for autoantibodies to GAD65 and IA-2b. Diabetes Care33(4), 754–756 (2010).
  • Burbelo PD, Hoshino Y, Leahy H et al. Serological diagnosis of human herpes simplex virus type 1 and 2 infections by luciferase immunoprecipitation system assay. Clin. Vaccine Immunol.16(3), 366–371 (2009).
  • Hoshino Y, Pesnicak L, Dowdell KC et al. Protection from herpes simplex virus (HSV)-2 infection with replication-defective HSV-2 or glycoprotein D2 vaccines in HSV-1-seropositive and HSV-1-seronegative guinea pigs. J. Infect. Dis.200(7), 1088–1095 (2009).
  • Burbelo PD, Ching KH, Mattson TL, Light JS, Bishop LR, Kovacs JA. Rapid antibody quantification and generation of whole proteome antibody response profiles using LIPS (luciferase immunoprecipitation systems). Biochem. Biophys. Res. Commun.352(4), 889–895 (2007).
  • Burbelo PD, Issa AT, Ching KH et al. Highly quantitative serological detection of anti-cytomegalovirus (CMV) antibodies. Virol. J.6, 45 (2009).
  • Burbelo PD, Leahy HP, Iadarola MJ, Nutman TB. A four-antigen mixture for rapid assessment of Onchocerca volvulus infection. PLoS Negl. Trop. Dis.3(5), e438 (2009).
  • Burbelo PD, Kovacs JA, Ching KH et al. Proteome-wide anti-HCV and anti-HIV antibody profiling for predicting and monitoring response to HCV treatment in HIV co-infected patients. J. Infect. Dis. (2010) (In Press).
  • Burbelo PD, Leahy HP, Groot S et al. Four-antigen mixture containing v-cyclin for serological screening of human herpesvirus 8 infection. Clin. Vaccine Immunol.16(5), 621–627 (2009).
  • Katano H, Iwasaki T, Baba N et al. Identification of antigenic proteins encoded by human herpesvirus 8 and seroprevalence in the general population and among patients with and without Kaposi’s sarcoma. J. Virol.74(8), 3478–3485 (2000).
  • Jenkins FJ, Hayes RB, Jackson A et al. Human herpesvirus 8 seroprevalence among prostate cancer case patients and control subjects. J. Infect. Dis.196(2), 208–211 (2007).
  • Laney AS, Peters JS, Manzi SM, Kingsley LA, Chang Y, Moore PS. Use of a multiantigen detection algorithm for diagnosis of Kaposi’s sarcoma-associated herpesvirus infection. J. Clin. Microbiol.44(10), 3734–3741 (2006).
  • Andrews JA, Bligh WJ, Chiodini PL, Bradley JE, Nde PN, Lucius R. The role of a recombinant hybrid protein based ELISA for the serodiagnosis of Onchocerca volvulus. J. Clin. Pathol.61(3), 347–351 (2008).
  • Houghton RL, Benson DR, Reynolds LD et al. A multi-epitope synthetic peptide and recombinant protein for the detection of antibodies to Trypanosoma cruzi in radioimmunoprecipitation-confirmed and consensus-positive sera. J. Infect. Dis.179(5), 1226–1234 (1999).
  • Nde PN, Pogonka T, Bradley JE, Titanji VP, Lucius R. Sensitive and specific serodiagnosis of onchocerciasis with recombinant hybrid proteins. Am. J. Trop. Med. Hyg.66(5), 566–571 (2002).
  • Burbelo PD. Distinct profiles of antibodies to Kaposi’s sarcoma-associated herpesvirus antigens in patients with kaposi sarcoma, multicentric Castleman’s disease, and primary effusion lymphoma. J. Infect. Dis.198(3), 444–451 (2010).
  • Burbelo PD, Meoli E, Leahy HP et al. Anti-HTLV antibody profiling reveals an antibody signature for HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Retrovirology5, 96 (2008).
  • Burbelo PD, Ching KH, Issa AT et al. Rapid serological detection of autoantibodies associated with Sjogren’s syndrome. J. Transl. Med.7, 83 (2009).
  • Randle BJ, Epstein MA. A highly sensitive enzyme-linked immunosorbent assay to quantitate antibodies to Epstein–Barr virus membrane antigen gp340. J. Virol. Methods9(3), 201–208 (1984).
  • Beigel JH, Voell J, Huang CY, Burbelo PD, Lane HC. Safety and immunogenicity of multiple and higher doses of an inactivated influenza A/H5N1 vaccine. J. Infect. Dis.200(4), 501–509 (2009).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.