1,091
Views
1
CrossRef citations to date
0
Altmetric
Review

Ocular Complications of Antineoplastic Therapies

, , , ORCID Icon, ORCID Icon & ORCID Icon
Article: FSO871 | Received 05 Dec 2022, Accepted 15 May 2023, Published online: 01 Jun 2023

References

  • KondoN , TakahashiA , OnoK , OhnishiT. DNA damage induced by alkylating agents and repair pathways. J. Nucleic Acids.2010, 543531 (2010).
  • BrownA , KumarS , TchounwouPB. Cisplatin-Based Chemotherapy of Human Cancers. J. Cancer Sci. Ther.11(4), 97 (2019).
  • LiY , LiY , LiJ , PiG , TanW. Paclitaxel- and/or cisplatin-induced ocular neurotoxicity: a case report and literature review. Onco. Targets Ther.7, 1361–1366 (2014).
  • WildingG , CarusoR , LawrenceTSet al.Retinal toxicity after high-dose cisplatin therapy. J. Clin. Oncol.3(12), 1683–1689 (1985).
  • CaraceniA , MartiniC , SpattiG , ThomasA , OnofrjM. Recovering optic neuritis during systemic cisplatin and carboplatin chemotherapy. Acta. Neurol. Scand.96(4), 260–261 (1997).
  • PippittCHJr , MussHB , HomesleyHD , JobsonVW. Cisplatin-associated cortical blindness. Gynecol. Oncol.12, 253–255 (1981).
  • CohenRJ , CuneoRA , CrucigerMP , JackmanAE. Transient left homonymous hemianopsia and encephalopathy following treatment of testicular carcinoma with cisplatinum, vinblastine, and bleomycin. J. Clin. Oncol.1(6), 392–393 (1983).
  • NatarajanG , MalathiR , HollerE. Increased DNA-binding activity of cis-1,1-cyclobutanedicarboxylatodiammineplatinum(II) (carboplatin) in the presence of nucleophiles and human breast cancer MCF-7 cell cytoplasmic extracts: activation theory revisited. Biochem. Pharmacol.58(10), 1625–1629 (1999).
  • RankinEM , PittsJF. Ophthalmic toxicity during carboplatin therapy. Ann. Oncol.4(4), 337–338 (1993).
  • MulvihillA , BudningA , JayVet al.Ocular motility changes after subtenon carboplatin chemotherapy for retinoblastoma. Arch. Ophthalmol.121(8), 1120–1124 (2003).
  • KwanAS , SahuA , PalexesG. Retinal ischemia with neovascularization in cisplatin related retinal toxicity. Am. J. Ophthalmol.141(1), 196–197 (2006).
  • ColvinOM. An overview of cyclophosphamide development and clinical applications. Curr. Pharm. Des.5(8), 555–560 (1999).
  • JackMK , HicksJD. Ocular complications in high-dose chemoradiotherapy and marrow transplantation. Ann. Ophthalmol.13(6), 709–711 (1981).
  • KendeG , SirkinSR , ThomasPR , FreemanAI. Blurring of vision: a previously undescribed complication of cyclophosphamide therapy. Cancer44(1), 69–71 (1979).
  • StevensA , SpoonerD. Lacrimal duct stenosis and other ocular toxicity associated with adjuvant cyclophosphamide, methotrexate and 5-fluorouracil combination chemotherapy for early stage breast cancer. Clin. Oncol. (R. Coll. Radiol.).13(6), 438–440 (2001).
  • ShingletonBJ , BienfangDC , AlbertDM , EnsmingerWD , ChandlerWF , GreenbergHS. Ocular toxicity associated with high-dose carmustine. Arch. Ophthalmol.100(11), 1766–1772 (1982).
  • GrimsonBS , MahaleyMSJr , DubeyHD , DudkaL. Ophthalmic and central nervous system complications following intracarotid BCNU (Carmustine). J Clin. Neuroophthalmol.1(4), 261–264 (1981).
  • LouieAC , TurrisiAT , MuggiaFM , BonoVHJr. Visual abnormalities following nitrosourea treatment. Med. Pediatr. Oncol.5(1), 245–247 (1978).
  • JohnsonDW , CagnoniPJ , SchossauTMet al.Optic disc and retinal microvasculopathy after high-dose chemotherapy and autologous hematopoietic progenitor cell support. Bone Marrow Transplant.24(7), 785–792 (1999).
  • ChrousosGA , OldfieldEH , DoppmanJL , CoganDG. Prevention of ocular toxicity of carmustine (BCNU) with supraophthalmic intracarotid infusion. Ophthalmology93(11), 1471–1475 (1986).
  • NakamuraT , UedaT , UchidaM. Gan To Kagaku Ryoho.19(3), 409–420 (1992).
  • RitchPS , HansenRM , HeuerDK. Ocular toxicity from high-dose cytosine arabinoside. Cancer51(3), 430–432 (1983).
  • MargilethDA , PoplackDG , PizzoPA , LeventhalBG. Blindness during remission in two patients with acute lymphoblastic leukemia: a possible complication of multimodality therapy. Cancer39(1), 58–61 (1977).
  • HigaGM , GockermanJP , HuntAL , JonesMR , HorneBJ. The use of prophylactic eye drops during high-dose cytosine arabinoside therapy. Cancer68(8), 1691–1693 (1991).
  • ÖzcanG , UçakhanÖÖ. Cytarabine-Induced Corneal Toxicity: Clinical Features and Relief of Symptoms with Loteprednol Etabonate 0.5% in Two Patients. Turk. J.Ophthalmol.51(2), 114–117 (2021).
  • ZhangN , YinY , XuSJ , ChenWS. 5-Fluorouracil: mechanisms of resistance and reversal strategies. Molecules.13(8), 1551–1569 (2008).
  • KhawPT , SherwoodMB , MacKaySL , RossiMJ , SchultzG. Five-minute treatments with fluorouracil, floxuridine, and mitomycin have long-term effects on human Tenon's capsule fibroblasts. Arch. Ophthalmol.110(8), 1150–1154 (1992).
  • ShapiroMS , ThoftRA , FriendJ , ParrishRK , GresselMG. 5-Fluorouracil toxicity to the ocular surface epithelium. Invest. Ophthalmol. Vis. Sci.26(4), 580–583 (1985).
  • BrinkHM , BeexLV. Punctal and canalicular stenosis associated with systemic fluorouracil therapy. Report of five cases and review of the literature. Doc. Ophthalmol.90(1), 1–6 (1995).
  • EisemanAS , FlanaganJC , BrooksAB , MitchellEP , PembertonCH. Ocular surface, ocular adnexal, and lacrimal complications associated with the use of systemic 5-fluorouracil. Ophthalmic Plast. Reconstr. Surg.19(3), 216–224 (2003).
  • BukhariDA , AlessaSK , BeheiriSI. Corneal Epithelial Hyperplasia after 5-Fluorouracil Injection. Case Rep. Ophthalmol.9(1), 254–256 (2018).
  • RainaAJ , GilbarPJ , GrewalGD , HolcombeDJ. Optic neuritis induced by 5-fluorouracil chemotherapy: case report and review of the literature. J. Oncol. Pharm. Pract.26(2), 511–516 (2020).
  • ChristophidisN , VajdaFJ , LucasI , LouisWJ. Ocular side effects with 5-fluorouracil. Aust. N. Z. J. Med.9(2), 143–144 (1979).
  • AndersonBJr. Necrotizing uveitis incident to perfusion of intractraial malignancies with nitrogen mustard or related compounds. Trans. Am. Ophthalmol. Soc.58, 95–104 (1960).
  • al-TweigeriT , NabholtzJM , MackeyJR. Ocular toxicity and cancer chemotherapy. A review. Cancer78(7), 1359–1373 (1996).
  • ChoonaraIA , OverendM , BaileyCC. Blurring of vision due to ifosfamide. Cancer Chemother. Pharmacol.20(4), 349 (1987).
  • SimpsonD , DunnC , CurranM , GoaKL. Oxaliplatin: a review of its use in combination therapy for advanced metastatic colorectal cancer. Drugs63(19), 2127–2156 (2003).
  • WaikhomB , FraunfelderFT , HennerWD. Severe ocular irritation and corneal deposits associated with capecitabine use. N. Engl. J. Med.343, 740–741 (2000).
  • KunklerAL , BinkleyEM , MantopoulosDet al.Known and novel ocular toxicities of biologics, targeted agents, and traditional chemotherapeutics. Graefes Arch Clin. Exp. Ophthalmol.257(8), 1771–1781 (2019).
  • ChunHG , Leyland-JonesBR , CarykSM , HothDF. Central nervous system toxicity of fludarabine phosphate. Cancer Treat Rep.70(10), 1225–1228 (1986).
  • KordValeshabad A , MielerWF , SetlurV , ThomasM , ShahidiM. Posterior segment toxicity after gemcitabine and docetaxel chemotherapy. Optom. Vis. Sci.92(5), e110–e113 (2015).
  • GreverMR , DoanCA , KrautEH. Pentostatin in the treatment of hairy-cell leukemia. Best Pract. Res. Clin. Haematol.16(1), 91–99 (2003).
  • VizelM , OsterMW. Ocular side effects of cancer chemotherapy. Cancer49(10), 1999–2002 (1982).
  • CapriG , MunzoneE , TarenziEet al.Optic nerve disturbances: a new form of paclitaxel neurotoxicity. J. Natl Cancer Inst.86(14), 1099–1101 (1994).
  • SkolnickCA , DoughmanDJ. Erosive conjunctivitis and punctual stenosis secondary to docetaxel (taxotere). Eye Contact Lens.29(2), 134–135 (2003).
  • PaulMK , MukhopadhyayAK. Tyrosine kinase - Role and significance in Cancer. Int. J. Med. Sci.1(2), 101–115 (2004).
  • JiaoQ , BiL , RenY , SongS , WangQ , WangYS. Advances in studies of tyrosine kinase inhibitors and their acquired resistance. Mol. Cancer.17(1), 36 (2018).
  • ThomsonRJ , MoshirfarM , RonquilloY. Tyrosine Kinase Inhibitors. In: StatPearls [Internet].StatPearls Publishing, FL, USA (2023).
  • AnX , TiwariAK , SunY , DingPR , AshbyCRJr , ChenZS. BCR-ABL tyrosine kinase inhibitors in the treatment of Philadelphia chromosome positive chronic myeloid leukemia: a review. Leuk. Res.34(10), 1255–1268 (2010).
  • IqbalN , IqbalN. Imatinib: a breakthrough of targeted therapy in cancer. Chemother. Res. Pract.2014, 357027 (2014).
  • FuC , GombosDS , LeeJet al.Ocular toxicities associated with targeted anticancer agents: an analysis of clinical data with management suggestions [published correction appears in Oncotarget. Oncotarget10(9), 1011–1013 (2019).
  • FraunfelderFW , SolomonJ , DrukerBJ , EsmaeliB , KuylJ. Ocular side-effects associated with imatinib mesylate (Gleevec). J. Ocul. Pharmacol. Ther.19(4), 371–375 (2003).
  • McClellandCM , HarocoposGJ , CusterPL. Periorbital edema secondary to imatinib mesylate. Clin. Ophthalmol.4, 427–431 (2010).
  • YılmazF , AlbayrakM , TığlıoğluPet al.Vitreous hemorrhage: a rare ophthalmic adverse effect due to imatinib treatment. Journal of Oncology Pharmacy Practice.28(3), 725–728 (2022).
  • LiuPCC , KoblishH , WuLet al.INCB054828 (pemigatinib), a potent and selective inhibitor of fibroblast growth factor receptors 1, 2, and 3, displays activity against genetically defined tumor models. PLOS One.15(4), e0231877 (2020).
  • AlekseevO , OjuokE , CousinsS. Multifocal serous retinopathy with pemigatinibtherapy for metastatic colon adenocarcinoma. Int. J. Retin. Vitr.7, 34 (2021).
  • BloomWR , EdakkunnathuA , KondapalliSS , BloomTD. Transient pemigatinib-induced subretinal fluid accumulation and serous retinal detachment. Clin. Exp. Optom.1–410.1080/08164622.2022.2086792 (2022).
  • CortesJE , KimDW , Pinilla-IbarzJet al.Ponatinib efficacy and safety in Philadelphia chromosome-positive leukemia: final 5-year results of the phase 2 PACE trial. Blood132(4), 393–404 doi:10.1182/blood-2016-09-739086 (2018).
  • ShinE , LimDH , HanJet al.Markedly increased ocular side effect causing severe vision deterioration after chemotherapy using new or investigational epidermal or fibroblast growth factor receptor inhibitors. BMC Ophthalmol20, 19 (2020).
  • BurgerJA. Bruton Tyrosine Kinase Inhibitors: Present and Future. Cancer J.25(6), 386–393 (2019).
  • MehrabanFar P , RulloJ , FarmerJ , UrtonT. Recurrent Uveitis Related to Ibrutinib for Treatment of Chronic Lymphocytic Leukemia. Ocul. Immunol. Inflamm.30(4), 1005–1008 (2022).
  • BohnM , Bravo-LjubeticL , LeeRWJ , PetrushkinH. Ibrutinib-related uveitis: a report of two severe cases. Eur. J. Ophthalmol.32(4), NP94–NP97 (2022).
  • ByrdJ , O'BrienS , BarrientosJCet al.Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemia. N. Eng. J. Med.371, 213–223 (2014).
  • FuC , GombosDS , LeeJet al.Ocular toxicities associated with targeted anticancer agents: an analysis of clinical data with management suggestions. Oncotarget.8(35), 58709–58727 (2017).
  • ProiettiI , SkrozaN , MicheliniSet al.BRAF inhibitors: molecular targeting and immunomodulatory actions. Cancers (Basel).12(7), 1823 (2020).
  • ChoeCH , McArthurGA , CaroI , KempenJH , AmaravadiRK. Ocular toxicity in BRAF mutant cutaneous melanoma patients treated with vemurafenib. Am. J. Ophthalmol.158(4), 831–837 (2014).
  • ChengY , TianH. Current Development Status of MEK Inhibitors. Molecules.22(10), 1551 (2017).
  • WrightCJ , McCormackPL. Trametinib: first global approval.. Drugs73(11), 1245-54 (2013). https://www.fda.gov/Drugs/InformationOnDrugs/ApprovedDrugs/ucm354478.htm
  • DuncanK , ChangL , PatronasM. MEK inhibitors: a new class of chemotherapeutic agents with ocular toxicity. Eye29, 1003–1012 (2015).
  • Méndez-MartínezS , CalvoP , Ruiz-MorenoOet al.OCULAR ADVERSE EVENTS ASSOCIATED WITH MEK INHIBITORS. Retina.39(8), 1435–1450 (2019).
  • SarnyS , NeumayerM , KoflerJ , El-ShabrawiY. Ocular toxicity due to trametinib and dabrafenib. BMC Ophthalmol.17(1), 146 (2017).
  • RoskoskiRJr. Anaplastic lymphoma kinase (ALK) inhibitors in the treatment of ALK-driven lung cancers. Pharmacol. Res.117, 343–356 (2017).
  • ChelalaE , HoyekS , ArejN , BaaklinyJ , AntounJ. Ocular and orbital side effects of ALK inhibitors: a review article. Future Oncol.15(16), 1939–1945 (2019).
  • AhmadR , MehtaH. The ocular adverse effects of oral drugs. Aust Prescr.44(5), 177 (2021).
  • WeiSC , DuffyCR , AllisonJP. Fundamental mechanisms of immune checkpoint blockade therapy. Cancer Discov.8(9), 1069–1086 (2018).
  • DalvinLA , ShieldsCL , OrloffM , SatoT , ShieldsJA. Checkpoint Inhibitor immune therapy: Systemic Indications and Ophthalmic Side Effects. Retina.38(6), 1063–1078 (2018).
  • NguyenM , IslamMR , LimSW , SahuA , TamjidB. Pembrolizumab Induced Ocular Hypotony With Near Complete Vision Loss, Interstitial Pulmonary Fibrosis and Arthritis. Front Oncol.9, 944 (2019).
  • ChanprapaphK , VachiramonV , RattanakaemakornP. Epidermal growth factor receptor inhibitors: a review of cutaneous adverse events and management. Dermatol. Res. Pract.2014, 734249 (2014).
  • DuboisEA , CohenAF. Panitumumab. Br. J. Clin. Pharmacol.68(4), 482–483 (2009).
  • ShahrokniA , MatuszczakJ , RajebiMR , SaifMW. Erlotinib-induced episcleritis in a patient with pancreatic cancer. JOP.9(2), 216–219 (2008).
  • GiustiRM , ShastriK , PilaroAMet al.U.S. Food and Drug Administration approval: panitumumab for epidermal growth factor receptor-expressing metastatic colorectal carcinoma with progression following fluoropyrimidine-, oxaliplatin-, and irinotecan-containing chemotherapy regimens. Clin. Cancer Res.14(5), 1296–1302 (2008).
  • VaxmanI , AbeykoonJ , DispenzieriAet al.“Real-life” data of the efficacy and safety of belantamab mafodotin in relapsed multiple myeloma—the Mayo Clinic experience. Blood Cancer J.11, 196 (2021).
  • WahabA , RafaeA , MushtaqK , KhakwaniM , KhanA. Ocular toxicity of belantamab mafodotin, an oncological perspective of management in relapsed and refractory multiple myeloma. Front Oncol.11, 678634 (2021).
  • Randall , KatrinaL. Rituximab in autoimmune diseases. Australian Prescriber39(4), 131–134 doi:10.18773/austprescr.2016.053 (2016).
  • CernyT , BorischB , IntronaM , JohnsonP , RoseAL. Mechanism of action of rituximab. Anticancer Drugs13(Suppl. 2), S3–S10 (2002).
  • MCastillejo Becerra C , DingY , KenolB , HendershotA , MearaAS. Ocular side effects of antirheumatic medications: a qualitative review. BMJ Open Ophthalmology5, e000331 (2020).
  • ForanJM , RohatinerAZ , CunninghamDet al.European phase II study of rituximab (chimeric anti-CD20 monoclonal antibody) for patients with newly diagnosed mantle-cell lymphoma and previously treated mantle-cell lymphoma, immunocytoma, and small B-cell lymphocytic lymphoma [published correction appears in J Clin Oncol 2000 May;18(9):2006]. J. Clin. Oncol.18(2), 317–324 (2000).
  • LeeYH , KimCH. Evolution of chimeric antigen receptor (CAR) T cell therapy: current status and future perspectives. Arch. Pharm. Res.42, 607–616 (2019).
  • MumtazAA , FischerA , LutfiFet al.Ocular adverse events associated with chimeric antigen receptor T-cell therapy: a case series and review. Br. J. Ophthalmol.10.1136/bjophthalmol-2021-320814 (2020).
  • AndrewFischer , AlbertLi. CAR T-Cell Therapy Associated Ocular Adverse Events Reported to the Food and Drug Administration. Invest. Ophthalmol. Vis. Sci.61(7), 3636 (2020).
  • NunesAT , AnnunziataCM. Proteasome inhibitors: structure and function. Semin. Oncol.44(6), 377–380 (2017).
  • SharmaA , PreussCV. Bortezomib. [Updated 2022 Sep 21]. In: StatPearls [Internet].StatPearls Publishing, FL, USA (2023).
  • SklarBA , GervasioKA , LengS , GhoshA , ChariA , WuAY. Management and outcomes of proteasome inhibitor associated chalazia and blepharitis: a case series. BMC Ophthalmol.19(1), 110 (2019).
  • VeysMC , DelforgeM , MombaertsI. Treatment with doxycycline for severe bortezomib-associated blepharitis. Clin Lymphoma Myeloma Leuk.16(7), e109–e112 (2016).
  • FoersterCG , CursiefenC , KruseFE. Persisting corneal erosion under cetuximab (Erbitux) treatment (epidermal growth factor receptor antibody). Cornea27(5), 612–614 (2008).
  • TodokoroD , ItakuraH , IbeT , KishiS. Anterior uveitis caused by ocular side effects of afatinib: a case report. Case Rep. Ophthalmol.7(1), 74–78 (2016).
  • DavisME. Ocular Toxicity of Tyrosine Kinase Inhibitors. Oncol. Nurs. Forum.43(2), 235–243 (2016).
  • LoriotY , NecchiA , ParkSHet al.Erdafitinib in locally advanced or metastatic urothelial carcinoma. N. Engl. J. Med.381(4), 338–348 (2019).
  • ChangM , KuriakoseRK , XuK , AlmeidaDRP , ChinEK. Chronic Unilateral Uveitis with Macular Edema Secondary to Dabrafenib for Pilocytic Astrocytoma. Case Rep. Ophthalmol12, 574–577 (2021).
  • SullivanRJ , WeberJ , PatelSet al.A phase Ib/II study of the BRAF inhibitor encorafenib plus the MEK inhibitor binimetinib in patients with BRAFV600E/K -mutant solid tumors. Clin Cancer Res.26(19), 5102–5112 (2020).
  • Urner-BlochU , UrnerM , StiegerP , FrauchigerAL , DummerR , GoldingerSM. Transient MEK inhibitor-associated retinopathy in metastatic melanoma. Ann. Oncol.25(7), 1437–1441 (2014).
  • WatanabeK , OtsuS , HirashimaYet al.A phase I study of binimetinib (MEK162) in Japanese patients with advanced solid tumors. Cancer Chemother. Pharmacol.77(6), 1157–1164 (2016).
  • StjepanovicN , Velazquez-MartinJP , BedardPL. Ocular toxicities of MEK inhibitors and other targeted therapies. Ann. Oncol.27(6), 998–1005 (2016).
  • TarhiniA. Immune-mediated adverse events associated with ipilimumab ctla-4 blockade therapy: the underlying mechanisms and clinical management. Scientifica (Cairo).2013, 857519 (2013).
  • PavlidisNA , PetrisC , BriassoulisEet al.Clear evidence that long-term, low-dose tamoxifen treatment can induce ocular toxicity. A prospective study of 63 patients. Cancer69(12), 2961–2964 (1992).
  • AshfordAR , DonevI , TiwariRP , GarrettTJ. Reversible ocular toxicity related to tamoxifen therapy. Cancer61(1), 33–35 (1988).