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Research Article

Ct, IL-18 Polymorphism, and Laboratory Biomarkers for Predicting Chemosensory Dysfunctions and Mortality in COVID-19

ORCID Icon, ORCID Icon & ORCID Icon
Article: FSO838 | Received 05 Dec 2022, Accepted 17 Feb 2023, Published online: 09 Mar 2023

References

  • LekhrajRampal M , SengLB. Coronavirus disease (COVID-19) pandemic. Med. J. Malays75(2), 95 (2020).
  • MarshallJC , MurthyS , DiazJet al.A minimal common outcome measure set for COVID-19 clinical research. Lancet Infect Dis20(8), e192–e197 (2020).
  • WHO.Coronavirus disease (COVID-19). https://www.who.int/health-topics/coronavirus#tab=tab_3 (March 24, 2020).
  • LechienJR , Chiesa-EstombaCM , DeSiati DRet al.Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study. Eur Arch Oto-Rhino-L277(8), 2251–2261 (2020).
  • HaehnerA , DrafJ , DrägerS , HummelT. Predictive value of sudden olfactory loss in the diagnosis of COVID-19. ORL82(4), 175–180 (2020).
  • MenniC , ValdesAM , FreidinMBet al.Real-time tracking of self-reported symptoms to predict potential COVID-19. Nat. Med.26(7), 1037–1040 (2020).
  • MaoL , JinH , WangMet al.Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol77(6), 683–690 (2020).
  • PollánM , Pérez-GómezB , Pastor-BarriusoRet al.Prevalence of SARS-CoV-2 in Spain (ENE-COVID): a nationwide, population-based seroepidemiological study. Lancet396(10250), 535–544 (2020).
  • Chiesa-EstombaCM , LechienJR , SaussezS. The alteration of smell and taste in COVID-19 patients. A diagnostic resource in primary care. Aten Primaria52(8), 592–593 (2020).
  • DesforgesM , LeCoupanec A , DubeauP , BourgouinA , LajoieL , DubéM. Coronavirus humanos y otros virus respiratorios:¿ patógenos oportunistas subestimados del sistema nervioso central?Virus12(1), 14 (2019).
  • CaoY , LiL , FengZet al.Comparative genetic analysis of the novel coronavirus (2019-nCoV/SARS-CoV-2) receptor ACE2 in different populations. Cell Discov6(1), 1–4 (2020).
  • XuH , ZhongL , DengJet al.High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa. Int J Oral Sci12(1), 1–5 (2020).
  • HuyutM , SoygüderS. The multi-relationship structure between some symptoms and features seen during the new coronavirus 19 infection and the levels of anxiety and depression post-Covid. East J Med27(1), 1–10 (2022).
  • FriskeMM , GiannoneF , SengerM , SeitzR , HanssonAC , SpanagelR. Chronic alcohol intake regulates expression of SARS-CoV2 infection-relevant genes in an organ-specific manner. Alcohol. Clin. Exp. Res. Doi: 10.1111/acer.14981 (2023).
  • RohD , LeeD-H , KimSWet al.The association between olfactory dysfunction and cardiovascular disease and its risk factors in middle-aged and older adults. Sci Rep11(1), 1248 (2021).
  • TsuchiyaH. Gustatory and Saliva Secretory Dysfunctions in COVID-19 Patients with Zinc Deficiency. Life12(3), 353 (2022).
  • MertogluC , HuyutMT , ArslanY , CeylanY , CobanTA. How do routine laboratory tests change in coronavirus disease 2019?Scand J Clin Lab Invest81(1), 24–33 (2021).
  • HuyutMT , ÜstündağH. Prediction of diagnosis and prognosis of COVID-19 disease by blood gas parameters using decision trees machine learning model: a retrospective observational study. Medical Gas Res12(2), 60 (2022).
  • HuyutMT , HuyutZ. Forecasting of Oxidant/Antioxidant levels of COVID-19 patients by using Expert models with biomarkers used in the Diagnosis/Prognosis of COVID-19. Int Immunopharmacol100(5), 108127 (2021).
  • AliAM , RostamHM , FatahMH , NooriCM , AliKM , TawfeeqHM. Serum troponin, D-dimer, and CRP level in severe coronavirus (COVID-19) patients. Immun Inflamm Dis10(3), e582 (2022).
  • DraméM , TabueTeguo M , ProyeEet al.Should RT-PCR be considered a gold standard in the diagnosis of COVID-19?J. Med. Virol.92(11), 2312–2313 (2020).
  • AlBayat S , MundodanJ , HasnainSet al.Can the cycle threshold (Ct) value of RT-PCR test for SARS CoV2 predict infectivity among close contacts?J Infect Public Health14(9), 1201–1205 (2021).
  • TomMR , MinaMJ. To interpret the SARS-CoV-2 test, consider the cycle threshold value. J Clin Infect Dis71(16), 2252–2254 (2020).
  • RajyalakshmiB , SamavedamS , ReddyPR , AluruN. Prognostic value of “Cycle Threshold” in confirmed COVID-19 patients. Indian J Crit Care Med25(3), 322 (2021).
  • AlbahraniS , AlghamdiM , ZakaryNet al.Initial viral cycle threshold values in patients with COVID-19 and their clinical significance. Eur. J. Med. Res.27(1), 101 (2022).
  • NolanKF , GreavesDR , WaldmannHJG. The human interleukin 18 gene IL 18 maps to 11q22. 2-q22. 3, closely linked to the DRD2 gene locus and distinct from mapped IDDM loci. Genomics51(1), 161–163 (1998).
  • GiedraitisV , HeB , HuangW-X , HillertJJJON. Cloning and mutation analysis of the human IL-18 promoter: a possible role of polymorphisms in expression regulation. J. Neuroimmunol.112(1–2), 146–152 (2001).
  • IvanskiF , FerminoBL , DeSouza Cassela PLCet al.ESTUDO DA ASSOCIAÇÃO DE POLIMORFISMOS GENÉTICOS DA IL-18 NA COVID-19. Braz J Infect Dis26, 102593 (2022).
  • SunH , GuoP , ZhangL , WangF. Serum Interleukin-6 Concentrations and the Severity of COVID-19 Pneumonia: A Retrospective Study at a Single Center in Bengbu City, Anhui Province, China, in January and February 2020. Med Sci Monit26, e926941 (2020).
  • ZhangJ , HaoY , OuWet al.Serum interleukin-6 is an indicator for severity in 901 patients with SARS-CoV-2 infection: a cohort study. J Transl Med18(1), 406 (2020).
  • GiannitrapaniL , AugelloG , MirarchiLet al.Outcome predictors in SARS-CoV-2 disease (COVID-19): the prominent role of IL-6 levels and an IL-6 gene polymorphism in a western Sicilian population. J. Infect.85(2), 174–211 (2022).
  • Gui-QiangW , LeiZ , XiaW , Yan-MeiJ , Fu-ShengW. Diagnosis and treatment protocol for COVID-19 patients (tentative 8th edition): interpretation of updated key points. Infect Dis Immun1(01), 17–19 (2021).
  • NhcNatcm. Diagnosis and Treatment Protocol for COVID-19 Patients (Tentative 8th Edition). Infect Dis Immun20(1), 8–16 (2020).
  • EkP , BöttigerB , DahlmanD , HansenKB , NymanM , NilssonAC. A combination of naso- and oropharyngeal swabs improves the diagnostic yield of respiratory viruses in adult emergency department patients. Infect Dis51(4), 241–248 (2019).
  • HuyutMT , VelichkoA , BelyaevM. Detection of Risk Predictors of COVID-19 Mortality with Classifier Machine Learning Models Operated with Routine Laboratory Biomarkers. Appl Sci12(23), 12180 (2022).
  • HuyutMT , VelichkoA. Diagnosis and Prognosis of COVID-19 disease using routine blood values and LogNNet neural network. Sensors22(13), 4820 (2022).
  • HuyutM. Automatic Detection of Severely and Mildly Infected COVID-19 Patients with Supervised Machine Learning Models. IRBM44(1), 100725 (2023).
  • VelichkoA , HuyutMT , BelyaevM , IzotovY , KorzunD. Machine Learning Sensors for Diagnosis of COVID-19 Disease Using Routine Blood Values for Internet of Things Application. Sensors22(20), 7886 (2022).
  • AksuF , ÇapanN , AksuKet al.C-reactive protein levels are raised in stable Chronic obstructive pulmonary disease patients independent of smoking behavior and biomass exposure. J Thorac Dis5(4), 414–421 (2013).
  • HuyutMT , IlkbaharF. The effectiveness of blood routine parameters and some biomarkers as a potential diagnostic tool in the diagnosis and prognosis of Covid-19 disease. Int Immunopharmacol98, 107838 (2021).
  • XieJ , CovassinN , FanZet al.Association between hypoxemia and mortality in patients with COVID-19. Presented at: Mayo Clinic Proceedings.95(6), 1138–1147 (2020).
  • YuH-H , QinC , ChenM , WangW , TianD-S. D-dimer level is associated with the severity of COVID-19. Thromb. Res.195, 219–225 (2020).
  • YalçinKS , KasapoğluB , AlanliR , KüçükayMB , KoşarA. The association of oxygen saturation, tomography findings and D-dimer levels in coronavirus disease 2019 patients. Blood Coagul. Fibrinolysis31(8), 558–561 (2020).
  • HuyutMT , HuyutZ , İlkbaharF , MertoğluC. What is the impact and efficacy of routine immunological, biochemical and hematological biomarkers as predictors of COVID-19 mortality?Int Immunopharmacol105, 108542 (2022).
  • JainA , PandeyAK , KaurJet al.Is there a correlation between viral load and olfactory & taste dysfunction in COVID-19 patients?Am. J. Otolaryngol.42(3), 102911–102911 (2021).
  • ChoRH , ToZW , YeungZWet al.COVID-19 viral load in the severity of and recovery from olfactory and gustatory dysfunction. The Laryngoscope130(11), 2680–2685 (2020).
  • TazikiBalajelini MH , RajabiA , MohammadiMet al.Virus load and incidence of olfactory, gustatory, respiratory, gastrointestinal disorders in COVID-19 patients: a retrospective cohort study. Clin. Otolaryngol.46(6), 1331–1338 (2021).
  • FinstererJ , StollbergerC. Causes of hypogeusia/hyposmia in SARS-CoV2 infected patients. J. Med. Virol.92(10), 1793–1794 (2020).
  • BuchanBW , HoffJS , GmehlinCGet al.Distribution of SARS-CoV-2 PCR cycle threshold values provide practical insight into overall and target-specific sensitivity among symptomatic patients. Am. J. Clin. Pathol.154(4), 479–485 (2020).
  • MertogluC , HuyutMT , OlmezH , TosunM , KantarciM , CobanTA. COVID-19 is more dangerous for older people and its severity is increasing: a case-control study. Med Gas Res12(2), 51 (2022).
  • GriswoldMG , FullmanN , HawleyCet al.Alcohol use and burden for 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet392(10152), 1015–1035 (2018).
  • ChakravartyD , NairSS , HammoudaNet al.Sex differences in SARS-CoV-2 infection rates and the potential link to prostate cancer. Commun Biol3(1), 1–12 (2020).
  • StackG , JonesE , MarsdenMet al.CD200 receptor restriction of myeloid cell responses antagonizes antiviral immunity and facilitates cytomegalovirus persistence within mucosal tissue. PLoS Pathog11(2), e1004641 (2015).
  • BwireGM. Coronavirus: Why Men are More Vulnerable to Covid-19 Than Women?SN Compr Clin Med2(7), 874–876 (2020).
  • KishabaT , TamakiH , ShimaokaY , FukuyamaH , YamashiroS. Staging of acute exacerbation in patients with idiopathic pulmonary fibrosis. Lung192(1), 141–149 (2014).
  • JamalSA , FarooqMU , BidariV. Challenges associated with using cycle threshold (Ct) value of reverse-transcription polymerase chain reaction (RT-PCR) as a criteria for infectiousness of coronavirus disease 2019 (COVID-19) patients in India. Infect. Control Hosp. Epidemiol.43(11), 1730–1731 (2022).
  • AntosA , KwongML , BalmorezT , VillanuevaA , MurakamiS. Unusually High Risks of COVID-19 Mortality with Age-Related Comorbidities: An Adjusted Meta-Analysis Method to Improve the Risk Assessment of Mortality Using the Comorbid Mortality Data. Infect Dis Rep13(3), 700–711 (2021).
  • ZhouF , YuT , DuRet al.Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet395(10229), 1054–1062 (2020).
  • SuleymanG , FadelRA , MaletteKMet al.Clinical characteristics and morbidity associated with coronavirus disease 2019 in a series of patients in metropolitan Detroit. JAMA Netw Open3(6), e2012270–e2012270 (2020).
  • PetrakisD , MarginăD , TsarouhasKet al.Obesity - a risk factor for increased COVID-19 prevalence, severity and lethality. Mol. Med. Rep22(1), 9–19 (2020).
  • FaamB , ZarkeshM , DaneshpourMS , AziziF , HedayatiM. The association between inflammatory markers and obesity-related factors in Tehranian adults: tehran lipid and glucose study. Iran J Basic Med Sci17(8), 577–582 (2014).
  • MoriconiD , MasiS , RebelosEet al.Obesity prolongs the hospital stay in patients affected by COVID-19, and may impact on SARS-COV-2 shedding. Obes Res Clin Pract14(3), 205–209 (2020).
  • Costela-RuizVJ , Illescas-MontesR , Puerta-PuertaJM , RuizC , Melguizo-RodríguezL. SARS-CoV-2 infection: the role of cytokines in COVID-19 disease. Cytokine Growth Factor Rev.54, 62–75 (2020).
  • KarraVK , GummaPK , ChowdhurySJet al.IL-18 polymorphisms in hepatitis B virus related liver disease. Cytokine73(2), 277–282 (2015).
  • Pérez-FloresI , SantiagoJL , Fernández-PérezCet al.Impacts of Interleukin-18 Polymorphisms on the Incidence of Delayed-Onset Cytomegalovirus Infection in a Cohort of Kidney Transplant Recipients. Open Forum Infect Dis6(9), ofz325 (2019).
  • SobtiR , SharmaV , AbitewAet al.IL-18 Gene promoter region 607C/A polymorphism in HIV-1 infected north indian population. Balkan J Med Genet14(2), 41 (2011).
  • CoutinhoLL , OliveiraCN , AlbuquerquePLet al.Elevated IL-18 predicts poor prognosis in critically ill COVID-19 patients at a Brazilian hospital in 2020-21. Future microbiology17, 1287–1294 (2022).
  • ChenW-J , YangJ-Y , LinJ-Het al.Nasopharyngeal shedding of severe acute respiratory syndrome—associated coronavirus is associated with genetic polymorphisms. J Clin Infect Dis42(11), 1561–1569 (2006).