Methods to measure T-cell responses

References

• Plebanski M, Aidoo M, Whittle HC, Hill AV. Precursor frequency analysis of cytotoxic T lymphocytes to pre-erythrocytic antigens of Plasmodium falciparum in West Africa. J. Immunol.158(6), 2849–2855 (1997).
   PubMed Web of Science ®Google Scholar
• Kuerten S, Nowacki TM, Kleen TO, Asaad RJ, Lehmann PV, Tary-Lehmann M. Dissociated production of perforin, granzyme B, and IFN-γ by HIV-specific CD8+ cells in HIV infection. AIDS Res. Hum. Retroviruses24(1), 62–71 (2008).
   PubMed Web of Science ®Google Scholar
• Swiniarski H, Sturmhoefel K, Lee K, Wolf SF, Dorner AJ, O’Toole M. A CTL assay requiring only 150 microliter of mouse blood. J. Immunol. Methods233(1–2), 1–11 (2000).
   PubMed Web of Science ®Google Scholar
• van Baalen CA, Gruters RA, Berkhoff EG, Osterhaus AD, Rimmelzwaan GF. FATT-CTL assay for detection of antigen-specific cell-mediated cytotoxicity. Cytometry A73(11), 1058–1065 (2008).
   PubMed Web of Science ®Google Scholar
• Kranz DM, Pasternack MS, Eisen HN. Recognition and lysis of target cells by cytotoxic T lymphocytes. Fed. Proc.46(2), 309–312 (1987).
   PubMedGoogle Scholar
• Moffat JM, Gebhardt T, Doherty PC, Turner SJ, Mintern JD. Granzyme A expression reveals distinct cytolytic CTL subsets following influenza A virus infection. Eur. J. Immunol.39(5), 1203–1210 (2009).
   PubMed Web of Science ®Google Scholar
• Taffs R, Sitkovsky M, Takayama H. Granule enzyme exocytosis assay for cytotoxic T lymphocyte activation. Curr. Protoc. Immunol.3(3), 16 (2001).
   PubMedGoogle Scholar
• Vanhoutte VJ, McAulay KA, McCarrell E, Turner M, Crawford DH, Haque T. Cytolytic mechanisms and T-cell receptor Vbeta usage by ex vivo generated Epstein–Barr virus-specific cytotoxic T lymphocytes. Immunology127(4), 577–586 (2009).
   PubMed Web of Science ®Google Scholar
• Ewen C, Kane KP, Shostak I et al. A novel cytotoxicity assay to evaluate antigen-specific CTL responses using a colorimetric substrate for granzyme B. J. Immunol. Methods276(1–2), 89–101 (2003).
   PubMed Web of Science ®Google Scholar
• Wonderlich J, Shearer G, Livingstone A, Brooks A. Induction and measurement of cytotoxic T lymphocyte activity. Curr. Protoc. Immunol.3(3), 11 (2006).
   PubMedGoogle Scholar
• Jerome KR, Sloan DD, Aubert M. Measurement of CTL-induced cytotoxicity: the caspase 3 assay. Apoptosis8(6), 563–571 (2003).
   PubMed Web of Science ®Google Scholar
• Valentovic MA, Ball JG. 2-aminophenol and 4-aminophenol toxicity in renal slices from Sprague-Dawley and Fischer 344 rats. J. Toxicol. Environ. Health A55(3), 225–240 (1998).
   PubMed Web of Science ®Google Scholar
• Kendig DM, Tarloff JB. Inactivation of lactate dehydrogenase by several chemicals: implications for in vitro toxicology studies. Toxicol. In Vitro21(1), 125–132 (2007).
   PubMed Web of Science ®Google Scholar
• Mishra D, Mishra PK, Dubey V, Nahar M, Dabadghao S, Jain NK. Systemic and mucosal immune response induced by transcutaneous immunization using hepatitis B surface antigen-loaded modified liposomes. Eur. J. Pharm. Sci.33(4–5), 424–433 (2008).
   PubMed Web of Science ®Google Scholar
• Tough DF, Sprent J, Stephens GL. Measurement of T and B cell turnover with bromodeoxyuridine. Curr. Protoc. Immunol. Chapter 4, Unit 4.7 (2007).
   PubMedGoogle Scholar
• Pietersz GA, Li W, Popovski V, Caruana JA, Apostolopoulos V, McKenzie IF. Parameters for using mannan–MUC1 fusion protein to induce cellular immunity. Cancer Immunol. Immunother.45(6), 321–326 (1998).
   PubMed Web of Science ®Google Scholar
• Li M, Davey GM, Sutherland RM et al. Cell-associated ovalbumin is cross-presented much more efficiently than soluble ovalbumin in vivo. J. Immunol.166(10), 6099–6103 (2001).
   PubMed Web of Science ®Google Scholar
• Sheng KC, Kalkanidis M, Pouniotis DS et al. Delivery of antigen using a novel mannosylated dendrimer potentiates immunogenicity in vitro and in vivo. Eur. J. Immunol.38(2), 424–436 (2008).
   PubMed Web of Science ®Google Scholar
• Parish CR, Glidden MH, Quah BJ, Warren HS. Use of the intracellular fluorescent dye CFSE to monitor lymphocyte migration and proliferation. Curr. Protoc. Immunol.4(4), 9 (2009).
   PubMedGoogle Scholar
• Quah BJ, Warren HS, Parish CR. Monitoring lymphocyte proliferation in vitro and in vivo with the intracellular fluorescent dye carboxyfluorescein diacetate succinimidyl ester. Nat. Protoc.2(9), 2049–2056 (2007).
   PubMed Web of Science ®Google Scholar
• Apostolopoulos V, Pietersz GA, Loveland BE, Sandrin MS, McKenzie IF. Oxidative/reductive conjugation of mannan to antigen selects for T1 or T2 immune responses. Proc. Natl Acad. Sci. USA92(22), 10128–10132 (1995).
   PubMed Web of Science ®Google Scholar
• Apostolopoulos V, Pietersz GA, McKenzie IF. Cell-mediated immune responses to MUC1 fusion protein coupled to mannan. Vaccine14(9), 930–938 (1996).
   PubMed Web of Science ®Google Scholar
• Lofthouse SA, Apostolopoulos V, Pietersz GA, Li W, McKenzie IF. Induction of T1 (cytotoxic lymphocyte) and/or T2 (antibody) responses to a mucin-1 tumour antigen. Vaccine15(14), 1586–1593 (1997).
   PubMed Web of Science ®Google Scholar
• Fifis T, Gamvrellis A, Crimeen-Irwin B et al. Size-dependent immunogenicity: therapeutic and protective properties of nano-vaccines against tumors. J. Immunol.173(5), 3148–3154 (2004).
   PubMed Web of Science ®Google Scholar
• Xiang SD, Scalzo-Inguanti K, Minigo G, Park A, Hardy CL, Plebanski M. Promising particle-based vaccines in cancer therapy. Expert Rev. Vaccines7(7), 1103–1119 (2008).
   PubMed Web of Science ®Google Scholar
• Xiang SD, Scholzen A, Minigo G et al. Pathogen recognition and development of particulate vaccines: does size matter? Methods40(1), 1–9 (2006).
   PubMed Web of Science ®Google Scholar
• Apostolopoulos V, Lofthouse SA, Popovski V, Chelvanayagam G, Sandrin MS, McKenzie IF. Peptide mimics of a tumor antigen induce functional cytotoxic T cells. Nat. Biotechnol.16(3), 276–280 (1998).
   PubMed Web of Science ®Google Scholar
• Apostolopoulos V, McKenzie IF, Lees C, Matthaei KI, Young IG. A role for IL-5 in the induction of cytotoxic T lymphocytes in vivo. Eur. J. Immunol.30(6), 1733–1739 (2000).
   PubMed Web of Science ®Google Scholar
• Apostolopoulos V, Osinski C, McKenzie IF. MUC1 cross-reactive Gal a(1,3)Gal antibodies in humans switch immune responses from cellular to humoral. Nat. Med.4(3), 315–320 (1998).
   PubMed Web of Science ®Google Scholar
• Lees CJ, Apostolopoulos V, Acres B, Ong CS, Popovski V, McKenzie IF. The effect of T1 and T2 cytokines on the cytotoxic T cell response to mannan-MUC1. Cancer Immunol. Immunother.48(11), 644–652 (2000).
   PubMed Web of Science ®Google Scholar
• Lees CJ, Apostolopoulos V, Acres B et al. Immunotherapy with mannan-MUC1 and IL-12 in MUC1 transgenic mice. Vaccine19(2–3), 158–162 (2000).
   PubMed Web of Science ®Google Scholar
• Lees CJ, Apostolopoulos V, McKenzie IF. Cytokine production from murine CD4 and CD8 cells after mannan-MUC1 immunization. J. Interferon Cytokine Res.19(12), 1373–1379 (1999).
   PubMed Web of Science ®Google Scholar
• McKenzie IF, Apostolopoulos V, Lees C et al. Oxidised mannan antigen conjugates preferentially stimulate T1 type immune responses. Vet. Immunol. Immunopathol.63(1–2), 185–190 (1998).
   PubMed Web of Science ®Google Scholar
• Dooms H, Kahn E, Knoechel B, Abbas AK. IL-2 induces a competitive survival advantage in T lymphocytes. J. Immunol.172(10), 5973–5979 (2004).
   PubMed Web of Science ®Google Scholar
• Saparov A, Wagner FH, Zheng R et al. Interleukin-2 expression by a subpopulation of primary T cells is linked to enhanced memory/effector function. Immunity11(3), 271–280 (1999).
   PubMed Web of Science ®Google Scholar
• Kovacs JA, Lempicki RA, Sidorov IA et al. Induction of prolonged survival of CD4+ T lymphocytes by intermittent IL-2 therapy in HIV-infected patients. J. Clin. Invest.115(8), 2139–2148 (2005).
   PubMed Web of Science ®Google Scholar
• Kondrack RM, Harbertson J, Tan JT, McBreen ME, Surh CD, Bradley LM. Interleukin 7 regulates the survival and generation of memory CD4 cells. J. Exp. Med.198(12), 1797–1806 (2003).
   PubMed Web of Science ®Google Scholar
• Picker LJ, Reed-Inderbitzin EF, Hagen SI et al. IL-15 induces CD4 effector memory T cell production and tissue emigration in nonhuman primates. J. Clin. Invest.116(6), 1514–1524 (2006).
   PubMed Web of Science ®Google Scholar
• Lori F, Weiner DB, Calarota SA, Kelly LM, Lisziewicz J. Cytokine-adjuvanted HIV-DNA vaccination strategies. Springer Semin. Immunopathol.28(3), 231–238 (2006).
   PubMed Web of Science ®Google Scholar
• Sun P, Schwenk R, White K et al. Protective immunity induced with malaria vaccine, RTS,S, is linked to Plasmodium falciparum circumsporozoite protein-specific CD4+ and CD8+ T cells producing IFN-γ. J. Immunol.171(12), 6961–6967 (2003).
   PubMed Web of Science ®Google Scholar
• Keating SM, Bejon P, Berthoud T et al. Durable human memory T cells quantifiable by cultured enzyme-linked immunospot assays are induced by heterologous prime boost immunization and correlate with protection against malaria. J. Immunol.175(9), 5675–5680 (2005).
   PubMed Web of Science ®Google Scholar
• Reece WH, Pinder M, Gothard PK et al. A CD4+ T-cell immune response to a conserved epitope in the circumsporozoite protein correlates with protection from natural Plasmodium falciparum infection and disease. Nat. Med.10(4), 406–410 (2004).
   PubMed Web of Science ®Google Scholar
• Plebanski M, Gilbert SC, Gupta S et al. Association of malaria parasite population structure, HLA, and immunological antagonism. Science279(5354), 1173–1177 (1998).
   PubMed Web of Science ®Google Scholar
• Plebanski M. Chapter I. Preparation of lymphocytes and identification of lymphocyte sub-populations. In: Lymphocytes – A Practical Approach. McMichael AJ (Ed.). IRL Press, Oxford, UK, 1–26 (1999)
   Google Scholar
• Flanagan KL, Plebanski M, Akinwunmi P et al. Broadly distributed T cell reactivity, with no immunodominant loci, to the pre-erythrocytic antigen thrombospondin-related adhesive protein of Plasmodium falciparum in West Africans. Eur. J. Immunol.29(6), 1943–1954 (1999).
   PubMed Web of Science ®Google Scholar
• Flanagan KL, Plebanski M, Odhiambo K et al. Cellular reactivity to the P. falciparumprotein trap in adult kenyans: novel epitopes, complex cytokine patterns, and the impact of natural antigenic variation. Am. J. Trop. Med. Hygiene74(3), 367–375 (2006).
   PubMed Web of Science ®Google Scholar