From Cancer to Rejuvenation: Incomplete Regeneration as the Missing Link (Part II: Rejuvenation circle)

References

• GOSSRJ. Principles of Regeneration.Academic Press, New York, USA (1969).
   Google Scholar
• BaramiyaMG , BaranovE. From cancer to rejuvenation: incomplete regeneration as the missing link (Part I: the same origin, different outcomes). Future Sci. OA6(3), FSO450 (2020).
   PubMed Web of Science ®Google Scholar
• BaramiyaMG. Cancer and anti-aging: same origin-different outcomes (paradigm shift) part.1. Reports Gerontol. Section Soc. Naturalists Moscow State Univ.65, 100–118 (2018).
   Google Scholar
• HernebringM , BrolénG , AguilaniuH , SembH , NyströmT. Elimination of damaged proteins during differentiation of embryonic stem cells. Proc. Natl Acad. Sci. USA103(20), 7700–7705 (2006).
   PubMed Web of Science ®Google Scholar
• HernebringM , FredrikssonÅ , LiljevaldMet al.Removal of damaged proteins during ES cell fate specification requires the proteasome activator PA28. Sci. Rep.3, 1381 (2013).
   PubMed Web of Science ®Google Scholar
• ColladoM , GilJ , EfeyanAet al.Tumour Biology: senescence in premalignant tumours. Nature436(7051), 642 (2005).
   PubMed Web of Science ®Google Scholar
• XiongS , FengY , ChengL. Cellular reprogramming as a therapeutic target in cancer. Trends Cell Biol.29(8), 623–634 (2019).
   PubMed Web of Science ®Google Scholar
• Cieślar-PobudaA , KnoflachV , RinghMVet al.Transdifferentiation and reprogramming: overview of the processes, their similarities and differences. Biochim. Biophys. Acta. Mol. Cell Res.1864(7), 1359–1369 (2017).
   PubMed Web of Science ®Google Scholar
• TaguchiJ , YamadaY. In vivo reprogramming for tissue regeneration and organismal rejuvenation. Curr. Opin. Genet. Dev.46, 132–140 (2017).
   PubMed Web of Science ®Google Scholar
• BaramiyaMG. Carcinogenesis, senescence and life duration: potential of transformed cells and restrain of senescence (hypothesis). Adv. Curr. Biol. (UspekhiSovremennoyBiologii).118(4), 421–440 (1998).
   Google Scholar
• WebbCW , GootwineE , SachsL. Developmental potential of myeloid leukemia cells injected into rat midgestation embryos. Dev. Biol.101(1), 221–224 (1984).
   PubMed Web of Science ®Google Scholar
• WeaverV , PetersenO , WangFet al.Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin bloking bodies. J. Cell. Biol.137(1), 231–245 (1997).
   PubMed Web of Science ®Google Scholar
• ColemanWB , WennerbergAE , SmithGJ , GrishamJW. Regulation of differentiation of diploid and some aneuploid rat liver epithelial (stemlike) cells by the hepatic microenvironment. Am. J. Pathol.142(5), 1373–1382 (1993).
   PubMed Web of Science ®Google Scholar
• LiL , ConnellyMC , WetmoreC , CurranT , MorganJI. Mouse embryos cloned from brain tumors. Cancer Res.63(11), 2733–2736 (2003).
   PubMed Web of Science ®Google Scholar
• LeeLMJ , SeftorEA , BondeG , CornellRA , HendrixMJC. The fate of human malignant melanoma cells transplanted into zebrafish embryos: assessment of migration and cell division in the absence of tumor formation. Dev. Dyn.233(4), 1560–1570 (2005).
   PubMed Web of Science ®Google Scholar
• GootwineE , WebbCG , SachsL. Participation of myeloid leukaemia cells injected into embryos in haematopoietic differentiation in adult mice. Nature299(5878), 63–65 (1982).
   PubMedGoogle Scholar
• ParkNI , GuilhamonP , DesaiKet al.ASCL1 reorganizes chromatin to direct neuronal fate and suppress tumorigenicity of glioblastoma stem cells. Cell Stem Cell21(2), 209–224 (2017).
   PubMed Web of Science ®Google Scholar
• NeedhamJ. New advances in the chemistry and biology of organized growth. Proc. R. Soc. Med.29(12), 1577–1626 (1936).
   PubMedGoogle Scholar
• WaddingtonCH. Cancer and the theory of organizers. Nature135, 606–608 (1935).
   Google Scholar
• ShvembergerIN. Normalization of Tumor Cells [in Russian].Nauka, Leningrad (1987).
   Google Scholar
• NancyP , TaglianiE , TayCS , AspP , LevyDE , ErlebacherA. Chemokine gene silencing in decidual stromal cells limits T cell access to the maternal-fetal interface. Science336(6086), 1317–1321 (2012).
   PubMed Web of Science ®Google Scholar
• TongM , AbrahamsVM , ChamleyLW. Immunological effects of placental extracellular vesicles. Immunol. Cell Biol. Epub ahead of print (2018).
   PubMed Web of Science ®Google Scholar
• NegishiY , TakahashiH , KuwabaraY , TakeshitaT. Innate immune cells in reproduction. J. Obstet. Gynaecol. Res.44(11), 2025–2036 (2018).
   PubMed Web of Science ®Google Scholar
• ZhaoHX , JiangF , ZhuYJet al.Enhanced immunological tolerance by HLA-G1 from neural progenitor cells (NPCs) derived from human embryonic stem cells (hESCs). Cell Physiol. Biochem.44(4), 1435–1444 (2017).
   PubMedGoogle Scholar
• HydeKJ , SchustDG. Immunologic challenges of human reproduction: an evolving story. Fertil. Steril.106(3), 499–4510 (2016).
   PubMed Web of Science ®Google Scholar
• FarjadianS , TabebordbarM , MokhtariM , SafaeiA , MalekzadehM , GhaderiA. HLA-G expression in tumor tissues and soluble HLA-G plasma levels in patients with gastrointestinal cancer. Asian Pac. J. Cancer Prev.19(10), 2731–2735 (2018).
   PubMedGoogle Scholar
• AmiotL , FerroneS , Grosse-WildeH , SeligerB. Biology of HLA-G in cancer: a candidate molecule for therapeutic intervention?Cell. Mol. Life Sci.68(3), 417–431 (2011).
   PubMed Web of Science ®Google Scholar
• LinA , YanWH. Heterogeneity of HLA-G expression in cancers: facing the challenges. Front. Immunol.9, 2164; eCollection (2018).
   PubMed Web of Science ®Google Scholar
• DerynckR , WeinbergRA. EMT cancer: more than meets the eye. Dev. Cell49(3), 313–316 (2019).
   PubMed Web of Science ®Google Scholar
• CurriGA , BagehaweKD. The masking of antigene on trophoblast and cancer cells. Lancet1(7492), 708–710 (1967).
   PubMed Web of Science ®Google Scholar
• ClaserEM , SpinkP , O'MearaRA. A screening test for substances inhibiting the cancer coagulative factor. Nature208, (5014), 1008–1009 (1965).
   PubMed Web of Science ®Google Scholar
• UnkellesJ , CordonS , RetchE. Secretion of plasminogen activator by stimulated macrophages. J. Exp. Med.139(4), 834–850 (1974).
   PubMed Web of Science ®Google Scholar
• Veiga-FernandesH , FreitasAA. The s(c)ensory immune system theory. Trends Immunol.38(10), 777–788 (2017).
   PubMed Web of Science ®Google Scholar
• MedzhitovR , SchneiderDS , SoaresMP. Disease tolerance as a defense strategy. Science335(6071), 936–941 (2012).
   PubMed Web of Science ®Google Scholar
• OcampoA , ReddyP , Martinez-RedondoPet al.In vivo amelioration of age-associated hallmarks by partial reprogramming. Cell167(7), 1719–1733 (2016).
   PubMed Web of Science ®Google Scholar
• BakerSG , KramerBS. Paradoxes in carcinogenesis: new opportunities for research directions. BMC Cancer7, 151 (2007).
   PubMed Web of Science ®Google Scholar
• BurgioE , MiglioreL. Towards a systemic paradigm in carcinogenesis: linking epigenetics and genetics. Mol. Biol. Rep.42(4), 777–790 (2015).
   PubMed Web of Science ®Google Scholar
• BrücherBLDM , JamallIS. Somatic mutation theory - why it's wrong for most cancers. Cell Physiol. Biochem.38(5), 1663–1680 (2016).
   PubMedGoogle Scholar
• WoodLD , DParsons W , JonesSet al.The genomic landscapes of human breast and colorectal cancers. Science318(5853), 1108–1113 (2007).
   PubMed Web of Science ®Google Scholar
• SonnenscheinC , SotoAM. Somatic mutation theory of carcinogenesis: why it should be dropped and replaced. Mol. Carcinog. 29(4), 205–211 (2000).
   Google Scholar
• SonnenscheinC , SotoAM. The society of cells: cancer and control of cell populations. Springer Verlag, New York (1999).
   Google Scholar
• DejosezM , UraH , BrandtVL , ZwakaTP. Safeguards for cell cooperation in mouse embryogenesis shown by genome-wide cheater screen. Science341(6153), 1511–1514 (2013).
   PubMed Web of Science ®Google Scholar
• BizzarriM , CucinaA , BiavaPMet al.Embryonic morphogenetic field induces phenotypic reversion in cancer cells. Review Article. Curr. Pharm. Biotechnol.12(2), 243–253 (2011).
   PubMed Web of Science ®Google Scholar
• Kasemeier-KulesaJC , TeddyJM , PostovitLMet al.M. Reprogramming multipotent tumor cells with the embryonic neural crest microenvironment. Dev. Dynam.237(10), 2657–2666 (2008).
   PubMed Web of Science ®Google Scholar
• HochedlingerK , BlellochR , BrennanCet al.Reprogramming of a melanoma genome by nuclear transplantation. Genes Dev.18(15), 1875–1885 (2004).
   PubMed Web of Science ®Google Scholar
• Seilem-AspangF , KratochwilK. In: Regenerationin Animals and Related Problems.KiortsisV, TrampuschH ( Eds). North Holland Publishing Co, Amsterdam, 452–473 (1965).
   Google Scholar
• RubinH. Cancer as a dynamic developmental disorder. Cancer Res.45(7), 2935–2942 (1985).
   PubMed Web of Science ®Google Scholar
• ColemanWB , WennerbergAE , SmithGJ , GrishamJW. Regulation of differentiation of diploid and some aneuploid rat liver epithelial (stemlike) cells by the hepatic microenvironment. Am. J. Pathol.142(5), 1373–1382 (1993).
   PubMed Web of Science ®Google Scholar
• TopczewskaJM , PostovitLM , MargaryanNVet al.Embryonic and tumorigenic pathways converge via Nodal signalling: role in melanoma aggressiveness. Nat. Med.12(8), 925–932 (2006).
   PubMed Web of Science ®Google Scholar
• HendrixMJC , SeftorEA , SeftorREB , Kasemeier-KulesaJ , KulesaPM , PostovitLM. Reprogramming metastatic tumour cells with embryonic microenvironments. Nat. Rev. Cancer7(4), 246–255 (2007).
   PubMed Web of Science ®Google Scholar
• HartY , AlonU. The utility of paradoxical components in biological circuits. Mol. Cell49(2), 213–221 (2013).
   PubMed Web of Science ®Google Scholar
• EicherEM , WashburnLL. Normal testis determination in the mouse depends on genetic interaction of a locus on chromosome 17 and the Y chromosome. Genetics123(1), 173–179 (1989).
   PubMed Web of Science ®Google Scholar
• KiddS. Characterization of the Drosophila cactus locus and analysis of interactions between cactus and dorsal proteins. Cell71(4), 623–635 (1992).
   PubMed Web of Science ®Google Scholar
• BinaykeA , MishraS , SumanP , DasS , ChanderH. Awakening the “guardian of genome”: reactivation of mutant p53. Cancer Chemother. Pharmacol.83(1), 1–15 (2019).
   PubMed Web of Science ®Google Scholar
• DonehowerLA , SoussiT , KorkutAet al.Integrated analysis of TP53 gene and pathway alterations in the Cancer Genome Atlas. Cell Rep.28(5), 1370–1384 (2019).
   PubMed Web of Science ®Google Scholar
• AnbarasanT , BourdonJC. The emerging landscape of p53 isoforms in physiology, cancer and degenerative diseases. Int. J. Mol. Sci.20(24), 6257 (2019).
   PubMed Web of Science ®Google Scholar
• DonehowerLA , SoussiT , KorkutAet al.Integrated analysis of TP53 gene and pathway alterations in The Cancer Genome Atlas. Cell Rep.28(5), 1370–1384 (2019).
   PubMed Web of Science ®Google Scholar
• KurokawaK , TanakaT , JKato J. p19ARF prevents G1 cyclin-dependent kinase activation by interacting with MDM2 and activating p53 in mouse fibroblasts. Oncogene18(17), 2718–2727 (1999).
   PubMed Web of Science ®Google Scholar
• NostrandJLV , AttardiLD. Guilty as CHARGED: p53's expanding role in disease. Cell Cycle13(24), 3798–3807 (2014).
   PubMed Web of Science ®Google Scholar
• DolcettiR , DoglioniC , MaestroRet al.p53 over-expression is an early event in the development of human squamous-cell carcinoma of the larynx: genetic and prognostic implications. Int. J. Cancer52(2), 178–182 (1992).
   PubMed Web of Science ®Google Scholar
• CruzIB , SnijdersPJ , MeijerCJet al.p53 expression above the basal cell layer in oral mucosa is an early event of malignant transformation and has predictive value for developing oral squamous cell carcinoma. J. Pathol.184(4), 360–368 (1998).
   PubMed Web of Science ®Google Scholar
• ValenteG , FerrariL , KerimSet al.Evidence of p53 immunohistochemical overexpression in ethmoidal mucosa of woodworkers. Cancer Detect. Prev.28(2), 99–106 (2004).
   PubMedGoogle Scholar
• WangX , LvW , QiFet al.Clinical effects of p53 overexpression in squamous cell carcinoma of the sinonasal tract: a systematic meta-analysis with PRISMA guidelines. Medicine (Baltimore)96(12), e6424 (2017).
   PubMed Web of Science ®Google Scholar
• GonfloniS , CaputoV , IannizzottoV. P63 in health and cancer. Int. J. Dev. Biol.59(1–3), 87–93 (2015).
   PubMed Web of Science ®Google Scholar
• StanticM , SakilHA , ZirathHet al.TAp73 suppresses tumor angiogenesis through repression of proangiogenic cytokines and HIF-1α activity. Proc. Natl Acad. Sci. USA.112(1), 220–225 (2015).
   PubMed Web of Science ®Google Scholar
• MelinoG , LaurenziVD , VousdenKH. p73: friend or foe in tumorigenesis. Nat. Rev. Cancer2(8), 605–615 (2002).
   PubMed Web of Science ®Google Scholar
• MehtaSY , MortenBC , AntonyJet al.Regulation of the interferon-gamma (IFN-γ) pathway by p63 and Δ133p53 isoform in different breast cancer subtypes. Oncotarget9(49), 29146–29161 (2018).
   PubMedGoogle Scholar
• GongL , PanX , LimCB , PoloA , LittleJB , YuanZM. A functional interplay between Δ133p53 and ΔNp63 in promoting glycolytic metabolism to fuel cancer cell proliferation. Oncogene37(16), 2150–2164 (2018).
   PubMed Web of Science ®Google Scholar
• WuJ , LiangS , BergholzJet al.ΔNp63α activates CD82 metastasis suppressor to inhibit cancer cell invasion. Cell Death Dis.5(6), e1280 (2014).
   PubMedGoogle Scholar
• ChenY , LiY , PengYet al.ΔNp63α down-regulates c-Myc modulator MM1 via E3 ligase HERC3 in the regulation of cell senescence. Cell Death Differ.25(12), 2118–2129 (2018).
   PubMed Web of Science ®Google Scholar
• HanA , LiJ , LiYet al.p63α modulates c-Myc activity via direct interaction and regulation of MM1 protein stability. Oncotarget7(28), 44277–44287 (2016).
   PubMedGoogle Scholar
• MeyerG , González-ArnayE , MollU , NemajerovaA , TissirF , González-GómezM. Cajal-Retzius neurons are required for the development of the human hippocampal fissure. J. Anat.235(3), 569–589 (2019).
   PubMed Web of Science ®Google Scholar
• SaifudeenZ , DiavolitsisV , StefkovaJ , DippS , FanH , El-DahrSS. Spatiotemporal switch from DeltaNp73 to TAp73 isoforms during nephrogenesis: impact on differentiation gene expression. J. Biol. Chem.280(24), 23094–23102 (2005).
   PubMed Web of Science ®Google Scholar
• BeitzingerMC Oswald C , Beinoraviciute-KellnerR , StieweT. Regulation of telomerase activity by the p53 family member p73. Oncogene25(6), 813–826 (2006).
   PubMed Web of Science ®Google Scholar
• WangL , XiaW , ChenH , XiaoZX. ΔNp63α modulates phosphorylation of p38 MAP kinase in regulation of cell cycle progression and cell growth. Biochem. Biophys. Res. Commun.509(3), 784–789 (2019).
   PubMed Web of Science ®Google Scholar
• MangiulliM , VallettiA , CaratozzoloMFet al.Identification and functional characterization of two new transcriptional variants of the human p63 gene. Nucleic Acids Res.37(18), 6092–6104 (2009).
   PubMed Web of Science ®Google Scholar
• KosterMI , DaiD , MarinariBet al.p63 induces key target genes required for epidermal morphogenesis. Proc. Natl Acad. Sci. USA104(9), 3255–3260 (2007).
   PubMed Web of Science ®Google Scholar
• AnbarasanT , BourdonJC. The emerging landscape of p53 isoforms in physiology, cancer and degenerative diseases. Int. J. Mol. Sci.20(24), 6257 (2019).
   PubMed Web of Science ®Google Scholar
• FujitaK , MondalAM , HorikawaIet al.p53 isoforms, Δ133p53 and p53β, are endogenous regulators of replicative cellular senescence. Nat. Cell Biol.11(9), 1135–1142 (2009).
   PubMed Web of Science ®Google Scholar
• MuhlinenN , HorikawaI , AlamFet al.p53 isoforms regulate premature aging in human cells. Oncogene37(18), 2379–2393 (2018).
   PubMed Web of Science ®Google Scholar
• ArsicN , GadeaG , LagerqvistELet al.The p53 isoform Δ133p53β promotes cancer stem cell potential. Stem Cell Reports4(4), 531–540 (2015).
   PubMed Web of Science ®Google Scholar
• CampbellH , FlemingN , RothIet al.Δ133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and RhoA-ROCK signalling. Nat. Commun.9(1), 254 (2018).
   PubMedGoogle Scholar
• KazantsevaM , MehtaS , EiholzerRAet al.A mouse model of the Δ133p53 isoform: roles in cancer progression and inflammation. Mamm. Genome29(11–12), 831–842 (2018).
   PubMed Web of Science ®Google Scholar
• FragouA , TzimagiorgisG , KarageorgopoulosCet al.Increased Δ133p53 mRNA in lung carcinoma corresponds with reduction of p21 expression. Mol. Med. Rep . 15(4), 1455–1460 (2017).
   Google Scholar
• RothI , CampbellH , RubioCet al.The Δ133p53 isoform and its mouse analogue Δ122p53 promote invasion and metastasis involving pro-inflammatory molecules interleukin-6 and CCL2. Oncogene35(38), 4981–4989 (2016).
   PubMed Web of Science ®Google Scholar
• SlatterTL , HungN , BowieSet al.Δ122p53, a mouse model of Δ133p53α, enhances the tumor-suppressor activities of an attenuated p53 mutant. Cell Death Dis.6(6), e1783 (2015).
   PubMedGoogle Scholar
• GongL , GongH , PanXet al.p53 isoform Δ113p53/Δ133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damage. Cell Res.25(3), 351–369 (2015).
   PubMed Web of Science ®Google Scholar
• GongH , ZhangY , JiangKet al.p73 coordinates with Δ133p53 to promote DNA double-strand break repair. Cell Death Differ.25(6), 1063–1079 (2018).
   PubMed Web of Science ®Google Scholar
• ChenJ , PengJ. Δ113p53/Δ133p53: survival and integrity. Oncotarget6(16), 13850–13851 (2015).
   PubMedGoogle Scholar
• HorikawaI , HarrisCC. Δ133p53: a p53 isoform enriched in human pluripotent stem cells. Cell Cycle16(18), 1631–1632 (2017).
   PubMed Web of Science ®Google Scholar
• HorikawaI , FujitaK , JenkinsLMet al.Autophagic degradation of the inhibitory p53 isoform D133p53a as a regulatory mechanism for p53-mediated senescence. Nat. Commun.5, 4706 (2014).
   PubMed Web of Science ®Google Scholar
• TurnquistC , BeckJA , HorikawaIet al.Radiation-induced astrocyte senescence is rescued by Δ133p53. Neuro. Oncol.21(4), 474–485 (2019).
   PubMed Web of Science ®Google Scholar
• MondalAM , HorikawaI , PineSRet al.p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes. J. Clin. Invest.123(12), 5247–5257 (2013).
   PubMed Web of Science ®Google Scholar
• MondalAM , ZhouH , HorikawaIet al.Δ133p53α, a natural p53 isoform, contributes to conditional reprogramming and long-term proliferation of primary epithelial cells. Cell Death Dis.9(7), 750 (2018).
   PubMedGoogle Scholar
• HorikawaI , ParkKY , IsogayaKet al.Δ133p53 represses p53-inducible senescence genes and enhances the generation of human induced pluripotent stem cells. Cell Death Differ.24(6), 1017–1028 (2017).
   PubMed Web of Science ®Google Scholar
• GongL , PanX , ChenHet al.p53 isoform Δ133p53 promotes efciency of induced pluripotent stem cells and ensures genomic integrity during reprogramming. Sci. Rep.6, 37281 (2016).
   PubMed Web of Science ®Google Scholar
• DuttaA , MagnenCL , MitrofanovaA , OuyangX , CalifanoA , Abate-ShenC. Identification of an NKX3.1-G9a-UTY transcriptional regulatory network that controls prostate differentiation. Science352(6293), 1576–1580 (2016).
   PubMed Web of Science ®Google Scholar
• MaiT , MarkovGJ , BradyJJet al.NKX3-1 is required for induced pluripotent stem cell reprogramming and can replace OCT4 in mouse and human iPSC induction. Nat. Cell Biol.20(8), 900–908 (2018).
   PubMed Web of Science ®Google Scholar
• CucinaA , BiavaPM , D'AnselmiFet al.Zebrafish embryo proteins induce apoptosis in human colon cancer cells (Caco2). Apoptosis11(9), 1617–1628 (2006).
   PubMed Web of Science ®Google Scholar
• GuoJ , HaoCh , WangC , LiL. Long noncoding RNA PVT1 modulates hepatocellular carcinoma cell proliferation and apoptosis by recruiting EZH2. Cancer Cell Int.18, 98; eCollection (2018).
   PubMed Web of Science ®Google Scholar
• KongR , ZhangEB , YinDDet al.Long noncoding RNA PVT1 indicates a poor prognosis of gastric cancer and promotes cell proliferation through epigenetically regulating p15 and p16. Mol Cancer14, 82 (2015).
   PubMed Web of Science ®Google Scholar
• RiquelmeE , SuraokarMB , JaimeRodriguez Jet al.Frequent coamplification and cooperation between C-MYC and PVT1 oncogenes promote malignant pleural mesothelioma. J. Thorac. Oncol.9(7), 998–1007 (2014).
   PubMed Web of Science ®Google Scholar
• TsengYY , BagchiA. The PVT1-MYC duet in cancer. Mol. Cell Oncol.2(2), e974467 (2015).
   PubMed Web of Science ®Google Scholar
• TsengYY , MoriarityBS , GongWet al.PVT1 dependence in cancer with MYC copy-number increase. Nature512(7512), 82–86 (2014).
   PubMed Web of Science ®Google Scholar
• ZhangY , YangG , LuoY. Long non-coding RNA PVT1 promotes glioma cell proliferation and invasion by targeting miR-200a. Exp. Ther. Med.17(2), 1337–1345 (2019).
   PubMed Web of Science ®Google Scholar
• ZhaoL , KongH , SunH , ChenZ , ChenB , ZhouM. LncRNA-PVT1 promotes pancreatic cancer cells proliferation and migration through acting as a molecular sponge to regulate miR-448. J. Cell. Physiol.233(5), 4044–4055 (2018).
   PubMed Web of Science ®Google Scholar
• ZhengX , HuH , LiS. High expression of lncRNA PVT1 promotes invasion by inducing epithelial-to-mesenchymal transition in esophageal cancer. Oncol. Lett.12(4), 2357–2362 (2016).
   PubMed Web of Science ®Google Scholar
• GuanY , KuoWL , StilwellJLet al.Amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer. Clin. Cancer Res.13(19), 5745–5755 (2007).
   PubMed Web of Science ®Google Scholar
• ChoSW , XuJ , SunRet al.Promoter of lncRNA gene PVT1 is a tumor-suppressor DNA boundary element. Cell173(6), 1398–1412.e22 (2018).
   PubMed Web of Science ®Google Scholar
• XuMD , WangY , WengWet al.A positive feedback loop of lncRNA-PVT1 and FOXM1 facilitates gastric cancer growth and invasion. Clin. Cancer Res.23(8), 2071–2080 (2017).
   PubMed Web of Science ®Google Scholar
• OliveroCE , Martínez-TerrobaE , ZimmerJet al.p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis. Mol. Cell77(4), 761–774e8 (2020).
   PubMed Web of Science ®Google Scholar
• BarsottiM , BeckermanR , LaptenkoO , HuppiK , CaplenNJ , PrivesC. p53-dependent induction of PVT1 and miR-1204. J. Biol. Chem.287(4), 2509–2519 (2012).
   PubMed Web of Science ®Google Scholar
• PorterJR , FisherBE , BaranelloLet al.Global inhibition with specific activation: how p53 and MYC redistribute the transcriptome in the DNA double-strand break response. Mol. Cell.67(6), 1013–1025,e9 (2017).
   PubMed Web of Science ®Google Scholar
• DuP , PirouzM , ChoiJet al.An intermediate pluripotent state controlled by microRNAs is required for the naive-to-primed stem cell transition. Cell Stem Cell22(6), 851–864 (2018).
   PubMed Web of Science ®Google Scholar
• Muñoz-GalvánS , Lucena-CacaceA , PerezM , Otero-AlbiolD , Gomez-CambroneroJ , AmancioCarnero A. Tumor cell-secreted PLD increases tumor stemness by senescence mediated communication with microenvironment. Oncogene38(8), 1309–1323 (2018).
   PubMed Web of Science ®Google Scholar
• AndaFC , MadabhushiR , ReiDet al.Cortical neurons gradually attain a post-mitotic state. Cell Res.26(9), 1033–1047 (2016).
   PubMed Web of Science ®Google Scholar
• JoplingC , SleepE , RayaM , MartíM , RayaA , BelmonteJCI. Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation. Nature464(7288), 606–609 (2010).
   PubMed Web of Science ®Google Scholar
• TzahorE , PossKD. Cardiac regeneration strategies: staying young at heart. Science356(6342), 1035–1039 (2017).
   PubMed Web of Science ®Google Scholar
• FieldsRD , AraqueA , Johansen-BergHet al.Glial biology in learning and cognition. Neuroscientist20(5), 426–431 (2014).
   PubMed Web of Science ®Google Scholar
• HalassaMM , FellinT , HaydonPG. The tripartite synapse: roles for gliotransmission in health and disease. Trends Mol. Med.13(2), 54–63 (2007).
   PubMed Web of Science ®Google Scholar
• FrancoCA , MoralesF , BoffoS , GiordanoA. CDK9: a key player in cancer and other diseases. J. Cell. Biochem.119(2), 1273–1284 (2018).
   PubMed Web of Science ®Google Scholar
• BywaterMJ , BurkhartDL , StraubeJet al.Reactivation of Myc transcription in the mouse heart unlocks its proliferative capacity. Nat. Commun.11(1), 1827 (2020).
   PubMed Web of Science ®Google Scholar
• PoplawskiGHD , KawaguchiR , NiekerkEVet al.Injured adult neurons regress to an embryonic transcriptional growth state. Nature2020. https://doi.org/10.1038/s41586-020-2200-5
   Web of Science ®Google Scholar
• ElsasserWM. Outline of a theory of cellular heterogeneity. Proc. Natl Acad. Sci. USA81(16), 5126–5129 (1984).
   PubMed Web of Science ®Google Scholar