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Future Science OA Volume 10, 2024 - Issue 1
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Research Article

Enhancing chemosensitivity of PANC1 pancreatic cancer cells to gemcitabine using ANGTPL4, Notch1 and NF-κβ1 siRNAs

Abdulfattah Al-Kadash1 Department of Pharmacology, Faculty of Medicine, The University of Jordan, Amman, 11942, Jordan;2 Cell Therapy Center, The University of Jordan, Amman, 11942, Jordan
,
Walhan Alshaer2 Cell Therapy Center, The University of Jordan, Amman, 11942, JordanCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-2946-7328
ORCID Icon,
Ismail Sami Mahmoud3 Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, The Hashemite University, Zarqa, 13133, Jordan
,
Suha Wehaibi2 Cell Therapy Center, The University of Jordan, Amman, 11942, Jordan
&
Malek Zihlif1 Department of Pharmacology, Faculty of Medicine, The University of Jordan, Amman, 11942, Jordan
Article: FSO918 | Received 31 Jul 2023, Accepted 05 Oct 2023, Published online: 20 May 2024

References

  • Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019 (US statistics). CA Cancer J. Clin. 69, 7–34 (2019).
  • Khader YS, Sharkas GF, Arkoub KH, Alfaqih MA, Nimri OF, Khader AM. The epidemiology and trend of cancer in Jordan, 2000–2013. J Cancer Epidemiol. 2018, 2937067 (2018).
  • Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 68, 394–424 (2018).
  • Yadav D, Lowenfels AB. The epidemiology of pancreatitis and pancreatic cancer. Gastroenterology 144, 1252–1261 (2013).
  • Ye J, Wen J, Ning Y, Li Y. Higher notch expression implies poor survival in pancreatic ductal adenocarcinoma: a systematic review and meta-analysis. Pancreatology. 18, 954–961 (2018).
  • Kirby MK, Ramaker RC, Gertz J et al. RNA sequencing of pancreatic adenocarcinoma tumors yields novel expression patterns associated with long-term survival and reveals a role for ANGPTL4. Molecular Oncology. 10, 1169–1182 (2016).
  • Pramanik KC, Makena MR, Bhowmick K, Pandey MK. Advancement of NF-κβ signaling pathway: a novel target in pancreatic cancer. Int. J. Mol. Sci. 19, 1–14 (2018).
  • Andersson ER, Sandberg R, Lendahl U. Notch signaling: simplicity in design, versatility in function. Development 138(17), 3593–3612 (2011).
  • Gharaibeh L, Elmadany N, Alwosaibai K, Alshaer W. Notch1 in cancer therapy: possible clinical implications and challenges. Mol. Pharmacol. 98(5), 559–576 (2020).
  • Silke J, O'reilly LA. NF-κβ and pancreatic cancer; chapter and verse. Cancers 13(18), 1–35 (2021).
  • Gordon ER, Wright CA, James M, Cooper SJ. Transcriptomic and functional analysis of ANGPTL4 overexpression in pancreatic cancer nominates targets that reverse chemoresistance. BMC Cancer 23(1), 524 (2023).
  • Goh YY, Pal M, Chong HC et al. Angiopoietin-like 4 interacts with matrix proteins to modulate wound healing. J. Biol. Chem. 285(43), 32999–33009 (2010).
  • Huang X, Zhang W, Shao Z et al. Origins and mechanisms of miRNAs and siRNAs. Sci. Rep. 48, 1–8 (2018).
  • Mini E, Nobili S, Caciagli B, Landini I, Mazzei T. Cellular pharmacology of gemcitabine. Ann. Oncol. 17, 7–12 (2006).
  • Fukunaga AK, Marsh S, Murry DJ, Hurley TD, Mcleod HL. Identification and analysis of single-nucleotide polymorphisms in the gemcitabine pharmacologic pathway. Pharmacogenomics Journal. 4, 307–314 (2004).
  • Jia Y, Xie J. Promising molecular mechanisms responsible for gemcitabine resistance in cancer. Genes and Diseases 2, 299–306 (2015).
  • Awasthi N, Zhang C, Schwarz AM et al. Comparative benefits of nab-paclitaxel over gemcitabine or polysorbate-based docetaxel in experimental pancreatic cancer. Carcinogenesis 34, 2361–2369 (2013).
  • Yamamoto M, Taguchi Y, Ito-Kureha T, Semba K, Yamaguchi N, Inoue JI. NF-κβ non-cell-autonomously regulates cancer stem cell populations in the basal-like breast cancer subtype. Nature Communications. 4, 1–13 (2013).
  • Ang HL, Tergaonkar V. Notch and NF-κβ signaling pathways: do they collaborate in normal vertebrate brain development and function? BioEssays 29, 1039–1047 (2007).

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