Genetics and coronary artery disease

References

• Thomas CB, Cohen BH. The familial occurrence of hyper-tension and coronary artery disease, with observations concerning obesity and diabetes. Ann Intern Med 1955; 42: 90–127.
   Google Scholar
• Schildkraut JM, Myers RH, Cupples LA, Kiely DK, Kannel WB. Coronary risk associated with age and sex of parental heart disease in the Framingham Study. Am J Car-diol 1989; 64: 555–9.
   Google Scholar
• Colditz GA, Rimm EB, Giovannucci E, Stampfer MJ, Rosner B, Willett WC. A prospective study of parental history of myocardial infarction and coronary artery disease in men. Am J Cardiol 1991; 67: 933–8.
   Google Scholar
• Ciruzzi M, Schargrodsky H, Rozlosnik J, Pramparo P, Delmonte H, Rudich V, Piskorz D, Negri E, Soifer S, La Vecchia C. Frequency of family history of acute myocar-dial infarction in patients with acute myocardial infarction. Argentine FRICAS (Factores de Riesgo Comnario en Amer-ica del Sur) Investigators. Am J Cardiol 1997; 80: 122–7.
   Google Scholar
• Nora JJ, Lortscher RH, Spangler RD, Nora AH, Kimberling WJ. Genetic-epidemiologic study of early-onset ischemic heart disease. Circulation 1980; 61: 503–8.
   Google Scholar
• Lloyd-Jones DM, Nam BH, D’Agostino RB, Sr, Levy D, Murabito JM, Wang TJ, Wilson PW, O’Donnell CJ. Parental cardiovascular disease as a risk factor for cardio-vascular disease in middle-aged adults: a prospective study of parents and offspring. JAMA 2004; 291: 2204–11.
   Google Scholar
• Marenberg ME, Risch N, Berkman LF, Floderus B, de Faire U. Genetic susceptibility to death from coronary heart disease in a study of twins. N Engl J Med 1994; 330: 1041–6.
   Google Scholar
• Frings AM, Mayer B, Bocker W, Hengstenberg C, Willemsen D, Riegger GA, Schunkert H. Comparative coro-nary anatomy in six twin pairs with coronary artery dis-ease. Heart 2000; 83: 47–50.
   Google Scholar
• Nathoe HM, Stella PR, Eefting FD, De Jaegere PP. Angio-graphic findings in monozygotic twins with coronary artery disease. Am J Cardiol 2002; 89: 1006–9.
   Google Scholar
• Khot UN, Khot MB, Bajzer CT, Sapp SK, Ohman EM, Brener SJ, Ellis SG, Lincoff AM, Topol EJ. Prevalence of conventional risk factors in patients with coronary heart disease. JAMA 2003; 290: 898–904.
   Google Scholar
• Hamsten A, de Faire U. Risk factors for coronary artery disease in families of young men with myocardial infarc-tion. Am J Cardiol 1987; 59: 14–9.
   Google Scholar
• Khaw KT, Barrett-Connor E. Family history of heart attack: a modifiable risk factor? Circulation 1986; 74: 239–44.
   Google Scholar
• Jomini V, Oppliger-Pasquali S, Wietlisbach V, Rodondi N, Jotterand V, Paccaud F, Darioli R, Nicod P, Mooser V. Contribution of major cardiovascular risk factors to famil-ial premature coronary artery disease: the GENECARD project. J Am Coll Cardiol 2002; 40: 676–84.
   Google Scholar
• Rallidis LS, Megalou AA, Papageorgakis NH, Trikas AG, Chatzidimitriou GI, Tsitouris GK. Plasminogen activator inhibitor 1 is elevated in the children of men with prema-ture myocardial infarction. Thromb Haemost 1996; 76: 417–21.
   Google Scholar
• Mills JD, Mansfield MW, Grant PJ. Tissue plasminogen activator, fibrin D-dimer, and insulin resistance in the relatives of patients with premature coronary artery dis-ease. Arterioscler Thromb Vasc Biol 2002; 22: 704–9.
   Google Scholar
• Mills J, Mansfield M, Grant P. Elevated fibrinogen in the healthy male relatives of patients with severe, premature coronary artery disease. Eur Heart J 2002; 23: 1276–81.
   Google Scholar
• Margaglione M, Cappucci G, Colaizzo D, Vecchione G, Grandone E, Di Minno G. C-reactive protein in offspring is associated with the occurrence of myocardial infarction in first-degree relatives. Arterioscler Thromb Vasc Biol 2000; 20: 198–203.
   Google Scholar
• Shea S, Ottman R, Gabrieli C, Stein Z, Nichols A. Family history as an independent risk factor for coronary artery disease. J Am Coll Cardiol 1984; 4: 793–801.
   Google Scholar
• Barrett-Connor E, Khaw K. Family history of heart attack as an independent predictor of death due to cardiovascu-lar disease. Circulation 1984; 69: 1065–9.
   Google Scholar
• Rader DJ, Cohen J, Hobbs HH. Monogenic hypercholes-terolemia: new insights in pathogenesis and treatment. J Clin Invest 2003; 111: 1795–803.
   Google Scholar
• Aalst-Cohen ES, Jansen AC, de Jongh S, Sauvage Nolting PR, Kastelein JJ. Clinical, diagnostic, and therapeutic aspects of familial hypercholesterolemia. Semin Vasc Med 2004; 4: 31–41.
   Google Scholar
• Boren J, Ekstrom U, Agren B, Nilsson-Ehle P, Innerarity TL. The molecular mechanism for the genetic disorder familial defective apolipoprotein B100. J Biol Chem 2001; 276: 9214–8.
   Google Scholar
• Oram JF. Tangier disease and ABCA1 Biochim Biophys Acta 2000; 1529: 321–30.
   Google Scholar
• Sorci-Thomas MG, Thomas MJ. The effects of altered apolipoprotein A-I structure on plasma HDL concentra-tion. Trends Cardiovasc Med 2002; 12: 121–8.
   Google Scholar
• Sirtori CR, Calabresi L, Franceschini G, Baldassarre D, Amato M, Johansson J, Salvetti M, Monteduro C, Zuni R, Muiesan ML, Agabiti-Rosei E. Cardiovascular status of carriers of the apolipoprotein A-I(Milano) mutant: the Limone sul Garda study. Circulation 2001; 103: 1949–54.
   Google Scholar
• Nissen SE, Tsunoda T, Tuzcu EM, Schoenhagen P, Cooper CJ, Yasin M, Eaton GM, Lauer MA, Sheldon WS, Grines CL, Halpern S, Crowe T, Blankenship JC, Kerensky R. Effect of recombinant ApoA-I Milano oncoronary atherosclerosis in patients with acute coronary syndromes: a randomized controlled trial. JAMA 2003; 290: 2292–300.
   Google Scholar
• Stalenhoef AF. Interaction between genes and environment in inherited lipid disorders determines clinical presentation. Cardiovasc Drugs Ther 2002; 16: 271–2.
   Google Scholar
• Jansen AC, van Wissen S, Defesche JC, Kastelein JJ. Phe-notypic variability in familial hypercholesterolaemia: an update. Curr Opin Lipidol 2002; 13: 165–71.
   Google Scholar
• Wittekoek ME, Moll E, Pimstone SN, Trip MD, Lansberg PJ, Defesche JC, van Doormaal JJ, Hayden MR, Kastelein JJ. A frequent mutation in the lipoprotein lipase gene (D9N) deteriorates the biochemical and clinical phe-notype of familial hypercholesterolemia. Arterioscler Thromb Vasc Biol 1999; 19: 2708–13.
   Google Scholar
• Wittekoek ME, Pimstone SN, Reymer PW, Feuth L, Botma GJ, Defesche JC, Prins M, Hayden MR, Kastelein JJ. A common mutation in the lipoprotein lipase gene (N291S) alters the lipoprotein phenotype and risk for cardiovascu-lar disease in patients with familial hypercholesterolemia. Circulation 1998; 97: 729–35.
   Google Scholar
• Francke S, Manraj M, Lacquemant C, Lecoeur C, Lepretre F, Passa P, Hebe A, Corset L, Yan SL, Lahmidi S, Jankee S, Gunness TK, Ramjuttun US, Balgobin V, Dina C, Froguel P. A genome-wide scan for coronary heart disease suggests in Indo-Mauritians a susceptibility locus on chromosome 16p13 and replicates linkage with the meta-bolic syndrome on 3q27. Hum Mol Genet 2001; 10: 2751–65.
   Google Scholar
• Pajukanta P, Cargill M, Viitanen L, Nuotio I, Kareinen A, Perola M, Terwilliger JD, Kempas E, Daly M, Lilja H, Rioux JD, Brettin T, Viikari JS, Ronnemaa T, Laakso M, Lander ES, Peltonen L. Two loci on chromosomes 2 and X for premature coronary heart disease identified in early-and late-settlement populations of Finland. Am J Hum Genet 2000; 67: 1481–93.
   Google Scholar
• Broeckel U, Hengstenberg C, Mayer B, Holmer S, Martin LJ, Comuzzie AG, Blangero J, Nurnberg P, Reis A, Riegger GA, Jacob HJ, Schunkert H. A comprehensive link-age analysis for myocardial infarction and its related risk factors. Nat Genet 2002; 30: 210–4.
   Google Scholar
• Wang Q, Rao S, Shen GQ, Li L, Moliterno DJ, Newby LK, Rogers WJ, Cannata R, Zirzow E, Elston RC, Topol EJ. Premature myocardial infarction novel susceptibility locus on chromosome 1P34-36 identified by genomewide linkage analysis. Am J Hum Genet 2004; 74: 262–71.
   Google Scholar
• Wang L, Fan C, Topol SE, Topol EJ, Wang Q. Mutation of MEF2A in an inherited disorder with features of coronary artery disease. Science 2003; 302: 1578–81.
   Google Scholar
• Archacki SR, Angheloiu G, Tian XL, Tan FL, DiPaola N, Shen GQ, Moravec C, Ellis S, Topol EJ, Wang Q. Identifi-cation of new genes differentially expressed in coronary artery disease by expression profiling. Physiol Genomics 2003; 15: 65–74.
   Google Scholar
• You SA, Archacki SR, Angheloiu G, Moravec CS, Rao S, Kinter M, Topol EJ, Wang Q. Proteomic approach to coro-nary atherosclerosis shows ferritin light chain as a signifi-cant marker: evidence consistent with iron hypothesis in atherosclerosis. Physiol Genomics 2003; 13: 25–30.
   Google Scholar
• Whincup PH, Cook DG, Phillips AN, Shaper AG. ABO blood group and ischaemic heart disease in British men. BMJ 1990; 300: 1679–82.
   Google Scholar
• Garrison RI, Havlik RI, Harris RB, Feinleib M, Kannel WB, Padgett SJ. ABO blood group and cardiovacular disease: the Framingham study. Atherosclerosis 1976; 25: 311–8.
   Google Scholar
• Van Houte 0, Kesteloot H. An epidemiological survey of risk factors for ischemic heart disease in 42,804 men. I. Serum cholesterol value. Acta Cardiol 1972; 27: 527–64.
   Google Scholar
• von Beckerath N, Koch W, Mehilli J, Gorchakova 0, Braun S, Schomig A, Kastrati A. ABO locus 01 allele and risk of myocardial infarction. Blood Coagul Fibrinolysis 2004; 15: 61–7.
   Google Scholar
• Wheeler J, Keavney B, Watkins H, Collins R, Danesh J. Four paraoxonase gene polymorphisms in 11212 cases of coronary heart disease and 12786 controls: meta-analysis of 43 studies. Lancet 2004; 363: 689–95.
   Google Scholar
• Yamada Y, Izawa H, Ichihara S, Takatsu F, Ishihara H, Hirayama H, Sone T, Tanaka M, Yokota M. Prediction of the risk of myocardial infarction from polymorphisms in candidate genes. N Engl J Med 2002; 347: 1916–23.
   Google Scholar
• Ozaki K, Ohnishi Y, Iida A, Sekine A, Yamada R, Tsunoda T, Sato H, Sato H, Hori M, Nakamura Y, Tanaka T. Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarc-tion. Nat Genet 2002; 32: 650–4.
   Google Scholar
• Topol EJ, McCarthy J, Gabriel S, Moliterno DJ, Rogers WJ, Newby LK, Freedman M, Metivier J, Cannata R, O’Donnell CJ, Kottke-Marchant K, Murugesan G, Plow EF, Stenina 0, Daley GQ. Single nucleotide poly-morphisms in multiple novel thrombospondin genes may be associated with familial premature myocardial infarc-tion. Circulation 2001; 104: 2641–4.
   Google Scholar
• McCarthy JJ, Parker A, Salem R, Moliterno DJ, Wang Q, Plow EF, Rao S, Shen G, Rogers WJ, Newby LK, Cannata R, Glatt K, Topol EJ. Large scale association analysis for identification of genes underlying premature coronary heart disease: cumulative perspective from analy-sis of 111 candidate genes. J Med Genet 2004; 41: 334–41.
   Google Scholar
• Stengard JH, Weiss KM, Sing CF. An ecological study of association between coronary heart disease mortality rates in men and the relative frequencies of common allelic vari-ations in the gene coding for apolipoprotein E. Hum Genet 1998; 103: 234–41.
   Google Scholar
• Wilson PW, Schaefer EJ, Larson MG, Ordovas JM. Apolipoprotein E alleles and risk of coronary disease. A meta-analysis. Arterioscler Thromb Vasc Biol 1996; 16: 1250–5.
   Google Scholar
• Ilveskoski E, Perola M, Lehtimaki T, Laippala P. Savolainen V, Pajarinen J, Pennila A, Lalu KH, Mannikko A, Liesto KK, Koivula T, Karhunen PJ. Age-dependent association of apolipoprotein E genotype with coronary and aortic atherosclerosis in middle-aged men: an autopsy study. Circulation 1999; 100: 608–13.
   Google Scholar
• Liu S, Ma J, Ridker PM, Breslow JL, Stampfer MJ. A prospective study of the association between APOE geno-type and the risk of myocardial infarction among appar-ently healthy men. Atherosclerosis 2003; 166: 323–9.
   Google Scholar
• Eichner JE, Dunn ST, Perveen G, Thompson DM, Stewart KE, Stroehla BC. Apolipoprotein E polymorphism and cardiovascular disease: a HuGE review. Am J Epidemiol 2002; 155: 487–95.
   Google Scholar
• Boekholdt SM, Bijsterveld NR, Moons AH, Levi M, Buller HR, Peters RJ. Genetic variation in coagulation and fibrinolytic proteins and their relation with acute myocar-dial infarction: a systematic review. Circulation 2001; 104: 3063–8.
   Google Scholar
• French JK, Van De Water NS, Sutton TM, Lund M, Gao W, McDowell J, Liu-Stratton Y, Pohorence J, Szymanski D, Goldschmidt-Clermont P, White HD, Browett PJ, Cooke G. Potential thrombophilic mutations/polymorphisms in patients with no flow-limiting steno-sis after myocardial infarction. Am Heart J 2003; 145: 118–24.
   Google Scholar
• Atherosclerosis, Thrombosis, and Vascular Biology Italian Study Group. No evidence of association between prothrombotic gene polymorphisms and the development of acute myocardial infarction at a young age. Circulation 2003; 107: 1117–22.
   Google Scholar
• Wang XL, Raveendran M, Wang J. Genetic influence on cigarette-induced cardiovascular disease. Frog Cardiovasc Dis 2003; 45: 361–82.
   Google Scholar
• Humphries SE, Talmud PJ, Hawe E, Bolla M, Day IN, Miller GJ. Apolipoprotein E4 and coronary heart disease in middle-aged men who smoke: a prospective study. Lancet 2001; 358: 115–9.
   Google Scholar
• Keavney B, Parish S, Palmer A, Clark S, Youngman L, Danesh J, McKenzie C, Delepine M, Lathrop M, Peto R, Collins R. Large-scale evidence that the cardiotoxicity of smoking is not significantly modified by the apolipoprotein E epsilon2/epsilon3/epsilon4 genotype. Lancet 2003; 361: 396–8.
   Google Scholar
• Senti M, Elosua R, Tomas M, Sala J, Masia R, Ordovas JM, Shen H, Marrugat J. Physical activity modulates the combined effect of a common variant of the lipoprotein lipase gene and smoking on serum triglyceride levels and high-density lipoprotein cholesterol in men. Hum Genet 2001; 109: 385–92.
   Google Scholar
• Hokanson JE, Kamboh MI, Scarboro S, Eckel RH, Hamman RE Effects of the hepatic lipase gene and physical activity on coronary heart disease risk. Am J Epidemiol 2003; 158: 836–43.
   Google Scholar
• Chasman DI, Posada D, Subrahmanyan L, Cook NR, Stanton VP, Jr., Ridker PM. Pharmacogenetic study of statin therapy and cholesterol reduction. JAMA 2004; 291: 2821–7.
   Google Scholar
• Kuivenhoven JA, Jukema JW, Zwinderman AH, de Knijff P, McPherson R, Bruschke AV, Lie KI, Kastelein JJ. The role of a common variant of the cholesteryl ester transfer protein gene in the progression of coronary atherosclerosis. The Regression Growth Evaluation Statin Study Group. N Engl J Med 1998; 338: 86–93.
   Google Scholar
• Gerdes LU, Gerdes C, Kervinen K, Savolainen M, Klausen IC, Hansen PS, Kesaniemi YA, Faergeman 0. The apolipoprotein epsilon4 allele determines prognosis and the effect on prognosis of simvastatin in survivors of myocar-dial infarction: a sub study of the Scandinavian simvastatin survival study. Circulation 2000; 101: 1366–71.
   Google Scholar
• Blankenberg S, Rupprecht HJ, Bickel C, Jiang XC, Poirier 0, Lackner KJ, Meyer J, Cambien F, Tiret L. Com-mon genetic variation of the cholesteryl ester transfer pro-tein gene strongly predicts future cardiovascular death in patients with coronary artery disease. J Am Coll Cardiol 2003; 41: 1983–9.
   Google Scholar
• Boekholdt SM, Agema WR, Peters RJ, Zwinderman AH, van der Wall EE, Reitsma PH, Kastelein JJ, Jukema JW. Variants of toll-like receptor 4 modify the efficacy of statin therapy and the risk of cardiovascular events. Circulation 2003; 107: 2416–21.
   Google Scholar
• Carlquist JF, Muhlestein JB, Horne BD, Hart NI, Bair TL, Molhuizen HO, Anderson JL. The cholesteryl ester trans-fer protein Taq1B gene polymorphism predicts clinical ben-efit of statin therapy in patients with significant coronary artery disease. Am Heart J2003; 146: 1007–14.
   Google Scholar
• de Maat MP, Jukema JW, Ye S, Zwinderman AH, Moghaddam PH, Beekman M, Kastelein JJ, van Boven AJ, Bruschke AV, Humphries SE, Kluft C, Henney AM. Effect of the stromelysin-1 promoter on efficacy of pravastatin in coronary atherosclerosis and restenosis. Am J Cardiol 1999; 83: 852–6.
   Google Scholar
• Elrayess MA, Webb KE, Flavell DM, Syvanne M, Taskinen MR, Frick MH, Nieminen MS, Kesaniemi YA, Pasternack A, Jukema JW, Kastelein JJ, Zwinderman AH, Humphries SE. A novel functional polymorphism in the PECAM-1 gene (53G> A) is associated with progression of atherosclerosis in the LOCAT and REGRESS studies. Atherosclerosis 2003; 168: 131–8.
   Google Scholar
• Kajinami K, Brousseau ME, Ordovas JM, Schaefer EJ. Polymorphisms in the multidrug resistance-1 (MDR1) gene influence the response to atorvastatin treatment in a gender-specific manner. Am J Cardiol 2004; 93: 1046–50.
   Google Scholar
• Kunnas TA, Lehtimaki T, Laaksonen R, Ilveskoski E, Janatuinen T, Vesalainen R, Nuutila P. Karhunen PJ, Knuuti J, Nikkari ST. Endothelial nitric oxide synthase genotype modulates the improvement of coronary blood flow by pravastatin: a placebo-controlled PET study. J Mol Med 2002; 80: 802–7.
   Google Scholar
• Marian AJ, Safavi F, Ferlic L, Dunn JK, Gotto AM, Ballantyne CM. Interactions between angiotensin-I con-verting enzyme insertion/deletion polymorphism and response of plasma lipids and coronary atherosclerosis to treatment with fluvastatin: the lipoprotein and coronary atherosclerosis study. J Am Coll Cardiol 2000; 35: 89–95.
   Google Scholar
• Undas A, Sydor WJ, Brummel K, Musial J, Mann KG, Szczeklik A. Aspirin alters the cardioprotective effects of the factor XIII Va134Leu polymorphism. Circulation 2003; 107: 17–20.
   Google Scholar
• O’Connor FF, Shields DC, Fitzgerald A, Cannon CP, Braunwald E, Fitzgerald DJ. Genetic variation in glyco-protein IIb/IIIa (GPIIb/IIIa) as a determinant of the responses to an oral GPIIb/IIIa antagonist in patients with unstable coronary syndromes. Blood 2001; 98: 3256–60.
   Google Scholar
• Angiolillo DJ, Fernandez-Ortiz A, Bernardo E, Ramirez C, Escaned J, Moreno R, Hernandez-Antolin R, Sabate M, Trabetti E, Pignatti PF, Macaya C. 807 C/T Polymorphism of the glycoprotein Ia gene and pharmacogenetic modula-tion of platelet response to dual antiplatelet treatment. Blood Coagul Fibrinolysis 2004; 15: 427–33.
   Google Scholar
• Angiolillo DJ, Fernandez-Ortiz A, Bernardo E, Alfonso F, Sabate M, Fernandez C, Stranieri C, Trabetti E, Pignatti PF, Macaya C. RA polymorphism and platelet reactivity following clopidogrel loading dose in patients undergoing coronary stent implantation. Blood Coagul Fibrinolysis 2004; 15: 89–93.
   Google Scholar
• Shields DC, Fitzgerald AP, O’Neill PA, Muckian C, KennyD, Moran B, Cannon CP, Byrne CE, Fitzgerald DJ. The contribution of genetic factors to thrombotic and bleeding outcomes in coronary patients randomised to IIb/IIIa antagonists. Pharmacogenomics J 2002; 2: 182–90.
   Google Scholar
• De Sutter J, De Bacquer D, Kotseva K, Sans S, Pyorala K, Wood D, De Backer G. Screening of family members of patients with premature coronary heart disease; results from the EUROASPIRE II family survey. Eur Heart J2003; 24: 249–57.
   Google Scholar
• Girelli D, Russo C, Ferraresi P, Olivieri 0, Pinotti M, Friso S, Manzato F, Ma77ucco A, Bernardi F, Corrocher R. Polymorphisms in the factor VII gene and the risk of myocardial infarction in patients with coronary artery dis-ease. N Engl J Med 2000; 343: 774–80.
   Google Scholar
• Ogawa M, Abe S, Biro S, Saigo M, Kihara T, Setoyama S, Matsuoka T, Toda H, Toni H, Atsuchi Y, Toyama Y, Tateishi S, Minagoe S, Maruyama I, Tei C. R353Q polymorphism, activated factor VII, and risk of premature myocardial infarction in Japanese men. Circ J2004; 68: 520–5.
   Google Scholar
• Kohler HP, Stickland MH, Ossei-Gerning N, Carter A, Mikkola H, Grant PJ. Association of a common polymorphism in the factor XIII gene with myocardial infarction. Thromb Haemost 1998; 79: 8–13.
   Google Scholar
• Boekholdt SM, Trip MD, Peters RJ, Engelen M, Boer JM, Feskens EJ, Zwinderman AH, Kastelein JJ, Reitsma PH. Thrombospondin-2 polymorphism is associated with a reduced risk of premature myocardial infarction. Arte-rioscler Thromb Vasc Biol 2002; 22: e24–e27.
   Google Scholar
• Wessel J, Topol EJ, Ji M, Meyer J, McCarthy JJ. Replica-tion of the association between the thrombospondin-4 A387P polymorphism and myocardial infarction. Am Heart J 2004; 147: 905–9.
   Google Scholar
• Chao TH, Li YH, Chen JH, Wu HL, Shi GY, Tsai WC, Chen PS, Liu PY. Relation of thrombomodulin gene poly-morphisms to acute myocardial infarction in patients . Am J Cardiol 2004; 93: 204–7.
   Google Scholar
• Gonzalez-Conejero R, Corral J, Roldan V, Martinez C, Marin F, Rivera J, Iniesta JA, Lozano ML, Marco P, Vicente V. A common polymorphism in the annexin V Kozak sequence (-1C> T) increases translation efficiency and plasma levels of annexin V, and decreases the risk of myocardial infarction in young patients. Blood 2002; 100: 2081–6.
   Google Scholar
• Georges JL, Loukaci V, Poirier 0, Evans A, Luc G, Arveiler D, Ruidavets JB, Cambien F, Tiret L. Interleukin-6 gene polymorphisms and susceptibility to myocardial infarction: the ECTIM study. Etude Cas-Temoin de l’Infarctus du Myocarde. J Mol Med 2001; 79: 300–5.
   Google Scholar
• Zee RY, Cook NR, Cheng S, Erlich HA, Lindpaintner K, Lee RT, Ridker PM. Threonine for alanine substitution in the eotaxin (CCL11) gene and the risk of incident myocar-dial infarction. Atherosclerosis 2004; 175: 91–4.
   Google Scholar
• Ozaki K, Inoue K, Sato H, lida A, Ohnishi Y, Sekine A, Sato H, Odashiro K, Nobuyoshi M, Hon M, Nakamura Y, Tanaka T. Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin-alpha secretion in vitro. Nature 2004; 429: 72–5.
   Google Scholar
• Helgadottir A, Manolescu A, Thorleifsson G, Gretarsdottir S, Jonsdottir H, Thorsteinsdottir U, Samani NJ, Gudmundsson G, Grant SF, Thorgeirsson G, Sveinbjornsdottir S, Valdimarsson EM, Matthiasson SE, Johannsson H, Gudmundsdottir 0, Gurney ME, Sainz J, Thorhallsdottir M, Andresdottir M, Frigge ML, Topol EJ, Kong A, Gudnason V, Hakonarson H, Gulcher JR, Stefansson K. The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. Nat Genet 2004; 36: 233–9.
   Google Scholar
• Poirier 0, Nicaud V, Gariepy J, Courbon D, Elbaz A, Morrison C, Kee F, Evans A, Arveiler D, Ducimetiere P, Amarenco P, Cambien F. Polymorphism R92Q of the tumour necrosis factor receptor 1 gene is associated with myocardial infarction and carotid intima-media thickness-the ECTIM, AXA, EVA and GENIC Studies. Eur J Hum Genet 2004; 12: 213–9.
   Google Scholar
• Ortlepp JR, Vesper K, Mevissen V, Schmitz F, Janssens U, Franke A, Hanrath P, Weber C, Zerres K, Hoffmann R. Chemokine receptor (CCR2) genotype is associated with myocardial infarction and heart failure in patients under 65 years of age. J Mol Med 2003; 81: 363–7.
   Google Scholar
• Shimada K, Watanabe Y, Mokuno H, Iwama Y, Daida H, Yamaguchi H. Common polymorphism in the promoter of the CD14 monocyte receptor gene is associated with acutemyocardial infarction in Japanese men. Am J Cardiol 2000;86: 682-4, A8.
   Google Scholar
• Yamada Y, Izawa H, Ichihara S, Takatsu F, Ishihara H, Hirayama H, Sone T, Tanaka M, Yokota M. Prediction of the risk of myocardial infarction from polymorphisms in candidate genes. N Engl J Med 2002; 347: 1916–23.
   Google Scholar
• Ladenvall P, Johansson L, Jansson JH, Jern S, Nilsson TK, Tjarnlund A, Jern C, Boman K. Tissue-type plasminogen activator -7,351C/T enhancer polymorphism is associated with a first myocardial infarction. Thromb Haemost 2002;87: 105–9.
   Google Scholar
• Beyzade S, Zhang S, Wong YK, Day IN, Eriksson P, Ye S. Influences of matrix metalloproteinase-3 gene variation on extent of coronary atherosclerosis and risk of myocardial infarction. J Am Coll Cardiol 2003; 41: 2130–7.
   Google Scholar
• Nojiri T, Morita H, Imai Y, Maemura K, Ohno M, Ogasawara K, Aizawa T, Saito A, Hayashi D, Hirata Y, Sugiyama T, Yamazaki T, Nagai R. Genetic variations of matrix metalloproteinase-1 and -3 promoter regions and their associations with susceptibility to myocardial infarc-tion in Japanese. Int J Cardiol 2003; 92: 181–6.
   Google Scholar
• Herrmann SM, Whatling C, Brand E, Nicaud V, Gariepy J, Simon A, Evans A, Ruidavets JB, Arveiler D, Luc G, Tiret L, Henney A, Cambien F. Polymorphisms of the human matrix gla protein (MGP) gene, vascular calcifica-tion, and myocardial infarction. Arterioscler Thromb Vasc Biol 2000; 20: 2386–93.
   Google Scholar
• Ridker PM, Cook NR, Cheng S, Erlich HA, Lindpaintner K, Plutzky J, Zee RY. Alanine for proline substitution in the peroxisome proliferator-activated receptor gamma-2 (PPARG2) gene and the risk of incident myocardial infarc-tion. Arterioscler Thromb Vasc Biol 2003; 23: 859–63.
   Google Scholar
• Endler G, Mannhaher C, Sunder-Plassmann H, Schillinger M, Klimesch A, Exner M, Kapiotis S, Meier S, Kunz F, Raiger E, Huber K, Wagner 0, Sunder-Plassmann R. The K121Q polymorphism in the plasma cell membrane glyco-protein 1 gene predisposes to early myocardial infarction. J Mol Med 2002; 80: 791–5.
   Google Scholar
• Casorelli I, De S, V, Leone AM, Chiusolo P, Burzotta F, Paciaroni K, Rossi E, Andreotti F, Leone G, Maseri A. The C807T/G873A polymorphism in the platelet glycoprotein Ia gene and the risk of acute coronary syndrome in the Ital-ian population. Br J Haematol 2001; 114: 150–4.
   Google Scholar
• Mikkelsson J, Perola M, Penttila A, Karhunen PJ. Platelet glycoprotein Ibalpha HPA-2 Met/VNTR B haplotype as a genetic predictor of myocardial infarction and sudden car-diac death. Circulation 2001; 104: 876–80.
   Google Scholar
• Bojesen SE, Juul K, Schnohr P, Tybjaerg-Hansen A, Nordestgaard BG. Platelet glycoprotein IIb/IIIa Pl(A2)/P1(A2) homozygosity associated with risk of ischemic cardiovascular disease and myocardial infarction in young men: the Copenhagen City Heart Study. J Am Coll Cardiol 2003; 42: 661–7.
   Google Scholar
• Croft SA, Samani NJ, Teare MD, Hampton KK, Steeds RP, Channer KS, Daly ME. Novel platelet membrane glyco-protein VI dimorphism is a risk factor for myocardial infarc-tion. Circulation 2001; 104: 1459–63.
   Google Scholar
• Fumeron F, Betoulle D, Nicaud V, Evans A, Kee F, Ruidavets JB, Arveiler D, Luc G, Cambien F. Serotonin transporter gene polymorphism and myocardial infarction: Etude Cas-Temoins de l’Infarctus du Myocarde (ECTIM). Circulation 2002; 105: 2943–5.
   Google Scholar
• Webb KE, Martin JF, Hamsten A, Eriksson P, Iacoviello L, Gattone M, Donati MB, Di Castelnuovo A, Erusalimsky J, Humphries SE. Polymorphisms in the thrombopoietin geneare associated with risk of myocardial infarction at a young age. Atherosclerosis 2001; 154: 703–11.
   Google Scholar
• Sen-Banerjee S, Siles X, Campos H. Tobacco smoking mod-ifies association between Gln-Arg192 polymorphism of human paraoxonase gene and risk of myocardial infarc-tion. Arterioscler Thromb Vasc Biol 2000; 20: 2120–6.
   Google Scholar
• Wilson MH, Grant PJ, Hardie U, Wild CP. Glutathione S-transferase M1 null genotype is associated with a decreased risk of myocardial infarction. FASEB J2000; 14: 791–6.
   Google Scholar
• Koide S, Kugiyama K, Sugiyama S, Nakamura S, Fukushima H, Honda 0, Yoshimura M, Ogawa H. Association of poly-morphism in glutamate-cysteine ligase catalytic subunit gene with coronary vasomotor dysfunction and myocardial infarc-tion. J Am Coll Cardiol 2003; 41: 539–45.
   Google Scholar
• Nakamura S, Kugiyama K, Sugiyama S, Miyamoto S, Koide S, Fukushima H, Honda 0, Yoshimura M, Ogawa H. Polymorphism in the 5’-flanking region of human gluta-mate-cysteine ligase modifier subunit gene is associated with myocardial infarction. Circulation 2002; 105: 2968–73.
   Google Scholar
• Jiang H, Klein RM, Niederacher D, Du M, Marx R, Horlitz M, Boerrigter G, Lapp H, Scheffold T, Krakau I, Gulker H. C/T polymorphism of the intercellular adhesion molecule-1 gene (exon 6, codon 469). A risk factor for coro-nary heart disease and myocardial infarction. Int J Cardiol 2002; 84: 171–7.
   Google Scholar
• Kee F, Morrison C, Evans AE, McCrum E, McMaster D, Dallongeville J, Nicaud V, Poirier 0, Cambien F. Polymor-phisms of the P-selectin gene and risk of myocardial infarc-tion in men and women in the ECTIM extension study. Etude cas-temoin de l’infarctus myocarde. Heart 2000; 84: 548–52.
   Google Scholar
• Tregouet DA, Barbaux S, Escolano S, Tahri N, Golmard JL, Tiret L, Cambien F. Specific haplotypes of the P-selectin gene are associated with myocardial infarction. Hum Mol Genet 2002; 11: 2015–23.
   Google Scholar
• Sasaoka T, Kimura A, Hohta SA, Fukuda N, Kurosawa T, Izumi T. Polymorphisms in the platelet-endothelial cell adhesion molecule-1 (PECAM-1) gene, Asn563Ser and Gly670Arg, associated with myocardial infarction in the Japanese. Ann N Y Acad Sci 2001; 947: 259–69.
   Google Scholar
• Fernandez-Arcas N, Dieguez-Lucena JL, Munoz-Moran E, Ruiz-Galdon M, Espinosa-Caliani S, Aranda-Lara P, Rius-Diaz F, Gaitan-Arroyo MJ, Teresa-Galvan E, Reyes-Engel A. Both alleles of the M235T polymorphism of the angiotensinogen gene can be a risk factor for myocardial infarction. Clin Genet 2001; 60: 52–7.
   Google Scholar
• Cambien F, Poirier 0, Lecerf L, Evans A, Cambou JP, Arveiler D, Luc G, Bard JM, Bara L, Ricard S. Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction. Nature 1992; 359: 641–4.
   Google Scholar
• Gonzalez P, Diez-Juan A, Coto E, Alvarez V, Reguero JR, Batalla A, Andres V. A single-nucleotide polymorphism in the human p27kipl gene (-838C > A) affects basal promoter activ-ity and the risk of myocardial infarction. BMC Biol 2004; 2: 5.
   Google Scholar
• Fan YM, Salonen JT, Koivu TA, Tuomainen TP, Nyysso-nen K, Lakka TA, Salonen R, Seppanen K, Nikkari ST, Tahvanainen E, Lehtimaki T. Hepatic lipase C-480T poly-morphism modifies the effect of HDL cholesterol on the risk of acute myocardial infarction in men: a prospective population based study. J Med Genet 2004; 41: e28.
   Google Scholar
• Hubacek JA, Skodova Z, Adamkova V, Lanska V, Poledne R. The influence of APOAV polymorphisms (T-1131 > C and S19> W) on plasma triglyceride levels and risk of myocardial infarction. Clin Genet 2004; 65: 126–30.
   Google Scholar
• Tregouet DA, Ricard S, Nicaud V, Arnould I, Soubigou S, Rosier M, Duverger N, Poirier 0, Mace S, Kee F, Morrison C, Denefle P, Tiret L, Evans A, Deleuze JF, Cambien F. In-depth haplotype analysis of ABCA1 gene polymorphisms in relation to plasma ApoAl levels and myocardial infarction. Arterioscler Thromb Vasc Biol 2004; 24: 775–81.
   Google Scholar
• Chiodini BD, Barlera S, Franzosi MG, Beceiro VL, Introna M, Tognoni G. APO B gene polymorphisms and coronary artery disease: a meta-analysis. Atherosclerosis 2003; 167: 355–66.
   Google Scholar
• Brscic E, Bergerone S, Gagnor A, Colajanni E, Matullo G, Scaglione L, Cassader M, Gaschino G, Di Leo M, Brusca A, Pagano GF, Piazza A, Trevi GP. Acute myocar-dial infarction in young adults: prognostic role of angiotensin-converting enzyme, angiotensin II type I recep-tor, apolipoprotein E, endothelial constitutive nitric oxide synthase, and glycoprotein Ma genetic polymorphisms at medium-term follow-up. Am Heart J 2000; 139: 979–84.
   Google Scholar
• Mango R, Clementi F, Borgiani P, Forleo GB, Federici M, Contino G, Giardina E, Garza L, Fahdi IE, Lauro R, Mehta JL, Novelli G, Romeo F. Association of single nucleotide polymorphisms in the oxidised LDL receptor 1 (OLR1) gene in patients with acute myocardial infarction. J Med Genet 2003; 40: 933–6.
   Google Scholar
• Tatsuguchi M, Furutani M, Hinagata J, Tanaka T, Furutani Y, Imamura S, Kawana M, Masaki T, Kasanuki H, Sawamura T, Matsuoka R. Oxidized LDL receptor gene (OLR1) is associated with the risk of myocar-dial infarction. Biochem Biophys Res Commun 2003; 303: 247–50.
   Google Scholar
• Holmer SR, Hengstenberg C, Kraft HG, Mayer B, Poll M, Kurzinger S, Fischer M, Lowel H, Klein G, Riegger GA, Schunkert H. Association of polymorphisms of the apolipoprotein(a) gene with lipoprotein(a) levels and myocardial infarction. Circulation 2003; 107: 696–701.
   Google Scholar
• Gonzalez P, Alvarez R, Reguero JR, Batalla A, Alvarez V, Cortina A, Cubero GI, Garcia-Castro M, Coto E. Variation in the lipoprotein receptor-related protein, alpha2-macroglobulin and lipoprotein receptor-associated protein genes in relation to plasma lipid levels and risk of early myocardial infarction. Coron Artery Dis 2002; 13: 251–4.
   Google Scholar
• Cipollone F, Toniato E, Martinotti S, Fazia M, Iezzi A, Cuccurullo C, Pini B, Ursi S, Vitullo G, Averna M, Arca M, Montali A, Campagna F, Ucchino S, Spigonardo F, Taddei S, Virdis A, Ciabattoni G, Notarbartolo A, Cuccurullo F, Mezzetti A. A polymorphism in the cyclooxygenase 2 gene as an inherited protective factor against myocardial infarc-tion and stroke. JAMA 2004; 291: 2221–8.
   Google Scholar
• Fatini C, Sofi F, Sticchi E, Gensini F, Gori AM, Fedi S, Lapini I, Rostagno C, Comeglio M, Brogi D, Gensini G, Abbate R. Influence of endothelial nitric oxide synthase gene polymorphisms (G894T, 4a4b, T-786C) and hyperho-mocysteinemia on the predisposition to acute coronary syn-dromes. Am Heart J2004; 147: 516–21.
   Google Scholar
• Kunnas TA, Ilveskoski E, Niskakangas T, Laippala P. Kajander OA, Mikkelsson J, Goebeler S, Penttila A, Perola M, Nikkari ST, Karhunen PJ. Association of the endothelial nitric oxide synthase gene polymorphism with risk of coronary artery disease and myocardial infarction in middle-aged men. J Mol Med 2002; 80: 605–9.
   Google Scholar
• Gruchala M, Ciecwierz D, Wasag B, Targonski R, Dubaniewicz W, Nowak A, Sobiczewski W, Ochman K, Romanowski P, Limon J, Rynkiewicz A. Association of theScaI atrial natriuretic peptide gene polymorphism with non-fatal myocardial infarction and extent of coronary artery disease. Am Heart J2003; 145: 125–31.
   Google Scholar
• Nakayama T, Soma M, Saito S, Honye J, Sato M, Aoi N, Kosuge K, Haketa A, Kanmatsuse K, Kokubun S. Mis-sense mutation of exon 3 in the type A human natriuretic peptide receptor gene is associated with myocardial infarc-tion. Med Sci Monit 2003; 9: CR505-CR510.
   Google Scholar
• Nakayama T, Soma M, Saito S, Honye J, Yajima J, Rahmutula D, Kaneko Y, Sato M, Uwabo J, Aoi N, Kosuge K, Kunimoto M, Kanmatsuse K, Kokubun S. Association of a novel single nucleotide polymorphism of the prostacyclin synthase gene with myocardial infarction. Am Heart J2002; 143: 797–801.
   Google Scholar
• Yokota M, Ichihara S, Lin TL, Nakashima N, Yamada Y Association of a T29-> C polymorphism of the transforming growth factor-beta 1 gene with genetic susceptibility to myocardial infarction in Japanese. Circulation 2000; 101: 2783–7.
   Google Scholar
• Yamada S, Akita H, Kanazawa K, Ishida T, Hirata K, Ito K, Kawashima S, Yokoyama M. T102C polymorphism of the serotonin (5-HT) 2A receptor gene in patients with non-fatal acute myocardial infarction. Atherosclerosis 2000; 150: 143–8.
   Google Scholar
• Eriksson AL, Skrtic S, Niklason A, Hulten LM, Wiklund 0, Hedner T, Ohlsson C. Association between the low activity genotype of catechol-O-methyltransferase and myocardial infarction in a hypertensive population. Eur Heart J2004; 25: 386–91.
   Google Scholar
• Shearman AM, Cupples LA, Demissie S, Peter I, Schmid CH, Karas RH, Mendelsohn ME, Housman DE, Levy D. Association between estrogen receptor alpha gene variation and cardiovascular disease. JAMA 2003; 290: 2263–70.
   Google Scholar
• Iwai C, Akita H, Kanazawa K, Shiga N, Terashima M, Matsuda Y, Takai E, Miyamoto Y, Shimizu M, Kajiya T, Hayashi T, Yokoyama M. Arg389Gly polymorphism of the human betal-adrenergic receptor in patients with nonfatal acute myocardial infarction. Am Heart J2003; 146: 106–9.
   Google Scholar
• Snapir A, Mikkelsson J, Perola M, Penttila A, Scheinin M, Karhunen PJ. Variation in the alpha2B-adrenoceptor gene as a risk factor for prehospital fatal myocardial infarction and sudden cardiac death. J Am Coll Cardiol 2003; 41: 190–4.
   Google Scholar
• Cannon CP, Battler A, Brindis RG, Cox JL, Ellis SG, Every NR, Flaherty JT, Harrington RA, Krumholz HM, Simoons ML, Van de Werf FJ, Weintraub WS, Mitchell KR, Morrisson SL, Brindis RG, Anderson HV, Cannom DS, Chitwood WR, Cigarroa JE, Collins-Nakai RL, Ellis SG, Gibbons RJ, Grover FL, Heidenreich PA, Khandheria BK, Knoebel SB, Krumholz HL, Malenka DJ, Mark DB, Mckay CR, Passamani ER, Radford MJ, Riner RN, Schwartz JB, Shaw RE, Shemin RJ, Van Fossen DB, Verrier ED, Watkins MW, Phoubandith DR, Furnelli T. American College of Cardiology key data elements and definitions for measuring the clinical management and outcomes of patients with acute coronary syndromes. A report of the American College of Cardiology Task Force on Clinical Data Standards (Acute Coronary Syndromes Writing Com-mittee). J Am Coll Cardiol 2001; 38: 2114–30.
   Google Scholar
• Hauser ER, Crossman DC, Granger CB, Haines JL, Jones CJ, Mooser V, McAdam B, Winkelmann BR, Wiseman AH, Muhlestein JB, Bartel AG, Dennis CA, Dowdy E, Estabrooks S, Eggleston K, Francis S, Roche K, levenger PW, Huang L, Pedersen B, Shah S, Schmidt S, Haynes C, West S, Asper D, Booze M, Sharma S, Sundseth S, Middleton L, Roses AD, Hauser MA, Vance JM, Pericak-Vance MA, Kraus WE. A genomewide scan for early-onset coronary artery disease in 438 families: the GENECARD Study. Am J Hum Genet 2004; 75(3): 436–47.
   Google Scholar
• Hauser ER, Mooser V, Crossman DC, Haines JL, Jones CH, Winkelmann BR, Schmidt S, Scott WK, Roses AD, Pericak-Vance MA, Granger CB, Kraus WE. Design of the Genet-ics of Early Onset Cardiovascular Disease (GENECARD) study. Am Heart J2003; 145: 602–13.
   Google Scholar
• Harrap SB, Zammit KS, Wong ZY, Williams FM, Bahlo M, Tonkin AM, Anderson ST. Genome-wide linkage analysis of the acute coronary syndrome suggests a locus on chro-mosome 2. Arterioscler Thromb Vasc Biol 2002; 22: 874–8.
   Google Scholar
• Casas JP, Bautista LE, Humphries SE, Hingorani AD. Endothelial nitric oxide synthase genotype and ischemic heart disease: meta-analysis of 26 studies involving 23028 subjects. Circulation 2004; 109: 1359–65.
   Google Scholar
• Morgan TM, Coffey CS, Krumholz HM. Overestimation of genetic risks owing to small sample sizes in cardiovascular studies. Clin Genet 2003; 64: 7–17.
   Google Scholar
• Klerk M, Verhoef P, Clarke R, Blom HJ, Kok FJ, Schouten EG. MTHFR 677C—> T polymorphism and risk of coronary heart disease: a meta-analysis. JAMA 2002; 288: 2023–31.
   Google Scholar
• Di Castelnuovo A, de Gaetano G, Donati MB, Iacoviello L. Platelet glycoprotein receptor IIIa polymorphism PLA1/PLA2 and coronary risk: a meta-analysis. Thromb Haemost 2001; 85: 626–33.
   Google Scholar
• Burzotta F, Paciaroni K, De S, V, Crea F, Maseri A, Leone G, Andreotti F. G20210A prothrombin gene poly-morphism and coronary ischaemic syndromes: a pheno-type-specific meta-analysis of 12 034 subjects. Heart 2004; 90: 82–6.
   Google Scholar