846
Views
0
CrossRef citations to date
0
Altmetric
Review

Oleuropein impact on colorectal cancer

ORCID Icon, ORCID Icon, &
Article: FSO | Received 14 Jul 2023, Accepted 20 Sep 2023, Published online: 23 May 2024

References

  • Borzì AM, Biondi A, Basile F, Luca S, Vicari ES, Vacante M. Olive oil effects on colorectal cancer. Nutrients 11(1), 11010032–11010048 (2019).
  • Malki A, Elruz RA, Gupta I, Allouch A, Vranic S, Al Moustafa A-E. Molecular mechanisms of colon cancer progression and metastasis: recent insights and advancements. Int. J. Mol. Sci. 22(1), 130–155 (2020).
  • Esmeeta A, Adhikary S, Dharshnaa V et al. Plant-derived bioactive compounds in colon cancer treatment: an updated review. Biomed. Pharmacother. 153, 113384–113396 (2022).
  • Debela DT, Muzazu SG, Heraro KD et al. New approaches and procedures for cancer treatment: current perspectives. SAGE Open Med. 9, 20503121211034366–20503121211034366 (2021).
  • Johdi NA, Sukor NF. Colorectal cancer immunotherapy: options and strategies.Front Immunol 11, 11–30 (2020).
  • Zhang Y, Chen Z, Li J. The current status of treatSignal transduct target therment for colorectal cancer in China: a systematic review. Medicine 96(40), e8242–e8248 (2017).
  • Xie Y-H, Chen Y-X, Fang J-Y. Comprehensive review of targeted therapy for colorectal cancer. Signal Transduct Target Ther. 5(1), 1–30 (2020).
  • Benarba B, Pandiella A. Colorectal cancer and medicinal plants: principle findings from recent studies. Biomed. Pharmacother. 107, 408–423 (2018).
  • Nsairat H, Khater D, Sayed U, Odeh F, Al Bawab A, Alshaer W. Liposomes: structure, composition, types, and clinical applications. Heliyon 8(5), e09394–e09409 (2022).
  • Khater D, Nsairat H, Odeh F et al. Design, preparation, and characterization of effective dermal and transdermal lipid nanoparticles: a review. Cosmetics 8(2), 1–43 (2021).
  • Islam MR, Akash S, Rahman MM et al. Colon cancer and colorectal cancer: prevention and treatment by potential natural products. Chem. Biol. Interact. 368, 110170–110195 (2022).
  • Al-Samydai A, Al Qaraleh M, Al Azzam KM et al. Formulating co-loaded nanoliposomes with gallic acid and quercetin for enhanced cancer therapy. Heliyon 9(6), e17267–e17279 (2023).
  • Gamli Ö. The health effects of oleuropein, one of the major phenolic compounds of olives, Olea europaea L. Ital. J. Food Sci. 28(2), 355–358 (2016).
  • Mahmood TH, Al-Samydai A, Sulaibi MA et al. Development of pegylated nano-phytosome formulation with oleuropein and rutin to compare anti-colonic cancer activity with olea europaea leaves extract. Chem. Biodivers. 20(8), e202300534 (2023).
  • Imran M, Nadeem M, Gilani SA, Khan S, Sajid MW, Amir RM. Antitumor perspectives of oleuropein and its metabolite hydroxytyrosol: recent updates. J. Food Sci. 83(7), 1781–1791 (2018).
  • Barbaro B, Toietta G, Maggio R et al. Effects of the olive-derived polyphenol oleuropein on human health. Int. J. Mol. Sci. 15(10), 18508–18524 (2014).
  • Larussa T, Oliverio M, Suraci E et al. Oleuropein decreases cyclooxygenase-2 and interleukin-17 expression and attenuates inflammatory damage in colonic samples from ulcerative colitis patients. Nutrients 9(4), 391–405 (2017).
  • Pojero F, Gervasi F, Fiore SD et al. Anti-inflammatory effects of nutritionally relevant concentrations of oleuropein and hydroxytyrosol on peripheral blood mononuclear cells: an age-related analysis. Int. J. Mol. Sci. 24(13), 29–51 (2023).
  • Emma MR, Augello G, Di Stefano V et al. Potential uses of olive oil secoiridoids for the prevention and treatment of cancer: a narrative review of preclinical studies. Int. J. Mol. Sci. 22(3), 1234–1256 (2021).
  • Sun W, Frost B, Liu J. Oleuropein, unexpected benefits!. Oncotarget 8(11), 17409–17410 (2017).
  • Cárdeno A, Sánchez-Hidalgo M, Rosillo MA, Alarcón De La Lastra C. Oleuropein, a secoiridoid derived from olive tree, inhibits the proliferation of human colorectal cancer cell through downregulation of HIF-1α. Nutr. Cancer 65(1), 147–156 (2013).
  • Giner E, Recio MC, Ríos JL, Cerdá-Nicolás JM, Giner RM. Chemopreventive effect of oleuropein in colitis-associated colorectal cancer in c57bl/6 mice. Mol. Nutr. Food Res. 60(2), 242–255 (2016).
  • Shamshoum H, Vlavcheski F, Tsiani E. Anticancer effects of oleuropein. Biofactors 43(4), 517–528 (2017).
  • Liman R, Çoban FK, Ciğerci IH, Bulduk İ, Bozkurt S. Antiangiogenic and apoptotic effects of oleuropein on breast cancer cells. J. Pharm. Res. Int. 16(4), 1–10 (2017).
  • Liu L, Ahn KS, Shanmugam MK et al. Oleuropein induces apoptosis via abrogating NF-κB activation cascade in estrogen receptor–negative breast cancer cells. J. Cell. Biochem. 120(3), 4504–4513 (2019).
  • Scicchitano S, Vecchio E, Battaglia AM et al. The double-edged sword of oleuropein in ovarian cancer cells: from antioxidant functions to cytotoxic effects. Int. J. Mol. Sci. 24(1), 842–856 (2023).
  • Costales-Carrera A, Fernández-Barral A, Bustamante-Madrid P et al. Comparative study of organoids from patient-derived normal and tumor colon and rectal tissue. Cancers 12(8), 2302–2322 (2020).
  • Rawla P, Sunkara T, Barsouk A. Epidemiology of colorectal cancer: incidence, mortality, survival, and risk factors. Gastroenterol. Rev. 14(2), 89–103 (2019).
  • Patel BB, Majumdar AP. Synergistic role of curcumin with current therapeutics in colorectal cancer: minireview. Nutr Cancer 61(6), 842–848 (2009).
  • Rawla P, Sunkara T, Barsouk AJGRPG. Epidemiology of colorectal cancer: incidence, mortality, survival, and risk factors. Prz Gastroenterol 14(2), 89–103 (2019).
  • Rahimi Pordanjani S, Baeradeh N, Lotfi MH, Pourmohammadi BJRJOMS. Epidemiology of colorectal cancer: incidence, mortality, survival rates and risk factors. RJMS 23(144), 41–50 (2016).
  • Akimoto N, Ugai T, Zhong R et al. Rising incidence of early-onset colorectal cancer—A call to action. Nat Rev Clin Oncol.18(4), 230–243 (2021).
  • Frostberg E, Petersen AH, Bojesen A, Rahr HB, Lindebjerg J, Rønlund KJC. The prevalence of pathogenic or likely pathogenic germline variants in a nationwide cohort of young colorectal cancer patients using a panel of 18 genes associated with colorectal cancer. Cancers 13(20),5094–5106 (2021).
  • Dominguez-Valentin M, Nakken S, Tubeuf H et al. Results of multigene panel testing in familial cancer cases without genetic cause demonstrated by single gene testing.Sci Rep 9(1), 1–9 (2019).
  • Vaill M, Kawanishi K, Varki N, Gagneux P, Varki AJPR. Comparative physiological anthropogeny: exploring molecular underpinnings of distinctly human phenotypes. Physiol Rev 103(3), 2171–2229 2023).
  • Gupta S, Kalaivani S, Rajasundaram A, Ameta GK, Oleiwi AK, Dugbakie BNJBRI. Prediction performance of deep learning for colon cancer survival prediction on SEER data. Biomed Res Int 2022, 1467070–1467080 (2022).
  • Hossain MS, Karuniawati H, Jairoun AA et al. Colorectal cancer: a review of carcinogenesis, global epidemiology, current challenges, risk factors, preventive and treatment strategies. Cancers 14(7),1732–1757 (2022).
  • Mettu NB, Ou F-S, Zemla TJ et al. Assessment of capecitabine and bevacizumab with or without atezolizumab for the treatment of refractory metastatic colorectal cancer: a randomized clinical trial. JAMA OPEN 5(2),e2149040–e214054 (2022).
  • Xie Y-H, Chen Y-X, Fang J-YJST, Therapy T. Comprehensive review of targeted therapy for colorectal cancer. Signal Transduct Target Ther 5(1), 1–30 (2020).
  • Hasbullah HH, Musa MJIJOMS. Gene therapy targeting p53 and KRAS for colorectal cancer treatment: a myth or the way forward? Int J Mol Sci 22(21), 11941 (2021).
  • Weng J, Li S, Zhu Z et al. Exploring immunotherapy in colorectal cancer. Journal of Hematology & Oncology 15(1), 1–28 (2022).
  • Boland PM, Ma WW. Immunotherapy for Colorectal Cancer. Cancers 9(5),50–62 (2017).
  • Patel U, Abernathy J, Savani BN, Oluwole O, Sengsayadeth S, Dholaria BJE. CAR T cell therapy in solid tumors: a review of current clinical trials. EJHaem 3, 24–31 (2022).
  • Mahmoud IS, Hatmal MMM, Abuarqoub D et al. 1,4-naphthoquinone is a potent inhibitor of IRAK1 kinases and the production of inflammatory cytokines in THP-1 differentiated macrophages. ACS Omega 6(39), 25299–25310 (2021).
  • Jia SN, Han YB, Yang R, Yang ZC. Chemokines in colon cancer progression. Presented at: Seminars in Cancer Biology 86(Pt 3), 400–407 (2022).
  • Borowczak J, Szczerbowski K, Maniewski M et al. The role of inflammatory cytokines in the pathogenesis of colorectal carcinoma—recent findings and review. Biomedicines 10(7), 1670 (2022).
  • Al Tbakhi B, Nsairat H, Alshaer W et al. Cinnamaldehyde–cucurbituril complex: investigation of loading efficiency and its role in enhancing cinnamaldehyde in vitro anti-tumor activity. RSC Adv. 12(12), 7540–7549 (2022).
  • Odeh F, Nsairat H, Alshaer W et al. Remote loading of curcumin-in-modified β-cyclodextrins into liposomes using a transmembrane pH gradient. RSC Advances. 9(64), 37148–37161 (2019).
  • Odeh F, Adaileh F, Alshaer W et al. Synthesis of mono-amino substituted γ-CD: host–guest complexation and in vitro cytotoxicity investigation. Molecules 27(5),1683–1696 (2022).
  • Ali Abdalla YO, Subramaniam B, Nyamathulla S et al. Natural products for cancer therapy: a review of their mechanism of actions and toxicity in the past decade.J Trop Med 2022(11 ), 5794350–5794370 (2022).
  • Storniolo CE, Sacanella I, Lamuela-Raventos RM, Moreno JJ. Bioactive compounds of Mediterranean cooked tomato sauce (sofrito) modulate intestinal epithelial cancer cell growth through oxidative stress/arachidonic acid cascade regulation. ACS Omega. 5(28), 17071–17077 (2020).
  • Mazzei R, Piacentini E, Nardi M et al. Production of plant-derived oleuropein aglycone by a combined membrane process and evaluation of its breast anticancer properties.Front Bioeng Biotechnol 8,908–922 (2020).
  • Asgharzade S, Sheikhshabani SH, Ghasempour E et al. The effect of oleuropein on apoptotic pathway regulators in breast cancer cells. Eur J Pharmacol 886,173509–173518 (2020).
  • Márquez K, Márquez N, Ávila F et al. Oleuropein-enriched extract from olive mill leaves by homogenizer-assisted extraction and its antioxidant and antiglycating activities. Front. Nutr. 9, 1253–1267 (2022).
  • Markellos C, Ourailidou M-E, Gavriatopoulou M, Halvatsiotis P, Sergentanis TN, Psaltopoulou TJPO. Olive oil intake and cancer risk: a systematic review and meta-analysis.PLoS One 17(1),e0261649–e0261670 (2022).
  • Zheng Y, Liu Z, Yang X, Liu L, Ahn KSJPR. An updated review on the potential antineoplastic actions of oleuropein.Phytother Res 36(1), 365–379 (2022).
  • Rishmawi S, Haddad F, Dokmak G, Karaman R. A comprehensive review on the anti-cancer effects of oleuropein. Life (Basel). 12(8),1140–1158 (2022).
  • Dixon DA, Blanco FF, Bruno A, Patrignani P. Mechanistic aspects of COX-2 expression in colorectal neoplasia. Recent Results Cancer Res. 191, 7–37 (2013).
  • Garcia-Bates TM, Peslak SA, Baglole CJ, Maggirwar SB, Bernstein SH, Phipps RP. Peroxisome proliferator-activated receptor gamma overexpression and knockdown: impact on human B cell lymphoma proliferation and survival. Cancer Immunol. 58(7), 1071–1083 (2009).
  • El-Tanani M, Nsairat H, Mishra V et al. Ran GTPase and its importance in cellular signaling and malignant phenotype. Int. J. Mol. Sci. 24(4), 3065–3080 (2023).
  • Antoniou C, Hull J.The Anti-cancer Effect of Olea europaea L. Products: a Review. Current Nutrition Reports 10(1),99–124 (2021).
  • Imran M, Nadeem M, Gilani SA, Khan S, Sajid MW, Amir RM. Antitumor perspectives of oleuropein and its metabolite hydroxytyrosol: recent updates. J Food Sci. 83(7), 1781–1791 (2018).
  • Notarnicola M, Pisanti S, Tutino V et al. Effects of olive oil polyphenols on fatty acid synthase gene expression and activity in human colorectal cancer cells. Genes Nutr 6(1), 63–69 (2011).
  • Ruzzolini J, Chioccioli S, Monaco N et al. Oleuropein-rich leaf extract as a broad inhibitor of tumour and macrophage INOS in an Apc mutant rat model. 10(10), 1577–1592 (2021).
  • Bernini R, Carastro I, Palmini G et al. Lipophilization of hydroxytyrosol-enriched fractions from Olea europaea L. byproducts and evaluation of the in vitro effects on a model of colorectal cancer cells. J. Agricultural Food Chem. 65(31), 6506–6512 (2017).
  • Terzuoli E, Giachetti A, Ziche M, Donnini S. Hydroxytyrosol, a product from olive oil, reduces colon cancer growth by enhancing epidermal growth factor receptor degradation. Mol. Nutr. Food Res. 60(3), 519–529 (2016).
  • Karković Marković A, Torić J, Barbarić M, Jakobušić Brala C. Hydroxytyrosol, tyrosol and derivatives and their potential effects on human health. Molecules 24(10), 24102001–24102040 (2019).
  • Llor X, Pons E, Roca A et al. The effects of fish oil, olive oil, oleic acid and linoleic acid on colorectal neoplastic processes. Clinical Nutr. 22(1), 71–79 (2003).
  • Gill CI, Boyd A, Mcdermott E et al. Potential anti-cancer effects of virgin olive oil phenols on colorectal carcinogenesis models in vitro. Int. J. Cancer 117(1), 1–7 (2005).
  • Sun L, Luo C, Liu J. Hydroxytyrosol induces apoptosis in human colon cancer cells through ROS generation. Food Function. 5(8), 1909–1914 (2014).
  • Balkan E. Investigation of the effects of plant phenolic oleuropein on expression levels of xenobiotic metabolizing enzymes along with potential cytotoxic and genotoxic impact on human colon cancer cell line HT-29. Middle East Technical Univ. 1(1), 1–95 (2018).
  • Corona G, Deiana M, Incani A, Vauzour D, Assunta Dessì M, Spencer JPE. Inhibition of p38/CREB phosphorylation and COX-2 expression by olive oil polyphenols underlies their anti-proliferative effects. Biochem. Biophys. Res. Commun. 362(3), 606–611 (2007).
  • Hamdi HK, Castellon R. Oleuropein, a non-toxic olive iridoid, is an anti-tumor agent and cytoskeleton disruptor. Biochem. Biophys. Res. Commun. 334(3), 769–778 (2005).
  • Kim DY, Park S, Yun J et al. Oleuropein induces apoptosis in colorectal tumor spheres via mitochondrial fission. Mol.Cell. Toxicol. 19, 311–319 (2022).
  • Storniolo CE, Cabral M, Busquets MA, Martín-Venegas R, Moreno JJ. Dual behavior of long-chain fatty acids and their cyclooxygenase/lipoxygenase metabolites on human intestinal Caco-2 cell growth. Front. Pharmacol. 11, 529976 (2020).
  • Storniolo CE, Martínez-Hovelman N, Martínez-Huélamo M, Lamuela-Raventos RM, Moreno JJ. Extra virgin olive oil minor compounds modulate mitogenic action of oleic acid on colon cancer cell line. J. Agricult. Food Chem. 67(41), 11420–11427 (2019).
  • Sepporta MV, Fuccelli R, Rosignoli P, Ricci G, Servili M, Fabiani R. Oleuropein Prevents Azoxymethane-Induced Colon Crypt Dysplasia and Leukocytes DNA Damage in A/J Mice. J. Med. Food 19(10), 983–989 (2016).
  • Giner E, Recio MC, Ríos JL, Cerdá-Nicolás JM, Giner RMJMN. Research F. Chemopreventive effect of oleuropein in colitis-associated colorectal cancer in c57bl/6 mice. Mol. Nutr Food Res. 60(2), 242–255 (2016).
  • Giner E, Andújar I, Recio MC, Ríos JL, Cerdá-Nicolás JM, Giner RM. Oleuropein ameliorates acute colitis in mice. J. Agricult. Food Chem. 59(24), 12882–12892 (2011).
  • Ríos JL, Giner E, Recio MC, Giner RM. Oleuropein inhibits key pathways involved in colon cancer and supresses associated colitis colorectal cancer in C57BL/6 mice. Planta Med. 80, 2–30 (2014).
  • Valaei A, Azadeh F, Mostafavi Niaki ST et al. Antioxidant and anticancer potentials of the olive and sesame mixture against dimethylhydrazine-induced colorectal cancer in Wistar rats. Biomed. Res. Int. 2022, 5440773 (2022).
  • Schwingshackl L, Schwedhelm C, Galbete C, Hoffmann GJN. Adherence to Mediterranean diet and risk of cancer: an updated systematic review and meta-analysis. Nutrients 9(10), 1063 (2017).
  • Park Y, Cho YJ, Sung N et al. Oleuropein suppresses endometriosis progression and improves the fertility of mice with endometriosis. J. Biomed. Sci. 29(1), 1–20 (2022).
  • Elamin MH, Elmahi AB, Daghestani MH et al. Synergistic anti-breast-cancer effects of combined treatment with oleuropein and doxorubicin in vivo. Altern. Ther. Health Med. 25(3), 17–24 (2019).