Hyperacute Transplantation of Umbilical Cord Mesenchymal Stromal Cells in a Model of Severe Intracerebral Hemorrhage

References

• KrishnamurthiRV , IkedaT , FeiginVL. Global, regional and country-specific burden of ischaemic stroke, intracerebral haemorrhage and subarachnoid haemorrhage: a systematic analysis of the Global Burden of Disease Study 2017. Neuroepidemiology54(2), 171–179 (2020).
   PubMed Web of Science ®Google Scholar
• BabiMA , JamesML. Spontaneous intracerebral hemorrhage: should we operate?Front. Neurol.8(645), 645 (2017).
   PubMedGoogle Scholar
• ShaoZ , TuS , ShaoA. Pathophysiological mechanisms and potential therapeutic targets in intracerebral hemorrhage. Front. Pharmacol.10(1079), 1079 (2019).
   PubMedGoogle Scholar
• InoueT , FushimiK. Stroke care units versus general medical wards for acute management of stroke in Japan. Stroke44(11), 3142–3147 (2013).
   PubMed Web of Science ®Google Scholar
• DabrowskaS , AndrzejewskaA , LukomskaB , JanowskiM. Neuroinflammation as a target for treatment of stroke using mesenchymal stem cells and extracellular vesicles. J. Neuroinflammation16(1), 178 (2019).
   PubMed Web of Science ®Google Scholar
• LaluMM , McintyreL , PuglieseCet al.Safety of cell therapy with mesenchymal stromal cells (SafeCell): a systematic review and meta-analysis of clinical trials. PLoS ONE7(10), e47559 (2012).
   PubMed Web of Science ®Google Scholar
• Rosado-De-CastroPH , DeCarvalho FG , DeFreitas GR , Mendez-OteroR , Pimentel-CoelhoPM. Review of preclinical and clinical studies of bone marrow-derived cell therapies for intracerebral hemorrhage. Stem Cells Int.2016, 4617983 (2016).
   PubMed Web of Science ®Google Scholar
• KrauseM , PhanTG , MaH , SobeyCG , LimR. Cell-based therapies for stroke: are we there yet?Front. Neurol.10(656), 656 (2019).
   PubMedGoogle Scholar
• SataniN , CaiC , GiridharKet al.World-wide efficacy of bone marrow derived mesenchymal stromal cells in preclinical ischemic stroke models: systematic review and meta-analysis. Front. Neurol.10(405), 405 (2019).
   PubMedGoogle Scholar
• TurnbullMT , ZubairAC , MeschiaJF , FreemanWD. Mesenchymal stem cells for hemorrhagic stroke: status of preclinical and clinical research. NPJ Regen. Med.4, 10 (2019).
   PubMed Web of Science ®Google Scholar
• MelloTG , Rosado-De-CastroPH , CamposRMPet al.Intravenous human umbilical cord-derived mesenchymal stromal cell administration in models of moderate and severe intracerebral hemorrhage. Stem Cells Dev.29(9), 586–598 (2020).
   PubMed Web of Science ®Google Scholar
• VuQ , XieK , EckertM , ZhaoW , CramerSC. Meta-analysis of preclinical studies of mesenchymal stromal cells for ischemic stroke. Neurology82(14), 1277–1286 (2014).
   PubMed Web of Science ®Google Scholar
• MracskoE , VeltkampR. Neuroinflammation after intracerebral hemorrhage. Front. Cell. Neurosci.8(388), 388 (2014).
   PubMedGoogle Scholar
• AlencarAKN , Pimentel-CoelhoPM , MontesGCet al.Human mesenchymal stem cell therapy reverses Su5416/hypoxia-induced pulmonary arterial hypertension in mice. Front. Pharmacol.9, 1395 (2018).
   PubMed Web of Science ®Google Scholar
• SchwarzS , HussR , Schulz-SiegmundMet al.Bone marrow-derived mesenchymal stem cells migrate to healthy and damaged salivary glands following stem cell infusion. Int. J. Oral Sci.6(3), 154–161 (2014).
   PubMed Web of Science ®Google Scholar
• BoltzeJ , ArnoldA , WalczakP , JolkkonenJ , CuiL , WagnerDC. The dark side of the force - constraints and complications of cell therapies for stroke. Front. Neurol.6, 155 (2015).
   PubMed Web of Science ®Google Scholar
• SilachevDN , GoryunovKV , ShpilyukMAet al.Effect of MSCs and MSC-derived extracellular vesicles on human blood coagulation. Cells8(3), 258 (2019).
   PubMed Web of Science ®Google Scholar
• HegyiB , KornyeiZ , FerencziSet al.Regulation of mouse microglia activation and effector functions by bone marrow-derived mesenchymal stem cells. Stem Cells Dev.23(21), 2600–2612 (2014).
   PubMed Web of Science ®Google Scholar
• ChiossoneL , ConteR , SpaggiariGMet al.Mesenchymal stromal cells induce peculiar alternatively activated macrophages capable of dampening both innate and adaptive immune responses. Stem Cells34(7), 1909–1921 (2016).
   PubMed Web of Science ®Google Scholar
• WeiZZ , GuX , FerdinandAet al.Intranasal delivery of bone marrow mesenchymal stem cells improved neurovascular regeneration and rescued neuropsychiatric deficits after neonatal stroke in rats. Cell Transplant.24(3), 391–402 (2015).
   PubMed Web of Science ®Google Scholar
• DeGodoy MA , SaraivaLM , DeCarvalho LRPet al.Mesenchymal stem cells and cell-derived extracellular vesicles protect hippocampal neurons from oxidative stress and synapse damage induced by amyloid-beta oligomers. J. Biol. Chem.293(6), 1957–1975 (2018).
   PubMed Web of Science ®Google Scholar
• KempK , HaresK , MallamE , HeesomKJ , ScoldingN , WilkinsA. Mesenchymal stem cell-secreted superoxide dismutase promotes cerebellar neuronal survival. J. Neurochem.114(6), 1569–1580 (2010).
   PubMed Web of Science ®Google Scholar
• Puig-PijuanT , DeGodoy MA , PinheiroCarvalho LRet al.Human Wharton's jelly mesenchymal stem cells protect neural cells from oxidative stress through paracrine mechanisms. Future Sci. OA6(9), FSO627 (2020).
   PubMed Web of Science ®Google Scholar
• BoltzeJ , LukomskaB , JolkkonenJ , ConsortiumM-I. Mesenchymal stromal cells in stroke: improvement of motor recovery or functional compensation?J. Cereb. Blood Flow Metab.34(8), 1420–1421 (2014).
   PubMed Web of Science ®Google Scholar
• WeissARR , DahlkeMH. Immunomodulation by mesenchymal stem cells (MSCs): mechanisms of action of living, apoptotic, and dead MSCs. Front. Immunol.10(1191), 1191 (2019).
   PubMedGoogle Scholar
• Rosado-De-CastroPH , Pimentel-CoelhoPM , GutfilenBet al.Radiopharmaceutical stem cell tracking for neurological diseases. BioMed Res. Int.2014, 417091 (2014).
   PubMed Web of Science ®Google Scholar
• AcostaSA , TajiriN , HooverJ , KanekoY , BorlonganCV. Intravenous bone marrow stem cell grafts preferentially migrate to spleen and abrogate chronic inflammation in stroke. Stroke46(9), 2616–2627 (2015).
   PubMed Web of Science ®Google Scholar
• WangZ , HeD , ZengY-Yet al.The spleen may be an important target of stem cell therapy for stroke. J. Neuroinflammation16(1), 20 (2019).
   PubMedGoogle Scholar
• DeWitte SFH , LukF , SierraParraga JMet al.Immunomodulation By therapeutic mesenchymal stromal cells (MSC) is triggered through phagocytosis of MSC by monocytic cells. Stem Cells36(4), 602–615 (2018).
   PubMed Web of Science ®Google Scholar
• GalleuA , Riffo-VasquezY , TrentoCet al.Apoptosis in mesenchymal stromal cells induces in vivo recipient-mediated immunomodulation. Sci. Transl. Med.9(416), eaam7828 (2017).
   PubMed Web of Science ®Google Scholar
• ChoiBY , KimOJ , MinSH , JeongJH , SuhSW , ChungTN. Human placenta-derived mesenchymal stem cells reduce mortality and hematoma size in a rat intracerebral hemorrhage model in an acute phase. Stem Cells Int.2018, 1658195 (2018).
   PubMed Web of Science ®Google Scholar
• XieJ , WangB , WangL , DongF , BaiG , LiuY. Intracerebral and intravenous transplantation represents a favorable approach for application of human umbilical cord mesenchymal stromal cells in intracerebral hemorrhage rats. Med. Sci. Monit.22, 3552–3561 (2016).
   PubMed Web of Science ®Google Scholar
• LoprestiMA , BruceSS , CamachoEet al.Hematoma volume as the major determinant of outcomes after intracerebral hemorrhage. J. Neurol. Sci.345(1-2), 3–7 (2014).
   PubMed Web of Science ®Google Scholar