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Editorial

Computationally optimized antigens to overcome influenza viral diversity

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Pages 267-269 | Published online: 09 Jan 2014

References

  • Subbarao K, Luke C. H5N1 viruses and vaccines. PLoS Pathogens 3(3), e40 (2007).
  • Treanor JJ, Wilkinson BE, Masseoud F et al. Safety and immunogenicity of a recombinant hemagglutinin vaccine for H5 influenza in humans. Vaccine 19(13–14), 1732–1737 (2001).
  • Stephenson I, Bugarini R, Nicholson K et al. Cross reactivity to highly pathogenic avian influenza H5N1 viruses after vaccination with nonadjuvanted and MF59 adjuvanted influenza A/Duck/Singapore/97 (H5N3) vaccine: a potential priming strategy. J. Infect. Dis. 191(8), 1210–1215 (2005).
  • Cinatl J Jr, Michaelis M, Doerr H. The threat of avian influenza A (H5N1). Part IV: development of vaccines. Med. Microb. Immunol. 196(4), 213–225 (2007).
  • Finnefrock AC, Liu X, Opalka DW et al. HIV Type 1 vaccines for worldwide use: predicting in-clade and cross-clade breadth of immune responses. AIDS Res. Hum. Retroviruses 23(10), 1283–1292 (2007).
  • Kesturu GS, Colleton BA, Liu Y et al. Minimization of genetic distances by the consensus, ancestral, and center-of-tree (COT) sequences for HIV-1 variants within an infected individual and the design of reagents to test immune reactivity. Virology 348(2), 437–448 (2006).
  • Gao F, Liao H-X, Hahn BH et al. Centralized HIV-1 envelope immunogens and neutralizing antibodies. Curr. HIV Res. 5(6), 572–577 (2007).
  • Malm M, Rollman E, Ustav M et al. Crossclade protection induced by human immunodeficiency virus-1 DNA immunogens expressing consensus sequences of multiple genes and epitopes from subtypes A, B, C, and FGH. Viral Immunol. 18(4), 678–688 (2005).
  • Laddy DJ, Yan J, Khan AS et al. Electroporation of synthetic DNA antigens offers protection in nonhuman primates challenged with highly pathogenic avian influenza virus. J. Virol. 83(9), 4624–4630 (2009).
  • Giles BM, Bissel SJ, DeAlmeida DR et al. Antibody breadth and protective efficacy is increased by vaccination with computationally optimized hemagglutinin but not with polyvalent hemagglutinin base H5N1 VLP vaccines. Clin. Vaccine Immunol. doi:10.1128/CVI.05533-11 (2011) (Epub ahead of print).
  • Giles BM, Crevar CJ, Carter DM et al. Computationally-optimized hemagglutinin expressed on a virus-like particle vaccine elicits broadly-reactive antibodies that protect non-human primates from H5N1 clade 2 influenza infection. J. Infect. Dis. (2011) (In Press).
  • Gao F, Weaver EA, Lu Z et al. Antigenicity and immunogenicity of a synthetic human immunodeficiency virus Type 1 group M consensus envelope glycoprotein. J. Virol. 79(2), 1154–1163 (2005).
  • Hamano T, Sawanpanyalert P, Yanai H et al. Determination of HIV Type 1 CRF01_AE gag p17 and env-V3 consensus sequences for HIV/AIDS vaccine design. AIDS Res. Hum. Retroviruses 20(3), 337–340 (2004).
  • Krohn K, Stanescu I, Blazevic V et al. A DNA HIV-1 vaccine based on a fusion gene expressing non-structural and structural genes of consensus sequence of the A-C subtypes and the ancestor sequence of the F-H subtypes. Preclinical and clinical studies. Microbe. Infect. 7(14), 1405–1413 (2005).
  • Mwau M, Cebere I, Sutton J et al. A human immunodeficiency virus 1 (HIV-1) clade A vaccine in clinical trials: stimulation of HIV-specific T-cell responses by DNA and recombinant modified vaccinia virus Ankara (MVA) vaccines in humans. J. Gen. Virol. 85(4), 911–919 (2004).
  • Tompkins SM, Zhao Z-S, Lo C-Y et al. Matrix protein 2 vaccination and protection against influenza viruses, including subtype H5N1. Emer. Infect. Dis. 13(3), 426–435 (2007).
  • Laddy DJ, Yan J, Corbitt N et al. Immunogenicity of novel consensus-based DNA vaccines against avian influenza. Vaccine 25(16), 2984–2989 (2007).
  • Laddy DJ, Yan J, Kutzler M et al. Heterosubtypic protection against pathogenic human and avian influenza viruses via in vivo electroporation of synthetic consensus DNA antigens. PLoSONE 3(6), e2517 (2008).
  • Giles BM, Ross TM. Development of a computationally optimized broadly reactive (COBRA) hemagglutinin for elicitation of protective antibodies against multiple clades of H5N1. Vaccine 29, 3043–3054 (2011).
  • Horimoto T, Kawaoka Y. Influenza: lessons from past pandemics, warnings from current incidents. Nat. Rev. Microbiol. 3(8), 591–600 (2005).
  • Taubenberger JK, Kash JC. Influenza virus evolution, host adaptation, and pandemic formation. Cell Host Microbe 7(6), 440–451 (2010).
  • Lipatov AS, Govorkova EA, Webby RJ et al. Influenza: emergence and control. J. Virol. 78(17), 8951–8959 (2004).

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