REGIONAL DIFFERENCES OF HFE (C282Y, H63D) ALLELE FREQUENCIES IN THE NETHERLANDS

REFERENCES

• Lucotte G, Dieterlen F. A European allele map of the C282Y mutation of hemochromatosis: Celtic versus Viking origin of the mutation? Blood Cells Mol Dis 2003; 31: 262–267.
   PubMed Web of Science ®Google Scholar
• Roest M, van der Schouw YT, de Valk B, Marx JJ, Tempelman MJ, de Groot PG, Sixma JJ, Banga JD. Heterozygosity for a hereditary hemochromatosis gene is associated with cardiovascular death in women. Circulation 1999; 100: 1268–1273.
   PubMed Web of Science ®Google Scholar
• Milman N, Pedersen P. Evidence that the Cys282Tyr mutation of the HFE gene originated from a population in Southern Scandinavia and spread with the Vikings. Clin Genet 2003; 64: 36–47.
   PubMed Web of Science ®Google Scholar
• Distante S, Robson KJ, Graham-Campbell J, Arnaiz-Villena A, Brissot P and Worwood M. The origin and spread of the HFE-C282Y haemochromatosis mutation. Hum Genet 2004; 115: 269–279.
   PubMed Web of Science ®Google Scholar
• Whittington CA. Was the C282Y mutation an Irish Gaelic mutation that the Vikings help disseminate? Medical Hypothesis 2006; 67: 1270–1273.
   Web of Science ®Google Scholar
• Feder JN, Gnirke A, Thomas W, Tsuchihashi Z, Ruddy DA, Basava A, Dormishian F, Donmingo R Jr, Ellis MC, Fullan A, Hinton LM, Jones NL, Kimmel BE, Kronmal GS, Lauer P, Lee VK, Loeb DB, Mapa FA, McClelland E, Meyer NC, Mintier GA, Moeller N, Moore T, Morikang E, Prass CE, Quintana L, Starnes SM, Schatzman RC, Brunke KJ, Drayna DT, Risch NJ, Bacon BR, Wolff RK. A novel MHC class I-like gene is mutated in patients with hereditary hemochromatosis. Nat Genet 1996; 13: 399–408
   PubMed Web of Science ®Google Scholar
• Feder JN, Tsuchihashi Z, Irrinki A, Lee VK, Mapa FA, Morikang E, Prass CE, Starnes SM, Wolff RK, Parkkila S, Sly WS, Schatzman RC. The hemochromatosis founder mutation in HLA-H disrupts beta2-microglobulin interaction and cell surface expression. J Biol Chem 1997; 272: 14025–4028.
   PubMed Web of Science ®Google Scholar
• Limdi JK, Crampton JR. Hereditary haemochromatosis. QJM 2004; 97: 315–324.
   PubMed Web of Science ®Google Scholar
• Camaschella C, Roetto A and De Gobbi M. Genetic haemochromatosis: genes and mutations associated with iron loading. Best Pract Res Clin Haematol 2002; 15: 261–276.
   Web of Science ®Google Scholar
• Tuomainen TP, Kontula K, Nyyssonen K, Lakka TA, Helio T, Salonen JT. Increased risk of acute myocardial infarction in carriers of the hemochromatosis gene Cys282Tyr mutation: a prospective cohort study in men in eastern Finland. Circulation 1999; 100: 1274–1279.
   PubMed Web of Science ®Google Scholar
• Rasmussen ML, Folsom AR, Catellier DJ, Tsai MY, Garg U, Eckfeldt JH. A prospective study of coronary heart disease and the hemochromatosis gene (HFE) C282Y mutation: the Atheroclerosis Risk in Communities (ARIC) Study. Atherosclerosis 2001; 154: 739–746.
   PubMed Web of Science ®Google Scholar
• Van der A DL et al. HFE mutations and risk of coronary heart disease in middle-aged women. Eur J Clin Invest 2006; 36: 682–690. (Meta-analysis included)
   Web of Science ®Google Scholar
• Van der A DL et al. Mutations in the HFE gene and Cardiovascular Disease Risk - an individual patient data meta-analysis of 53 880 subjects. Circ. Cardiovasc Genet 2008; 1: 43–50.
   Web of Science ®Google Scholar
• Verschuren WMM, van Leer E, Blokstra A, Bueno de Mesquita HB, Smit HA, Seidell JC, Kromhout D. Cardiovascular disease risk factors in the Netherlands. Neth J Cardiol 1993; 4: 205–210.
   Google Scholar
• Prentice RL. A case-cohort design for epidemiologic cohort studies and disease prevention trials. Biometrika 1986; 73: 1–11.
   Web of Science ®Google Scholar
• Stott MK, Fellowes AP, Upton JD, Burt MJ, George PM. Simple multiplex PCR for the simultaneous detection of the C282Y and H63D hemochromatosis (HFE) gene mutations. Clin Chem 1999; 45: 426–428.
   Web of Science ®Google Scholar
• Hulthen L, Lindstedt G, Lundberg PA, Hallberg L. Effect of a mild infection on serum ferritin concentration - clinical and epidemiological implications. Eur J of Clin Nutr 1998; 52: 376–379.
   PubMed Web of Science ®Google Scholar
• Hallberg L, Hulthén L. High serum ferritin is not identical to high iron stores. Am J Clin Nutr 2003; 78: 1225–1226.
   PubMed Web of Science ®Google Scholar
• Barlow WE, Ichikawa L, Rosner D, Izumi S. Analysis of case-cohort designs. J Clin Epidemiol 1999; 52: 1165–1172.
   PubMed Web of Science ®Google Scholar
• Njajou OT, Houwing-Duistermaat JJ, Osborne RH, Vaessen N, Vergeer J, Heeringa J, Pols HA, Hofman A, van Duijn CM. A population-based study of the effect of the HFE C282Y and H63D mutations on iron metabolism. Eur J Hum Genet 2003; 11: 225–231.
   PubMed Web of Science ®Google Scholar
• Fox CJ, Cullen DJ, Knuiman MW, Cumpston GN, Divitini ML, Rossi E, Gochee PA, Powell LW and Olynyk JK. Effects of body iron stores and haemochromatosis on coronary heart disease outcomes in the Busselton health study. J Cardiovasc Risk 2002; 9: 287–293.
   Google Scholar
• Adams PC, Reboussin DM, Barton JC, McLaren CE, Eckfeldt JH, McLaren GD, Dawkins FW, Acton RT, Harris EL, Gordeuk VR, Leiendecker-Foster C, Speechley M, Snively BM, Holup JL, Thomson E, Scholinsky P; Hemochromatosis and Iron Overload Screening (HEIRS) Study Research Investigators. Hemochromatosis and Iron-Overload in a racially diverse population. N Engl J Med 2005; 352: 1769–1778.
   PubMed Web of Science ®Google Scholar
• Ellervik C, Tybjaerg-Hansen A, Grande P, Appleyard M and Nordestgaard BG. Hereditary hemochromatosis and risk of ischemic heart disease. A prospective study and a case-control study. Circulation 2005; 112: 185–193.
   Web of Science ®Google Scholar