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Meta-Analysis

Low dose insulin infusion versus the standard dose in children with diabetic ketoacidosis: a meta-analysis

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Article: FSO956 | Received 24 Jul 2023, Accepted 13 Dec 2023, Published online: 12 Apr 2024

References

  • Nakhla M, Rahme E, Simard M, Larocque I, Legault L, Li P. Risk of ketoacidosis in children at the time of diabetes mellitus diagnosis by primary caregiver status: a population-based retrospective cohort study. Can. Med. Assoc. J. 190(14), E416–E421 (2018).
  • Edge JA, Ford-Adams ME, Dunger DB. Causes of death in children with insulin dependent diabetes 1990-96. Arch. Dis. Child. 81(4), 318–323 (1999).
  • Lawrence SE, Cummings EA, Gaboury I, Daneman D. Population-based study of incidence and risk factors for cerebral edema in pediatric diabetic ketoacidosis. J. Pediatr. 146(5), 688–692 (2005).
  • Curtis JR, To T, Muirhead S, Cummings E, Daneman D. Recent Trends in Hospitalization for Diabetic Ketoacidosis in Ontario Children. Diabetes Care 25(9), 1591–1596 (2002).
  • Home, Resources, diabetes L with 5th edition | IDF Diabetes Atlas [Internet]. Available from: https://diabetesatlas.org/atlas/fifth-edition/
  • Kidie AA, Lakew AM, Ayele T. Frequency of Diabetic Ketoacidosis and Its Determinants Among Pediatric Diabetes Mellitus Patients in Northwest Ethiopia. Diabetes Metab. Syndr. Obes. Targets Ther. 14, 4819–4827 (2021).
  • Diabetic ketoacidosis – Symptoms, diagnosis and treatment | BMJ Best Practice [Internet]. Available from: https://bestpractice.bmj.com/topics/en-gb/3000097
  • Glaser N, Fritsch M, Priyambada L et al. ISPAD Clinical Practice Consensus Guidelines 2022: diabetic ketoacidosis and hyperglycemic hyperosmolar state. Pediatr. Diabetes 23(7), 835–856 (2022).
  • Neu A, Willasch A, Ehehalt S, Hub R, Ranke MB. DIARY Group Baden-Wuerttemberg. Ketoacidosis at onset of Type 1 diabetes mellitus in children–frequency and clinical presentation. Pediatr. Diabetes 4(2), 77–81 (2003).
  • de Siqueira LFM. Cerebrovascular complications of diabetic ketoacidosis in children. Arq. Bras. Endocrinol. Metabol. 55(4), 288–290 (2011).
  • Bialo SR, Agrawal S, Boney CM, Quintos JB. Rare complications of pediatric diabetic ketoacidosis. World J. Diabetes 6(1), 167–174 (2015).
  • Jayashree M, Williams V, Iyer R. Fluid Therapy For Pediatric Patients With Diabetic Ketoacidosis: Current Perspectives. Diabetes Metab. Syndr. Obes. Targets Ther. 12, 2355–2361 (2019).
  • Gosmanov AR, Gosmanova EO, Kitabchi AE. Hyperglycemic crises: diabetic ketoacidosis and hyperglycemic hyperosmolar state. In: Endotext. [MDText.com, Inc (2021). cited 2023 Nov 15]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK279052/
  • Bohn D, Daneman D. Diabetic ketoacidosis and cerebral edema. Curr. Opin. Pediatr. 14(3), 287–291 (2002).
  • Raghupathy P. Diabetic ketoacidosis in children and adolescents. Indian J. Endocrinol. Metab. 19(7), 55 (2015).
  • Luzi L, Barrett EJ, Groop LC, Ferrannini E, DeFronzo RA. Metabolic effects of low-dose insulin therapy on glucose metabolism in diabetic ketoacidosis. Diabetes 37(11), 1470–1477 (1988).
  • Burghen GA, Etteldorf JN, Fisher JN, Kitabchi AQ. Comparison of high-dose and low-dose insulin by continuous intravenous infusion in the treatment of diabetic ketoacidosis in children. Diabetes Care 3(1), 15–20 (1980).
  • Kitabchi AE. The efficacy of low-dose versus conventional therapy of insulin for treatment of diabetic ketoacidosis. Ann. Intern. Med. 84(6), 633 (1976).
  • Dunger DB, Sperling MA, Acerini CL et al. European Society for Paediatric Endocrinology/Lawson Wilkins Pediatric Endocrine Society consensus statement on diabetic ketoacidosis in children and adolescents. Pediatrics 113(2), e133–e140 (2004).
  • Rameshkumar R, Satheesh P, Jain P et al. Low-dose (0.05 unit/kg/hour) vs standard-dose (0.1 unit/kg/hour) insulin in the management of pediatric diabetic ketoacidosis: a randomized double-blind controlled trial. Indian Pediatr. 58(7), 617–623 (2021).
  • Saikia D, Mittal M, Kanakaraju C, Dhingra D, Kumar M. Efficacy and safety of low dose insulin infusion against standard dose insulin infusion in children with diabetic ketoacidosis – An open labelled randomized controlled trial. Indian J. Endocrinol. Metab. 26(2), 173 (2022).
  • Kumar UA. To Study efficacy and safety of low dose insulin against standard dose insulin infusion inchildren with diabetic ketoacidosis: an open label randomized controlled trail. Eur. J. Mol. Clin. Med. 9(3), 1778–1786 (2022).
  • Oster JR, Singer I. Hyponatremia, hyposmolality, and hypotonicity: tables and fables. Arch. Intern. Med. 159(4), 333 (1999).
  • Hoorn EJ, Carlotti APCP, Costa LAA et al. Preventing a drop in effective plasma osmolality to minimize the likelihood of cerebral edema during treatment of children with diabetic ketoacidosis. J. Pediatr. 150(5), 467–473 (2007).
  • Carlotti APCP. Importance of timing of risk factors for cerebral oedema during therapy for diabetic ketoacidosis. Arch. Dis. Child. 88(2), 170–173 (2003).
  • Cochrane Handbook for Systematic Reviews of Interventions | Cochrane Training [Internet]. Available from: https://training.cochrane.org/handbook
  • Page MJ, McKenzie JE, Bossuyt PM et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372, n71 (2021).
  • EndNote | The best reference management tool [Internet]. Available from: https://endnote.com/
  • Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A. Rayyan-a web and mobile app for systematic reviews. Syst. Rev. 5(1), 210 (2016).
  • Risk of Bias 2 (RoB 2) tool | Cochrane Methods [Internet]. Available from: https://methods.cochrane.org/risk-bias-2
  • RevMan | Cochrane Training [Internet]. Available from: https://training.cochrane.org/online-learning/core-software/revman
  • Closing the Gap between methodologists and end-users: r as a computational back-end | journal of statistical software [Internet]. Available from: https://www.jstatsoft.org/article/view/v049i05
  • Nallasamy K, Jayashree M, Singhi S, Bansal A. Low-dose vs standard-dose insulin in pediatric diabetic ketoacidosis: a randomized clinical trial. JAMA Pediatr. 168(11), 999 (2014).
  • Edge JA, Jakes RW, Roy Y et al. The UK case-control study of cerebral oedema complicating diabetic ketoacidosis in children. Diabetologia 49(9), 2002–2009 (2006).
  • Bradley P, Tobias JD. Serum glucose changes during insulin therapy in pediatric patients with diabetic ketoacidosis. Am. J. Ther. 14(3), 265–268 (2007).
  • Kaur DS, Gupta DHV, Kaul DV, Sethi DGK, Singh DM, Singh DH. Comparison of two different doses of insulin in pediatric diabetic ketoacidosis – a randomized controlled trial. Int. J. Pharma Bio Sci. 11(3), (2020).
  • Puttha R, Cooke D, Subbarayan A et al. Low dose (0.05 units/kg/h) is comparable with standard dose (0.1 units/kg/h) intravenous insulin infusion for the initial treatment of diabetic ketoacidosis in children with Type 1 diabetes-an observational study. Pediatr. Diabetes 11(1), 12–17 (2010).
  • Moulik NR, Jayashree M, Singhi S, Bhalla AK, Attri S. Nutritional status and complications in children with diabetic ketoacidosis. Pediatr. Crit. Care Med. 13(4), e227–e233 (2012).
  • Kitabchi AE. Low-dose insulin therapy in diabetic ketoacidosis: fact or fiction? Diabetes Metab. Rev. 5(4), 337–363 (1989).
  • De Fronzo RA, Hendler R, Simonson D. Insulin resistance is a prominent feature of insulin-dependent diabetes. Diabetes 31(9), 795–801 (1982).
  • Soler NG, Wright AD, Fitzgerald MG, Malins JM. Comparative study of different insulin regimens in management of diabetic ketoacidosis. The Lancet 306(7947), 1221–1224 (1975).
  • Al Hanshi S, Shann F. Insulin infused at 0.05 versus 0.1 units/kg/hr in children admitted to intensive care with diabetic ketoacidosis. Pediatr. Crit Care Med. 12(2), 137–140 (2011).