240
Views
14
CrossRef citations to date
0
Altmetric
Editorial

PfEMP1 as a target of human immunity and a vaccine candidate against malaria

, &
Pages 105-108 | Published online: 09 Jan 2014

References

  • Richards JS, Beeson JG. The future for blood-stage vaccines against malaria. Immunol. Cell Biol. 87(5), 377–390 (2009).
  • Beeson JG, Brown GV. Pathogenesis of Plasmodium falciparum malaria: the roles of parasite adhesion and antigenic variation. Cell. Mol. Life Sci. 59(2), 258–271 (2002).
  • Leech JH, Barnwell JW, Miller LH, Howard RJ. Identification of a strain-specific malarial antigen exposed on the surface of Plasmodium falciparum-infected erythrocytes. J. Exp. Med. 159(6), 1567–1575 (1984).
  • Marsh K, Howard RJ. Antigens induced on erythrocytes by P. falciparum: expression of diverse and conserved determinants. Science 231(4734), 150–153 (1986).
  • Bull PC, Lowe BS, Kortok M, Molyneux CS, Newbold CI, Marsh K. Parasite antigens on the infected red cell surface are targets for naturally acquired immunity to malaria. Nat. Med. 4(3), 358–360 (1998).
  • Smith JD, Chitnis CE, Craig AG et al. Switches in expression of Plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytes. Cell 82(1), 101–110 (1995).
  • Mackintosh CL, Christodoulou Z,Mwangi TW et al. Acquisition of naturally occurring antibody responses to recombinant protein domains of Plasmodium falciparum erythrocyte membrane protein 1. Malar. J. 7, 155 (2008).
  • Magistrado PA, Lusingu J, Vestergaard LS et al. Immunoglobulin G antibody reactivity to a group A Plasmodium falciparum erythrocyte membrane protein 1 and protection from P. falciparum malaria. Infect. Immun. 75(5), 2415–2420 (2007).
  • Chan JA, Howell KB, Reiling L et al. Targets of antibodies against Plasmodium falciparum-infected erythrocytes in malaria immunity. J. Clin. Invest. 122(9), 3227–3238 (2012).
  • Udeinya IJ, Miller LH, McGregor IA, Jensen JB. Plasmodium falciparum strain-specific antibody blocks binding of infected erythrocytes to amelanotic melanoma cells. Nature 303(5916), 429–431 (1983).
  • Celada A, Cruchaud A, Perrin LH. Opsonic activity of human immune serum on in vitro phagocytosis of Plasmodium falciparum infected red blood cells by monocytes. Clin. Exp. Immunol. 47(3), 635–644 (1982).
  • Fowkes FJ, McGready R, Cross NJ et al. New insights into acquisition, boosting, and longevity of immunity to malaria in pregnant women. J. Infect. Dis. 206(10), 1612–1621 (2012).
  • Baruch DI, Gamain B, Barnwell JW et al. Immunization of Aotus monkeys with a functional domain of the Plasmodium falciparum variant antigen induces protection against a lethal parasite line. Proc. Natl Acad. Sci. USA 99(6), 3860–3865 (2002).
  • Gratepanche S, Gamain B, Smith JD, Robinson BA, Saul A, Miller LH. Induction of crossreactive antibodies against the Plasmodium falciparum variant protein. Proc. Natl Acad. Sci. USA 100(22), 13007–13012 (2003).
  • Ahuja S, Pettersson F, Moll K, Jonsson C, Wahlgren M, Chen Q. Induction of cross-reactive immune responses to NTS-DBL-1α/x of PfEMP1 and in vivo protection on challenge with Plasmodium falciparum. Vaccine 24(35–36), 6140–6154 (2006).
  • Ghumra A, Khunrae P, Ataide R et al. Immunisation with recombinant PfEMP1 domains elicits functional rosette-inhibiting and phagocytosis-inducing antibodies to Plasmodium falciparum. PLoS ONE 6(1), e16414 (2011).
  • Salanti A, Dahlbäck M, Turner L et al. Evidence for the involvement of VAR2CSA in pregnancy-associated malaria. J. Exp. Med. 200(9), 1197–1203 (2004).
  • Hommel M, Elliott SR, Soma V et al. Evaluation of the antigenic diversity of placenta-binding Plasmodium falciparum variants and the antibody repertoire among pregnant women. Infect. Immun. 78(5), 1963–1978 (2010).
  • Drew DR, Hodder AN, Wilson DW et al. Defining the antigenic diversity of Plasmodium falciparum apical membrane protein 1 and the requirements for a multi-allele vaccine against malaria. PLoS One doi:10.1371/journal.pone.0051023 (2012).
  • Avril M, Tripathi AK, Brazier AJ et al. A restricted subset of var genes mediates adherence of Plasmodium falciparum-infected erythrocytes to brain endothelial cells. Proc. Natl Acad. Sci. USA 109(26), E1782–E1790 (2012).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.