Carotid intima-media thickness: more than a research tool?

References

• Pignoli P, Tremoli E, Poli A, Oreste P, Paoletti R. Intimal plus medial thickness of the arterial wall: a direct measure-ment with ultrasound imaging. Circulation 1986; 74: 1399–1406.
   Google Scholar
• Schulte-Altedorneburg G, Droste DW, Felszeghy S, Kellermann M, Popa V, Hegedus K, Hegedus C, Schmid M, Modis L, Ringelstein EB, Csiba L. Accuracy of in vivo carotid B-mode ultrasound compared with pathological analysis: intima-media thickening, lumen diameter, and cross-sectional area. Stroke 2001; 32: 1520–4.
   Google Scholar
• Bots ML, Grobbee DE. Intima media thickness as a surro-gate marker for generalised atherosclerosis. Cardiovasc Drugs Ther 2002; 16: 341–351.
   Google Scholar
• Touboul PJ, Hennerici MG, Meairs S, Adams H, Amarenco P, Bornstein N, Csiba L, Desvarieux M, Ebrahim S, Fatar M, Hernandez HR, Jaff M, Kownator S, Prati P. Rundek T, Sitzer M, Schminke U, Tardif JC, Taylor A, Vicaut E, Woo KS, Zannad F, Zureik M. Mannheim carotid intima-media thickness consensus (2004–2006). An update on behalf of the Advisory Board of the 3rd and 4th Watching the Risk Symposium, 13th and 15th European Stroke Conferences, Mannheim, Germany, 2004, and Brussels, Belgium, 2006. Cerebrovasc Dis 2007; 23: 75–80.
   Google Scholar
• Glagov S, Weisenberg E, Zarins CK, Stankunavicius R, Kolettis GJ. Compensatory enlargement of human athero-sclerotic coronary arteries. N Engl J Med 1987; 316: 1371–5.
   Google Scholar
• Roman MJ, Naqvi TZ, Gardin JM, Gerhard-Herman M, Jaff M, Mohler E. Clinical application of noninvasive vascular ultrasound in cardiovascular risk stratification: a report from the American Society of Echocardiography and the Society of Vascular Medicine and Biology. J Am Soc Echocardiogr 2006; 19: 943–54.
   Google Scholar
• O’Leary DH, Polak JF. Intima-media thickness: a tool for atherosclerosis imaging and event prediction. Am J Cardiol 2002; 90: 18L-21L.
   Google Scholar
• Gepner AD, Wyman RA, Korcarz CE, Aeschlimann SE, Stein JH. An abbreviated carotid intima-media thickness scanning protocol to facilitate clinical screening for sub-clinical atherosclerosis. J Am Soc Echocardiogr 2007; 20: 1269–75.
   Google Scholar
• Kastelein JJ, Akdim F, Stroes ES, Zwinderman AH, Bots ML, Stalenhoef AF, Visseren FL, Sijbrands EJ, Trip MD, Stein EA, Gaudet D, Duivenvoorden R, Veltri EP, Marais AD, de Groot E. Simvastatin with or without ezetimibe infamilial hypercholesterolemia. N Engl J Med 2008; 358: 1431–43.
   Google Scholar
• Crouse JR, III, Raichlen JS, Riley WA, Evans GW, Palmer MK, O’Leary DH, Grobbee DE, Bots ML. Effect of rosu-vastatin on progression of carotid intima-media thickness in low-risk individuals with subclinical atherosclerosis: the METEOR Trial. JAMA 2007; 297: 1344–53.
   Google Scholar
• Heiss G, Sharrett AR, Barnes R, Chambless LE, Szklo M, Alzola C. Carotid atherosclerosis measured by B-mode ultrasound in populations: associations with cardiovascular risk factors in the ARIC study. Am J Epidemiol 1991; 134: 250–6.
   Google Scholar
• Chambless LE, Heiss G, Folsom AR, Rosamond W, Szklo M, Sharrett AR, Clegg LX. Association of coronary heart disease incidence with carotid arterial wall thickness and major risk factors: the Atherosclerosis Risk in Communities (ARIC) Study, 1987–1993. Am J Epidemiol 1997; 146: 483–94.
   Google Scholar
• Mack WJ, LaBree L, Liu C, Selzer RH, Hodis HN. Corre-lations between measures of atherosclerosis change using carotid ultrasonography and coronary angiography. Ather-osclerosis 2000; 150: 371–9.
   Google Scholar
• Craven TE, Ryu JE, Espeland MA, Kahl FR, McKinney WM, Toole JF, McMahan MR, Thompson CJ, Heiss G, Crouse JR. Evaluation of the associations between carotid artery atherosclerosis and coronary artery stenosis. A case-control study. Circulation 1990; 82: 1230–42.
   Google Scholar
• Pasterkamp G, Schoneveld AH, Hillen B, Banga JD, Haudenschild CC, Borst C. Is plaque formation in the com-mon carotid artery representative for plaque formation and luminal stenosis in other atherosclerotic peripheral arteries? A post mortem study. Atherosclerosis 1998; 137: 205–10.
   Google Scholar
• del Sol AT, Moons KG, Hollander M, Hofman A, Koudstaal PJ, Grobbee DE, Breteler MM, Witteman JC, Bots ML. Is carotid intima-media thickness useful in cardiovascular disease risk assessment? The Rotterdam Study. Stroke 2001; 32: 1532–8.
   Google Scholar
• Iglesias del Sol SA, Bots ML, Grobbee DE, Hofman A, Wit-teman JC. Carotid intima-media thickness at different sites: relation to incident myocardial infarction; The Rotterdam Study. Eur Heart J 2002; 23: 934–40.
   Google Scholar
• Van der Meer I, Bots ML, Hofman A, del Sol AT, van der Kuip DA, Witteman JC. Predictive value of noninvasive measures of atherosclerosis for incident myocardial infarc-tion: the Rotterdam Study. Circulation 2004; 109: 1089–94.
   Google Scholar
• Hollander M, Bots ML, del Sol AT, Koudstaal PJ, Witte-man JC, Grobbee DE, Hofman A, Breteler MM. Carotid plaques increase the risk of stroke and subtypes of cerebral infarction in asymptomatic elderly: the Rotterdam study. Circulation 2002; 105: 2872–7.
   Google Scholar
• Howard G, Sharrett AR, Heiss G, Evans GW, Chambless LE, Riley WA, Burke GL. Carotid artery intimal-medial thickness distribution in general populations as evaluated by B-mode ultrasound. ARIC Investigators. Stroke 1993; 24: 1297–1304.
   Google Scholar
• Lorenz MW, von Kegler S, Steinmetz H, Markus HS, Sitzer M. Carotid intima-media thickening indicates a higher vascular risk across a wide age range: prospective data from the Carotid Atherosclerosis Progression Study (CAPS). Stroke 2006; 37: 87–92.
   Google Scholar
• Lorenz MW, Markus HS, Bots ML, Rosvall M, Sitzer M. Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analy-sis. Circulation 2007; 115: 459–67.
   Google Scholar
• O’Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson SK, Jr. Carotid-artery intima and media thick-ness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med 1999; 340: 14–22.
   Google Scholar
• O’Leary DH, Polak JF, Kronmal RA, Savage PJ, Borhani NO, Kittner SJ, Tracy R, Gardin JM, Price TR, Furberg CD. Thickening of the carotid wall. A marker for athero-sclerosis in the elderly? Cardiovascular Health Study Col-laborative Research Group. Stroke 1996; 27: 224–31.
   Google Scholar
• Rosvall M, Janzon L, Berglund G, Engstrom G, Hedblad B. Incident coronary events and case fatality in relation to common carotid intima-media thickness. J Intern Med 2005; 257: 430–7.
   Google Scholar
• Rosvall M, Janzon L, Berglund G, Engstrom G, Hedblad B. Incidence of stroke is related to carotid IMT even in the absence of plaque. Atherosclerosis 2005; 179: 325–31.
   Google Scholar
• De Groot E, Zwinderman AH, van der Steen AF, Ackerstaff RG, Montauban van Swijndregt AD, Bom N, Lie KI, Bruschke AV. Variance components analysis of carotid and femoral intima-media thickness measurements. REGRESS Study Group, Interuniversity Cardiology Institute of The Netherlands, Utrecht, The Netherlands. Regression Growth Evaluation Statin Study. Ultrasound Med Biol 1998; 24: 825–32.
   Google Scholar
• Duivenvoorden R, De Groot E, Stroes ES, Kastelein JJ. Surrogate markers in clinical trials - Challenges and oppor-tunities. Atherosclerosis 2009; 1: 8–16.
   Google Scholar
• Sankatsing RR, De Groot E, Jukema JW, de Feyter PJ, Pennell DJ, Schoenhagen P, Nissen SE, Stroes ES, Kastelein JJ. Surrogate markers for atherosclerotic disease. Curr Opin Lipidol 2005; 16: 434–41.
   Google Scholar
• De Groot E, van Leuven SI, Duivenvoorden R, Meuwese MC, Akdim F, Bots ML, Kastelein JJ. Measurement of carotid intima-media thickness to assess progression and regression of atherosclerosis. Nat Clin Pract Cardiovasc Med 2008; 5: 280–8.
   Google Scholar
• Duivenvoorden R, Nederveen AJ, De Groot E, Kastelein JJ. Atherosclerosis imaging as a benchmark in the development of novel cardiovasular drugs. Curr Opin Lipidol 2007; 18: 613–21.
   Google Scholar
• Hodis HN, Mack WJ, Lobo RA, Shoupe D, Sevanian A, Mahrer PR, Selzer RH, Liu Cr CR, Liu Ch CH, Azen SP. Estrogen in the prevention of atherosclerosis. A random-ized, double-blind, placebo-controlled trial. Ann Intern Med 2001; 135: 939–53.
   Google Scholar
• Salonen JT, Nyyssönen K, Salonen R, Lakka HM, Kaikko-nen J, Porkkala-Sarataho E, Voutilainen S, Lakka TA, Rissanen T, Leskinen L, Tuomainen TP, Valkonen VP, Ristonmaa U, Poulsen HE. Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) study: a randomized trial of the effect of vitamins E and C on 3-year progression of carotid atherosclerosis. J Intern Med 2000; 248: 377–86.
   Google Scholar
• Azen SP, Qian D, Mack WJ, Sevanian A, Selzer RH, Liu CR, Liu CH, Hodis HN. Effect of supplementary anti-oxidant vitamin intake on carotid arterial wall intima-media thickness in a controlled clinical trial of cholesterol lower-ing. Circulation 1996; 94: 2369–72.
   Google Scholar
• Hodis HN, Mack WJ, LaBree L, Mahrer PR, Sevanian A, Liu CR, Liu CH, Hwang J, Selzer RH, Azen SP. Alpha-tocopherol supplementation in healthy individuals reduces low-density lipoprotein oxidation but not atherosclerosis: the Vitamin E Atherosclerosis Prevention Study (VEAPS). Circulation 2002; 106: 1453–9.
   Google Scholar
• Hodis HN, Mack WJ, Dustin L, Mahrer PR, Azen SP, Detrano R, Selhub J, Alaupovic P, Liu CR, Liu CH, Hwang J, Wilcox AG, Selzer RH. High-dose B vitamin supplemen-tation and progression of subclinical atherosclerosis: a ran-domized controlled trial. Stroke 2009; 40: 730–6.
   Google Scholar
• Markus RA, Mack WJ, Azen SP, Hodis HN. Influence of lifestyle modification on atherosclerotic progression deter-mined by ultrasonographic change in the common carotid intima-media thickness. Am J Clin Nutr 1997; 65: 1000–4.
   Google Scholar
• Byington RP, Furberg CD, Crouse JR, III, Espeland MA, Bond MG. Pravastatin, Lipids, and Atherosclerosis in the Carotid Arteries (PLAC-II). Am J Cardiol 1995; 76: 54C-59C.
   Google Scholar
• Espeland MA, O’Leary DH, Terry JG, Morgan T, Evans G, Mudra H. Carotid intimal-media thickness as a surrogate for cardiovascular disease events in trials of HMG-CoA reductase inhibitors. Curr Control Trials Cardiovasc Med 2005; 6: 3.
   Google Scholar
• Hodis HN, Mack WJ, LaBree L, Selzer RH, Liu C, Liu C, Alaupovic P, Kwong-Fu H, Azen SP. Reduction in carotid arterial wall thickness using lovastatin and dietary therapy: a randomized controlled clinical trial. Ann Intern Med 1996; 124: 548–56.
   Google Scholar
• Smilde TJ, van Wissen S, Wollersheim H, Trip MD, Kastelein JJ, Stalenhoef AF. Effect of aggressive versus conventional lipid lowering on atherosclerosis progression in familial hypercholesterolaemia (ASAP): a prospective, randomised, double-blind trial. Lancet 2001; 357: 577–81.
   Google Scholar
• Taylor AJ, Kent SM, Flaherty PJ, Coyle LC, Markwood TT, Vemalis MN. ARBITER: Arterial Biology for the Investi-gation of the Treatment Effects of Reducing Cholesterol: a randomized trial comparing the effects of atorvastatin and pravastatin on carotid intima medial thickness. Circulation 2002; 106: 2055–60.
   Google Scholar
• Kastelein JJ, van Leuven SI, Burgess L, Evans GW, Kuiven-hoven JA, Barter PJ, Revkin JH, Grobbee DE, Riley WA, Shear CL, Duggan WT, Bots ML. Effect of torcetrapib on carotid atherosclerosis in familial hypercholesterolemia. N Engl J Med 2007; 356: 1620–30.
   Google Scholar
• Barter PJ, Caulfield M, Eriksson M, Grundy SM, Kastelein JJ, Komajda M, Lopez-Sendon J, Mosca L, Tardif JC, Waters DD, Shear CL, Revkin JH, Buhr KA, Fisher MR, Tall AR, Brewer B. Effects of torcetrapib in patients at high risk for coronary events. N Engl J Med 2007; 357: 2109–22.
   Google Scholar
• Nissen SE, Tuzcu EM, Brewer HB, Sipahi I, Nicholls SJ, Ganz P, Schoenhagen P, Waters DD, Pepine CJ, Crowe TD, Davidson MH, Deanfield JE, Wisniewski LM, Hanyok JJ, Kassalow LM. Effect of ACAT inhibition on the progression of coronary atherosclerosis. N Engl J Med 2006; 354: 1253–63.
   Google Scholar
• Meuwese MC, De Groot E, Duivenvoorden R, Trip MD, Ose L, Maritz FJ, Basart DC, Kastelein JJ, Habib R, Davidson MH, Zwinderman AH, Schwocho LR, Stein EA. ACAT inhibition and progression of carotid atherosclerosis in patients with familial hypercholesterolemia: the CAPTI-VATE randomized trial. JAMA 2009; 301: 1131–9.
   Google Scholar
• Taylor AJ, Merz CN, Udelson JE. 34th Bethesda Confer-ence: Executive summary-can atherosclerosis imaging tech-niques improve the detection of patients at risk for ischemic heart disease? J Am Coll Cardiol 2003; 41: 1860–62.
   Google Scholar
• Third Report of the National Cholesterol Education Pro-gram (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treat-ment Panel III) final report. Circulation 2002; 106: 3143–21.
   Google Scholar
• Mancia G, De Backer G, Dominiczak A, Cifkova R, Fagard R, Germano G, Grassi G, Heagerty AM, Kjeldsen SE, Lau-rent S, Narkiewicz K, Ruilope L, Rynkiewicz A, Schmieder RE, Struijker Boudier HA, Zanchetti A, Vahanian A, Camm J, De Caterina R, Dean V, Dickstein K, Filippatos G, Funck-Brentano C, Hellemans I, Kristensen SD, McGregor K, Sechtem U, Silber S, Tendera M, Widimsky P, Zamorano JL, Kjeldsen SE, Erdine S, Narkiewicz K, Kiowski W, Agabiti-Rosei E, Ambrosioni E, Cifkova R, Dominiczak A, Fagard R, Heagerty AM, Laurent S, Lindholm LH, Mancia G, Manolis A, Nilsson PM, Redon J, Schmieder RE, Struijker-Boudier HA, Viigimaa M, Filippatos G, Adamopoulos S, Agabiti-Rosei E, Ambrosioni E, Bertomeu V, Clement D, Erdine S, Farsang C, Gaita D, Kiowski W, Lip G, MaIlion JM, Manolis AJ, Nilsson PM, O’Brien E, Ponikowski P, Redon J, Ruschitzka F, Tamargo J, van Zwieten P, ViigimaaM, Waeber B, Williams B, Zamorano JL, The task force for the management of arterial hypertension of the European Society of Hypertension, e task force for the management of arterial hypertension of the European Society of Cardio-logy: 2007 Guidelines for the management of arterial hyper-tension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J 2007; 28: 1462–1536.
   Google Scholar
• Greenland P, Abrams J, Aurigemma GP, Bond MG, Clark LT, Criqui MH, Crouse JR, III, Friedman L, Fuster V, Herrington DM, Kuller LH, Ridker PM, Roberts WC, Stanford W, Stone N, Swan HJ, Taubert KA, Wexler L. Prevention Conference V: Beyond secondary prevention: identifying the high-risk patient for primary prevention: non-invasive tests of atherosclerotic burden: Writing Group III. Circulation 2000; 101: E16–E22.
   Google Scholar
• Stein JH, Korcarz CE, Hurst RT, Lonn E, Kendall CB, Mohler ER, Najjar SS, Rembold CM, Post WS. Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: a consensus state-ment from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force. Endorsed by the Society for Vascular Medicine. J Am Soc Echo cardiogr 2008; 21: 93–111.
   Google Scholar
• Stein JH, Fraizer MC, Aeschlimann SE, Nelson-Worel J, McBride PE, Douglas PS. Vascular age: integrating carotid intima-media thickness measurements with global coronary risk assessment. Clin Cardiol 2004; 27: 388–92.
   Google Scholar
• Wyman RA, Gimelli G, McBride PE, Korcarz CE, Stein JH. Does detection of carotid plaque affect physician behavior or motivate patients? Am Heart J 2007; 154: 1072–7.
   Google Scholar