Combination of Quercetin and 2-methoxyestradiol Inhibits epithelial–mesenchymal Transition in PC-3 Cell Line Via Wnt Signaling Pathway

References

• JemalA , SiegelR , WardE , MurrayT , XuJ , ThunMJ. Cancer statistics, 2007. CA Cancer J. Clin.57(1), 43–66 (2007).
   PubMed Web of Science ®Google Scholar
• HeerbothS , HousmanG , LearyMet al.EMT and tumor metastasis. Clin. Transl. Med.4(1), 6 (2015).
   PubMedGoogle Scholar
• YangJ , WeinbergRA. Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev. Cell14(6), 818–829 (2008).
   PubMed Web of Science ®Google Scholar
• MoustakasA , HeldinP. TGFβ and matrix-regulated epithelial to mesenchymal transition. Biochim. Biophys. Acta1840(8), 2621–2634 (2014).
   PubMed Web of Science ®Google Scholar
• CaoZ , KyprianouN. Mechanisms navigating the TGF-B pathway in prostate cancer. Asian J. Urol.2(1), 11–18 (2015).
   PubMedGoogle Scholar
• AkhurstRJ , DerynckR. TGF-β signaling in cancer - a double-edged sword. Trends Cell Biol.11(11), S44–51 (2001).
   PubMed Web of Science ®Google Scholar
• XuJ , LamouilleS , DerynckR. TGF-B-induced epithelial to mesenchymal transition. Cell Res.19(2), 156–172 (2009).
   PubMed Web of Science ®Google Scholar
• Odero-MarahV , HawsawiO , HendersonV , SweeneyJ. Epithelial-mesenchymal transition (EMT) and prostate cancer. Adv. Exp. Med. Biol.101–110 (2018).
   PubMed Web of Science ®Google Scholar
• AnastasJN , MoonRT. WNT signalling pathways as therapeutic targets in cancer. Nat. Rev. Cancer13(1), 11–26 (2013).
   PubMed Web of Science ®Google Scholar
• ValkenburgKC , GraveelCR , Zylstra-DiegelCR , ZhongZ , WilliamsBO. Wnt/β-catenin signaling in normal and cancer stem cells. Cancers (Basel)3(2), 2050–2079 (2011).
   PubMedGoogle Scholar
• BaruahMM , KhandwekarAP , SharmaN. Quercetin modulates Wnt signaling components in prostate cancer cell line by inhibiting cell viability, migration, and metastases. Tumor Biol.37(10), 14025–14034 (2016).
   PubMedGoogle Scholar
• KimGT , LeeSH , KimIl J , KimYM. Quercetin regulates the sestrin 2-AMPK-p38 MAPK signaling pathway and induces apoptosis by increasing the generation of intracellular ROS in a p53-independent manner. Int. J. Mol. Med.33(4), 863–869 (2014).
   PubMed Web of Science ®Google Scholar
• ChanST , YangNC , HuangCS , LiaoJW , YehSL. Quercetin Enhances the antitumor activity of trichostatin a through upregulation of p53 protein expression in vitro and in vivo. PLoS ONE8(1), e54255 (2013).
   PubMed Web of Science ®Google Scholar
• WangG , SongL , WangH , XingN. Quercetin synergizes with 2-methoxyestradiol inhibiting cell growth and inducing apoptosis in human prostate cancer cells. Oncol. Rep.30(1), 357–363 (2013).
   PubMed Web of Science ®Google Scholar
• BhatFA , SharmilaG , BalakrishnanSet al.Quercetin reverses EGF-induced epithelial to mesenchymal transition and invasiveness in prostate cancer (PC-3) cell line via EGFR/PI3K/Akt pathway. J. Nutr. Biochem.25(11), 1132–1139 (2014).
   PubMed Web of Science ®Google Scholar
• PiaoS , KangM , LeeYJet al.Cytotoxic effects of escin on human castration-resistant prostate cancer cells through the induction of apoptosis and G2/M cell cycle arrest. Urology84(4), 982.e1–982.e7 (2014).
   PubMed Web of Science ®Google Scholar
• BaruahM , SharmaN , KhandwekarA. Flavonoids and prostate cancer. Am. Int. J. Res. Formal. Appl. Nat. Sci.15(1), 1–7 (2016).
   Google Scholar
• YangF , SongL , WangH , WangJ , XuZ , XingN. Quercetin in prostate cancer: chemotherapeutic and chemopreventive effects, mechanisms and clinical application potential (review). Oncol. Rep.33(6), 2659–2668 (2015).
   PubMed Web of Science ®Google Scholar
• GraefeEU , WittigJ , MuellerSet al.Pharmacokinetics and bioavailability of quercetin glycosides in humans. J. Clin. Pharmacol.41(5), 492–499 (2001).
   PubMed Web of Science ®Google Scholar
• MueckAO , SeegerH. 2-methoxyestradiol - Biology and mechanism of action. Steroids75(10), 625–631 (2010).
   PubMed Web of Science ®Google Scholar
• FotsisT , ZhangY , PepperMSet al.The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth. Nature368(6468), 237–239 (1994).
   PubMed Web of Science ®Google Scholar
• EhtedaA , GalettisP , PillaiK , MorrisDL. Combination of Albendazole and 2-Methoxyestradiol significantly improves the survival of HCT-116 tumor-bearing nude mice. BMC Cancer13, 86 (2013).
   PubMed Web of Science ®Google Scholar
• Van VeldhuizenPJ , RayG , BanerjeeSet al.2-Methoxyestradiol modulates β-catenin in prostate cancer cells: a possible mediator of 2-methoxyestradiol-induced inhibition of cell growth. Int. J. Cancer122(3), 567–571 (2008).
   PubMed Web of Science ®Google Scholar
• VisagieM , TheronA , MqocoTet al.Sulphamoylated 2-methoxyestradiol analogues induce apoptosis in adenocarcinoma cell lines. PLoS ONE8(9), 1–13 (2013).
   Web of Science ®Google Scholar
• YangF , SongL , WangH , WangJ , XuZ , XingN. Combination of quercetin and 2-methoxyestradiol enhances inhibition of human prostate cancer LNCaP and PC-3 cells xenograft tumor growth. PLoS ONE10(5), e0128277 (2015).
   PubMed Web of Science ®Google Scholar
• AmbrosiniG , AdidaC , AltieriDC. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat. Med.3(8), 917–921 (1997).
   PubMed Web of Science ®Google Scholar
• SonpavdeG , PondGR , BerryWRet al.Serum alkaline phosphatase changes predict survival independent of PSA changes in men with castration-resistant prostate cancer and bone metastasis receiving chemotherapy. Urol. Oncol. Semin. Orig. Investig.30(5), 607–613 (2012).
   PubMed Web of Science ®Google Scholar
• CookRJ , ColemanR , BrownJet al.Markers of bone metabolism and survival in men with hormone-refractory metastatic prostate cancer. Clin Cancer Res.12(9), 3361–3367 (2006).
   PubMedGoogle Scholar
• RadiskyDC. Epithellial-mesenchymal transition. J. Cell Sci.118(19), 4325–4326 (2005).
   PubMed Web of Science ®Google Scholar
• NisticòP , BissellMJ , RadiskyDC. Epithelial-mesenchymal transition: general principles and pathological relevance with special emphasis on the role of matrix metalloproteinases. Cold Spring Harb. Perspect. Biol.4(2), a011908 (2012).
   PubMed Web of Science ®Google Scholar
• NietoMA. The ins and outs of the epithelial to mesenchymal transition in health and disease. Annu. Rev. Cell Dev. Biol.27, 347–376 (2011).
   PubMed Web of Science ®Google Scholar
• López-NouoaJM , NietoMA. Inflammation and EMT: an alliance towards organ fibrosis and cancer progression. EMBO Mol. Med.1(6–7), 303–314 (2009).
   PubMed Web of Science ®Google Scholar
• GrantCM , KyprianouN. Epithelial mesenchymal transition (EMT) in prostate growth and tumor progression. Transl. Androl. Urol.2(4), 202–211 (2013).
   PubMedGoogle Scholar
• GravdalK , HalvorsenOJ , HaukaasSA , AkslenLA. A switch from E-cadherin to N-cadherin expression indicates epithelial to mesenchymal transition and is of strong and independent importance for the progress of prostate cancer. Clin. Cancer Res.13(23), 7003–7011 (2007).
   PubMed Web of Science ®Google Scholar
• VijayababuMR , KanagarajP , ArunkumarA , IlangovanR , AruldhasMM , ArunakaranJ. Quercetin-induced growth inhibition and cell death in prostatic carcinoma cells (PC-3) are associated with increase in p21 and hypophosphorylated retinoblastoma proteins expression. J. Cancer Res. Clin. Oncol.131(11), 765–771 (2005).
   PubMed Web of Science ®Google Scholar
• KumarAP , GarciaGE , SlagaTJ. 2-Methoxyestradiol blocks cell-cycle progression at G2/M phase and inhibits growth of human prostate cancer cells. Mol. Carcinog.31(3), 111–124 (2001).
   PubMed Web of Science ®Google Scholar
• ChangYF , HsuYC , HungHFet al.Quercetin induces oxidative stress and potentiates the apoptotic action of 2-methoxyestradiol in human hepatoma cells. Nutr. Cancer61(5), 735–745 (2009).
   PubMed Web of Science ®Google Scholar
• MetwalliAR , RosnerIL , CullenJet al.Elevated alkaline phosphatase velocity strongly predicts overall survival and the risk of bone metastases in castrate-resistant prostate cancer. Urol. Oncol. Semin. Orig. Investig.32(6), 761–768 (2014).
   PubMed Web of Science ®Google Scholar
• BuchetR , MillánJL , MagneD. Chapter 3 multisystemic functions of alkaline phosphatases. Methods Mol. Biol.1053, 27–51 (2013).
   PubMedGoogle Scholar
• RaoSR , SnaithAE , MarinoDet al.Tumour-derived alkaline phosphatase regulates tumour growth, epithelial plasticity and disease-free survival in metastatic prostate cancer. Br. J. Cancer116(2), 227–236 (2017).
   PubMed Web of Science ®Google Scholar
• NeuwirthováJ , GálB , SmilekP , UrbánkováP. Potential of the flavonoid quercetin to prevent and treat cancer – current status of research. Klin. Onkol.31(3), 184–190 (2018).
   PubMedGoogle Scholar
• KangY. Epithelial-mesenchymal transitions twist in development and metastasis. Cell118(3), 277–279 (2004).
   PubMed Web of Science ®Google Scholar
• LinT-H , HsuW-H , TsaiP-Het al.Dietary flavonoids, luteolin and quercetin, inhibit invasion of cervical cancer by reduction of UBE2S through epithelial–mesenchymal transition signaling. Food Funct.8(4), 1558–1568 (2017).
   PubMed Web of Science ®Google Scholar
• ParkCH , ChangJY , HahmER , ParkS , KimHK , YangCH. Quercetin, a potent inhibitor against β-catenin/Tcf signaling in SW480 colon cancer cells. Biochem. Biophys. Res. Commun.328(1), 227–234 (2005).
   PubMed Web of Science ®Google Scholar
• KawaharaT , Kawaguchi-IharaN , OkuhashiY , ItohM , NaraN , TohdaS. Cyclopamine and quercetin suppress the growth of leukemia and lymphoma cells. Anticancer Res.29(11), 4629–4632 (2009).
   PubMed Web of Science ®Google Scholar